{"id":"https://openalex.org/W2025757842","doi":"https://doi.org/10.2131/jts.23.supplementii_181","title":"EXCITATORY AMINO ACIDS AND LEAD-INDUCED NEUROTOXICITY","display_name":"EXCITATORY AMINO ACIDS AND LEAD-INDUCED NEUROTOXICITY","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2025757842","doi":"https://doi.org/10.2131/jts.23.supplementii_181","mag":"2025757842","pmid":"https://pubmed.ncbi.nlm.nih.gov/9760459"},"language":"en","primary_location":{"id":"doi:10.2131/jts.23.supplementii_181","doi":"https://doi.org/10.2131/jts.23.supplementii_181","is_oa":true,"landing_page_url":"https://doi.org/10.2131/jts.23.supplementii_181","pdf_url":"https://www.jstage.jst.go.jp/article/jts1976/23/SupplementII/23_SupplementII_181/_pdf","source":{"id":"https://openalex.org/S148595626","display_name":"The Journal of Toxicological Sciences","issn_l":"0388-1350","issn":["0388-1350","1880-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697822","host_organization_name":"Japanese Society of Toxicological Sciences","host_organization_lineage":["https://openalex.org/P4322697822"],"host_organization_lineage_names":["Japanese Society of Toxicological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jts1976/23/SupplementII/23_SupplementII_181/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111624207","display_name":"Tangeng Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tangeng MA","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077788483","display_name":"Hwei\u2010Hsien Chen","orcid":"https://orcid.org/0000-0002-8509-6448","observed_orcids":["https://orcid.org/0000-0002-8509-6448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hwei-Hsien CHEN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111782365","display_name":"Dong Koo Lim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong K. LIM","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082682636","display_name":"Arthur S. Hume","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arthur S. HUME","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109947739","display_name":"Ing Kang Ho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ing K. HO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3271,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.53568546,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"23","issue":"SupplementII","first_page":"181","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lead-neurotoxicity","display_name":"lead neurotoxicity","score":0.972000002861023},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.8500000238418579},{"id":"https://openalex.org/keywords/excitatory-amino-acids","display_name":"excitatory amino acids","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mk-801-binding","display_name":"MK-801 binding","score":0.878000020980835},{"id":"https://openalex.org/keywords/lead-acetate","display_name":"lead acetate","score":0.8529999852180481},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"hippocampal formation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.8420000076293945},{"id":"https://openalex.org/keywords/prenatal-lead-exposure","display_name":"prenatal lead exposure","score":0.843999981880188},{"id":"https://openalex.org/keywords/postnatal-lead-exposure","display_name":"postnatal lead exposure","score":0.7770000100135803},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.847000002861023},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7363941073417664},{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.6324160695075989},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.5929877161979675},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.5916107892990112},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.590863823890686},{"id":"https://openalex.org/C2779224224","wikidata":"https://www.wikidata.org/wiki/Q338810","display_name":"Lead acetate","level":3,"score":0.5505969524383545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5296525359153748},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5266653895378113},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5257509350776672},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5016372203826904},{"id":"https://openalex.org/C2777836312","wikidata":"https://www.wikidata.org/wiki/Q4386371","display_name":"Dizocilpine","level":4,"score":0.4744492769241333},{"id":"https://openalex.org/C2778317145","wikidata":"https://www.wikidata.org/wiki/Q2998089","display_name":"Perirhinal cortex","level":4,"score":0.4492748975753784},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38944312930107117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33686619997024536},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3284314274787903},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.21677884459495544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21664664149284363},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.10111501812934875},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016291","descriptor_name":"Dizocilpine