{"id":"https://openalex.org/W2025810246","doi":"https://doi.org/10.1046/j.1365-2990.2002.t01-1-00410.x","title":"Differential expression of phosphorylated translation initiation factor 2 alpha in Alzheimer's disease and Creutzfeldt\u2013Jakob's disease","display_name":"Differential expression of phosphorylated translation initiation factor 2 alpha in Alzheimer's disease and Creutzfeldt\u2013Jakob's disease","publication_year":2002,"publication_date":"2002-11-24","ids":{"openalex":"https://openalex.org/W2025810246","doi":"https://doi.org/10.1046/j.1365-2990.2002.t01-1-00410.x","mag":"2025810246","pmid":"https://pubmed.ncbi.nlm.nih.gov/12445160"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2990.2002.t01-1-00410.x","doi":"https://doi.org/10.1046/j.1365-2990.2002.t01-1-00410.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2990.2002.t01-1-00410.x","pdf_url":null,"source":{"id":"https://openalex.org/S148217029","display_name":"Neuropathology and Applied Neurobiology","issn_l":"0305-1846","issn":["0305-1846","1365-2990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropathology and Applied Neurobiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010636987","display_name":"Isidr\u00f3 Ferrer","orcid":"https://orcid.org/0000-0001-9888-8754","observed_orcids":["https://orcid.org/0000-0001-9888-8754"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"I. Ferrer","raw_affiliation_strings":["Departament de Biologia Cellular i Anatomia Patol\u00f2gica, Universitat de Barcelona, Neurol\u00f2gics, Universitat de Barcelona-Hospital Clinic, Barcelona, Spain. 8082ifa@comb.es","Departament de Biologia Cellular i Anatomia Patol\u00f2gica, Universitat de Barcelona, Campus de Bellvitge and Banc de Teixits Neurol\u00f2gics, Universitat de Barcelona-Hospital Clinic, Barcelona, Spain","Institut de Neuropatologia, Hospital Princeps d'Espanya, Hospitalet de Llobregat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Biologia Cellular i Anatomia Patol\u00f2gica, Universitat de Barcelona, Neurol\u00f2gics, Universitat de Barcelona-Hospital Clinic, Barcelona, Spain. 8082ifa@comb.es","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Departament de Biologia Cellular i Anatomia Patol\u00f2gica, Universitat de Barcelona, Campus de Bellvitge and Banc de Teixits Neurol\u00f2gics, Universitat de Barcelona-Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institut de Neuropatologia, Hospital Princeps d'Espanya, Hospitalet de Llobregat","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010636987"],"corresponding_institution_ids":["https://openalex.org/I71999127"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.8187,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.64834594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"28","issue":"6","first_page":"441","last_page":"451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9240000247955322},{"id":"https://openalex.org/keywords/jnk-sapk","display_name":"SAPK/JNK","score":0.8050000071525574},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.968999981880188},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8830000162124634},{"id":"https://openalex.org/keywords/superoxide-dismutase-1","display_name":"superoxide dismutase 1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/amyloid-angiopathy","display_name":"amyloid angiopathy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7329999804496765},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.620876669883728},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6171433925628662},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6106679439544678},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5164180397987366},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.469772070646286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4544045329093933},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.43967169523239136},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.417621910572052},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3671371042728424},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35674840211868286},