{"id":"https://openalex.org/W2025249339","doi":"https://doi.org/10.1073/pnas.1313446110","title":"Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins","display_name":"Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins","publication_year":2013,"publication_date":"2013-10-07","ids":{"openalex":"https://openalex.org/W2025249339","doi":"https://doi.org/10.1073/pnas.1313446110","mag":"2025249339","pmid":"https://pubmed.ncbi.nlm.nih.gov/24101494","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3876253"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1313446110","doi":"https://doi.org/10.1073/pnas.1313446110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1313446110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3876253","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019380109","display_name":"Malene Bech Vester-Christensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Malene B. Vester-Christensen","raw_affiliation_strings":["Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and School of Dentistry, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and School of Dentistry, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049912825","display_name":"Adnan Halim","orcid":"https://orcid.org/0000-0003-1629-187X","observed_orcids":["https://orcid.org/0000-0003-1629-187X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Adnan Halim","raw_affiliation_strings":["Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","aCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"aCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006678037","display_name":"Hiren Jitendra Joshi","orcid":"https://orcid.org/0000-0002-8192-2829","observed_orcids":["https://orcid.org/0000-0002-8192-2829"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hiren Jitendra Joshi","raw_affiliation_strings":["Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","aCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"aCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073934804","display_name":"Catharina Steentoft","orcid":"https://orcid.org/0000-0002-1424-6736","observed_orcids":["https://orcid.org/0000-0002-1424-6736"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Catharina Steentoft","raw_affiliation_strings":["Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","aCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"aCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071450562","display_name":"Eric Bennett","orcid":"https://orcid.org/0000-0002-4976-0647","observed_orcids":["https://orcid.org/0000-0002-4976-0647"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Eric P. Bennett","raw_affiliation_strings":["Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","School of Dentistry, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark","bSchool of Dentistry, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"School of Dentistry, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"bSchool of Dentistry, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005032064","display_name":"Steven B. Levery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Steven B. Levery","raw_affiliation_strings":["Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","aCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"aCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030965826","display_name":"Sergey Y. Vakhrushev","orcid":"https://orcid.org/0000-0002-0418-5765","observed_orcids":["https://orcid.org/0000-0002-0418-5765","https://orcid.org/0000-0003-1401-0296"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Sergey Y. Vakhrushev","raw_affiliation_strings":["Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","aCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"aCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058714848","display_name":"Henrik Clausen","orcid":"https://orcid.org/0000-0002-0915-5055","observed_orcids":["https://orcid.org/0000-0002-0915-5055"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henrik Clausen","raw_affiliation_strings":["Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","aCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"aCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":null,"apc_paid":null,"fwci":8.0355,"has_fulltext":false,"cited_by_count":152,"citation_normalized_percentile":{"value":0.98634964,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"110","issue":"52","first_page":"21018","last_page":"21023"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cadherins","display_name":"cadherins","score":0.9829999804496765},{"id":"https://openalex.org/keywords/plexins","display_name":"plexins","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alpha-dystroglycan","display_name":"alpha-dystroglycan","score":0.9139999747276306},{"id":"https://openalex.org/keywords/congenital-muscular-dystrophy","display_name":"congenital muscular dystrophy","score":0.781000018119812},{"id":"https://openalex.org/keywords/extracellular-domain","display_name":"extracellular domain","score":0.5149999856948853},{"id":"https://openalex.org/keywords/breast-cancer-cells","display_name":"breast cancer cells","score":0.6029999852180481},{"id":"https://openalex.org/keywords/glycosylation-site-mapping","display_name":"glycosylation site