{"id":"https://openalex.org/W2025849040","doi":"https://doi.org/10.1039/b206642d","title":"Cu(ii) ion coordination to SPARC: a model study on short peptide fragments","display_name":"Cu(ii) ion coordination to SPARC: a model study on short peptide fragments","publication_year":2003,"publication_date":"2003-01-02","ids":{"openalex":"https://openalex.org/W2025849040","doi":"https://doi.org/10.1039/b206642d","mag":"2025849040"},"language":"en","primary_location":{"id":"doi:10.1039/b206642d","doi":"https://doi.org/10.1039/b206642d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b206642d","pdf_url":null,"source":{"id":"https://openalex.org/S36793815","display_name":"New Journal of Chemistry","issn_l":"0398-9836","issn":["0398-9836","1144-0546","1369-9261"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New Journal of Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042378941","display_name":"Maurizio Remelli","orcid":"https://orcid.org/0000-0002-5705-3352","observed_orcids":["https://orcid.org/0000-0002-5705-3352"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Maurizio Remelli","raw_affiliation_strings":["Dipartimento di Chimica, Universit\u00e0 di Ferrara, Via L. Borsari 46, Ferrara, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Chimica, Universit\u00e0 di Ferrara, Via L. Borsari 46, Ferrara, Italia","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027103801","display_name":"Marek \u0141uczkowski","orcid":"https://orcid.org/0000-0002-5721-8380","observed_orcids":["https://orcid.org/0000-0002-5721-8380"]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marek \u0141uczkowski","raw_affiliation_strings":["Faculty of Chemistry, University of Wroc\u0142aw, F. Joliot-Curie 14, Wroc\u0142aw, Poland","Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, Wroclaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, University of Wroc\u0142aw, F. Joliot-Curie 14, Wroc\u0142aw, Poland","institution_ids":["https://openalex.org/I219388962"]},{"raw_affiliation_string":"Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, Wroclaw, Poland","institution_ids":["https://openalex.org/I219388962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057515518","display_name":"Arkadiusz Bonna","orcid":"https://orcid.org/0000-0002-3957-7849","observed_orcids":["https://orcid.org/0000-0002-3957-7849"]},"institutions":[{"id":"https://openalex.org/I40413290","display_name":"University of Gda\u0144sk","ror":"https://ror.org/011dv8m48","country_code":"PL","type":"education","lineage":["https://openalex.org/I40413290"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Arkadiusz Mieczys\u0142aw Bonna","raw_affiliation_strings":["Faculty of Chemistry, University of Gdansk, Sobieskiego 18/1, Gda\u0144sk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, University of Gdansk, Sobieskiego 18/1, Gda\u0144sk, Poland","institution_ids":["https://openalex.org/I40413290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111856023","display_name":"Zbigniew Ma\u0107kiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40413290","display_name":"University of Gda\u0144sk","ror":"https://ror.org/011dv8m48","country_code":"PL","type":"education","lineage":["https://openalex.org/I40413290"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Zbigniew Mackiewicz","raw_affiliation_strings":["Faculty of Chemistry, University of Gdansk, Sobieskiego 18/1, Gda\u0144sk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, University of Gdansk, Sobieskiego 18/1, Gda\u0144sk, Poland","institution_ids":["https://openalex.org/I40413290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002249349","display_name":"Chiara Conato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Conato","raw_affiliation_strings":["Dipartimento di Chimica, Universit\u00e0 di Ferrara, Via L. Borsari 46, Ferrara, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Chimica, Universit\u00e0 di Ferrara, Via L. Borsari 46, Ferrara, Italia","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050708434","display_name":"Henryk Koz\u0142owski","orcid":"https://orcid.org/0000-0001-5769-8583","observed_orcids":["https://orcid.org/0000-0001-5769-8583"]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Henryk Koz\u0142owski","raw_affiliation_strings":["Faculty of Chemistry, University of Wroc\u0142aw, F. Joliot-Curie 14, Wroc\u0142aw, Poland","Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, Wroclaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, University of Wroc\u0142aw, F. Joliot-Curie 14, Wroc\u0142aw, Poland","institution_ids":["https://openalex.org/I219388962"]},{"raw_affiliation_string":"Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, Wroclaw, Poland","institution_ids":["https://openalex.org/I219388962"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042378941","https://openalex.org/A5050708434"],"corresponding_institution_ids":["https://openalex.org/I201324441","https://openalex.org/I219388962"],"apc_list":null,"apc_paid":null,"fwci":1.0875,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.68579838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"27","issue":"2","first_page":"245","last_page":"250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.36500000953674316,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.36500000953674316,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.20759999752044678,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.09279999881982803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sparc","display_name":"SPARC","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cu-ii-complexes","display_name":"copper(II) complexes","score":0.9390000104904175},{"id":"https://openalex.org/keywords/peptide-fragments","display_name":"peptide fragments","score":0.6859999895095825},{"id":"https://openalex.org/keywords/histidine-coordination","display_name":"histidine coordination","score":0.6669999957084656},{"id":"https://openalex.org/keywords/amide-nitrogen","display_name":"amide nitrogen","score":0.7009999752044678},{"id":"https://openalex.org/keywords/copper-binding-site","display_name":"copper