{"id":"https://openalex.org/W2024988974","doi":"https://doi.org/10.1002/ajmg.1566","title":"Effects of misspecification of allele frequencies on the power of Haseman-Elston sib-pair linkage method for quantitative traits","display_name":"Effects of misspecification of allele frequencies on the power of Haseman-Elston sib-pair linkage method for quantitative traits","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2024988974","doi":"https://doi.org/10.1002/ajmg.1566","mag":"2024988974","pmid":"https://pubmed.ncbi.nlm.nih.gov/11746011"},"language":"en","primary_location":{"id":"doi:10.1002/ajmg.1566","doi":"https://doi.org/10.1002/ajmg.1566","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajmg.1566","pdf_url":null,"source":{"id":"https://openalex.org/S4210224978","display_name":"American Journal of Medical Genetics","issn_l":"0148-7299","issn":["0148-7299","1096-8628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000406916","display_name":"Diptasri M. Mandal","orcid":"https://orcid.org/0000-0003-1383-4971","observed_orcids":["https://orcid.org/0000-0003-1383-4971"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diptasri M. Mandal","raw_affiliation_strings":["Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091519811","display_name":"Alexander F. Wilson","orcid":"https://orcid.org/0000-0002-6682-8156","observed_orcids":["https://orcid.org/0000-0002-6682-8156"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander F. Wilson","raw_affiliation_strings":["National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067921126","display_name":"Joan Wilson","orcid":"https://orcid.org/0000-0002-9153-2920","observed_orcids":["https://orcid.org/0000-0002-9153-2920"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joan E. Bailey-Wilson","raw_affiliation_strings":["National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067921126"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"],"apc_list":null,"apc_paid":null,"fwci":0.182,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.53848301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"103","issue":"4","first_page":"308","last_page":"313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.16779999434947968,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haseman-elston-regression","display_name":"Haseman-Elston regression","score":0.9229999780654907},{"id":"https://openalex.org/keywords/sib-pair-linkage-analysis","display_name":"sib-pair linkage analysis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/statistical-power","display_name":"statistical power","score":0.8880000114440918},{"id":"https://openalex.org/keywords/quantitative-traits","display_name":"quantitative traits","score":0.8799999952316284},{"id":"https://openalex.org/keywords/marker-loci","display_name":"marker loci","score":0.6959999799728394},{"id":"https://openalex.org/keywords/environmental-impact","display_name":"environmental impact","score":0.35100001096725464},{"id":"https://openalex.org/keywords/nuclear-family","display_name":"nuclear family","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7354223728179932},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.7060552835464478},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6871482133865356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6844596862792969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6441544890403748},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.6203478574752808},{"id":"https://openalex.org/C190789776","wikidata":"https://www.wikidata.org/wiki/Q767511","display_name":"Genetic marker","level":3,"score":0.5423132181167603},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5212119817733765},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.5069041848182678},{"id":"https://openalex.org/C137132547","wikidata":"https://www.wikidata.org/wiki/Q4752570","display_name":"Ancestry-informative marker","level":5,"score":0.49888110160827637},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.4911081790924072},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.463215172290802},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.45510661602020264},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.193803071975708},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016555","descriptor_name":"Matched-Pair Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/ajmg.1566","doi":"https://doi.org/10.1002/ajmg.1566","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajmg.1566","pdf_url":null,"source":{"id":"https://openalex.org/S4210224978","display_name":"American Journal of Medical Genetics","issn_l":"0148-7299","issn":["0148-7299","1096-8628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics","raw_type":"journal-article"},{"id":"doi:10.1002/ajmg.1566.abs","doi":"https://doi.org/10.1002/ajmg.1566.abs","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajmg.1566.abs","pdf_url":null,"source":{"id":"https://openalex.org/S4210224978","display_name":"American Journal of Medical Genetics","issn_l":"0148-7299","issn":["0148-7299","1096-8628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics","raw_type":"journal-article"},{"id":"pmid:11746011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11746011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of medical genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2882500740","display_name":"Human Genetic Analysis Resource","funder_award_id":"P41RR003655","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W205526579","https://openalex.org/W1499406536","https://openalex.org/W1555364640","https://openalex.org/W1953663792","https://openalex.org/W1970420590","https://openalex.org/W1977104259","https://openalex.org/W1999843368","https://openalex.org/W2005972657","https://openalex.org/W2008313801","https://openalex.org/W2108421907","https://openalex.org/W2123869079"],"related_works":["https://openalex.org/W2008313801","https://openalex.org/W1964511379","https://openalex.org/W1594833695","https://openalex.org/W1953663792","https://openalex.org/W2135540138","https://openalex.org/W2013935385","https://openalex.org/W1970420590","https://openalex.org/W1583037475","https://openalex.org/W2065331145","https://openalex.org/W2108422947"],"abstract_inverted_index":{"It":[0],"is":[1,22,29,151,172,179],"well":[2],"known":[3,23],"that":[4,14],"the":[5,15,19,40,56,59,82,131,159,176],"Haseman-Elston":[6],"(H-E)":[7],"sib-pair":[8,61],"linkage":[9],"method":[10,62],"does":[11],"not":[12,180],"assume":[13],"genetic":[16],"model":[17],"underlying":[18],"trait":[20,93],"phenotype":[21],"without":[24],"error,":[25],"although":[26],"this":[27,54],"assumption":[28],"made":[30],"for":[31,65,90,163],"marker":[32,41,83,95,133,139,146,177],"loci.":[33],"However,":[34],"misspecification":[35],"of":[36,58,68,105,130,158],"allele":[37,79,147],"frequencies":[38,80],"at":[39,81],"locus":[42,178],"decreases":[43],"power":[44,57,168],"when":[45,70,169,175],"some":[46,71],"or":[47,72],"all":[48,73],"parental":[49,74,138],"genotypes":[50],"are":[51],"unknown.":[52],"In":[53],"study,":[55],"H-E":[60],"was":[63],"compared":[64],"different":[66],"types":[67,104],"traits":[69,106],"data":[75,124],"were":[76,85,88,107,125],"missing":[77],"and":[78,94,120,135,144,174],"loci":[84,96],"misspecified.":[86],"Data":[87],"generated":[89],"a":[91,114,164],"quantitative":[92],"in":[97,156,167],"nuclear":[98],"families":[99],"using":[100,127],"G.A.S.P.":[101],"(V3.3).":[102],"Three":[103],"simulated":[108,123],"with":[109,113,141],"two":[110],"equifrequent":[111],"alleles":[112],"random":[115],"environmental":[116],"effect":[117],"(10%,":[118],"30%,":[119],"50%).":[121],"The":[122],"analyzed":[126],"(i)":[128],"one":[129],"parent's":[132],"data,":[134,140],"(ii)":[136],"no":[137],"both":[142],"correct":[143],"incorrect":[145],"frequencies.":[148],"This":[149],"test":[150],"found":[152],"to":[153],"be":[154],"robust":[155],"most":[157],"situations":[160],"considered":[161],"except":[162],"slight":[165],"decrease":[166],"sample":[170],"size":[171],"small":[173],"very":[181],"polymorphic.":[182]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
