{"id":"https://openalex.org/W2025010023","doi":"https://doi.org/10.1016/j.jalz.2013.08.223","title":"P4\u2013390: Cognitive correlates of striatal amyloid deposition in preclinical and early autosomal dominant Alzheimer's disease","display_name":"P4\u2013390: Cognitive correlates of striatal amyloid deposition in preclinical and early autosomal dominant Alzheimer's disease","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W2025010023","doi":"https://doi.org/10.1016/j.jalz.2013.08.223","mag":"2025010023"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2013.08.223","doi":"https://doi.org/10.1016/j.jalz.2013.08.223","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2013.08.223","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053071315","display_name":"Beth Ellen Snitz","orcid":"https://orcid.org/0000-0002-9978-1374","observed_orcids":["https://orcid.org/0000-0002-9978-1374"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth Snitz","raw_affiliation_strings":["University of Pittsburgh Pittsburgh, Pennsylvania, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Pittsburgh, Pennsylvania, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068373508","display_name":"Eric McDade","orcid":"https://orcid.org/0000-0002-6764-3866","observed_orcids":["https://orcid.org/0000-0002-6764-3866"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric McDade","raw_affiliation_strings":["University of Pittsburgh Pittsburgh, Pennsylvania, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Pittsburgh, Pennsylvania, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054979710","display_name":"Ellen Romich","orcid":"https://orcid.org/0000-0002-8233-4703","observed_orcids":["https://orcid.org/0000-0002-8233-4703"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Romich","raw_affiliation_strings":["University of Pittsburgh Pittsburgh, Pennsylvania, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Pittsburgh, Pennsylvania, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056508217","display_name":"Howard Jay Aizenstein","orcid":"https://orcid.org/0000-0003-4897-6582","observed_orcids":["https://orcid.org/0000-0003-4897-6582"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Aizenstein","raw_affiliation_strings":["University of Pittsburgh Pittsburgh, Pennsylvania, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Pittsburgh, Pennsylvania, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038365193","display_name":"Zana Ikonomovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zana Ikonomovic","raw_affiliation_strings":["University of Pittsburgh Pittsburgh, Pennsylvania, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Pittsburgh, Pennsylvania, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111684854","display_name":"Elizabeth Sarles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Sarles","raw_affiliation_strings":["University of Pittsburgh Pittsburgh, Pennsylvania, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Pittsburgh, Pennsylvania, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052543984","display_name":"Katy Zorich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katy Zorich","raw_affiliation_strings":["University of Pittsburgh Pittsburgh, Pennsylvania, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Pittsburgh, Pennsylvania, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074758454","display_name":"Julie C. Price","orcid":"https://orcid.org/0000-0001-7131-4865","observed_orcids":["https://orcid.org/0000-0001-7131-4865"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Price","raw_affiliation_strings":["University of Pittsburgh Pittsburgh, Pennsylvania, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Pittsburgh, Pennsylvania, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029440312","display_name":"Chester A. Mathis","orcid":"https://orcid.org/0000-0001-9811-0950","observed_orcids":["https://orcid.org/0000-0001-9811-0950"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chester Mathis","raw_affiliation_strings":["University of Pittsburgh Pittsburgh, Pennsylvania, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Pittsburgh, Pennsylvania, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036841670","display_name":"William Edward Klunk","orcid":"https://orcid.org/0000-0001-5512-0251","observed_orcids":["https://orcid.org/0000-0001-5512-0251"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Klunk","raw_affiliation_strings":["University of Pittsburgh Pittsburgh, Pennsylvania, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Pittsburgh, Pennsylvania, United States","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14486377,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"4S_Part_22","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6967999935150146,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6967999935150146,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.3009999990463257,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autosomal-dominant-alzheimer-s-disease","display_name":"autosomal dominant Alzheimer's