binding site","score":0.6159999966621399},{"id":"https://openalex.org/keywords/potentiometric-titration","display_name":"potentiometric titration","score":0.8040000200271606},{"id":"https://openalex.org/keywords/ph-dependent-complexation","display_name":"pH-dependent complexation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/extracellular-matrix-glycoprotein","display_name":"extracellular matrix glycoprotein","score":0.6869999766349792},{"id":"https://openalex.org/keywords/angiogenesis-regulation","display_name":"angiogenesis regulation","score":0.5320000052452087},{"id":"https://openalex.org/keywords/metal-peptide-interactions","display_name":"metal-peptide interactions","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9561388492584229},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8197413086891174},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.6322429180145264},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6178695559501648},{"id":"https://openalex.org/C167392928","wikidata":"https://www.wikidata.org/wiki/Q4820777","display_name":"Tripeptide","level":3,"score":0.6099784970283508},{"id":"https://openalex.org/C13935069","wikidata":"https://www.wikidata.org/wiki/Q2157266","display_name":"Oligopeptide","level":3,"score":0.6007552742958069},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5568737983703613},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5515800714492798},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5250520706176758},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47575753927230835},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.4453813433647156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4152584373950958},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.22950014472007751},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1852397322654724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1039/b206642d","doi":"https://doi.org/10.1039/b206642d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b206642d","pdf_url":null,"source":{"id":"https://openalex.org/S36793815","display_name":"New Journal of Chemistry","issn_l":"0398-9836","issn":["0398-9836","1144-0546","1369-9261"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New Journal of Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:sfera.unife.it:11392/1208088","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11392/1208088","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320330412","display_name":"Scheme for Promotion of Academic and Research Collaboration","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W208372907","https://openalex.org/W1963966659","https://openalex.org/W1963976420","https://openalex.org/W1977986857","https://openalex.org/W1987239717","https://openalex.org/W1988141427","https://openalex.org/W1991321989","https://openalex.org/W1998236525","https://openalex.org/W2016715104","https://openalex.org/W2033254705","https://openalex.org/W2070458959","https://openalex.org/W2071725424","https://openalex.org/W2079263573","https://openalex.org/W2095724936","https://openalex.org/W2099776142","https://openalex.org/W2137331183","https://openalex.org/W2164442310","https://openalex.org/W2754505612"],"related_works":["https://openalex.org/W2002346610","https://openalex.org/W2039445971","https://openalex.org/W2329217097","https://openalex.org/W1995707357","https://openalex.org/W2004146290","https://openalex.org/W1963943870","https://openalex.org/W4413994963","https://openalex.org/W2498105668","https://openalex.org/W2050943100","https://openalex.org/W2082926116"],"abstract_inverted_index":{"SPARC":[0,34,91,202],"(secreted":[1],"protein,":[2],"acidic":[3],"and":[4,29,44,60,92,103,113,124,132,141,198],"rich":[5],"in":[6,25,58,105,193],"cysteine)":[7],"is":[8,42,97,135,161,166],"a":[9,23,50,111],"glycoprotein":[10],"of":[11,36,52,64,86,152,157,185],"the":[12,17,61,83,108,120,148,153,158,169,186,194,205],"extracellular":[13],"matrix":[14],"that":[15,54],"mediates":[16],"cell-matrix":[18],"interactions.":[19],"It":[20],"plays":[21],"also":[22],"role":[24,85],"angiogenesis,":[26],"tumorigenesis,":[27],"caractogenesis":[28],"wound":[30],"healing.":[31],"The":[32,155,183],"human":[33],"consists":[35],"three":[37,121,159,177],"distinct":[38],"modules.":[39],"Module":[40],"II":[41],"follistatin-like":[43],"its":[45,93],"hydrolysis":[46],"gives":[47],"rise":[48],"to":[49,69,80,176,204],"number":[51],"oligopeptides":[53],"can":[55,200],"regulate":[56],"angiogenesis":[57],"vivo":[59],"biological":[62,84],"activity":[63],"which":[65],"has":[66],"been":[67],"related":[68],"their":[70,100,130],"association":[71],"with":[72,119],"endogenous":[73],"or":[74],"exogenous":[75],"copper":[76],"ion.":[77,207],"In":[78,107],"order":[79],"completely":[81],"understand":[82],"metal":[87],"complexes":[88,118],"formed":[89],"by":[90,168],"fragments,":[94,126],"more":[95],"information":[96],"needed":[98],"on":[99,116],"stoichiometry,":[101],"stability":[102],"structure":[104],"solution.":[106],"present":[109],"paper":[110],"potentiometric":[112],"spectroscopic":[114],"investigation":[115],"Cu(II)":[117,206],"SPARC122\u2013126,":[122],"SPARC121\u2013126":[123],"SPARC120\u2013126":[125],"protected":[127],"at":[128],"both":[129],"amino":[131],"carboxylic":[133],"ends,":[134],"reported.":[136],"These":[137],"peptides":[138],"(Ac-HKLHL-NH2,":[139],"Ac-GHKLHL-NH2":[140],"Ac-KGHKLHL-NH2,":[142],"respectively)":[143],"constitute":[144],"good":[145],"models":[146],"for":[147],"strong":[149],"copper-binding":[150],"site":[151],"protein.":[154],"behaviour":[156],"ligands":[160],"very":[162],"similar:":[163],"complex":[164],"formation":[165],"started":[167],"two":[170,187],"His":[171],"residues,":[172],"subsequently":[173],"involving":[174],"up":[175],"amido":[178],"nitrogens,":[179],"as":[180],"pH":[181,196],"increases.":[182],"coordination":[184],"histydyl":[188],"imidazoles":[189],"promotes":[190],"amide":[191],"ionization":[192],"physiological":[195],"range":[197],"this":[199],"explain":[201],"binding":[203]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}