{"id":"https://openalex.org/W2025218148","doi":"https://doi.org/10.1152/ajpgi.00182.2003","title":"Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells","display_name":"Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells","publication_year":2004,"publication_date":"2004-01-31","ids":{"openalex":"https://openalex.org/W2025218148","doi":"https://doi.org/10.1152/ajpgi.00182.2003","mag":"2025218148","pmid":"https://pubmed.ncbi.nlm.nih.gov/14512286"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00182.2003","doi":"https://doi.org/10.1152/ajpgi.00182.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00182.2003","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102016183","display_name":"Jing Nan Lu","orcid":"https://orcid.org/0000-0002-0153-9361","observed_orcids":["https://orcid.org/0000-0002-0153-9361"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Lu","raw_affiliation_strings":["Department of Pediatrics, Northwestern University, Feinberg School of Medicine, 2650 Ridge Ave., Evanston, IL 60201, USA","Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Northwestern University, Feinberg School of Medicine, 2650 Ridge Ave., Evanston, IL 60201, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029057757","display_name":"Michael S. Caplan","orcid":"https://orcid.org/0000-0003-3498-3503","observed_orcids":["https://orcid.org/0000-0003-3498-3503"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Caplan","raw_affiliation_strings":["","Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067041776","display_name":"Anita P. Saraf","orcid":"https://orcid.org/0000-0001-7096-7418","observed_orcids":["https://orcid.org/0000-0001-7096-7418"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita P. Saraf","raw_affiliation_strings":["","Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380655","display_name":"Dan Li","orcid":"https://orcid.org/0000-0001-5904-871X","observed_orcids":["https://orcid.org/0000-0001-5904-871X","https://orcid.org/0009-0001-2569-4366"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Li","raw_affiliation_strings":["","Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111710404","display_name":"Luba Adler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luba Adler","raw_affiliation_strings":["","Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100671624","display_name":"Xuesong Liu","orcid":"https://orcid.org/0000-0002-7736-0077","observed_orcids":["https://orcid.org/0000-0002-7736-0077"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuesong Liu","raw_affiliation_strings":["","Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026417091","display_name":"Tam\u00e1s Jilling","orcid":"https://orcid.org/0000-0002-6200-3851","observed_orcids":["https://orcid.org/0000-0002-6200-3851"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamas Jilling","raw_affiliation_strings":["","Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":0.7102,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.64790436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"286","issue":"2","first_page":"G340","last_page":"G350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9449999928474426},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.7289999723434448},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9539999961853027},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mucosal-injury","display_name":"mucosal injury","score":0.8709999918937683},{"id":"https://openalex.org/keywords/enterocytes","display_name":"enterocytes","score":0.453000009059906},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6915099620819092},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.662227988243103},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5669932961463928},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5528414845466614},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.539231538772583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.514777660369873},{"id":"https://openalex.org/C172043667","wikidata":"https://www.wikidata.org/wiki/Q4780529","display_name":"Apoptosis-inducing factor","level":5,"score":0.5066302418708801},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.4655618965625763},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4578072726726532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3460721969604492},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.33485767245292664},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.32932454347610474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18621933460235596},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1350768804550171}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpgi.00182.2003","doi":"https://doi.org/10.1152/ajpgi.00182.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00182.2003","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:14512286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14512286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.884.6291","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.884.6291","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajpgi.physiology.org/content/ajpgi/286/2/G340.