{"id":"https://openalex.org/W2025726537","doi":"https://doi.org/10.1111/cns.12309","title":"Low\u2010density Lipoprotein Receptor: A Promising Therapeutic Target to Promote Cerebral Beta\u2010amyloid Clearance?","display_name":"Low\u2010density Lipoprotein Receptor: A Promising Therapeutic Target to Promote Cerebral Beta\u2010amyloid Clearance?","publication_year":2014,"publication_date":"2014-08-04","ids":{"openalex":"https://openalex.org/W2025726537","doi":"https://doi.org/10.1111/cns.12309","mag":"2025726537","pmid":"https://pubmed.ncbi.nlm.nih.gov/25091057","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6493077"},"language":"en","primary_location":{"id":"doi:10.1111/cns.12309","doi":"https://doi.org/10.1111/cns.12309","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.12309","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.12309","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.12309","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088645194","display_name":"Jade de Oliveira","orcid":"https://orcid.org/0000-0003-1454-2866","observed_orcids":["https://orcid.org/0000-0003-1454-2866"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jade de Oliveira","raw_affiliation_strings":["Departamento de Bioqu\u00edmica Universidade Federal de Santa Catarina Florian\u00f3polis Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica Universidade Federal de Santa Catarina Florian\u00f3polis Brazil","institution_ids":["https://openalex.org/I4104125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016797870","display_name":"Andreza Fabro De Bem","orcid":"https://orcid.org/0000-0003-1090-5244","observed_orcids":["https://orcid.org/0000-0003-1090-5244"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andreza Fabro de Bem","raw_affiliation_strings":["Departamento de Bioqu\u00edmica Universidade Federal de Santa Catarina Florian\u00f3polis Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica Universidade Federal de Santa Catarina Florian\u00f3polis Brazil","institution_ids":["https://openalex.org/I4104125"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056255179","display_name":"Eduardo Luiz Gasnhar Moreira","orcid":"https://orcid.org/0000-0003-2306-2207","observed_orcids":["https://orcid.org/0000-0003-2306-2207"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Eduardo Luiz Gasnhar Moreira","raw_affiliation_strings":["Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Biotecnologia e Bioci\u00eancias Centro de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Santa Catarina Florian\u00f3polis Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Biotecnologia e Bioci\u00eancias Centro de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Santa Catarina Florian\u00f3polis Brazil","institution_ids":["https://openalex.org/I4104125"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056255179"],"corresponding_institution_ids":["https://openalex.org/I4104125"],"apc_list":{"value":4140,"currency":"USD","value_usd":4140},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09301803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"9","first_page":"877","last_page":"878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.984000027179718},{"id":"https://openalex.org/keywords/amyloid-beta-clearance","display_name":"amyloid-beta clearance","score":0.7760000228881836},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9169999957084656},{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.8029999732971191},{"id":"https://openalex.org/keywords/amyloid-beta-metabolism","display_name":"amyloid-beta metabolism","score":0.6600000262260437},{"id":"https://openalex.org/keywords/amyloid-plaque-formation","display_name":"amyloid plaque formation","score":0.5529999732971191},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.47999998927116394},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6389999985694885},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.6660000085830688},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.5929999947547913},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.5389999747276306},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.44200000166893005},{"id":"https://openalex.org/keywords/apoe2","display_name":"APOE2","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5581181645393372},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.46944400668144226},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.4628905653953552