{"id":"https://openalex.org/W2025812985","doi":"https://doi.org/10.1046/j.1365-2281.1997.t01-1-02020.x","title":"Effects of low\u2010dose transdermal scopolamine on autonomic cardiovascular control in healthy young subjects","display_name":"Effects of low\u2010dose transdermal scopolamine on autonomic cardiovascular control in healthy young subjects","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W2025812985","doi":"https://doi.org/10.1046/j.1365-2281.1997.t01-1-02020.x","mag":"2025812985","pmid":"https://pubmed.ncbi.nlm.nih.gov/9156960"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2281.1997.t01-1-02020.x","doi":"https://doi.org/10.1046/j.1365-2281.1997.t01-1-02020.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2281.1997.t01-1-02020.x","pdf_url":null,"source":{"id":"https://openalex.org/S58807641","display_name":"Clinical Physiology","issn_l":"0144-5979","issn":["0144-5979","1365-2281"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113632597","display_name":"R. Vesalainen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"R. K. Vesalainen","raw_affiliation_strings":["University of Turku, Finland","University of Turku,Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turku, Finland","institution_ids":["https://openalex.org/I155660961"]},{"raw_affiliation_string":"University of Turku,Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005625873","display_name":"Kari U. O. Tahvanainen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"K. U. O. Tahvanainen","raw_affiliation_strings":["Tampere University Hospital, Tampere, Finland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tampere University Hospital, Tampere, Finland,","institution_ids":["https://openalex.org/I4210126318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070954879","display_name":"Timo J. Kaila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"T. J. Kaila","raw_affiliation_strings":["Turku University Central Hospital, Turku, Finland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Turku University Central Hospital, Turku, Finland,","institution_ids":["https://openalex.org/I2801970007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012093987","display_name":"Ilkka M Kantola","orcid":"https://orcid.org/0000-0002-6228-522X","observed_orcids":["https://orcid.org/0000-0002-6228-522X"]},"institutions":[{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"I. M. Kantola","raw_affiliation_strings":["Turku University Central Hospital, Turku, Finland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Turku University Central Hospital, Turku, Finland,","institution_ids":["https://openalex.org/I2801970007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044709539","display_name":"Tom Kuusela","orcid":"https://orcid.org/0000-0002-1436-9138","observed_orcids":["https://orcid.org/0000-0002-1436-9138"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"T. A. Kuusela","raw_affiliation_strings":["University of Turku, Turku, Finland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turku, Turku, Finland,","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023540674","display_name":"Dwain L. Eckberg","orcid":"https://orcid.org/0000-0003-3790-871X","observed_orcids":["https://orcid.org/0000-0003-3790-871X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. L. Eckberg","raw_affiliation_strings":["Virginia Commonwealth University, Medical College of Virginia, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Commonwealth University, Medical College of Virginia, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I2801770128","https://openalex.org/I72019824"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5012093987"],"corresponding_institution_ids":["https://openalex.org/I2801970007"],"apc_list":null,"apc_paid":null,"fwci":1.276,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.81361018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"17","issue":"2","first_page":"135","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transdermal-scopolamine","display_name":"transdermal scopolamine","score":0.9459999799728394},{"id":"https://openalex.org/keywords/autonomic-cardiovascular-control","display_name":"autonomic cardiovascular control","score":0.878000020980835},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.9369999766349792},{"id":"https://openalex.org/keywords/blood-pressure-variability","display_name":"blood pressure variability","score":0.7689999938011169},{"id":"https://openalex.org/keywords/posture","display_name":"posture","score":0.5899999737739563},{"id":"https://openalex.org/keywords/standing-posture","display_name":"standing