{"id":"https://openalex.org/W2025534638","doi":"https://doi.org/10.1249/01.mss.0000353366.57030.88","title":"Increased Skeletal Muscle Mass And Improved Contractile Properties Of Skeletal Muscles Of Old Myostatin-deficient Mice","display_name":"Increased Skeletal Muscle Mass And Improved Contractile Properties Of Skeletal Muscles Of Old Myostatin-deficient Mice","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W2025534638","doi":"https://doi.org/10.1249/01.mss.0000353366.57030.88","mag":"2025534638"},"language":"en","primary_location":{"id":"doi:10.1249/01.mss.0000353366.57030.88","doi":"https://doi.org/10.1249/01.mss.0000353366.57030.88","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000353366.57030.88","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027580707","display_name":"Christopher L. Mendias","orcid":"https://orcid.org/0000-0002-2384-0171","observed_orcids":["https://orcid.org/0000-0002-2384-0171"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L. Mendias","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI","(No relationships reported)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027080502","display_name":"Konstantin I. Bakhurin","orcid":"https://orcid.org/0000-0003-3660-4343","observed_orcids":["https://orcid.org/0000-0003-3660-4343"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Konstantin I. Bakhurin","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI","(No relationships reported)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071424209","display_name":"Carol S. Davis","orcid":"https://orcid.org/0000-0003-3082-8995","observed_orcids":["https://orcid.org/0000-0003-3082-8995"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol S. Davis","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI","(No relationships reported)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109004985","display_name":"John A. Faulkner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Faulkner","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI","(No relationships reported)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13219687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"5","first_page":"34","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myostatin","display_name":"myostatin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mstn-knockout-mice","display_name":"Mstn knockout mice","score":0.9129999876022339},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.6299999952316284},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7009999752044678},{"id":"https://openalex.org/keywords/skeletal-muscle-mass","display_name":"skeletal muscle mass","score":0.953000009059906},{"id":"https://openalex.org/keywords/muscle-contractile-properties","display_name":"muscle contractile properties","score":0.7979999780654907},{"id":"https://openalex.org/keywords/isometric-force","display_name":"isometric force","score":0.828000009059906},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.7990000247955322},{"id":"https://openalex.org/keywords/edl-muscle","display_name":"EDL muscle","score":0.8740000128746033},{"id":"https://openalex.org/keywords/muscle-growth","display_name":"muscle growth","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.9791015386581421},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.8041625618934631},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7746729850769043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7597063779830933},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7314807772636414},{"id":"https://openalex.org/C2776104385","wikidata":"https://www.wikidata.org/wiki/Q1954164","display_name":"Soleus muscle","level":3,"score":0.5390687584877014},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5366038680076599},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.5257124304771423},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.456277996301651},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3595264256000519},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23193106055259705}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1249/01.mss.0000353366.57030.88","doi":"https://doi.org/10.1249/01.mss.0000353366.57030.88","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000353366.57030.88","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W141966924","https://openalex.org/W7099503238","https://openalex.org/W2100924222","https://openalex.org/W2166665499","https://openalex.org/W2097306933","https://openalex.org/W2102638170","https://openalex.org/W1983415262","https://openalex.org/W1537864035","https://openalex.org/W2045585382","https://openalex.org/W2645697508"],"abstract_inverted_index":{"Myostatin":[0],"(GDF-8)":[1],"is":[2,25],"a":[3,26,142,152,188,214,222,245,258],"negative":[4],"regulator":[5],"of":[6,11,21,29,46,57,60,73,103,106,110,119,133,148,165,178,203,206,210,219,229,251,264,269],"muscle":[7,31,51,176,191,272],"mass.":[8],"The":[9],"inhibition":[10,45,263],"myostatin":[12,47,265],"increases":[13],"both":[14],"the":[15,55,70,101,111,120,128,146,159,175,201,226,230,234,242,261,267,270],"mass":[16,32,52,102,192],"and":[17,33,53,75,92,117,151,181,217,233],"force":[18,34,131,163],"generating":[19,35],"capacity":[20,36],"skeletal":[22,30,50,58],"muscles.":[23],"There":[24],"progressive":[27],"loss":[28],"that":[37,44,109,118,274],"occurs":[38,276],"with":[39,100,127,137,200,277],"aging.":[40,278],"PURPOSE:":[41],"We":[42],"hypothesized":[43],"would":[48],"increase":[49,144,154,216,247],"enhance":[54],"contractility":[56],"muscles":[59,77,105,135,205,228],"old":[61,83],"mice.":[62,97,157,197,253],"METHODS:":[63],"To":[64],"test":[65],"our":[66],"hypothesis,":[67],"we":[68],"measured":[69],"contractile":[71],"properties":[72],"EDL":[74,104,134,166],"soleus":[76,173,204,227],"from":[78,136],"28":[79],"to":[80],"30":[81],"month":[82],"male":[84],"wild":[85],"type":[86],"(MSTN+/+),":[87],"MSTN":[88,93],"heterozygous":[89],"null":[90,95],"(MSTN+/-)":[91],"homozygous":[94],"(MSTN-/-)":[96],"RESULTS:":[98],"Compared":[99],"MSTN+/+":[107,138,179,207,235],"mice,":[108,139,208,221,236],"MSTN+/-":[112,149,182,211,252],"mice":[113,122,150,180,183,212,232],"was":[114,141,193,239],"41%":[115],"greater":[116,190],"MSTN-/-":[121,156,196,220,231],"70%":[123,246],"greater.":[124],"Furthermore,":[125,198],"compared":[126,199],"maximum":[129,161],"isometric":[130,162],"(Po)":[132],"there":[140],"48%":[143],"in":[145,249,266],"Po":[147,202],"29%":[153],"for":[155,195,241,260],"For":[158,172,225],"specific":[160],"(sPo)":[164],"muscles,":[167,174],"no":[168,237],"differences":[169],"were":[170,184],"observed.":[171],"masses":[177],"not":[185],"different,":[186],"but":[187,244],"50%":[189],"observed":[194,240],"those":[209,218],"showed":[213],"69%":[215],"77%":[223],"increase.":[224],"difference":[238],"sPos,":[243],"occurred":[248],"sPo":[250],"CONCLUSIONS:":[254],"Our":[255],"results":[256],"support":[257],"role":[259],"therapeutic":[262],"prevention":[268],"severe":[271],"atrophy":[273],"often":[275]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
