{"id":"https://openalex.org/W2025554698","doi":"https://doi.org/10.1016/0162-3109(90)90005-y","title":"Anti-allergic properties of cyclosporin A: inhibition of mediator release from human basophils and rat basophilic leukemia cells (RBL-2H3)","display_name":"Anti-allergic properties of cyclosporin A: inhibition of mediator release from human basophils and rat basophilic leukemia cells (RBL-2H3)","publication_year":1990,"publication_date":"1990-07-01","ids":{"openalex":"https://openalex.org/W2025554698","doi":"https://doi.org/10.1016/0162-3109(90)90005-y","mag":"2025554698","pmid":"https://pubmed.ncbi.nlm.nih.gov/1699910"},"language":"en","primary_location":{"id":"doi:10.1016/0162-3109(90)90005-y","doi":"https://doi.org/10.1016/0162-3109(90)90005-y","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0162-3109(90)90005-y","pdf_url":null,"source":{"id":"https://openalex.org/S131233414","display_name":"Immunopharmacology","issn_l":"0162-3109","issn":["0162-3109","1879-047X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041313393","display_name":"Charles I. Ezeamuzie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charles I. Ezeamuzie","raw_affiliation_strings":["Department of Pharmacology, University College London, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London, U.K","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063839160","display_name":"E. S. K. Assem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"El-Sayed K. Assem","raw_affiliation_strings":["Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, U.K","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063839160"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":0.7636,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.70571071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"20","issue":"1","first_page":"31","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anti-allergic-effects","display_name":"anti-allergic effects","score":0.8569999933242798},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.953000009059906},{"id":"https://openalex.org/keywords/basophils","display_name":"basophils","score":0.8799999952316284},{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/leukotriene-release","display_name":"leukotriene release","score":0.9649999737739563},{"id":"https://openalex.org/keywords/ige-mediated-release","display_name":"IgE-mediated release","score":0.734000027179718},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.8880000114440918},{"id":"https://openalex.org/keywords/calmodulin-antagonists","display_name":"calmodulin antagonists","score":0.7289999723434448},{"id":"https://openalex.org/keywords/immunosuppressive-drugs","display_name":"immunosuppressants","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.8936255574226379},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6255897879600525},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.558854877948761},{"id":"https://openalex.org/C2777456892","wikidata":"https://www.wikidata.org/wiki/Q107988","display_name":"Basophil","level":4,"score":0.5069468021392822},{"id":"https://openalex.org/C2779014961","wikidata":"https://www.wikidata.org/wiki/Q415168","display_name":"Ionophore","level":3,"score":0.47216862440109253},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4685571789741516},{"id":"https://openalex.org/C2779543280","wikidata":"https://www.wikidata.org/wiki/Q2704310","display_name":"Leukotriene C4","level":4,"score":0.4358532130718231},{"id":"https://openalex.org/C187507357","wikidata":"https://www.wikidata.org/wiki/Q18027062","display_name":"Histamine N-methyltransferase","level":5,"score":0.4121851325035095},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.40498122572898865},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3807160258293152},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35096973180770874},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34634891152381897},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.3454006314277649},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2265688180923462},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22361323237419128},{"id":"https://openalex.org/C34400551","wikidata":"https://www.wikidata.org/wiki/Q311568","display_name":"Histamine H2 receptor","level":4,"score":0.10699781775474548},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07117357850074768},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.06282210350036621},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000327","descriptor_name":"Adsorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006633","descriptor_name":"Histamine Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015289","descriptor_name":"Leukotrienes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015471","descriptor_name":"Leukemia, Basophilic, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0162-3109(90)90005-y","doi":"https://doi.org/10.1016/0162-3109(90)90005-y","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0162-3109(90)90005-y","pdf_url":null,"source":{"id":"https://openalex.org/S131233414","display_name":"Immunopharmacology","issn_l":"0162-3109","issn":["0162-3109","1879-047X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology","raw_type":"journal-article"},{"id":"pmid:1699910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1699910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320351","display_name":"Commonwealth Scholarship Commission","ror":"https://ror.org/051x4wh35"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W121524232","https://openalex.org/W638728623","https://openalex.org/W1492540115","https://openalex.org/W1516484156","https://openalex.org/W1543640403","https://openalex.org/W1600941832","https://openalex.org/W1602360551","https://openalex.org/W1769725273","https://openalex.org/W1965201803","https://openalex.org/W1971318524","https://openalex.org/W1986665470","https://openalex.org/W1988117823","https://openalex.org/W1997078403","https://openalex.org/W1997411530","https://openalex.org/W2001692359","https://openalex.org/W2003290185","https://openalex.org/W2012339595","https://openalex.org/W2025538534","https://openalex.org/W2027704731","https://openalex.org/W2030260282","https://openalex.org/W2030928136","https://openalex.org/W2041985793","https://openalex.org/W2042697096","https://openalex.org/W2044603466","https://openalex.org/W2048345403","https://openalex.org/W2052431868","https://openalex.org/W2052548709","https://openalex.org/W2052741482","https://openalex.org/W2053639195","https://openalex.org/W2054628600","https://openalex.org/W2059409746","https://openalex.org/W2061542800","https://openalex.org/W2062036553","https://openalex.org/W2062120260","https://openalex.org/W2064283927","https://openalex.org/W2065750004","https://openalex.org/W2067305334","https://openalex.org/W2071789586","https://openalex.org/W2076595756","https://openalex.org/W2080064179","https://openalex.org/W2085201888","https://openalex.org/W2089850443","https://openalex.org/W2090454518","https://openalex.org/W2093662571","https://openalex.org/W2111243602","https://openalex.org/W2139949747","https://openalex.org/W2166988798","https://openalex.org/W2281179837","https://openalex.org/W2399482548","https://openalex.org/W2411072647","https://openalex.org/W2413880795","https://openalex.org/W2470869994","https://openalex.org/W2505652849","https://openalex.org/W4210809420","https://openalex.org/W4289993926","https://openalex.org/W4313343410"],"related_works":["https://openalex.org/W2076595756","https://openalex.org/W1590126152","https://openalex.org/W2022945960","https://openalex.org/W2079843436","https://openalex.org/W1623863155","https://openalex.org/W2090326098","https://openalex.org/W2065750004","https://openalex.org/W2323819113","https://openalex.org/W2097517368","https://openalex.org/W1999676228"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}