},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42907634377479553},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.42098289728164673},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3903539478778839},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.38783591985702515},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38743841648101807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35804328322410583},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26264843344688416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2622627913951874},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.18521597981452942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17209872603416443},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16240808367729187},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1272127330303192},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0748368501663208},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/cns.12309","doi":"https://doi.org/10.1111/cns.12309","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.12309","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.12309","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5559332","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6493077","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6493077","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6493077","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neurosci Ther","raw_type":"Text"},{"id":"pmid:25091057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25091057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS neuroscience & therapeutics","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1111/cns.12309","doi":"https://doi.org/10.1111/cns.12309","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.12309","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.12309","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323349","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","ror":"https://ror.org/0503xdx77"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2025726537.pdf","grobid_xml":"https://content.openalex.org/works/W2025726537.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1571164484","https://openalex.org/W1582666826","https://openalex.org/W1981117587","https://openalex.org/W1983805020","https://openalex.org/W2017624892","https://openalex.org/W2026723397","https://openalex.org/W2045170882","https://openalex.org/W2084201491","https://openalex.org/W2134137024","https://openalex.org/W2145017801"],"related_works":["https://openalex.org/W2992119391","https://openalex.org/W4210682447","https://openalex.org/W2114079398","https://openalex.org/W4389306047","https://openalex.org/W1582666826","https://openalex.org/W4380877271","https://openalex.org/W1994470054","https://openalex.org/W4386592749","https://openalex.org/W4289134963","https://openalex.org/W2972578173"],"abstract_inverted_index":{"In":[0,140,158,624,834,916],"1985,":[1],"the":[2,43,65,71,89,100,109,126,129,132,142,150,187,192,271,289,294,359,380,455,470,474,517,528,585,621,656,673,701,707,731,746,755,758,776,786,793,796,818,841,846,874,896,914,932,937,958,974,982],"Nobel":[3],"Prize":[4],"in":[5,42,55,64,70,108,131,149,191,209,236,251,278,293,315,338,358,397,433,449,494,516,545,550,562,593,620,706,730,757,805,817,831,850,876,951],"Physiology":[6],"or":[7],"Medicine":[8],"was":[9,500,510,570],"awarded":[10],"jointly":[11],"to":[12,60,87,124,155,287,430,489,502,512,548,638,672,723,814,930,981],"Michael":[13],"S.":[14],"Brown":[15],"and":[16,75,91,136,144,163,194,200,203,211,230,239,267,326,347,373,387,409,438,535,541,575,597,611,615,628,646,661,668,683,689,714,826,870,902,924,1002,1015],"Joseph":[17],"L.":[18],"Goldstein":[19],"for":[20,651,728,800,894,969],"their":[21,29,625,948],"discoveries":[22],"on":[23,446,531,608,947],"regulation":[24,898],"of":[25,67,79,93,111,119,128,134,147,178,216,248,273,291,296,304,333,343,354,361,379,392,415,473,498,527,583,587,613,676,681,704,749,789,820,843,899,939,954,961,1029],"cholesterol":[26],"metabolism.":[27,321],"Among":[28],"findings,":[30],"they":[31],"determined":[32],"that":[33,168,222,309,317,330,368,377,420,432,469,520,549,557,579,602,633,641,665,693,741,766,785,840,905],"familial":[34],"hypercholesterolemia":[35],"(FH)":[36],"is":[37,84,428,467,522,581,782,798,942],"caused":[38,394],"by":[39,99,265,389,436,457,699,771,1019],"genetic":[40],"defects":[41],"low-density":[44],