Maleate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2131/jts.23.supplementii_181","doi":"https://doi.org/10.2131/jts.23.supplementii_181","is_oa":true,"landing_page_url":"https://doi.org/10.2131/jts.23.supplementii_181","pdf_url":"https://www.jstage.jst.go.jp/article/jts1976/23/SupplementII/23_SupplementII_181/_pdf","source":{"id":"https://openalex.org/S148595626","display_name":"The Journal of Toxicological Sciences","issn_l":"0388-1350","issn":["0388-1350","1880-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697822","host_organization_name":"Japanese Society of Toxicological Sciences","host_organization_lineage":["https://openalex.org/P4322697822"],"host_organization_lineage_names":["Japanese Society of Toxicological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Toxicological Sciences","raw_type":"journal-article"},{"id":"pmid:9760459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9760459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of toxicological sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2131/jts.23.supplementii_181","doi":"https://doi.org/10.2131/jts.23.supplementii_181","is_oa":true,"landing_page_url":"https://doi.org/10.2131/jts.23.supplementii_181","pdf_url":"https://www.jstage.jst.go.jp/article/jts1976/23/SupplementII/23_SupplementII_181/_pdf","source":{"id":"https://openalex.org/S148595626","display_name":"The Journal of Toxicological Sciences","issn_l":"0388-1350","issn":["0388-1350","1880-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697822","host_organization_name":"Japanese Society of Toxicological Sciences","host_organization_lineage":["https://openalex.org/P4322697822"],"host_organization_lineage_names":["Japanese Society of Toxicological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Toxicological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2025757842.pdf","grobid_xml":"https://content.openalex.org/works/W2025757842.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060979954","https://openalex.org/W2077947995","https://openalex.org/W2443802867","https://openalex.org/W1974810329","https://openalex.org/W2045421013","https://openalex.org/W2396563888","https://openalex.org/W2076917037","https://openalex.org/W2158525829","https://openalex.org/W2053574023","https://openalex.org/W2083691068"],"abstract_inverted_index":{"The":[0,224],"NMDA":[1,22,102,251,275],"receptor":[2,23],"non-competitive":[3],"antagonist,":[4],"[3H]MK-801,":[5],"was":[6,71],"used":[7],"as":[8],"a":[9,96,180,228,258,286],"ligand":[10,272],"for":[11,44,232],"an":[12],"autoradiographic":[13],"study":[14],"to":[15,101,256,274],"determine":[16],"the":[17,74,77,105,119,143,187,195,245,278],"effects":[18,164],"of":[19,60,80,129,165,247,271],"lead":[20,32,61,153,166,178],"on":[21,167],"in":[24,51,62,98,104,118,154,183,186,194,209,215,244,261,277,288],"rat":[25],"brain.":[26],"Adult":[27],"male":[28],"rats":[29,136],"were":[30,49,137,170,212],"given":[31],"acetate,":[33,38],"100":[34],"mg/kg,":[35],"or":[36],"sodium":[37],"36":[39],"mg/kg":[40],"(control),":[41],"by":[42],"i.p.":[43],"7":[45],"days.":[46],"Lead":[47,93],"levels":[48],"detected":[50],"blood":[52],"(41.1":[53],"micrograms/dl)":[54],"and":[55,115,117,126,140,191,193,197,204,218,234,239,266,281],"brain":[56,64,75],"(16.7-29.4":[57],"micrograms/g).":[58],"Concentrations":[59],"various":[63],"regions":[65,241],"did":[66],"not":[67],"differ.":[68],"[3H]MK-801":[69,99,168,184,210],"binding":[70,81,100,169,185,211,273],"heterogeneous":[72],"throughout":[73],"with":[76,150],"following":[78],"order":[79],"densities:":[82],"hippocampal":[83,106,225,279],"formation":[84,107,226,280],">":[85,87,89,91],"cortex":[86,217],"caudate-putamen":[88],"thalamus":[90],"brainstem.":[92],"exposure":[94],"caused":[95,179],"decrease":[97],"receptors":[103,252,276],"including":[108,189],"CA2":[109],"stratum":[110,113],"radiatum,":[111],"CA3":[112],"radiatum":[114],"presubiculum,":[116],"agranular":[120],"insular,":[121],"cingulate,":[122],"entorhinal,":[123],"orbital,":[124],"parietal":[125],"perirhinal":[127],"areas":[128,200,283],"cerebral":[130],"cortex.":[131],"In":[132],"another":[133],"experiment,":[134],"female":[135],"exposed":[138],"pre-":[139],"post-natally":[141],"from":[142],"4th":[144],"+/-":[145],"1":[146],"post":[147],"conception":[148],"day":[149,174],"1,000":[151],"ppm":[152],"their":[155],"drinking":[156],"water.":[157],"This":[158],"treatment":[159],"continued":[160],"after":[161],"weaning.":[162],"No":[163],"found":[171,214],"at":[172,201,205,221],"postnatal":[173],"(PM)":[175],"28.":[176],"However,":[177],"significant":[181],"increase":[182],"hippocampus":[188],"CA1":[190],"CA2,":[192],"occipital":[196],"temporal":[198],"cortical":[199,238,282],"PN":[202,206,222],"56":[203],"112.":[207,223],"Increases":[208],"also":[213],"entorhinal":[216],"dentate":[219],"gyrus":[220],"is":[227],"critical":[229],"neural":[230],"structure":[231],"learning":[233,265],"memory":[235],"processes,":[236],"whereas":[237],"subcortical":[240],"are":[242],"involved":[243],"modulation":[246],"complex":[248],"behavioral":[249],"processes.":[250],"have":[253],"been":[254],"shown":[255],"play":[257,285],"key":[259],"role":[260,287],"synaptic":[262],"plasticity":[263],"underlying":[264],"memory.":[267],"Therefore,":[268],"lead-induced":[269,289],"alterations":[270],"may":[284],"neurotoxicity.":[290]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
