{"id":"https://openalex.org/W2025168331","doi":"https://doi.org/10.1016/s0006-291x(02)00424-2","title":"The novel type I serine\u2013threonine kinase receptor Alk8 binds TGF-\u03b2 in the presence of TGF-\u03b2RII","display_name":"The novel type I serine\u2013threonine kinase receptor Alk8 binds TGF-\u03b2 in the presence of TGF-\u03b2RII","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2025168331","doi":"https://doi.org/10.1016/s0006-291x(02)00424-2","mag":"2025168331","pmid":"https://pubmed.ncbi.nlm.nih.gov/12054694"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-291x(02)00424-2","doi":"https://doi.org/10.1016/s0006-291x(02)00424-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-291x(02)00424-2","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111805202","display_name":"Mark P. de Caestecker","orcid":"https://orcid.org/0000-0001-7926-1673","observed_orcids":["https://orcid.org/0000-0001-7926-1673"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark P de Caestecker","raw_affiliation_strings":["Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN 37232-2372, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN 37232-2372, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109137031","display_name":"Martyn J. Bottomley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martyn Bottomley","raw_affiliation_strings":["Laboratory of Cell Regulation and Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Regulation and Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100821283","display_name":"Sucharita Bhattacharyya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sucharita Bhattacharyya","raw_affiliation_strings":["Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN 37232-2372, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN 37232-2372, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006931548","display_name":"Tracie L. Payne-Ferreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4405268108","display_name":"The Forsyth Institute","ror":"https://ror.org/05tr9gt18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405268108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracie L Payne","raw_affiliation_strings":["Department of Cytokine Biology and Harvard-Forsyth Department of Oral Biology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytokine Biology and Harvard-Forsyth Department of Oral Biology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4405268108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111977995","display_name":"Anita B. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita B Roberts","raw_affiliation_strings":["Laboratory of Cell Regulation and Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Regulation and Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068312032","display_name":"Pamela Crotty Yelick","orcid":"https://orcid.org/0000-0001-6817-008X","observed_orcids":["https://orcid.org/0000-0001-6817-008X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4405268108","display_name":"The Forsyth Institute","ror":"https://ror.org/05tr9gt18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405268108"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pamela C Yelick","raw_affiliation_strings":["Department of Cytokine Biology and Harvard-Forsyth Department of Oral Biology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytokine Biology and Harvard-Forsyth Department of Oral Biology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4405268108"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5068312032"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4405268108"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.478,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.55787361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"293","issue":"5","first_page":"1556","last_page":"1565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-receptor","display_name":"TGF-beta receptor","score":0.5870000123977661},{"id":"https://openalex.org/keywords/tgf-betarii","display_name":"TGF-\u03b2RII","score":0.734000027179718},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8090000152587891},{"id":"https://openalex.org/keywords/type-i-receptor","display_name":"type I receptor","score":0.5479999780654907},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.7699999809265137},{"id":"https://openalex.org/keywords/tgf-beta-superfamily","display_name":"TGF-beta superfamily","score":0.8709999918937683},{"id":"https://openalex.org/keywords/receptor-signaling-complex","display_name":"receptor signaling complex","score":0.6019999980926514},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C111001777","wikidata":"https://www.wikidata.org/wiki/Q3562192","display_name":"TGF beta signaling pathway","level":3,"score":0.7516517043113708},{"id":"https://openalex.org/C73568257","wikidata":"https://www.wikidata.org/wiki/Q7273271","display_name":"R-SMAD","level":5,"score":0.7002702355384827},{"id":"https://openalex.org/C175554068","wikidata":"https://www.wikidata.org/wiki/Q14914463","display_name":"ACVRL1","level":5,"score":0.6563107371330261},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5917282700538635},{"id":"https://openalex.org/C6061869","wikidata":"https://www.wikidata.org/wiki/Q18250377","display_name":"Endoglin","level":4,"score":0.5637607574462891},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5529996752738953},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.536166787147522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5307638049125671},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5191423296928406},{"id":"https://openalex.org/C171020997","wikidata":"https://www.wikidata.org/wiki/Q14911585","display_name":"TGF beta receptor 2","level":5,"score":0.5179721117019653},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.5033637881278992},{"id":"https://openalex.org/C2778649528","wikidata":"https://www.wikidata.org/wiki/Q4677603","display_name":"Activin receptor","level":3,"score":0.4881599545478821},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47106072306632996},{"id":"https://openalex.org/C73834784","wikidata":"https://www.wikidata.org/wiki/Q17849752","display_name":"BMPR2","level":4,"score":0.44207048416137695},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.3711564540863037},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3538801074028015},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3509289026260376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2832445800304413},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.2629581093788147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1690637171268463},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077294","descriptor_name":"Receptor, Transforming Growth Factor-beta Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D030201","descriptor_name":"Activin Receptors, Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0006-291x(02)00424-2","doi":"https://doi.org/10.1016/s0006-291x(02)00424-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-291x(02)00424-2","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:12054694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12054694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1750655836","https://openalex.org/W1879493681","https://openalex.org/W1930281617","https://openalex.org/W1985400766","https://openalex.org/W1986117279","https://openalex.org/W1992533419","https://openalex.org/W1995473388","https://openalex.org/W1996059262","https://openalex.org/W2012634492","https://openalex.org/W2021263701","https://openalex.org/W2028854652","https://openalex.org/W2039458025","https://openalex.org/W2050902851","https://openalex.org/W2078107700","https://openalex.org/W2083786962","https://openalex.org/W2084866479","https://openalex.org/W2089710998","https://openalex.org/W2092099867","https://openalex.org/W2102051477","https://openalex.org/W2121586803","https://openalex.org/W2132660815","https://openalex.org/W2133193835","https://openalex.org/W2144464927","https://openalex.org/W2149417485","https://openalex.org/W2157444265","https://openalex.org/W2163504684","https://openalex.org/W2164218605","https://openalex.org/W2262976102","https://openalex.org/W4296927411","https://openalex.org/W6672681105","https://openalex.org/W6679588972"],"related_works":["https://openalex.org/W2028854652","https://openalex.org/W2320404683","https://openalex.org/W2060840668","https://openalex.org/W82489587","https://openalex.org/W7206769936","https://openalex.org/W2167928512","https://openalex.org/W2066945967","https://openalex.org/W462979737","https://openalex.org/W2084877581","https://openalex.org/W473348831"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