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3808380692","display_name":null,"funder_award_id":"R01-HD-37581-01A1","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6400306966","display_name":"The Role of PAF and TLR in NEC","funder_award_id":"R01HD037581","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W91786725","https://openalex.org/W97746810","https://openalex.org/W1430656059","https://openalex.org/W1547009799","https://openalex.org/W1553717629","https://openalex.org/W1611516688","https://openalex.org/W1642763135","https://openalex.org/W1750740856","https://openalex.org/W1824579594","https://openalex.org/W1964405922","https://openalex.org/W1964617786","https://openalex.org/W1965732972","https://openalex.org/W1980171212","https://openalex.org/W1980449301","https://openalex.org/W1982410119","https://openalex.org/W1987862420","https://openalex.org/W1994287166","https://openalex.org/W1996174406","https://openalex.org/W1996562091","https://openalex.org/W1998383129","https://openalex.org/W2007057690","https://openalex.org/W2009382824","https://openalex.org/W2014329746","https://openalex.org/W2027934896","https://openalex.org/W2027953426","https://openalex.org/W2028547258","https://openalex.org/W2034891814","https://openalex.org/W2044012845","https://openalex.org/W2051803873","https://openalex.org/W2057863866","https://openalex.org/W2064225392","https://openalex.org/W2070183804","https://openalex.org/W2071343795","https://openalex.org/W2073495799","https://openalex.org/W2082037077","https://openalex.org/W2084922679","https://openalex.org/W2086365629","https://openalex.org/W2095032336","https://openalex.org/W2095067232","https://openalex.org/W2105128357","https://openalex.org/W2113234505","https://openalex.org/W2134979684","https://openalex.org/W2156315926","https://openalex.org/W2156781200","https://openalex.org/W2179711287","https://openalex.org/W2189959642","https://openalex.org/W2300672688","https://openalex.org/W2301504136","https://openalex.org/W2326838035","https://openalex.org/W2396370145","https://openalex.org/W2465313423","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2608144873","https://openalex.org/W2046762153","https://openalex.org/W2102421607","https://openalex.org/W2320611859","https://openalex.org/W2392669497","https://openalex.org/W3173072524","https://openalex.org/W2398112701","https://openalex.org/W2163266044","https://openalex.org/W2135113066","https://openalex.org/W2036106740"],"abstract_inverted_index":{"Plateletactivating":[0],"factor":[1],"(PAF)":[2],"is":[3],"a":[4,36,58,77,189,211],"key":[5],"mediator":[6],"in":[7,38,48,208,249],"pathogenesis":[8],"of":[9,16,30,57,80,135,175,191,218,225,238,241,246,256],"inflammatory":[10],"bowel":[11],"diseases":[12],"(IBDs)":[13],"but":[14],"mechanisms":[15],"PAF-induced":[17,39],"mucosal":[18,40],"injury":[19],"are":[20,197,228],"poorly":[21],"understood.":[22],"To":[23],"determine":[24],"whether":[25],"apoptosis":[26,31,247],"and":[27,44,64,72,76,102,112,126,138,147,216,222,243],"the":[28,55,81,133,198,239],"Bcl-2-family":[29],"regulatory":[32],"gene":[33],"products":[34],"play":[35],"role":[37,240],"injury,":[41],"we":[42],"stably":[43],"conditionally":[45],"overexpressed":[46],"bcl-2":[47,136,176,232],"rat":[49],"small":[50],"intestinal":[51],"epithelial":[52,250],"cells-6":[53],"under":[54,229],"control":[56,230],"lactose-inducible":[59],"promoter.":[60],"Western":[61],"blot":[62],"analysis":[63],"immuno-histochemistry":[65],"were":[66],"used":[67],"to":[68,73,130,145,180,200],"verify":[69],"inducible":[70,120],"Bcl-2":[71,75,82,116,244],"analyze":[74],"proapoptotic":[78],"member":[79],"family,":[83],"Bax,":[84],"subcellular":[85],"distribution.":[86],"DNA":[87,167,182],"fragmentation":[88,168],"was":[89,95,106,118,127],"quantified":[90],"by":[91,97,108,121,156,231],"ELISA,":[92],"caspase":[93],"activity":[94],"measured":[96],"using":[98],"fluorogenic":[99],"peptide":[100],"substrates,":[101],"mitochondrial":[103,148,192,219],"membrane":[104,149,193,220],"potential":[105,150,221],"assayed":[107],"5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine":[109],"iodide":[110],"(JC-1)":[111],"fluorescence":[113],"digital":[114],"imaging.":[115],"expression":[117,233],"highly":[119],"lactose":[122],"analog":[123],"isopropyl-beta-(d)-thiogalactoside":[124],"(IPTG)":[125],"localized":[128],"predominantly":[129],"mitochondria.":[131],"In":[132],"absence":[134],"overexpression":[137],"after":[139],"treatment":[140],"with":[141,164],"PAF,":[142],"Bax":[143,186,214],"translocated":[144],"mitochondria,":[146],"collapsed":[151],"within":[152],"1":[153],"h,":[154],"followed":[155],"caspase-3":[157,184],"activation,":[158,185],"which":[159],"peaked":[160],"at":[161,170],"6":[162],"h":[163],"an":[165],"ensuing":[166],"maximizing":[169],"18":[171],"h.":[172],"After":[173],"IPTG-induction":[174],"expression,":[177],"PAF":[178,203,242],"failed":[179],"induce":[181],"fragmentation,":[183],"translocation,":[187],"or":[188,259],"collapse":[190,217],"potential.":[194],"These":[195],"data":[196],"first":[199],"show":[201],"that":[202,223],"can":[204],"activate":[205],"apoptotic":[206],"machinery":[207],"enterocytes":[209],"via":[210],"mechanism":[212],"involving":[213],"translocation":[215],"both":[224],"these":[226],"events":[227],"levels.":[234],"A":[235],"better":[236,257],"understanding":[237],"family":[245],"regulators":[248],"cell":[251],"death":[252],"might":[253],"aid":[254],"design":[255],"therapeutic":[258],"preventive":[260],"strategies":[261],"for":[262],"IBDs.":[263]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}