"lipoprotein":[45],"receptor":[46],"(LDLR).":[47],"FH":[48,94,172,279],"heterozygotes":[49],"(1:500)":[50],"exhibit":[51,173],"a":[52,61,116,174,183,302,331,339,351,395,434,523,563,718,725,761,892,965],"50%":[53],"deficiency":[54],"LDLR":[56,130,148,292,310,334,381,393,402,421,441,459,509,529,558,580,603,645,677,694,729,742,767,821,844,890,907,934,962],"expression,":[57],"which":[58,458],"leads":[59],"twofold":[62],"increase":[63,931],"number":[66],"LDL":[68,114],"particles":[69],"blood":[72,779,797],"from":[73,487,775,792,973,1022],"birth":[74],"an":[76,312,642],"increased":[77,401,745,812,866],"risk":[78],"cardiovascular":[80],"disease.":[81,139],"This":[82,256],"prevalence":[83],"sufficiently":[85],"high":[86,176],"warrant":[88],"diagnosis":[90],"treatment":[92],"at":[95],"primary":[96,590],"health":[97],"care":[98],"World":[101],"Health":[102],"Organization.":[103],"Given":[104],"its":[105,773],"pivotal":[106],"role":[107,127,290,314,727],"metabolism":[110,462,770],"apolipoprotein":[112,475],"B-100-containing":[113],"particles,":[115],"great":[117],"deal":[118],"attention":[120],"has":[121,463],"been":[122,928],"devoted":[123],"understanding":[125],"pathogenesis":[133],"atherosclerosis":[135],"coronary":[137],"heart":[138],"contrast,":[141],"physiological":[143],"pathological":[145],"roles":[146],"brain":[151,708,719,777,794],"are":[152,285,979,1017],"only":[153],"beginning":[154],"be":[156,560,649,829,964],"revealed.":[157],"this":[159,207,832,835,917],"regard,":[160,836],"Daniel":[161],"Zamb\u00f3n":[162,266],"colleagues":[164,201,268,348,374,439,576,629,690,715],"1":[165,269],"recently":[166,838],"reported":[167,264,329],"middle-aged":[169,223,252],"patients":[170],"with":[171,260,678,857,865,878],"particularly":[175],"incidence":[177],"mild":[179],"cognitive":[180,188],"impairment":[181],"(MCI),":[182],"transitional":[184],"state":[185],"between":[186,644],"decline":[189],"observed":[190,839],"elderly":[193],"proper":[195],"dementia.":[196,490],"Of":[197],"note,":[198],"Ramirez":[199],"2":[202],"we":[204,220,243,837],"3":[205],"corroborated":[206],"observation":[208,258,272],"ApoB100/LDLr\u2212/\u2212":[210],"LDLr\u2212/\u2212":[212,224,253,854],"experimental":[213,952],"mouse":[214,341,496,622],"models":[215,497,953],"FH,":[217],"respectively.":[218],"Specifically,":[219,655,737,853],"found":[221,501,556,578,601,740,929],"mice":[225,254,367,540,547,851,855],"exhibited":[226],"working,":[227],"spatial":[228],"reference,":[229],"procedural":[231],"memory":[232],"impairments":[233],"without":[234,275],"alterations":[235],"exploratory":[237],"activities":[238],"anxiety-related":[240],"responses.":[241],"Moreover,":[242,573],"did":[244],"not":[245,571],"observe":[246],"signs":[247],"stroke-related":[249],"features":[250],"3.":[255],"latter":[257],"agrees":[259],"previous":[261],"clinical":[262],"data":[263],"regarding":[270],"MCI":[274,488],"cerebrovascular":[276],"disease":[277,298],"patients.":[280],"Currently,":[281],"significant":[282],"research":[283,1020],"efforts":[284],"attempting":[286],"investigate":[288],"development":[295],"Alzheimer's":[297],"(AD)-like":[299],"pathology.":[300],"Notably,":[301,553,712],"series":[303],"elegant":[305],"studies":[306,887],"have":[307,888,927],"shown":[308,511],"plays":[311],"important":[313,429,799],"pathways":[316],"modulate":[318],"amyloid-\u03b2":[319],"(A\u03b2)":[320],"On":[322],"one":[323,763,808],"hand,":[324],"Katsouri":[325,534,596],"Georgopoulos":[327,536,598],"4":[328,537,599],"lack":[332],"aggravated":[335],"amyloid":[336,355,362,447,481,505,532,543,566,697],"deposition":[337,448,482,544,698],"transgenic":[340,366,451],"model":[342],"AD.":[344],"Conversely,":[345,491],"Kim":[346,688],"5":[349,691],"demonstrated":[350,376,692],"marked":[352],"reduction":[353],"plaque":[356,506],"formation":[357],"brains":[360],"precursor":[363],"protein":[364],"(APP)":[365],"overexpress":[369],"LDLR.":[370],"Accordingly,":[371],"Basak":[372,574,627],"6":[375,577,630],"modulation":[378],"levels":[382,515,901,908,960],"altered":[383],"both":[384,406,666],"A\u03b2":[385,398,407,424,461,588,634,647,653,705,735,753,769,790,824,900,911,971],"uptake":[386,408,586,825],"degradation":[388,912],"astrocytes.":[390],"Deletion":[391],"decrease":[396],"uptake,":[399],"whereas":[400,568],"expression":[403],"significantly":[404,503,744],"enhanced":[405],"clearance":[410,774,827,972],"6.":[411,687],"Taken":[412,884],"together,":[413,885],"all":[414],"these":[416,546,554