{"id":"https://openalex.org/W2025533709","doi":"https://doi.org/10.1271/bbb.62.225","title":"Biosynthesis of2H-Labeled Phenylalanine by a New Methylotrophic MutantBrevibacterium methylicum","display_name":"Biosynthesis of2H-Labeled Phenylalanine by a New Methylotrophic MutantBrevibacterium methylicum","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2025533709","doi":"https://doi.org/10.1271/bbb.62.225","mag":"2025533709","pmid":"https://pubmed.ncbi.nlm.nih.gov/27388513"},"language":"en","primary_location":{"id":"doi:10.1271/bbb.62.225","doi":"https://doi.org/10.1271/bbb.62.225","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.62.225","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110549107","display_name":"\u041e. \u0412. \u041c\u043e\u0441\u0438\u043d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I208875869","display_name":"Moscow State University of Fine Chemical Technologies","ror":"https://ror.org/04aty2659","country_code":"RU","type":"education","lineage":["https://openalex.org/I208875869"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Oleg V. MOSIN","raw_affiliation_strings":["a Department of Biotechnology, M.V. Lomonosov State Academy of Fine Chemical Technology","Department of Biotechnology, M.V. Lomonosov State Academy of Fine Chemical Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Biotechnology, M.V. Lomonosov State Academy of Fine Chemical Technology","institution_ids":["https://openalex.org/I208875869"]},{"raw_affiliation_string":"Department of Biotechnology, M.V. Lomonosov State Academy of Fine Chemical Technology","institution_ids":["https://openalex.org/I208875869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034289219","display_name":"\u0421\u043a\u043b\u0430\u0434\u043d\u0435\u0432 \u0414\u043c\u0438\u0442\u0440\u0438\u0439 \u0410\u043d\u0430\u0442\u043e\u043b\u044c\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0001-6929-6397","observed_orcids":["https://orcid.org/0000-0001-6929-6397"]},"institutions":[{"id":"https://openalex.org/I4210163576","display_name":"Genetika","ror":"https://ror.org/05hr7qe62","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210163576"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dimitry A. SKLADNEV","raw_affiliation_strings":["b Laboratory of Genetics of Methylotrophs, Russian State Scientific Centre for Genetics and Selection of Industrial Microorganisms GNIIGENETIKA","Laboratory of Genetics of Methylotrophs, Russian State Scientific Centre for Genetics and Selection of Industrial Microorganisms GNIIGENETIKA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Laboratory of Genetics of Methylotrophs, Russian State Scientific Centre for Genetics and Selection of Industrial Microorganisms GNIIGENETIKA","institution_ids":["https://openalex.org/I4210163576"]},{"raw_affiliation_string":"Laboratory of Genetics of Methylotrophs, Russian State Scientific Centre for Genetics and Selection of Industrial Microorganisms GNIIGENETIKA","institution_ids":["https://openalex.org/I4210163576"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088176215","display_name":"\u0412. \u0418. \u0428\u0432\u0435\u0446","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I208875869","display_name":"Moscow State University of Fine Chemical Technologies","ror":"https://ror.org/04aty2659","country_code":"RU","type":"education","lineage":["https://openalex.org/I208875869"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vitalyi I. SHVETS","raw_affiliation_strings":["a Department of Biotechnology, M.V. Lomonosov State Academy of Fine Chemical Technology","Department of Biotechnology, M.V. Lomonosov State Academy of Fine Chemical Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Biotechnology, M.V. Lomonosov State Academy of Fine Chemical Technology","institution_ids":["https://openalex.org/I208875869"]},{"raw_affiliation_string":"Department of Biotechnology, M.V. Lomonosov State Academy of Fine Chemical Technology","institution_ids":["https://openalex.org/I208875869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3272,"currency":"USD","value_usd":3272},"apc_paid":null,"fwci":0.1938,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.41341477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"62","issue":"2","first_page":"225","last_page":"229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.3540000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.3540000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.3237000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.20810000598430634,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenylalanine-biosynthesis","display_name":"phenylalanine biosynthesis","score":0.968999981880188},{"id":"https://openalex.org/keywords/deuterium-labeling","display_name":"deuterium labeling","score":0.7540000081062317},{"id":"https://openalex.org/keywords/methionine-salvage-pathway","display_name":"methionine salvage