{"id":"https://openalex.org/W2025045895","doi":"https://doi.org/10.1002/anie.200703625","title":"Diazirine\u2010Based DNA Photo\u2010Cross\u2010Linking Probes for the Study of Protein\u2013DNA Interactions","display_name":"Diazirine\u2010Based DNA Photo\u2010Cross\u2010Linking Probes for the Study of Protein\u2013DNA Interactions","publication_year":2007,"publication_date":"2007-11-12","ids":{"openalex":"https://openalex.org/W2025045895","doi":"https://doi.org/10.1002/anie.200703625","mag":"2025045895","pmid":"https://pubmed.ncbi.nlm.nih.gov/17994596"},"language":"en","primary_location":{"id":"doi:10.1002/anie.200703625","doi":"https://doi.org/10.1002/anie.200703625","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.200703625","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057071511","display_name":"Uddhav Kumar Shigdel","orcid":"https://orcid.org/0000-0003-2259-3719","observed_orcids":["https://orcid.org/0000-0003-2259-3719"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uddhav\u2005Kumar Shigdel","raw_affiliation_strings":["Department of Chemistry, University of Chicago, 5735 South Ellis Avenue Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Chicago, 5735 South Ellis Avenue Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101730401","display_name":"Junliang Zhang","orcid":"https://orcid.org/0000-0002-2630-4534","observed_orcids":["https://orcid.org/0000-0002-2630-4534"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Junliang Zhang","raw_affiliation_strings":["Current address: Department of Chemistry, East China Normal University, Shanghai, P.R. China","Department of Chemistry, University of Chicago, 5735 South Ellis Avenue Chicago, IL 60637, USA,","Department of Chemistry, University of Chicago, 5735 South Ellis Avenue Chicago, IL 60637, USA, Fax: (+1)\u2009773-702-0805"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Department of Chemistry, East China Normal University, Shanghai, P.R. China","institution_ids":["https://openalex.org/I66867065"]},{"raw_affiliation_string":"Department of Chemistry, University of Chicago, 5735 South Ellis Avenue Chicago, IL 60637, USA,","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Chemistry, University of Chicago, 5735 South Ellis Avenue Chicago, IL 60637, USA, Fax: (+1)\u2009773-702-0805","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091114864","display_name":"Chuan He","orcid":"https://orcid.org/0000-0003-4319-7424","observed_orcids":["https://orcid.org/0000-0003-4319-7424","https://orcid.org/0000-0002-9983-7526","https://orcid.org/0000-0002-6171-810X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuan He","raw_affiliation_strings":["Department of Chemistry, University of Chicago, 5735 South Ellis Avenue Chicago, IL 60637, USA, Fax: (+1)\u2009773-702-0805"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Chicago, 5735 South Ellis Avenue Chicago, IL 60637, USA, Fax: (+1)\u2009773-702-0805","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":1.588,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.81364846,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"47","issue":"1","first_page":"90","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.5468999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.16410000622272491,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.10350000113248825,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diazirine","display_name":"diazirine","score":0.9520000219345093},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.8539999723434448},{"id":"https://openalex.org/keywords/dna-modification","display_name":"DNA modification","score":0.5130000114440918},{"id":"https://openalex.org/keywords/major-groove","display_name":"major groove","score":0.6050000190734863},{"id":"https://openalex.org/keywords/minor-groove","display_name":"minor groove","score":0.9940000176429749},{"id":"https://openalex.org/keywords/steric-hindrance","display_name":"steric hindrance","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C2780815831","wikidata":"https://www.wikidata.org/wiki/Q5272198","display_name":"Diazirine","level":2,"score":0.9409272074699402},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.7640364170074463},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.6872314214706421},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6022820472717285},{"id":"https://openalex.org/C2779472054","wikidata":"https://www.wikidata.org/wiki/Q2377973","display_name":"Groove (engineering)","level":2,"score":0.497531920671463},{"id":"https://openalex.org/C3019303373","wikidata":"https://www.wikidata.org/wiki/Q60535862","display_name":"Minor groove","level":3,"score":0.4723421335220337},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4270641803741455},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21510446071624756},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2006905972957611},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17658504843711853},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13808804750442505},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003978","descriptor_name":"Diazomethane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010777","descriptor_name":"Photochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015265","descriptor_name":"Site-Specific DNA-Methyltransferase (Adenine-Specific)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019853","descriptor_name":"O(6)-Methylguanine-DNA Methyltransferase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/anie.200703625","doi":"https://doi.org/10.1002/anie.200703625","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.200703625","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"pmid:17994596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17994596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W239396163","https://openalex.org/W1907545229","https://openalex.org/W1967386642","https://openalex.org/W1970484245","https://openalex.org/W1979392838","https://openalex.org/W1983525029","https://openalex.org/W1987197853","https://openalex.org/W1987369601","https://openalex.org/W1988735506","https://openalex.org/W1993859324","https://openalex.org/W1997974036","https://openalex.org/W2006119433","https://openalex.org/W2008466187","https://openalex.org/W2012613470","https://openalex.org/W2018512856","https://openalex.org/W2024653434","https://openalex.org/W2036544061","https://openalex.org/W2040410429","https://openalex.org/W2042064130","https://openalex.org/W2055690563","https://openalex.org/W2066892428","https://openalex.org/W2073756834","https://openalex.org/W2077890483","https://openalex.org/W2078329768","https://openalex.org/W2084407647","https://openalex.org/W2085901776","https://openalex.org/W2086732117","https://openalex.org/W2092633225","https://openalex.org/W2100274522","https://openalex.org/W2122116402","https://openalex.org/W2123797085","https://openalex.org/W2134368434","https://openalex.org/W2143527741","https://openalex.org/W2153298725","https://openalex.org/W2163901484","https://openalex.org/W2949140131","https://openalex.org/W4241480733"],"related_works":["https://openalex.org/W2139106508","https://openalex.org/W2289393042","https://openalex.org/W2144128092","https://openalex.org/W4400773691","https://openalex.org/W2982510672","https://openalex.org/W2950603843","https://openalex.org/W3104893025","https://openalex.org/W1964068098","https://openalex.org/W4386844107","https://openalex.org/W7204012884"],"abstract_inverted_index":{"Small":[0],"modification,":[1],"large":[2],"effect:":[3],"Diazirine":[4],"can":[5],"be":[6,29,41],"installed":[7],"quickly":[8],"and":[9],"simply":[10],"in":[11,36],"the":[12],"major":[13],"or":[14],"minor":[15],"groove":[16],"of":[17],"DNA":[18],"for":[19,31],"efficient":[20],"photo-cross-linking":[21],"to":[22,43],"proteins":[23],"(see":[24],"picture).":[25],"This":[26],"method":[27],"should":[28],"suitable":[30],"mapping":[32],"out":[33],"protein\u2013DNA":[34],"interactions,":[35],"particular":[37],"those":[38],"that":[39],"may":[40],"sensitive":[42],"steric":[44],"hindrance.":[45]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}