,738,886],"findings":[417],"clearly":[418],"indicate":[419],"can":[422,635],"regulate":[423,513],"levels.":[425],"Nonetheless,":[426],"it":[427],"note":[431],"study":[435],"Fryer":[437],"7,":[440],"deletion":[442,493,604],"had":[443,605],"no":[444,606,1027],"effect":[445],"huAPP":[450],"mice.":[452,552,883],"To":[453],"date,":[454],"mechanism":[456,564],"modulates":[460],"remained":[464],"unclear.":[465],"It":[466,781],"known":[468],"\u03b54":[471],"allele":[472],"E":[476],"(APOE)":[477],"gene":[478],"accelerates":[479],"cerebral":[480],"as":[483,485,891],"well":[484],"progression":[486],"ApoE":[492,514,521,569],"most":[495],"AD":[499],"inhibit":[504],"formation.":[507],"Although":[508],"brain,":[518],"suggesting":[519,640],"potential":[524],"key":[525],"mediator":[526],"effects":[530,849],"deposition,":[533,567],"generated":[538],"5XFAD/ApoE\u2212/\u2212LDLr\u2212/\u2212":[539],"compared":[542],"5XFAD/ApoE\u2212/\u2212":[551],"researchers":[555],"might":[559,809,828],"involved":[561],"affecting":[565],"involved.":[572],"capable":[582],"promoting":[584,772,970],"into":[589,778,795],"astrocytes":[591],"even":[592],"ApoE\u2212/\u2212":[594],"cells.":[595],"also":[600,810],"impact":[607],"APP":[609],"processing":[610],"production":[612],"\u03b1":[614],"\u03b2":[616],"carboxy":[617],"terminal":[618],"fragments":[619],"brain.":[623,915],"study,":[626],"provided":[631,903],"evidence":[632,904],"directly":[636],"bind":[637,671],"LDLR,":[639],"interaction":[643],"could":[648,670,764],"responsible":[650],"LDLR-mediated":[652],"uptake.":[654],"authors":[657,739,978,1025],"showed":[658],"via":[659,860],"immunoprecipitation":[660],"surface":[662],"plasmon":[663],"resonance":[664],"A\u03b240":[667],"A\u03b242":[669],"extracellular":[674,975],"domain":[675],"KD":[679],"values":[680],"47.4":[682],"37.4":[684],"nm,":[685],"respectively":[686],"overexpression":[695,743],"decreases":[696],"altering":[700],"steady-state":[702],"concentration":[703],"interstitial":[709],"fluid":[710],"(ISF).":[711],"Castellano":[713],"8":[716],"used":[717],"efflux":[720],"index":[721],"method":[722],"demonstrate":[724],"unique":[726],"blood\u2013brain":[732],"barrier":[733],"(BBB)-mediated":[734],"clearance.":[736],"appearance":[747],"rate":[748],"endogenously":[750],"produced":[751],"human":[752],"(from":[754],"brain)":[756],"blood.":[759],"As":[760],"result,":[762],"conclude":[765],"affects":[768],"8.":[780],"worth":[783],"noting":[784],"continuous":[787],"removal":[788],"species":[791],"preventing":[801],"potentially":[802],"neurotoxic":[803,848],"accumulations":[804],"ISF.":[806],"Consequently,":[807],"expect":[811],"susceptibility":[813],"A\u03b2-induced":[815,847],"neurotoxicity":[816],"case":[819],"dysfunction":[822],"because":[823],"impaired":[830],"context.":[833],"absence":[842],"potentiated":[845],"9.":[852],"treated":[856,880],"A\u03b21\u201340":[858],"peptide":[859],"acute":[861],"intracerebroventricular":[862],"injection":[863],"presented":[864],"astrogliosis,":[867],"oxidative":[868],"stress,":[869],"cell":[871],"permeability":[872],"within":[873,913],"hippocampus":[875],"comparison":[877],"identically":[879],"wild-type":[881],"C57Bl/6":[882],"identified":[889],"pathway":[893],"mediating":[895],"cellular":[897],"increasing":[906,957],"may":[909,963],"promote":[910],"context,":[918],"some":[919],"compounds,":[920],"including":[921],"tamoxifen,":[922],"statins,":[923],"gemfibrozil":[925],"10,":[926],"hepatic":[933],"levels;":[935],"therefore,":[936],"use":[938],"such":[940],"compounds":[941],"incumbent":[943],"upon":[944],"novel":[945],"investigations":[946],"therapeutic":[949,967],"potentials":[950],"amyloidosis.":[955],"Furthermore,":[956],"glial":[959],"feasible":[966],"strategy":[968],"space.":[976],"The":[977,1024],"thankful":[980],"Brazilian":[983],"institutions:":[984],"Conselho":[985],"Nacional":[986],"de":[987,994,996,998,1004,1010],"Desenvolvimento":[988],"Cient\u00edfico":[989],"e":[990],"Tecnol\u00f3gico":[991],"(CNPq),":[992],"Coordena\u00e7\u00e3o":[993],"Aperfei\u00e7oamento":[995],"Pessoal":[997],"N\u00edvel":[999],"Superior":[1000],"(CAPES),":[1001],"Funda\u00e7\u00e3o":[1003],"Apoio":[1005],"\u00e0":[1006],"Pesquisa":[1007],"do":[1008],"Estado":[1009],"Santa":[1011],"Catarina":[1012],"(FAPESC).":[1013],"ELGM":[1014],"AFB":[1016],"supported":[1018],"fellowships":[1021],"CNPq\u2013Brazil.":[1023],"declare":[1026],"conflict":[1028],"interest.":[1030]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