pathway","score":0.6119999885559082},{"id":"https://openalex.org/keywords/methanol-metabolism","display_name":"methanol metabolism","score":0.47099998593330383},{"id":"https://openalex.org/keywords/alanine","display_name":"alanine","score":0.4790000021457672},{"id":"https://openalex.org/keywords/valine","display_name":"valine","score":0.996999979019165},{"id":"https://openalex.org/keywords/leucine","display_name":"leucine","score":0.9240000247955322},{"id":"https://openalex.org/keywords/isoleucine","display_name":"isoleucine","score":0.984000027179718},{"id":"https://openalex.org/keywords/dansyl-chloride-derivatization","display_name":"dansyl chloride derivatization","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.7763972282409668},{"id":"https://openalex.org/C2777305461","wikidata":"https://www.wikidata.org/wiki/Q484940","display_name":"Isoleucine","level":4,"score":0.7446737289428711},{"id":"https://openalex.org/C2778386651","wikidata":"https://www.wikidata.org/wiki/Q148611","display_name":"Brevibacterium","level":4,"score":0.7373390197753906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7061593532562256},{"id":"https://openalex.org/C2777573094","wikidata":"https://www.wikidata.org/wiki/Q483752","display_name":"Valine","level":3,"score":0.6572862863540649},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.6258049011230469},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5839787721633911},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.5538952946662903},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.5092447996139526},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.36640840768814087},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3553618788719177},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.35227662324905396},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.33778607845306396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11555251479148865},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.10291314125061035},{"id":"https://openalex.org/C175605896","wikidata":"https://www.wikidata.org/wiki/Q39833","display_name":"Microorganism","level":3,"score":0.08796164393424988},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1271/bbb.62.225","doi":"https://doi.org/10.1271/bbb.62.225","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.62.225","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},{"id":"pmid:27388513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27388513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, biotechnology, and biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1546783991","https://openalex.org/W2022603688","https://openalex.org/W2074070436","https://openalex.org/W2094411368","https://openalex.org/W2334391069"],"related_works":["https://openalex.org/W1756232742","https://openalex.org/W4318224712","https://openalex.org/W2276231149","https://openalex.org/W3140034478","https://openalex.org/W1501635534","https://openalex.org/W2504550067","https://openalex.org/W1563290390","https://openalex.org/W2143546483","https://openalex.org/W4239230684","https://openalex.org/W1949140257"],"abstract_inverted_index":{"The":[0,104],"biosynthesis":[1],"of":[2,9,47,65,71,74,84,99,111,113,122],"(2)H-labeled":[3,48],"phenylalanine":[4,131],"was":[5,92,134],"done":[6,93],"by":[7],"converse":[8],"low":[10],"molecular":[11],"weight":[12],"substrates":[13],"([U-(2)H]methanol":[14],"and":[15,52,56,90,138],"(2)H2O)":[16],"in":[17,59,127],"a":[18],"new":[19],"RuMP":[20],"facultative":[21],"methylotrophic":[22],"mutant":[23],"Brevibacterium":[24],"methylicum.":[25],"To":[26],"make":[27],"the":[28,44,62,75,81,96,100,109,132],"process":[29],"work,":[30],"adapted":[31],"cells":[32],"with":[33,43,87],"improved":[34],"growth":[35,85],"characteristics":[36],"were":[37,54,125],"used":[38],"on":[39],"minimal":[40],"medium":[41,86],"M9":[42],"maximum":[45],"content":[46],"substrates.":[49],"Alanine,":[50],"valine,":[51],"leucine/isoleucine":[53],"produced":[55],"accumulated":[57],"exogeneously":[58],"addition":[60],"to":[61,94,108],"main":[63],"product":[64],"biosynthesis.":[66],"Electron":[67],"impact":[68],"mass":[69],"spectrometry":[70],"methyl":[72],"esters":[73],"N-Dns-amino":[76],"acid":[77,115],"mixture":[78],"obtained":[79],"after":[80],"chemical":[82],"derivatization":[83],"dansyl":[88],"chloride":[89],"diazomethane,":[91],"calculate":[95],"deuterium":[97,123,140],"enrichment":[98,124,133],"amino":[101,114],"acids":[102],"synthesized.":[103],"experimental":[105],"data":[106],"testified":[107],"character":[110],"labeling":[112],"molecules":[116],"as":[117],"heterogeneous;":[118],"however,":[119],"high":[120],"levels":[121],"detected":[126],"all":[128],"presented":[129],"molecules-for":[130],"six,":[135],"leucine/isoleucine-five,":[136],"valine-five,":[137],"alanine-three":[139],"atoms.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":34},{"year":2013,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
