{"id":"https://openalex.org/W2025755958","doi":"https://doi.org/10.12691/ajbr-1-2-2","title":"Subcomponents of Vitamine B Complex Regulate the Growth and Development of Human Brain Derived Cells","display_name":"Subcomponents of Vitamine B Complex Regulate the Growth and Development of Human Brain Derived Cells","publication_year":2013,"publication_date":"2013-04-20","ids":{"openalex":"https://openalex.org/W2025755958","doi":"https://doi.org/10.12691/ajbr-1-2-2","mag":"2025755958"},"language":"en","primary_location":{"id":"doi:10.12691/ajbr-1-2-2","doi":"https://doi.org/10.12691/ajbr-1-2-2","is_oa":true,"landing_page_url":"https://doi.org/10.12691/ajbr-1-2-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210174402","display_name":"American Journal of Biomedical Research","issn_l":"2328-3947","issn":["2328-3947","2328-3955"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Biomedical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.12691/ajbr-1-2-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076987272","display_name":"Kristine Edgar Danielyan","orcid":"https://orcid.org/0000-0003-3109-7565","observed_orcids":["https://orcid.org/0000-0003-3109-7565"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"K.E. Danielyan","raw_affiliation_strings":["Scientific American"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific American","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076987272"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5452,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.69629573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":"2","first_page":"28","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12494","display_name":"Alcoholism and Thiamine Deficiency","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-vitamins","display_name":"B vitamins","score":0.9509999752044678},{"id":"https://openalex.org/keywords/pyridoxine","display_name":"pyridoxine","score":0.9649999737739563},{"id":"https://openalex.org/keywords/riboflavin","display_name":"riboflavin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thiamine","display_name":"thiamine","score":1.0},{"id":"https://openalex.org/keywords/nicotinamide","display_name":"nicotinamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cell-maturation","display_name":"cell maturation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/allopurinol","display_name":"allopurinol","score":0.9229999780654907},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C2776514930","wikidata":"https://www.wikidata.org/wiki/Q423746","display_name":"Pyridoxine","level":2,"score":0.8776638507843018},{"id":"https://openalex.org/C2776203871","wikidata":"https://www.wikidata.org/wiki/Q83187","display_name":"Thiamine","level":2,"score":0.7186510562896729},{"id":"https://openalex.org/C2779728014","wikidata":"https://www.wikidata.org/wiki/Q192423","display_name":"Nicotinamide","level":3,"score":0.580646276473999},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.5413520336151123},{"id":"https://openalex.org/C2780859938","wikidata":"https://www.wikidata.org/wiki/Q3065731","display_name":"Pyridoxal","level":3,"score":0.4747641086578369},{"id":"https://openalex.org/C3020471959","wikidata":"https://www.wikidata.org/wiki/Q183206","display_name":"B vitamins","level":2,"score":0.4689813256263733},{"id":"https://openalex.org/C2776155809","wikidata":"https://www.wikidata.org/wiki/Q130365","display_name":"Riboflavin","level":2,"score":0.4635410010814667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44332951307296753},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43733203411102295},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3955080509185791},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37360215187072754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35983172059059143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35926228761672974},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.351779580116272},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24272695183753967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13499313592910767}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.12691/ajbr-1-2-2","doi":"https://doi.org/10.12691/ajbr-1-2-2","is_oa":true,"landing_page_url":"https://doi.org/10.12691/ajbr-1-2-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210174402","display_name":"American