{"id":"https://openalex.org/W2025246782","doi":"https://doi.org/10.1016/j.jad.2012.01.049","title":"Fronto-temporo-insula gray matter alterations of first-episode, drug-na\u00efve and very late-onset panic disorder patients","display_name":"Fronto-temporo-insula gray matter alterations of first-episode, drug-na\u00efve and very late-onset panic disorder patients","publication_year":2012,"publication_date":"2012-03-05","ids":{"openalex":"https://openalex.org/W2025246782","doi":"https://doi.org/10.1016/j.jad.2012.01.049","mag":"2025246782","pmid":"https://pubmed.ncbi.nlm.nih.gov/22386047"},"language":"en","primary_location":{"id":"doi:10.1016/j.jad.2012.01.049","doi":"https://doi.org/10.1016/j.jad.2012.01.049","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jad.2012.01.049","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078777744","display_name":"Chien\u2010Han Lai","orcid":"https://orcid.org/0000-0001-8259-1171","observed_orcids":["https://orcid.org/0000-0001-8259-1171"]},"institutions":[{"id":"https://openalex.org/I4210122745","display_name":"Buddhist Tzu Chi General Hospital","ror":"https://ror.org/037r57b62","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210122745"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chien-Han Lai","raw_affiliation_strings":["Department of Psychiatry, Buddhist Tzu-Chi General Hospital, Taipei Branch, Taipei, Taiwan. t122336257@yahoo.com.tw","Brain Image Research Unit, Buddhist Tzu-Chi General Hospital, Taipei Branch, Taipei, Taiwan","Department of Psychiatry, Buddhist Tzu-Chi General Hospital, Taipei Branch, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Buddhist Tzu-Chi General Hospital, Taipei Branch, Taipei, Taiwan. t122336257@yahoo.com.tw","institution_ids":["https://openalex.org/I4210122745"]},{"raw_affiliation_string":"Brain Image Research Unit, Buddhist Tzu-Chi General Hospital, Taipei Branch, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210122745"]},{"raw_affiliation_string":"Department of Psychiatry, Buddhist Tzu-Chi General Hospital, Taipei Branch, Taipei, Taiwan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080942813","display_name":"Yu\u2010Te Wu","orcid":"https://orcid.org/0000-0002-6942-0340","observed_orcids":["https://orcid.org/0000-0002-6942-0340"]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Te Wu","raw_affiliation_strings":["Institute of Brain Science, National Yang Ming University, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Brain Science, National Yang Ming University, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078777744"],"corresponding_institution_ids":["https://openalex.org/I4210122745"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":6.8536,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.95967994,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"140","issue":"3","first_page":"285","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/panic-disorder","display_name":"panic disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-naive-patients","display_name":"drug-naive patients","score":0.8140000104904175},{"id":"https://openalex.org/keywords/grey-matter-volume","display_name":"gray matter volume","score":0.9620000123977661},{"id":"https://openalex.org/keywords/orbitofrontal-cortex","display_name":"orbitofrontal cortex","score":0.8309999704360962},{"id":"https://openalex.org/keywords/insular-cortex","display_name":"insula","score":0.7839999794960022},{"id":"https://openalex.org/keywords/inferior-frontal-cortex","display_name":"inferior frontal cortex","score":0.8059999942779541},{"id":"https://openalex.org/keywords/superior-temporal-gyrus","display_name":"superior temporal gyrus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/panic-disorder-severity-scale","display_name":"Panic Disorder Severity Scale","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C200134340","wikidata":"https://www.wikidata.org/wiki/Q845664","display_name":"Voxel-based morphometry","level":4,"score":0.6423161029815674},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.5977010130882263},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5614141821861267},{"id":"https://openalex.org/C2776559556","wikidata":"https://www.wikidata.org/wiki/Q18717","display_name":"Orbitofrontal cortex","level":4,"score":0.5018444061279297},{"id":"https://openalex.org/C104996578","wikidata":"https://www.wikidata.org/wiki/Q827617","display_name":"Insula","level":2,"score":0.4983813762664795},{"id":"https://openalex.org/C2777529043","wikidata":"https://www.wikidata.org/wiki/Q741713","display_name":"Panic disorder","level":3,"score":0.49650102853775024},{"id":"https://openalex.org/C2778013878","wikidata":"https://www.wikidata.org/wiki/Q646150","display_name":"Grey matter","level":4,"score":0.41261520981788635},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3761846125125885},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3547573983669281},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3371962904930115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32455185055732727},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.29552072286605835},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.26551300287246704},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.18199849128723145},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.17027530074119568},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.15703481435775757},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005625","descriptor_name":"Frontal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016584","descriptor_name":"Panic Disorder","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016584","descriptor_name":"Panic Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jad.2012.01.049","doi":"https://doi.org/10.1016/j.jad.2012.01.049","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jad.2012.01.049","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},{"id":"pmid:22386047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22386047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of affective disorders","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321026","display_name":"Ministry of Earth Sciences","ror":"https://ror.org/013cf5k59"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1974544428","https://openalex.org/W1974941543","https://openalex.org/W1976347099","https://openalex.org/W1976658908","https://openalex.org/W1977656447","https://openalex.org/W1979538778","https://openalex.org/W1980977334","https://openalex.org/W1982039197","https://openalex.org/W1990674336","https://openalex.org/W1992199891","https://openalex.org/W1992474739","https://openalex.org/W1999847495","https://openalex.org/W2000871300","https://openalex.org/W2011707267","https://openalex.org/W2014518515","https://openalex.org/W2016828770","https://openalex.org/W2032975205","https://openalex.org/W2041957427","https://openalex.org/W2043221697","https://openalex.org/W2043277071","https://openalex.org/W2048929474","https://openalex.org/W2050719365","https://openalex.org/W2054263853","https://openalex.org/W2070396195","https://openalex.org/W2070853043","https://openalex.org/W2086465348","https://openalex.org/W2095556743","https://openalex.org/W2099651786","https://openalex.org/W2102290181","https://openalex.org/W2110726956","https://openalex.org/W2114190291","https://openalex.org/W2123233680","https://openalex.org/W2132885794","https://openalex.org/W2136022845","https://openalex.org/W2138790588","https://openalex.org/W2148760245","https://openalex.org/W2156847020","https://openalex.org/W2156870567","https://openalex.org/W4237733791"],"related_works":["https://openalex.org/W1910976635","https://openalex.org/W2114190291","https://openalex.org/W2318088110","https://openalex.org/W2014518515","https://openalex.org/W4386371666","https://openalex.org/W2156847020","https://openalex.org/W2080891830","https://openalex.org/W2011707267","https://openalex.org/W1993839635","https://openalex.org/W2043426392"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}