{"id":"https://openalex.org/W2025546802","doi":"https://doi.org/10.1007/s00018-008-8249-1","title":"Atomic model of human cystic fibrosis transmembrane conductance regulator: Membrane-spanning domains and coupling interfaces","display_name":"Atomic model of human cystic fibrosis transmembrane conductance regulator: Membrane-spanning domains and coupling interfaces","publication_year":2008,"publication_date":"2008-07-02","ids":{"openalex":"https://openalex.org/W2025546802","doi":"https://doi.org/10.1007/s00018-008-8249-1","mag":"2025546802","pmid":"https://pubmed.ncbi.nlm.nih.gov/18597042","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11131860"},"language":"en","primary_location":{"id":"doi:10.1007/s00018-008-8249-1","doi":"https://doi.org/10.1007/s00018-008-8249-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00018-008-8249-1","pdf_url":null,"source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11131860/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111792196","display_name":"Jean\u2010Paul Mornon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145605","display_name":"Institut de min\u00e9ralogie, de physique des mat\u00e9riaux et de cosmochimie","ror":"https://ror.org/05abgg682","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2802818602","https://openalex.org/I39804081","https://openalex.org/I4210090127","https://openalex.org/I4210098836","https://openalex.org/I4210123595","https://openalex.org/I4210131494","https://openalex.org/I4210145605","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.-P. Mornon","raw_affiliation_strings":["Universit\u00e9 Pierre et Marie Curie-Paris 6, IMPMC-UMR7590, Campus Boucicaut, 140 rue de Lourmel, Paris 75015, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie-Paris 6, IMPMC-UMR7590, Campus Boucicaut, 140 rue de Lourmel, Paris 75015, France","institution_ids":["https://openalex.org/I4210145605","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113468425","display_name":"Pierre Lehn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I161929037","display_name":"Universit\u00e9 de Bretagne Occidentale","ror":"https://ror.org/01b8h3982","country_code":"FR","type":"education","lineage":["https://openalex.org/I161929037","https://openalex.org/I4405260085"]},{"id":"https://openalex.org/I4405260085","display_name":"Universit\u00e9 de Bretagne Occidentale","ror":"https://ror.org/0372th171","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260085"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Lehn","raw_affiliation_strings":["INSERM, U613, Brest, 29200, France","Universit\u00e9 de Bretagne Occidentale, Brest, 29200, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U613, Brest, 29200, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 de Bretagne Occidentale, Brest, 29200, France","institution_ids":["https://openalex.org/I161929037","https://openalex.org/I4405260085"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083064307","display_name":"Isabelle Callebaut","orcid":"https://orcid.org/0000-0003-3124-887X","observed_orcids":["https://orcid.org/0000-0003-3124-887X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I148261361","display_name":"Institut de physique du globe de Paris","ror":"https://ror.org/004gzqz66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I148261361","https://openalex.org/I204730241","https://openalex.org/I4210148025"]},{"id":"https://openalex.org/I4210145605","display_name":"Institut de min\u00e9ralogie, de physique des mat\u00e9riaux et de cosmochimie","ror":"https://ror.org/05abgg682","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2802818602","https://openalex.org/I39804081","https://openalex.org/I4210090127","https://openalex.org/I4210098836","https://openalex.org/I4210123595","https://openalex.org/I4210131494","https://openalex.org/I4210145605","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"I. Callebaut","raw_affiliation_strings":["CNRS, Paris, 75016, France","Institut de Physique Globe de Paris-IPGP, Paris, 75005, France","Universit\u00e9 Paris Diderot-Paris 7, Paris, 75013, France","Universit\u00e9 Pierre et Marie Curie-Paris 6, IMPMC-UMR7590, Campus Boucicaut, 140 rue de Lourmel, Paris, 75015, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Paris, 75016, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Institut de Physique Globe de Paris-IPGP, Paris, 75005, France","institution_ids":["https://openalex.org/I148261361"]},{"raw_affiliation_string":"Universit\u00e9 Paris Diderot-Paris 7, Paris, 75013, France","institution_ids":["https://openalex.org/I4387154366"]},{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie-Paris 6, IMPMC-UMR7590, Campus Boucicaut, 140 rue de Lourmel, Paris, 75015, France","institution_ids":["https://openalex.org/I4210145605","https://openalex.org/I4405264447"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5083064307"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I148261361","https://openalex.org/I4210145605","https://openalex.org/I4387154366","https://openalex.org/I4405264447"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":12.6265,"has_fulltext":false,"cited_by_count":163,"citation_normalized_percentile":{"value":0.98956059,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"65","issue":"16","first_page":"2594","last_page":"2612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cystic-fibrosis-transmembrane-conductance-regulator","display_name":"cystic fibrosis transmembrane conductance regulator","score":0.9869999885559082},{"id":"https://openalex.org/keywords/atomic-models","display_name":"atomic models","score":0.6850000023841858},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nucleotide-binding-domain","display_name":"nucleotide-binding domain","score":0.984000027179718},{"id":"https://openalex.org/keywords/sav1866","display_name":"Sav1866","score":0.9539999961853027},{"id":"https://openalex.org/keywords/intracellular-loop","display_name":"intracellular loop","score":0.800000011920929},{"id":"https://openalex.org/keywords/hydrogen-bond-network","display_name":"hydrogen bond network","score":0.6620000004768372},{"id":"https://openalex.org/keywords/substrate-translocation","display_name":"substrate translocation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C2778428886","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"Cystic fibrosis transmembrane conductance regulator","level":3,"score":0.929236650466919},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.6200335621833801},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.5576865077018738},{"id":"https://openalex.org/C121932024","wikidata":"https://www.wikidata.org/wiki/Q5159376","display_name":"Conductance","level":2,"score":0.5557432174682617},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5299630761146545},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5260417461395264},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5064440965652466},{"id":"https://openalex.org/C2777893369","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"\u0394F508","level":4,"score":0.4252520799636841},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.41426512598991394},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40416795015335083},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35800206661224365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30676305294036865},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24386045336723328},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1901397705078125},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1487252116203308},{"id":"https://openalex.org/C26873012","wikidata":"https://www.wikidata.org/wiki/Q214781","display_name":"Condensed matter physics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00018-008-8249-1","doi":"https://doi.org/10.1007/s00018-008-8249-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00018-008-8249-1","pdf_url":null,"source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},{"id":"pmid:18597042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18597042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular life sciences : CMLS","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11131860","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11131860/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Life Sci","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-00288535v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00288535","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular and Molecular Life Sciences, 2008, pp.1-39","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11131860","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11131860/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Life Sci","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1526474308","https://openalex.org/W1971003485","https://openalex.org/W2015199039","https://openalex.org/W2127402429","https://openalex.org/W2137704498","https://openalex.org/W2161849629"],"related_works":["https://openalex.org/W4213396289","https://openalex.org/W1991042615","https://openalex.org/W2048751695","https://openalex.org/W7098895703","https://openalex.org/W2161051140","https://openalex.org/W1963790115","https://openalex.org/W317957943","https://openalex.org/W2161849629","https://openalex.org/W2171278423","https://openalex.org/W2009538230"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