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3200041651725769},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31118908524513245},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.30993735790252686},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24687877297401428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24267050623893738},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.13226652145385742},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007562","descriptor_name":"Creutzfeldt-Jakob Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007562","descriptor_name":"Creutzfeldt-Jakob Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051958","descriptor_name":"Nuclear Receptor Coactivator 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2990.2002.t01-1-00410.x","doi":"https://doi.org/10.1046/j.1365-2990.2002.t01-1-00410.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2990.2002.t01-1-00410.x","pdf_url":null,"source":{"id":"https://openalex.org/S148217029","display_name":"Neuropathology and Applied Neurobiology","issn_l":"0305-1846","issn":["0305-1846","1365-2990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropathology and Applied Neurobiology","raw_type":"journal-article"},{"id":"pmid:12445160","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12445160","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropathology and applied neurobiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W111387551","https://openalex.org/W179188620","https://openalex.org/W181243607","https://openalex.org/W272568885","https://openalex.org/W960301813","https://openalex.org/W1542215809","https://openalex.org/W1549105044","https://openalex.org/W1549857563","https://openalex.org/W1588635193","https://openalex.org/W1634224068","https://openalex.org/W1662308449","https://openalex.org/W1896970469","https://openalex.org/W1965483182","https://openalex.org/W1972676451","https://openalex.org/W1983789627","https://openalex.org/W1984232007","https://openalex.org/W1985826307","https://openalex.org/W1988509015","https://openalex.org/W1992380863","https://openalex.org/W1996766499","https://openalex.org/W2010754688","https://openalex.org/W2014995109","https://openalex.org/W2018983416","https://openalex.org/W2020355061","https://openalex.org/W2022187494","https://openalex.org/W2024428750","https://openalex.org/W2027189256","https://openalex.org/W2029125930","https://openalex.org/W2032350023","https://openalex.org/W2032843390","https://openalex.org/W2038887966","https://openalex.org/W2040849685","https://openalex.org/W2042347168","https://openalex.org/W2049192526","https://openalex.org/W2049262684","https://openalex.org/W2049972682","https://openalex.org/W2054638295","https://openalex.org/W2057080108","https://openalex.org/W2062354055","https://openalex.org/W2063050557","https://openalex.org/W2065718536","https://openalex.org/W2069787626","https://openalex.org/W2071700771","https://openalex.org/W2073923559","https://openalex.org/W2092556927","https://openalex.org/W2096510701","https://openalex.org/W2116233369","https://openalex.org/W2121113374","https://openalex.org/W2165055107","https://openalex.org/W2168994316","https://openalex.org/W2179896419","https://openalex.org/W2288430548","https://openalex.org/W2338037359","https://openalex.org/W2407797694"],"related_works":["https://openalex.org/W2013806485","https://openalex.org/W283353572","https://openalex.org/W2417105776","https://openalex.org/W2077673010","https://openalex.org/W1992251936","https://openalex.org/W2169920915","https://openalex.org/W2999291506","https://openalex.org/W1988509015","https://openalex.org/W2076016642","https://openalex.org/W2013806951"],"abstract_inverted_index":{"Studies":[0],"in":[1,35,43,57,65,99,109,158,170,180,187,209,214,243,254,258,261,288,320,341,349,365,369,377,389,404,417,442,449],"vitro":[2],"have":[3,16,41],"shown":[4],"that":[5,224,269,428],"phosphorylated":[6,78,82,84,151,163,218,231,236,249,310,331,352,380,383,400,413],"translation":[7],"initiation":[8],"factor":[9],"2":[10,13,80,153,165,191,220,233,238,282,312,333,354,402,415,439],"alpha":[11,154,166,192,239,283