mapping","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.7326949238777161},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.6988632082939148},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4748437702655792},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.34948134422302246},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2637888789176941},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24835935235023499}],"mesh":[{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008358","descriptor_name":"Mannose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1313446110","doi":"https://doi.org/10.1073/pnas.1313446110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1313446110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3876253","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3876253","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:24101494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24101494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/ce852126-d6f2-45a1-9df3-955cd8cb3b6f","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/ce852126-d6f2-45a1-9df3-955cd8cb3b6f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vester-Christensen, M B, Halim, A, Joshi, H J, Steentoft, C, Bennett, E P, Levery, S B, Vakhrushev, S Y & Clausen, H 2013, 'Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 52, pp. 21018-23. https://doi.org/10.1073/pnas.1313446110","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3876253","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3876253","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W45281006","https://openalex.org/W1502661652","https://openalex.org/W1516087394","https://openalex.org/W1545030791","https://openalex.org/W1963757547","https://openalex.org/W1967481695","https://openalex.org/W1968896304","https://openalex.org/W1979452378","https://openalex.org/W1981447099","https://openalex.org/W1997526157","https://openalex.org/W2012622674","https://openalex.org/W2016582917","https://openalex.org/W2020140161","https://openalex.org/W2022086640","https://openalex.org/W2028159558","https://openalex.org/W2044340366","https://openalex.org/W2056602792","https://openalex.org/W2059140720","https://openalex.org/W2061078665","https://openalex.org/W2062628051","https://openalex.org/W2065551216","https://openalex.org/W2069494666","https://openalex.org/W2070552573","https://openalex.org/W2072918899","https://openalex.org/W2073724408","https://openalex.org/W2076025380","https://openalex.org/W2084198615","https://openalex.org/W2089368828","https://openalex.org/W2097437655","https://openalex.org/W2107441560","https://openalex.org/W2111005494","https://openalex.org/W2125648062","https://openalex.org/W2133843400","https://openalex.org/W2135736561","https://openalex.org/W2138687527","https://openalex.org/W2146926782","https://openalex.org/W2148020502","https://openalex.org/W2149893619","https://openalex.org/W2167132957","https://openalex.org/W2169438753","https://openalex.org/W2169550012","https://openalex.org/W2314554161","https://openalex.org/W2319601890","https://openalex.org/W2335139997"],"related_works":["https://openalex.org/W2615422437","https://openalex.org/W2069494666","https://openalex.org/W1964023928","https://openalex.org/W4399391731","https://openalex.org/W4413363590","https://openalex.org/W1903103667","https://openalex.org/W2133843400","https://openalex.org/W2020140161","https://openalex.org/W4210885942","https://openalex.org/W2165186422"],"abstract_inverted_index":{"The":[0,121,151],"metazoan":[1],"O-mannose":[2],"(O-Man)":[3],"glycoproteome":[4],"is":[5,33,102,156],"largely":[6],"unknown.":[7],"It":[8],"has":[9],"been":[10,52],"shown":[11],"that":[12,99,132],"up":[13],"to":[14,54,77,86,158],"30%":[15],"of":[16,20,29,71,82,126,142,161,168],"brain":[17],"O-glycans":[18],"are":[19],"the":[21,30,79,88],"O-Man":[22,38,42,83,89,100,127,153,169],"type,":[23],"but":[24],"essentially":[25],"only":[26],"alpha-dystroglycan":[27],"(\u03b1-DG)":[28],"dystrophin-glycoprotein":[31],"complex":[32],"well":[34],"characterized":[35],"as":[36],"an":[37],"glycoprotein.":[39],"Defects":[40],"in":[41,111,129],"glycosylation":[43,101],"underlie":[44],"congenital":[45],"muscular":[46],"dystrophies":[47],"and":[48,85,107,114,117,123,164],"considerable":[49],"efforts":[50],"have":[51],"devoted":[53],"explore":[55],"this":[56,92,139],"O-glycoproteome":[57],"without":[58],"much":[59],"success.":[60],"Here,":[61],"we":[62,97],"used":[63],"our":[64],"SimpleCell":[65,154],"strategy":[66,155],"using":[67],"nuclease-mediated":[68],"gene":[69],"editing":[70],"a":[72],"human":[73],"cell":[74,95,143,162],"line":[75,96],"(MDA-MB-231)":[76],"reduce":[78],"structural":[80],"heterogeneity":[81],"glycans":[84,128],"probe":[87],"glycoproteome.":[90],"In":[91],"breast":[93],"cancer":[94],"found":[98,104],"primarily":[103],"on":[105,109],"cadherins":[106,130],"plexins":[108],"\u03b2-strands":[110],"extracellular":[112],"cadherin":[113],"Ig-like,":[115],"plexin":[116],"transcription":[118],"factor":[119],"domains.":[120],"positions":[122],"evolutionary":[124],"conservation":[125],"suggest":[131],"they":[133],"play":[134],"important":[135],"functional":[136],"roles":[137],"for":[138],"large":[140],"group":[141],"adhesion":[144],"glycoproteins,":[145],"which":[146],"can":[147],"now":[148],"be":[149],"addressed.":[150],"developed":[152],"applicable":[157],"most":[159],"types":[160],"lines":[163],"enables":[165],"proteome-wide":[166],"discovery":[167],"protein":[170],"glycosylation.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
