{"id":"https://openalex.org/W2025384451","doi":"https://doi.org/10.1159/000343896","title":"Impact of Inflammation-Metaplasia-Adenocarcinoma Sequence and Prevention in Surgical Rat Models","display_name":"Impact of Inflammation-Metaplasia-Adenocarcinoma Sequence and Prevention in Surgical Rat Models","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2025384451","doi":"https://doi.org/10.1159/000343896","mag":"2025384451","pmid":"https://pubmed.ncbi.nlm.nih.gov/23343962"},"language":"en","primary_location":{"id":"doi:10.1159/000343896","doi":"https://doi.org/10.1159/000343896","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000343896","pdf_url":null,"source":{"id":"https://openalex.org/S28092622","display_name":"Digestion","issn_l":"0012-2823","issn":["0012-2823","1421-9867"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestion","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075738891","display_name":"Tomoharu Miyashita","orcid":"https://orcid.org/0000-0002-3771-0773","observed_orcids":["https://orcid.org/0000-0002-3771-0773"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoharu Miyashita","raw_affiliation_strings":["Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan. tomoharumiya@gmail.com","Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan. tomoharumiya@gmail.com","institution_ids":["https://openalex.org/I4210104330"]},{"raw_affiliation_string":"Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089725371","display_name":"Furhawn A. Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2802697821","display_name":"Johns Hopkins Bayview Medical Center","ror":"https://ror.org/04pwc8466","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I2802697821"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Furhawn A. Shah","raw_affiliation_strings":["Department of Surgery, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Md., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Md., USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2802697821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113479194","display_name":"Koichi Miwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132787","display_name":"Houju Memorial Hospital","ror":"https://ror.org/03fhnqw17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132787"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Miwa","raw_affiliation_strings":["Houju Memorial Hospital, Nomi, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houju Memorial Hospital, Nomi, and","institution_ids":["https://openalex.org/I4210132787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112259375","display_name":"Shozo Sasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shozo Sasaki","raw_affiliation_strings":["Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Koji Nishijima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Nishijima","raw_affiliation_strings":["Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061456550","display_name":"Katsunobu Oyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsunobu Oyama","raw_affiliation_strings":["Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048730959","display_name":"Itasu Ninomiya","orcid":"https://orcid.org/0000-0002-3356-5505","observed_orcids":["https://orcid.org/0000-0002-3356-5505"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Itasu Ninomiya","raw_affiliation_strings":["Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024644803","display_name":"Sachio Fushida","orcid":"https://orcid.org/0000-0001-5567-7383","observed_orcids":["https://orcid.org/0000-0001-5567-7383"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sachio Fushida","raw_affiliation_strings":["Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074701942","display_name":"Takashi Fujimura","orcid":"https://orcid.org/0000-0001-7442-5974","observed_orcids":["https://orcid.org/0000-0001-7442-5974"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Fujimura","raw_affiliation_strings":["Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084881751","display_name":"Takanori Hattori","orcid":"https://orcid.org/0000-0002-1968-3732","observed_orcids":["https://orcid.org/0000-0002-1968-3732"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Hattori","raw_affiliation_strings":["Department of Pathology, Shiga University of Medical Science, Otsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shiga University of Medical Science, Otsu, Japan","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062512150","display_name":"John W. Harmon","orcid":"https://orcid.org/0000-0002-2857-3850","observed_orcids":["https://orcid.org/0000-0002-2857-3850"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2802697821","display_name":"Johns Hopkins Bayview Medical Center","ror":"https://ror.org/04pwc8466","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I2802697821"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Harmon","raw_affiliation_strings":["Department of Surgery, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Md., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Md., USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2802697821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109830939","display_name":"Tetsuo Ohta","orcid":"https://orcid.org/0000-0002-1965-2864","observed_orcids":["https://orcid.org/0000-0002-1965-2864"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Ohta","raw_affiliation_strings":["Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa,","institution_ids":["https://openalex.org/I4210104330"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6136,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.92313425,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"87","issue":"1","first_page":"6","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11658","display_name":"Esophageal and GI Pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.8479999899864197},{"id":"https://openalex.org/keywords/duodenogastric-reflux","display_name":"bile