,313,334,403,416,440],"(TIF":[12],"alpha)":[14],"may":[15,40],"several":[17],"functions,":[18],"including":[19],"regulation":[20],"of":[21,25,30,68,102,112,121,142,172,205,246,266,299,319,323,412,419],"protein":[22,435],"synthesis,":[23],"control":[24,159],"cell":[26,348],"death":[27],"and":[28,53,70,74,93,98,119,123,133,146,185,212,251,273,336,368,394,426],"procurement":[29],"resistance":[31],"to":[32,62,77,195,279,446],"oxidative":[33,59,304,447],"stress":[34,60,357,448],"nerve":[36,420],"cells.":[37,343],"These":[38],"properties":[39],"implications":[42],"certain":[44,443],"human":[45],"neurodegenerative":[46],"diseases,":[47],"such":[48],"as":[49,360],"Alzheimer's":[50],"disease":[51,55],"(AD)":[52],"Creutzfeldt-Jakob's":[54],"(CJD),":[56],"which":[58,295],"appears":[61],"be":[63],"involved":[64,257],"the":[66,139,143,181,210,215,317],"process":[67],"neurodegeneration":[69],"neurone":[71],"death.":[72],"Single":[73],"double-labelling":[75],"immunohistochemistry":[76],"TIF":[79,152,164,190,219,232,237,281,311,332,353,401,414,438],"alpha,":[81,221],"SAPK/JNK,":[83],"p38,":[85,252],"tau,":[86],"Cu/Zn":[87],"superoxide":[88],"dismutase":[89],"1":[90,276,363],"(SOD":[91],"1)":[92],"cleaved":[94],"caspase-3":[95],"(17":[96],"kDa),":[97],"situ":[100,321],"end-labelling":[101,322],"nuclear":[103,324,338],"DNA":[104,325,339],"fragmentation,":[105],"was":[106,156,168,241,387],"carried":[107],"out":[108],"postmortem":[110],"samples":[111],"10":[113],"patients":[114,126],"with":[115,127,131,136,197,207,228,309,316,422,431],"AD":[116,350],"(stages":[117],"III":[118],"VI":[120],"Braak":[122],"Braak),":[124],"seven":[125],"CJD":[128],"(five":[129],"cases":[130,135],"methionine/methionine":[132],"two":[134],"methionine/valine":[137],"at":[138],"codon":[140],"129":[141],"PrP":[144],"gene)":[145],"eight":[147],"age-matched":[148],"controls.":[149],"No":[150,379],"immunoreactivity":[155,240,386],"found":[157,242],"brains,":[160],"but":[161,201],"strong":[162],"expression":[167,335,364,411],"observed":[169,388],"subpopulations":[171,418],"neurones":[173,196,206,227,247,393,444],"bearing":[174],"neurofibrillary":[175],"tangles":[176],"(NFTs)":[177],"or":[178,382],"pretangles":[179],"hippocampus,":[182],"entorhinal":[183],"cortex":[184],"isocortex":[186,216],"AD.":[188,262,450],"Phosphorylated":[189],"is":[193],"restricted":[194],"abnormal":[198,271,423],"tau":[199,259,272,424,432],"deposition,":[200,425],"only":[202],"approximately":[203],"80%":[204],"NFTs":[208,229],"hippocampus":[211],"60%":[213],"colocalize":[217],"thus":[222],"indicating":[223],"not":[225,307,398],"all":[226],"over-express":[230,399],"alpha.":[234,355],"Moreover,":[235,344,392],"a":[244,370],"percentage":[245],"expressing":[248],"SAPK/JNK":[250,381],"which,":[253],"turn,":[255],"are":[256,277,296,306],"phosphorylation":[260,441],"However,":[263],"dystrophic":[264],"neurites":[265],"senile":[267],"plaques":[268],"contain":[270],"express":[274],"SOD":[275,362],"negative":[278],"antiphosphorylated":[280],"antibodies.":[284],"Smooth":[285],"muscle":[286],"cells":[287,396,421],"blood":[289],"vessels":[290],"affected":[291],"by":[292],"amyloid":[293],"angiopathy,":[294],"putative":[297],"targets":[298],"beta":[300],"A":[301],"4":[302],"amyloid-derived":[303],"stress,":[305],"associated":[308],"immunoreactivity.":[314],"Double-staining":[315],"method":[318],"fragmentation":[326],"demonstrated":[327,376],"no":[328,345],"relationship":[329],"between":[330],"increased":[337],"vulnerability":[340],"individual":[342],"single":[346],"caspase-3-immunoreactive":[347],"expressed":[351],"Oxidative":[356],"response,":[358],"manifested":[359],"positive":[361],"Bergmann":[366],"glia":[367],"few":[371],"reactive":[372],"astrocytes,":[373],"has":[374],"been":[375],"CJD.":[378,405],"p38":[384],"kinase":[385],"these":[390],"cases.":[391],"glial":[395],"do":[397],"The":[406],"present":[407],"results":[408],"demonstrate":[409],"selective":[410],"suggest":[427],"factors":[429],"linked":[430],"deposition":[433],"regulate":[434],"synthesis":[436],"throughout":[437],"sensitive":[445]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}