{"id":"https://openalex.org/W2024970299","doi":"https://doi.org/10.1113/jphysiol.1988.sp017320","title":"Binding and biological actions of prostaglandin E2 and I2 in cells isolated from rabbit gastric mucosa.","display_name":"Binding and biological actions of prostaglandin E2 and I2 in cells isolated from rabbit gastric mucosa.","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W2024970299","doi":"https://doi.org/10.1113/jphysiol.1988.sp017320","mag":"2024970299","pmid":"https://pubmed.ncbi.nlm.nih.gov/2475608","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1190963"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.1988.sp017320","doi":"https://doi.org/10.1113/jphysiol.1988.sp017320","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1988.sp017320","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1190963","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040438950","display_name":"Dana Boyd Barr","orcid":"https://orcid.org/0000-0002-5566-2138","observed_orcids":["https://orcid.org/0000-0002-5566-2138"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D B Barr","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J A Duncan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J A Duncan","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007433062","display_name":"John Alan Kiernan","orcid":"https://orcid.org/0000-0002-3324-1092","observed_orcids":["https://orcid.org/0000-0002-3324-1092"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J A Kiernan","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108288677","display_name":"B. D. Soper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B D Soper","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112349319","display_name":"Barry L. Tepperman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B L Tepperman","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada","institution_ids":["https://openalex.org/I125749732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I125749732"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":1.2463,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.76768359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"405","issue":"1","first_page":"39","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.7839999794960022},{"id":"https://openalex.org/keywords/iloprost","display_name":"iloprost","score":0.9760000109672546},{"id":"https://openalex.org/keywords/prostaglandin-receptors","display_name":"prostaglandin receptors","score":0.6970000267028809},{"id":"https://openalex.org/keywords/oxyntic-mucosa","display_name":"oxyntic mucosa","score":0.8569999933242798},{"id":"https://openalex.org/keywords/parietal-cells","display_name":"parietal cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/mucous-cells","display_name":"mucous cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/gastric-acid-secretion","display_name":"gastric acid secretion","score":0.8740000128746033},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C2781103887","wikidata":"https://www.wikidata.org/wiki/Q20817139","display_name":"Iloprost","level":3,"score":0.8745316863059998},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.7249809503555298},{"id":"https://openalex.org/C2779743957","wikidata":"https://www.wikidata.org/wiki/Q1640093","display_name":"Parietal cell","level":4,"score":0.7113159894943237},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.6614471673965454},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5595688223838806},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.5319370031356812},{"id":"https://openalex.org/C2778266237","wikidata":"https://www.wikidata.org/wiki/Q962217","display_name":"Prostanoid","level":3,"score":0.5136775374412537},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.4627838730812073},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.450020432472229},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.44435590505599976},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4344521760940552},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4282170534133911},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.4166392683982849},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40508532524108887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3797163963317871},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3281727433204651},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2774119973182678},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.16413980722427368},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12906718254089355}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000632","descriptor_name":"Aminopyrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006633","descriptor_name":"Histamine Antagonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.1988.sp017320","doi":"https://doi.org/10.1113/jphysiol.1988.sp017320","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1988.sp017320","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1190963","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1190963","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:2475608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2475608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1190963","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1190963","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1682668202","https://openalex.org/W1936333617","https://openalex.org/W1966428196","https://openalex.org/W1982159886","https://openalex.org/W1992909660","https://openalex.org/W2027034855","https://openalex.org/W2036961586","https://openalex.org/W2043813981","https://openalex.org/W2055465500","https://openalex.org/W2071534708","https://openalex.org/W2081393460","https://openalex.org/W2088573156","https://openalex.org/W2109191216","https://openalex.org/W2122258650","https://openalex.org/W2126920214","https://openalex.org/W2128635872","https://openalex.org/W2169448347","https://openalex.org/W2231298982","https://openalex.org/W2278715806","https://openalex.org/W2395655095","https://openalex.org/W2402819167","https://openalex.org/W2419581125","https://openalex.org/W2462920353"],"related_works":["https://openalex.org/W2157481269","https://openalex.org/W1973905665","https://openalex.org/W1992909660","https://openalex.org/W2122258650","https://openalex.org/W2055809965","https://openalex.org/W1584178108","https://openalex.org/W1980428494","https://openalex.org/W2021961419","https://openalex.org/W2014285543","https://openalex.org/W1878290568"],"abstract_inverted_index":{"1.":[0],"We":[1],"have":[2],"investigated":[3],"the":[4,7,59,86],"binding":[5,35,46,57,77,153],"of":[6,10,18,24,32,181],"tritiated":[8],"forms":[9],"prostaglandin":[11],"E2":[12],"(PGE2)":[13],"and":[14,91,118],"a":[15,38,82],"stable":[16],"analogue":[17],"prostacyclin":[19],"(Iloprost)":[20],"to":[21,58,68,100,106,139,178,186],"isolated":[22],"cells":[23,50,98,114],"rabbit":[25],"oxyntic":[26,172],"mucosa.":[27],"2.":[28],"The":[29,175],"highest":[30],"degree":[31],"specific":[33],"[3H]PGE2":[34],"occurred":[36,47,142],"in":[37,42,49,97,113,129,137],"cellular":[39,191],"fraction":[40,62],"enriched":[41],"parietal":[43,60,87,119,130],"cells.":[44,54,75,88,120,174],"[3H]Iloprost":[45],"predominantly":[48],"identified":[51,115],"as":[52,116],"mucous":[53,117],"3.":[55],"PGE2":[56,90,121,150,169],"cell":[61,147],"was":[63],"associated":[64],"with":[65,81,158],"its":[66],"ability":[67],"inhibit":[69],"histamine-stimulated":[70],"aminopyrine":[71],"accumulation":[72],"by":[73],"these":[74],"Iloprost":[76,92,104,152,184],"did":[78,155],"not":[79,156],"correlate":[80,157],"biological":[83],"action":[84],"on":[85,145,171],"4.":[89],"reduced":[93,109,125],"Trypan":[94,110,126],"Blue":[95,111,127],"staining":[96,112,128],"exposed":[99],"10%":[101],"(w/v)":[102],"ethanol.":[103],"(10(-8)":[105,122],"10(-6)":[107],"M)":[108,123],"significantly":[124],"cell-enriched":[131],"fractions.":[132,148],"5.":[133],"Cyclic":[134],"AMP":[135,160],"stimulation":[136],"response":[138],"either":[140],"prostanoid":[141],"most":[143],"potently":[144],"non-parietal":[146],"However":[149],"or":[151],"affinities":[154],"cyclic":[159],"formation.":[161],"6.":[162],"These":[163],"data":[164],"provide":[165],"evidence":[166],"for":[167],"true":[168],"receptors":[170,176],"mucosal":[173],"appear":[177],"mediate":[179,190],"inhibition":[180],"acid":[182],"secretion.":[183],"binds":[185],"sites":[187],"which":[188],"might":[189],"protection.":[192]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}