posture","score":0.6439999938011169},{"id":"https://openalex.org/keywords/supine-position","display_name":"supine position","score":0.8830000162124634},{"id":"https://openalex.org/keywords/deep-breathing-test","display_name":"deep breathing test","score":0.6489999890327454},{"id":"https://openalex.org/keywords/rr-interval","display_name":"RR interval","score":0.5849999785423279},{"id":"https://openalex.org/keywords/finger-arterial-pressure","display_name":"finger arterial pressure","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.8977086544036865},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7287151217460632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7054821252822876},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6173040270805359},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6106042861938477},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5695494413375854},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.48975586891174316},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.48064151406288147},{"id":"https://openalex.org/C2778576352","wikidata":"https://www.wikidata.org/wiki/Q337188","display_name":"Scopolamine","level":2,"score":0.4480566680431366},{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.43537983298301697},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.4194182753562927},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3537226915359497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24203923344612122},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.09673210978507996},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2281.1997.t01-1-02020.x","doi":"https://doi.org/10.1046/j.1365-2281.1997.t01-1-02020.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2281.1997.t01-1-02020.x","pdf_url":null,"source":{"id":"https://openalex.org/S58807641","display_name":"Clinical Physiology","issn_l":"0144-5979","issn":["0144-5979","1365-2281"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Physiology","raw_type":"journal-article"},{"id":"pmid:9156960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9156960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical physiology (Oxford, England)","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2003866169","https://openalex.org/W2050484064","https://openalex.org/W2114267629","https://openalex.org/W2074775163","https://openalex.org/W2095479136","https://openalex.org/W2148719645","https://openalex.org/W2030929011","https://openalex.org/W2358265855","https://openalex.org/W2367920140","https://openalex.org/W2016549920"],"abstract_inverted_index":{"We":[0,26],"studied":[1],"how":[2],"posture":[3],"influences":[4],"the":[5,28,45,69,79,82,94,113,123,134,140,173],"effects":[6],"of":[7,21,97],"transdermal":[8,185],"scopolamine":[9,126,138,151,166,186],"on":[10],"autonomic":[11],"cardiovascular":[12],"regulation":[13],"in":[14,77,112,156,162,172,190],"a":[15],"randomized,":[16],"double-blind,":[17],"placebo-controlled":[18],"crossover":[19],"study":[20,147,181],"10":[22],"healthy":[23,163,191],"young":[24,192],"volunteers.":[25,164],"recorded":[27],"electrocardiogram":[29],"and":[30,33,49,52,57,73,81,100,105,159],"auscultatory":[31],"sphygmomanometric":[32],"continuous":[34],"non-invasive":[35],"finger":[36],"arterial":[37,58,75],"pressure":[38,59,76,90,189],"(Finapres":[39],"device)":[40],"to":[41],"obtain":[42],"signals":[43],"for":[44],"beat-by-beat":[46],"R-R":[47,55,71,98,130,143],"interval":[48,56,99,131,144],"systolic,":[50],"mean":[51,70],"diastolic":[53],"pressures.":[54],"variabilities":[60],"were":[61],"characterized":[62],"by":[63],"power":[64,111],"spectral":[65],"analysis.":[66],"Scopolamine":[67,92],"increased":[68,93,139],"intervals":[72],"reduced":[74],"both":[78,157],"supine":[80,124,158],"standing":[83,114,160,174],"positions,":[84],"but":[85],"did":[86,127],"not":[87,128],"affect":[88,129],"blood":[89,188],"variability.":[91,132],"total":[95],"variability":[96,170],"its":[101],"mid-":[102],"(0.07-0.15":[103],"Hz)":[104,108],"high-":[106],"(0.15-0.40":[107],"frequency":[109],"band":[110],"position":[115,175],"during":[116,176],"controlled":[117],"breathing":[118,136],"at":[119],"0.25":[120],"Hz.":[121],"In":[122,133],"position,":[125],"deep":[135],"test,":[137],"maximal":[141],"expiratory-inspiratory":[142],"ratio.":[145],"This":[146],"showed":[148],"that":[149,184],"low-dose":[150],"increases":[152,167],"vagal":[153,178],"cardiac":[154],"inhibition":[155],"positions":[161],"However,":[165],"heart":[168],"rate":[169],"only":[171],"partial":[177],"withdrawal.":[179],"The":[180],"also":[182],"demonstrates":[183],"decreases":[187],"subjects.":[193]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