disease","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C2781441883","wikidata":"https://www.wikidata.org/wiki/Q1632835","display_name":"Precuneus","level":3,"score":0.8340984582901001},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6610898375511169},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.5614566802978516},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.47860997915267944},{"id":"https://openalex.org/C2781073650","wikidata":"https://www.wikidata.org/wiki/Q4047010","display_name":"Pittsburgh compound B","level":4,"score":0.47601157426834106},{"id":"https://openalex.org/C2775968953","wikidata":"https://www.wikidata.org/wiki/Q783092","display_name":"Executive functions","level":3,"score":0.4430708885192871},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.43512362241744995},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4327836036682129},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.4238492250442505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2652103304862976},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.2465043067932129},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2013.08.223","doi":"https://doi.org/10.1016/j.jalz.2013.08.223","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2013.08.223","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2920936498","https://openalex.org/W2800868772","https://openalex.org/W3201148755","https://openalex.org/W2896925021","https://openalex.org/W1942921912","https://openalex.org/W4390198480","https://openalex.org/W2000397440","https://openalex.org/W2108041327","https://openalex.org/W2114134151","https://openalex.org/W2612334361"],"abstract_inverted_index":{"Amyloid":[0],"imaging":[1,72,132],"studies":[2],"have":[3],"shown":[4],"early":[5],"and":[6,13,52,62,66,73,86,123,215,230,253,265,275,298,317,334,347],"focal":[7],"striatal":[8,22,37,196,213,216,241,283,299,331],"deposition":[9],"in":[10,165,178,202,243],"preclinical":[11],"PS1":[12],"PS2":[14],"carriers":[15],"among":[16],"ADAD":[17,46,324],"families.":[18],"We":[19,40],"investigated":[20],"whether":[21],"amyloid":[23],"burden":[24],"was":[25,143,159,193,292],"associated":[26],"with":[27,54,195,240,282,305],"performance":[28,335],"on":[29,336],"cognitive":[30,38,95,217,300,342],"tests,":[31,76],"including":[32,77,97,246],"measures":[33,78,98,218],"putatively":[34],"sensitive":[35],"to":[36,172,186,261],"functions.":[39,88],"studied":[41],"n=11":[42],"cognitively":[43],"normal":[44],"(CN)":[45],"family":[47,325],"participants":[48,91,207,267],"(age":[49,56],"22\u201344":[50],"years)":[51],"n=3":[53],"MCI":[55,266],"35\u201348).":[57],"Participants":[58,69],"included":[59],"8":[60],"PS-1":[61],"4":[63],"APP":[64],"mutation-carriers,":[65],"2":[67],"non-carriers.":[68],"completed":[70,92],"PiB-PET":[71,131],"standard":[74],"neuropsychological":[75,236,307],"of":[79,107,150,156,290,344],"episodic":[80],"memory,":[81],"visuospatial":[82],"construction,":[83],"language,":[84],"attention":[85],"executive":[87],"As":[89],"well,":[90],"a":[93,151,160,341],"\u201cstriatal\u201d":[94],"battery":[96],"tapping":[99,225,272],"1)":[100],"procedural":[101],"learning":[102],"(serial":[103],"reaction":[104],"time":[105],"task":[106],"implicit":[108],"learning;":[109],"Rotary":[110],"Pursuit":[111],"task;":[112],"mirror":[113,227],"reading":[114,228],"task);":[115],"2)":[116],"risk-reward":[117,345],"decision":[118],"making":[119],"(Iowa":[120],"Gambling":[121,232,278,339],"Task);":[122],"3)":[124],"psychomotor":[125],"speed/dexterity":[126],"(finger":[127],"tapping;":[128],"grooved":[129],"pegboard).":[130],"data":[133],"were":[134,219,280],"acquired":[135],"50\u201370":[136],"minutes":[137],"after":[138],"injection.":[139],"Striatal":[140],"PiB":[141,163,181,197,214,242,284,296,332],"binding":[142],"computed":[144],"as":[145,302,304,313],"the":[146,166,179,203,276,327,337],"SUVR":[147,164,182,297,333],"(cerebellum":[148],"reference)":[149],"hand-drawn":[152],"anterior-ventral":[153,167,330],"striatum":[154,168],"region":[155],"interest.":[157],"Precuneus":[158],"comparison":[161],"ROI.":[162],"ranged":[169],"from":[170,184],"1.01":[171],"3.41":[173],"(mean":[174,188],"1.83;":[175],"SD":[176,190],"0.78);":[177],"precuneus":[180,295],"range":[183],"1.26":[185],"3.31":[187],"1.76;":[189],"0.53).":[191],"Age":[192],"correlated":[194,239,281],"(r=.67,":[198],"p<.01)":[199],"but":[200],"not":[201],"precuneus.":[204],"Among":[205],"CN":[206,244,264],"only,":[208],"partial":[209],"correlations":[210,291],"(age-controlled)":[211],"between":[212,294,329],"significant":[220],"(p\u2264.05,":[221],"two-tailed)":[222],"for":[223],"finger":[224,271],"(r=.65);":[226],"(r=.79)":[229],"Iowa":[231,277],"Task":[233,279],"(r=.74).":[234],"Traditional":[235],"tests":[237],"also":[238],"participants,":[245,326],"MMSE,":[247],"Boston":[248],"Naming":[249],"Test,":[250],"Block":[251],"Design":[252],"CERAD":[254],"Word":[255],"List":[256],"Learning":[257],"(partial":[258],"r's":[259],".63":[260],".78).":[262],"In":[263,322],"combined":[268],"(n=14),":[269],"only":[270],"(non-dominant":[273],"hand)":[274],"(see":[285],"Figure).":[286],"A":[287],"similar":[288],"pattern":[289],"observed":[293],"measures,":[301],"well":[303],"traditional":[306],"measures.":[308],"Corresponding":[309],"analyses":[310],"using":[311],"pons":[312],"reference":[314],"are":[315],"underway":[316],"will":[318],"be":[319],"presented.":[320],"Figure.":[321],"n=14":[323],"association":[328],"lowa":[338],"Task,":[340],"measure":[343],"sensitivity":[346],"learning.":[348]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}