{"id":"https://openalex.org/W2025199802","doi":"https://doi.org/10.1161/01.cir.62.6.1221","title":"Relative effects of aspirin on platelet aggregation and prostaglandin-mediated coronary vasodilatation in the dog.","display_name":"Relative effects of aspirin on platelet aggregation and prostaglandin-mediated coronary vasodilatation in the dog.","publication_year":1980,"publication_date":"1980-12-01","ids":{"openalex":"https://openalex.org/W2025199802","doi":"https://doi.org/10.1161/01.cir.62.6.1221","mag":"2025199802","pmid":"https://pubmed.ncbi.nlm.nih.gov/7438358"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.62.6.1221","doi":"https://doi.org/10.1161/01.cir.62.6.1221","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.62.6.1221","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.62.6.1221","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.62.6.1221","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079738724","display_name":"Norine L. Capurro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N L Capurro","raw_affiliation_strings":["N L Capurro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N L Capurro","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067687085","display_name":"Lewis C. Lipson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L C Lipson","raw_affiliation_strings":["L C Lipson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L C Lipson","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028576363","display_name":"Robert O. Bonow","orcid":"https://orcid.org/0000-0003-2277-3605","observed_orcids":["https://orcid.org/0000-0003-2277-3605","https://orcid.org/0000-0003-1458-1515"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R O Bonow","raw_affiliation_strings":["R O Bonow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R O Bonow","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018341192","display_name":"R. E. Goldstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R E Goldstein","raw_affiliation_strings":["R E Goldstein"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R E Goldstein","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109311831","display_name":"N. Raphael Shulman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N R Shulman","raw_affiliation_strings":["N R Shulman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N R Shulman","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112149294","display_name":"Stephen E. Epstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S E Epstein","raw_affiliation_strings":["S E Epstein"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S E Epstein","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5113,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.91793669,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"62","issue":"6","first_page":"1221","last_page":"1227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":1.0},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/coronary-vasodilation","display_name":"coronary vasodilation","score":0.875},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.8939999938011169},{"id":"https://openalex.org/keywords/adp-induced-platelet-aggregation","display_name":"ADP-induced aggregation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.9700000286102295},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ischemic-heart-disease","display_name":"ischemic heart disease","score":0.7039999961853027},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.9248145222663879},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.8579713106155396},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7754605412483215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7117511034011841},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.6937836408615112},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5484431982040405},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5288475751876831},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4463662803173065},{"id":"https://openalex.org/C2909076160","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Coronary vasodilator","level":3,"score":0.42192673683166504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3988737463951111},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.330502450466156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24698695540428162},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23297327756881714},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05530703067779541}],"mesh":[{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.cir.62.6.1221","doi":"https://doi.org/10.1161/01.cir.62.6.1221","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.62.6.1221","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.62.6.1221","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:7438358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7438358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.913.5054","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.913.5054","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/62/6/1221.full.pdf","raw_type":"text"},{"id":"mag:3139819029","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.62.6.7438358?related-urls=yes&legid=circulationaha%3B62%2F6%2F1221","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":{"id":"doi:10.1161/01.cir.62.6.1221","doi":"https://doi.org/10.1161/01.cir.62.6.1221","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.62.6.1221","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.62.6.1221","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320310638","display_name":"McGill University","ror":"https://ror.org/01pxwe438"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2025199802.pdf","grobid_xml":"https://content.openalex.org/works/W2025199802.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1980624336","https://openalex.org/W1983759759","https://openalex.org/W1984061640","https://openalex.org/W2002254855","https://openalex.org/W2008440251","https://openalex.org/W2021403302","https://openalex.org/W2025237854","https://openalex.org/W2038530665","https://openalex.org/W2040734725","https://openalex.org/W2065732704","https://openalex.org/W2077459776","https://openalex.org/W2088643391","https://openalex.org/W2148744277","https://openalex.org/W2150199749","https://openalex.org/W2162637702","https://openalex.org/W2889264609"],"related_works":["https://openalex.org/W2236537941","https://openalex.org/W7097704795","https://openalex.org/W2093817731","https://openalex.org/W2024697114","https://openalex.org/W1981639043","https://openalex.org/W2030702205","https://openalex.org/W2032266925","https://openalex.org/W2003363140","https://openalex.org/W3151823770","https://openalex.org/W2092011140"],"abstract_inverted_index":{"Aspirin,":[0],"as":[1],"an":[2],"inhibitor":[3],"of":[4,9,25,35,55,69,112,118,126,135,140,164,168,229],"platelet":[5,20,30,40,130,192,248],"aggregation,":[6],"may":[7],"be":[8],"benefit":[10],"in":[11,61,83,198],"ischemic":[12],"heart":[13],"disease.":[14],"However,":[15],"aspirin":[16,45,56,93,116,213,230,238],"blocks":[17],"not":[18,243],"only":[19],"aggregation":[21,41,68,139,163,193],"but":[22],"also":[23],"synthesis":[24],"prostacyclin,":[26],"a":[27],"vasodilator":[28],"and":[29,39,65,219,236],"deaggregator.":[31],"The":[32,132],"relative":[33,52,250],"sensitivity":[34,209],"prostaglandin-mediated":[36],"coronary":[37,62,84,199,234,252],"vasodilatation":[38,235],"to":[42,109,152,188,210,216,245,251],"inhibition":[43,211],"by":[44,91,212],"remains":[46],"uncertain.":[47],"We":[48],"therefore":[49],"investigated":[50],"the":[51,95,107,123,180,203],"dose-response":[53],"relationship":[54],"on":[57,66],"arachidonic":[58,76,113,195,232],"acid-induced":[59,196,233],"increments":[60,197],"blood":[63,85,200],"flow":[64,86],"ADP-induced":[67,191],"platelets.":[70],"In":[71],"11":[72,167],"open-chest":[73],"dogs,":[74,170],"intracoronary":[75],"acid,":[77],"0.1-3.0":[78],"mg,":[79],"produced":[80,138],"dose-related":[81],"increases":[82],"that":[87,137,225,237],"were":[88],"inhibited":[89,162],"progressively":[90,121],"i.v.":[92],"over":[94],"dose":[96,218],"range":[97],"0.3-3.0":[98,119],"mg/kg.":[99],"Aspirin":[100,157,183],"at":[101,158,174,184,239],"3":[102,110,159],"mg/kg":[103,120,160,186],"almost":[104],"completely":[105,161],"obliterated":[106],"response":[108],"mg":[111],"acid.":[114],"Similarly,":[115],"doses":[117,228,241],"raised":[122],"minimal":[124],"concentration":[125,134],"ADP":[127,136,173],"necessary":[128],"for":[129],"aggregation.":[131],"threshold":[133,217],"platelets":[141,165],"from":[142,147,166],"10":[143],"control":[144],"dogs":[145],"ranged":[146],"2.3":[148,175],"x":[149,154,176],"10(-6)":[150],"M":[151,178],"1.2":[153],"10(-5)":[155],"M.":[156],"12":[169],"even":[171],"with":[172,214],"10(-4)":[177],"concentration,":[179],"maximum":[181],"tested.":[182],"0.1":[185],"failed":[187],"inhibit":[189,231,247],"either":[190],"or":[194],"flow.":[201],"Thus,":[202],"two":[204],"test":[205],"systems":[206],"showed":[207],"similar":[208],"respect":[215],"maximal":[220],"effect.":[221],"These":[222],"results":[223],"show":[224],"very":[226],"low":[227,240],"does":[242],"appear":[244],"selectively":[246],"activity":[249],"vasodilatation.":[253]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}