Journal of Biomedical Research","issn_l":"2328-3947","issn":["2328-3947","2328-3955"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Biomedical Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.12691/ajbr-1-2-2","doi":"https://doi.org/10.12691/ajbr-1-2-2","is_oa":true,"landing_page_url":"https://doi.org/10.12691/ajbr-1-2-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210174402","display_name":"American Journal of Biomedical Research","issn_l":"2328-3947","issn":["2328-3947","2328-3955"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Biomedical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W17308123","https://openalex.org/W1563049574","https://openalex.org/W1828830410","https://openalex.org/W1963513209","https://openalex.org/W1971346765","https://openalex.org/W2020803551","https://openalex.org/W2060605020","https://openalex.org/W2064741030","https://openalex.org/W2066776936","https://openalex.org/W2073424126","https://openalex.org/W2090540375","https://openalex.org/W2097694759","https://openalex.org/W2119515450","https://openalex.org/W2244276231","https://openalex.org/W2317266371","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1976866735","https://openalex.org/W2320738925","https://openalex.org/W2329432707","https://openalex.org/W2140421777","https://openalex.org/W2610251854","https://openalex.org/W182599607","https://openalex.org/W2585832809","https://openalex.org/W2416283584","https://openalex.org/W4205123586","https://openalex.org/W2435754580"],"abstract_inverted_index":{"The":[0],"work":[1],"is":[2],"focused":[3],"on":[4],"the":[5,20,27,36,42,50,59,78,81,94,109,114,136,205,209],"role":[6],"of":[7,10,22,26,38,44,53,62,77,93,112,140,157,179,208],"single":[8],"components":[9,61,84,117,178],"Vitamin":[11,63,141,180],"B":[12,64,142,181],"complex:":[13],"pyridoxine,":[14],"riboflavin,":[15],"thiamine,":[16],"and":[17,24,87,123,173,189,213],"nicotinamide":[18,124],"in":[19,41,96,145,199],"processes":[21],"growth":[23,80],"development":[25,188],"human":[28],"brain":[29],"derived":[30],"cells.":[31],"We,":[32],"also,":[33],"have":[34,165],"assayed":[35],"activity":[37,150],"Xanthine":[39],"Oxidase":[40],"presence":[43],"above":[45],"mentioned":[46],"subcomponents":[47,139],"to":[48,185,195,203],"delineate":[49],"possible":[51],"mechanism":[52],"their":[54],"action.":[55],"Results":[56],"indicate":[57],"that":[58,167],"all":[60,137],"complex":[65,143,182],"might":[66,169],"be":[67,196],"responsible":[68,118],"for":[69,119],"cells\u2019":[70,79,90],"growth,":[71],"maturation,":[72],"proliferation.":[73],"During":[74],"early":[75],"period":[76],"most":[82,115],"important":[83,116],"were":[85,121],"thiamine":[86],"Pyridoxine,":[88],"initiating":[89],"proliferation":[91,214],"(number":[92],"cells":[95,187,210],"one":[97],"field:":[98],"2556,":[99],"17\u00b1355,":[100],"68,":[101],"2179,0\u00b1223,55,":[102],"resp)":[103],"vs":[104,129,160],"control":[105,130,161],"(1562,94\u00b1146,45),":[106],"whereas":[107],"during":[108],"late":[110],"stages":[111],"maturation":[113,212],"differentiation,":[120],"riboflavin":[122],"(3774.77\u00b1":[125],"188.41,":[126],"3558.82\u00b1152.90":[127],"resp.":[128],"2905\u00b1263.75;":[131],"p<0.035).":[132],"In":[133],"comparison":[134],"with":[135,171],"other":[138],"only":[144],"pyridoxine":[146],"containing":[147],"samples,":[148],"XO":[149,172],"was":[151],"specifically":[152],"inhibited":[153],"by":[154],"allopurinol":[155],"(percentile":[156],"inhibition":[158],"160,00\u00b160,00":[159],"31,03\u00b16,92,":[162],"p<0,05).":[163],"We":[164],"concluded":[166],"Pyridoxine":[168],"interact":[170],"regulate":[174],"its":[175],"activity.":[176],"All":[177],"are":[183,193],"able":[184],"initiate":[186],"growth;":[190],"however,":[191],"they":[192],"supposed":[194],"selectively":[197],"utilized":[198],"time":[200],"dependent":[201],"manner":[202],"guarantee":[204],"highest":[206],"efficiency":[207],"development,":[211]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
