{"id":"https://openalex.org/W2024976609","doi":"https://doi.org/10.1016/j.imlet.2005.08.005","title":"Cytokine-deficient mice as a model for generation of autologous anti-cytokine monoclonal antibodies","display_name":"Cytokine-deficient mice as a model for generation of autologous anti-cytokine monoclonal antibodies","publication_year":2005,"publication_date":"2005-09-10","ids":{"openalex":"https://openalex.org/W2024976609","doi":"https://doi.org/10.1016/j.imlet.2005.08.005","mag":"2024976609","pmid":"https://pubmed.ncbi.nlm.nih.gov/16176840"},"language":"en","primary_location":{"id":"doi:10.1016/j.imlet.2005.08.005","doi":"https://doi.org/10.1016/j.imlet.2005.08.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.imlet.2005.08.005","pdf_url":null,"source":{"id":"https://openalex.org/S71256826","display_name":"Immunology Letters","issn_l":"0165-2478","issn":["0165-2478","1879-0542"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology Letters","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2024976609"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024419623","display_name":"Valentin P. Shichkin","orcid":"https://orcid.org/0000-0002-4065-651X","observed_orcids":["https://orcid.org/0000-0002-4065-651X"]},"institutions":[{"id":"https://openalex.org/I4210120336","display_name":"Danylo Zabolotny Institute of Microbiology and Virology","ror":"https://ror.org/02qqsgs30","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210120336"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["UA","US"],"is_corresponding":true,"raw_author_name":"Valentin P. Shichkin","raw_affiliation_strings":["Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0563, USA. shvpmail@yahoo.com","Department of Interferon, D.K. Zabolotnyi Institute of Microbiology and Virology, Kiev 03143, Ukraine","Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0563, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0563, USA. shvpmail@yahoo.com","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Interferon, D.K. Zabolotnyi Institute of Microbiology and Virology, Kiev 03143, Ukraine","institution_ids":["https://openalex.org/I4210120336"]},{"raw_affiliation_string":"Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0563, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035947660","display_name":"Spivak NIa","orcid":"https://orcid.org/0000-0002-4394-7275","observed_orcids":["https://orcid.org/0000-0002-4394-7275"]},"institutions":[{"id":"https://openalex.org/I4210120336","display_name":"Danylo Zabolotny Institute of Microbiology and Virology","ror":"https://ror.org/02qqsgs30","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210120336"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Nikolai Y. Spivak","raw_affiliation_strings":["Department of Interferon, D.K. Zabolotnyi Institute of Microbiology and Virology, Kiev 03143, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interferon, D.K. Zabolotnyi Institute of Microbiology and Virology, Kiev 03143, Ukraine","institution_ids":["https://openalex.org/I4210120336"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024419623"],"corresponding_institution_ids":["https://openalex.org/I4210120336","https://openalex.org/I63135867"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":null,"fwci":0.1136,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.4508725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"102","issue":"2","first_page":"148","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.04450000077486038,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8640000224113464},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":1.0},{"id":"https://openalex.org/keywords/hybridoma-generation","display_name":"hybridoma generation","score":0.5720000267028809},{"id":"https://openalex.org/keywords/il-4-knockout-mice","display_name":"IL-4 knockout mice","score":0.6840000152587891},{"id":"https://openalex.org/keywords/antibody-affinity","display_name":"antibody affinity","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7815977334976196},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.7419874668121338},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.725546658039093},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.6419030427932739},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6041398644447327},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5550110936164856},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.535595178604126},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.47408926486968994},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.46728143095970154},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.4581552743911743},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.4536832571029663},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42273059487342834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41722720861434937},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0944494903087616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06519702076911926}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.imlet.2005.08.005","doi":"https://doi.org/10.1016/j.imlet.2005.08.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.imlet.2005.08.005","pdf_url":null,"source":{"id":"https://openalex.org/S71256826","display_name":"Immunology Letters","issn_l":"0165-2478","issn":["0165-2478","1879-0542"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology Letters","raw_type":"journal-article"},{"id":"pmid:16176840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16176840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W336368690","https://openalex.org/W1489601058","https://openalex.org/W1512983238","https://openalex.org/W1559183445","https://openalex.org/W1596243988","https://openalex.org/W1602460865","https://openalex.org/W1667545291","https://openalex.org/W1795974800","https://openalex.org/W1817803495","https://openalex.org/W1900655002","https://openalex.org/W1967365028","https://openalex.org/W1967667269","https://openalex.org/W1981049346","https://openalex.org/W1987692041","https://openalex.org/W2011608246","https://openalex.org/W2017375854","https://openalex.org/W2041647537","https://openalex.org/W2044004977","https://openalex.org/W2069295237","https://openalex.org/W2086217776","https://openalex.org/W2092192751","https://openalex.org/W2112970562","https://openalex.org/W2122976894","https://openalex.org/W2124566107","https://openalex.org/W2132403618","https://openalex.org/W2133395692","https://openalex.org/W2140612321","https://openalex.org/W2140649712","https://openalex.org/W2143877503","https://openalex.org/W2143885071","https://openalex.org/W2151381311","https://openalex.org/W2163925698","https://openalex.org/W2164422628","https://openalex.org/W2168822788","https://openalex.org/W2169648098","https://openalex.org/W2270424427","https://openalex.org/W2460719563","https://openalex.org/W2810374733","https://openalex.org/W3023923910","https://openalex.org/W6637844539","https://openalex.org/W6718801521"],"related_works":["https://openalex.org/W1993159536","https://openalex.org/W2187812713","https://openalex.org/W1997398818","https://openalex.org/W2072839721","https://openalex.org/W1494254017","https://openalex.org/W2016775543","https://openalex.org/W2007569317","https://openalex.org/W6921713692","https://openalex.org/W1605939307","https://openalex.org/W2058027780"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}