{"id":"https://openalex.org/W2024979614","doi":"https://doi.org/10.1016/j.bbamem.2008.08.027","title":"Cytokine regulation of tight junctions","display_name":"Cytokine regulation of tight junctions","publication_year":2008,"publication_date":"2008-10-09","ids":{"openalex":"https://openalex.org/W2024979614","doi":"https://doi.org/10.1016/j.bbamem.2008.08.027","mag":"2024979614","pmid":"https://pubmed.ncbi.nlm.nih.gov/18952050","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2699410"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbamem.2008.08.027","doi":"https://doi.org/10.1016/j.bbamem.2008.08.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamem.2008.08.027","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0005273608003064/pdf","source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2024979614"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0005273608003064/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054260081","display_name":"Christopher Capaldo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher T. Capaldo","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA","Department of Pathology & Laboratory Medicine, Emory University, Atlanta, GA, 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Pathology & Laboratory Medicine, Emory University, Atlanta, GA, 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042841599","display_name":"Asma Nusrat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Asma Nusrat","raw_affiliation_strings":["Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042841599"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":3870,"currency":"USD","value_usd":3870},"apc_paid":null,"fwci":1.6712,"has_fulltext":true,"cited_by_count":753,"citation_normalized_percentile":{"value":0.82987552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"1788","issue":"4","first_page":"864","last_page":"871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epithelial-barrier-function","display_name":"epithelial barrier function","score":0.8149999976158142},{"id":"https://openalex.org/keywords/endothelial-barrier","display_name":"endothelial barrier","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tight-junction-regulation","display_name":"tight junction regulation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/paracellular-permeability","display_name":"paracellular permeability","score":0.7229999899864197},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.5809999704360962},{"id":"https://openalex.org/keywords/barrier-function","display_name":"barrier function","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.9457167387008667},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4954437017440796},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4807557761669159},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4778044819831848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4723461866378784},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36250120401382446},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3225395679473877},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29158034920692444},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08671677112579346},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D062445","descriptor_name":"Claudin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062793","descriptor_name":"Occludin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bbamem.2008.08.027","doi":"https://doi.org/10.1016/j.bbamem.2008.08.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamem.2008.08.027","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0005273608003064/pdf","source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},{"id":"pmid:18952050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18952050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2699410","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2699410/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochim Biophys Acta","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.bbamem.2008.08.027","doi":"https://doi.org/10.1016/j.bbamem.2008.08.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamem.2008.08.027","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0005273608003064/pdf","source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1600785189","display_name":"Intestinal mucosal wound resealing","funder_award_id":"R01DK055679","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2947634406","display_name":"Structure function studies in intestinal epithelial JAM","funder_award_id":"R01DK061379","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8267059420","display_name":"Regulation of intestinal epithelial barrier function by intercellular junction proteins in health and disease","funder_award_id":"R01DK059888","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024979614.pdf","grobid_xml":"https://content.openalex.org/works/W2024979614.grobid-xml"},"referenced_works_count":108,"referenced_works":["https://openalex.org/W68432611","https://openalex.org/W123473090","https://openalex.org/W178434341","https://openalex.org/W1258881425","https://openalex.org/W1515675646","https://openalex.org/W1525871018","https://openalex.org/W1540456704","https://openalex.org/W1543006452","https://openalex.org/W1560056935","https://openalex.org/W1581723165","https://openalex.org/W1618627661","https://openalex.org/W1873256844","https://openalex.org/W1884525829","https://openalex.org/W1897118574","https://openalex.org/W1932880974","https://openalex.org/W1972899659","https://openalex.org/W1975007185","https://openalex.org/W1977245174","https://openalex.org/W1981310451","https://openalex.org/W1988658760","https://openalex.org/W1989195644","https://openalex.org/W1989210966","https://openalex.org/W1991253273","https://openalex.org/W1993379452","https://openalex.org/W1996574563","https://openalex.org/W1999809584","https://openalex.org/W2000119033","https://openalex.org/W2000208875","https://openalex.org/W2000709179","https://openalex.org/W2002556891","https://openalex.org/W2011199158","https://openalex.org/W2011356699","https://openalex.org/W2015373462","https://openalex.org/W2017443683","https://openalex.org/W2018397538","https://openalex.org/W2019937643","https://openalex.org/W2021448755","https://openalex.org/W2022364566","https://openalex.org/W2024005495","https://openalex.org/W2025383253","https://openalex.org/W2028919524","https://openalex.org/W2029561250","https://openalex.org/W2029878860","https://openalex.org/W2041102059","https://openalex.org/W2044767727","https://openalex.org/W2046142660","https://openalex.org/W2051016124","https://openalex.org/W2051045103","https://openalex.org/W2052763113","https://openalex.org/W2053491542","https://openalex.org/W2054376706","https://openalex.org/W2054625112","https://openalex.org/W2055222262","https://openalex.org/W2055637432","https://openalex.org/W2055991864","https://openalex.org/W2057626594","https://openalex.org/W2063090066","https://openalex.org/W2069962467","https://openalex.org/W2074896240","https://openalex.org/W2074936672","https://openalex.org/W2076588832","https://openalex.org/W2077762362","https://openalex.org/W2080954187","https://openalex.org/W2083735475","https://openalex.org/W2084429010","https://openalex.org/W2085966326","https://openalex.org/W2088892772","https://openalex.org/W2090307028","https://openalex.org/W2096791952","https://openalex.org/W2097929425","https://openalex.org/W2100483442","https://openalex.org/W2101173615","https://openalex.org/W2103536507","https://openalex.org/W2108765497","https://openalex.org/W2110174748","https://openalex.org/W2114315236","https://openalex.org/W2115334126","https://openalex.org/W2121414029","https://openalex.org/W2121527471","https://openalex.org/W2122039020","https://openalex.org/W2131432706","https://openalex.org/W2132226772","https://openalex.org/W2136845685","https://openalex.org/W2139057316","https://openalex.org/W2140410130","https://openalex.org/W2141710693","https://openalex.org/W2149199950","https://openalex.org/W2151957104","https://openalex.org/W2152241963","https://openalex.org/W2153204420","https://openalex.org/W2153753664","https://openalex.org/W2154447475","https://openalex.org/W2155153491","https://openalex.org/W2160401081","https://openalex.org/W2160674655","https://openalex.org/W2161789287","https://openalex.org/W2163779489","https://openalex.org/W2163830368","https://openalex.org/W2164692566","https://openalex.org/W2166710590","https://openalex.org/W2170027619","https://openalex.org/W2171647107","https://openalex.org/W2177396386","https://openalex.org/W2184260816","https://openalex.org/W2186717009","https://openalex.org/W2336324298","https://openalex.org/W2401887519","https://openalex.org/W4313348018"],"related_works":["https://openalex.org/W2112115346","https://openalex.org/W2494980409","https://openalex.org/W2004633453","https://openalex.org/W2090328173","https://openalex.org/W4413435674","https://openalex.org/W1885931187","https://openalex.org/W2173892503","https://openalex.org/W592256883","https://openalex.org/W2159590405","https://openalex.org/W2061583677"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":45},{"year":2025,"cited_by_count":44},{"year":2024,"cited_by_count":58},{"year":2023,"cited_by_count":54},{"year":2022,"cited_by_count":69},{"year":2021,"cited_by_count":68},{"year":2020,"cited_by_count":41},{"year":2019,"cited_by_count":55},{"year":2018,"cited_by_count":46},{"year":2017,"cited_by_count":48},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":31},{"year":2013,"cited_by_count":44},{"year":2012,"cited_by_count":39}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}