reflux","score":0.8109999895095825},{"id":"https://openalex.org/keywords/esophageal-inflammation","display_name":"esophageal inflammation","score":0.6790000200271606},{"id":"https://openalex.org/keywords/metaplasia","display_name":"metaplasia","score":0.9200000166893005},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7139999866485596},{"id":"https://openalex.org/keywords/rabeprazole","display_name":"rabeprazole","score":0.949999988079071},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.9309999942779541},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2779116819","wikidata":"https://www.wikidata.org/wiki/Q3515","display_name":"Rabeprazole","level":3,"score":0.8253025412559509},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.7606545686721802},{"id":"https://openalex.org/C2779357193","wikidata":"https://www.wikidata.org/wiki/Q660713","display_name":"Metaplasia","level":2,"score":0.6982386112213135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6637434363365173},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5878428220748901},{"id":"https://openalex.org/C2781025758","wikidata":"https://www.wikidata.org/wiki/Q421704","display_name":"Proton-pump inhibitor","level":2,"score":0.5649230480194092},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5643761157989502},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5231748223304749},{"id":"https://openalex.org/C2776497702","wikidata":"https://www.wikidata.org/wiki/Q872095","display_name":"Intestinal metaplasia","level":3,"score":0.522429883480072},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.47357377409935},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.44475528597831726},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4346197247505188},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36081141233444214},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3502182364463806}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008679","descriptor_name":"Metaplasia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053799","descriptor_name":"2-Pyridinylmethylsulfinylbenzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053799","descriptor_name":"2-Pyridinylmethylsulfinylbenzimidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D064750","descriptor_name":"Rabeprazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000343896","doi":"https://doi.org/10.1159/000343896","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000343896","pdf_url":null,"source":{"id":"https://openalex.org/S28092622","display_name":"Digestion","issn_l":"0012-2823","issn":["0012-2823","1421-9867"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestion","raw_type":"journal-article"},{"id":"pmid:23343962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23343962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestion","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W25460674","https://openalex.org/W63781701","https://openalex.org/W1971114351","https://openalex.org/W1989856051","https://openalex.org/W1990292757","https://openalex.org/W2018533484","https://openalex.org/W2022674159","https://openalex.org/W2047852966","https://openalex.org/W2060759530","https://openalex.org/W2061729110","https://openalex.org/W2068776651","https://openalex.org/W2069300021","https://openalex.org/W2075955172","https://openalex.org/W2086805455","https://openalex.org/W2092790149","https://openalex.org/W2104977330","https://openalex.org/W2119158273","https://openalex.org/W2138178697","https://openalex.org/W2138576529","https://openalex.org/W2150634345","https://openalex.org/W2156604928","https://openalex.org/W2314540303"],"related_works":["https://openalex.org/W2075955172","https://openalex.org/W2018533484","https://openalex.org/W2333129556","https://openalex.org/W1989856051","https://openalex.org/W2028034914","https://openalex.org/W2159438319","https://openalex.org/W2088183628","https://openalex.org/W2003837467","https://openalex.org/W2011859628","https://openalex.org/W2150634345"],"abstract_inverted_index":{"The":[0,54,138],"incidence":[1],"of":[2,41,48,61,83,88,95,113,148],"esophageal":[3,42,114],"cancer":[4],"continues":[5],"to":[6,30,33,79,116,121,164],"rise":[7],"in":[8,67,109,135,143,167],"the":[9,25,38,46,59,62,81,85,93,110,136,144],"Western":[10],"world.":[11],"Prior":[12],"studies":[13],"have":[14],"suggested":[15],"that":[16,102],"gastroduodenal":[17],"content":[18],"reflux":[19,22,75,104,132],"from":[20,28],"gastroesophageal":[21],"disease":[23],"induces":[24],"inflammation-mediated":[26],"progression":[27,145],"hyperplasia":[29],"metaplasia,":[31],"and":[32,65,90,146],"adenocarcinoma.":[34,117],"We":[35,100,118],"further":[36],"investigated":[37],"sequential":[39,86],"development":[40,87,147],"adenocarcinoma":[43,89],"(EADC)":[44],"with":[45,92,125,154],"use":[47,94],"an":[49,106],"established":[50],"surgical":[51,68],"rat":[52,69,74],"model.":[53],"present":[55],"paper":[56],"will":[57,162],"describe":[58],"impact":[60],"inflammation-metaplasia-adenocarcinoma":[63,139],"sequence":[64,140],"chemoprevention":[66,91,155],"models.":[70],"A":[71],"clinically":[72],"relevant":[73],"model":[76],"was":[77],"used":[78],"investigate":[80],"cause":[82],"carcinogenesis,":[84],"a":[96,127],"proton":[97,128],"pump":[98,129],"inhibitor.":[99,130],"found":[101],"duodenal":[103],"plays":[105],"important":[107,142],"role":[108],"inflammation-induced":[111],"transformation":[112,124],"mucosa":[115],"were":[119],"able":[120],"inhibit":[122],"this":[123],"rabeprazole,":[126],"Duodenal":[131],"promotes":[133],"inflammation":[134],"esophagus.":[137],"is":[141],"EADC.":[149],"Carcinogenesis":[150],"can":[151],"be":[152,165],"prevented":[153],"agents":[156],"such":[157],"as":[158],"rabeprazole.":[159],"These":[160],"results":[161],"need":[163],"validated":[166],"clinical":[168],"trials.":[169]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
