{"id":"https://openalex.org/W2024967189","doi":"https://doi.org/10.1016/0304-3959(89)90109-7","title":"Comparison of ketamine and pethidine in experimental and postoperative pain","display_name":"Comparison of ketamine and pethidine in experimental and postoperative pain","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2024967189","doi":"https://doi.org/10.1016/0304-3959(89)90109-7","mag":"2024967189","pmid":"https://pubmed.ncbi.nlm.nih.gov/2919093"},"language":"en","primary_location":{"id":"doi:10.1016/0304-3959(89)90109-7","doi":"https://doi.org/10.1016/0304-3959(89)90109-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3959(89)90109-7","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028452085","display_name":"A Maurset","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Atle Maurset","raw_affiliation_strings":["Department of Pharmacology, Oslo University School of Medicine, Blindern, 0316 Oslo 3 Norway","Atle Maurset, M.D., Department of Pharmacology, P.O. Box 1057, Blindern, 0316 Oslo 3, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Oslo University School of Medicine, Blindern, 0316 Oslo 3 Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Atle Maurset, M.D., Department of Pharmacology, P.O. Box 1057, Blindern, 0316 Oslo 3, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112146481","display_name":"Lasse Ansgar Skoglund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Lasse A. Skoglund","raw_affiliation_strings":["Department of Pharmacology, Oslo University School of Medicine, Blindern, 0316 Oslo 3 Norway","Submitted March 22, 1988; revised and accepted July 15, 1988","Submitted March 22, 1988","revised and accepted July 15, 1988"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Oslo University School of Medicine, Blindern, 0316 Oslo 3 Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Submitted March 22, 1988; revised and accepted July 15, 1988","institution_ids":[]},{"raw_affiliation_string":"Submitted March 22, 1988","institution_ids":[]},{"raw_affiliation_string":"revised and accepted July 15, 1988","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078099769","display_name":"Olav Hustveit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Olav Hustveit","raw_affiliation_strings":["Department of Pharmacology, Oslo University School of Medicine, Blindern, 0316 Oslo 3 Norway","Submitted March 22, 1988; revised and accepted July 15, 1988","Submitted March 22, 1988","revised and accepted July 15, 1988"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Oslo University School of Medicine, Blindern, 0316 Oslo 3 Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Submitted March 22, 1988; revised and accepted July 15, 1988","institution_ids":[]},{"raw_affiliation_string":"Submitted March 22, 1988","institution_ids":[]},{"raw_affiliation_string":"revised and accepted July 15, 1988","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089969011","display_name":"Ivar \u00d8ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ivar \u00d8ye","raw_affiliation_strings":["Department of Pharmacology, Oslo University School of Medicine, Blindern, 0316 Oslo 3 Norway","Submitted March 22, 1988; revised and accepted July 15, 1988","Submitted March 22, 1988","revised and accepted July 15, 1988"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Oslo University School of Medicine, Blindern, 0316 Oslo 3 Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Submitted March 22, 1988; revised and accepted July 15, 1988","institution_ids":[]},{"raw_affiliation_string":"Submitted March 22, 1988","institution_ids":[]},{"raw_affiliation_string":"revised and accepted July 15, 1988","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028452085"],"corresponding_institution_ids":["https://openalex.org/I184942183"],"apc_list":null,"apc_paid":null,"fwci":7.788,"has_fulltext":false,"cited_by_count":143,"citation_normalized_percentile":{"value":0.9820244,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"36","issue":"1","first_page":"37","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.17720000445842743,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.03610000014305115,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":1.0},{"id":"https://openalex.org/keywords/meperidine","display_name":"pethidine","score":1.0},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.7260000109672546},{"id":"https://openalex.org/keywords/ischemic-pain","display_name":"ischemic pain","score":0.9070000052452087},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.9769999980926514},{"id":"https://openalex.org/keywords/oral-surgery","display_name":"oral surgery","score":0.9549999833106995},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.9760000109672546},{"id":"https://openalex.org/keywords/opioid-receptor-antagonism","display_name":"opioid antagonism","score":0.781000018119812},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pcp-receptor","display_name":"PCP receptor","score":0.8320000171661377},{"id":"https://openalex.org/keywords/visual-analog-scale","display_name":"visual analogue scale","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2781168792","wikidata":"https://www.wikidata.org/wiki/Q55434","display_name":"Pethidine","level":3,"score":0.970359742641449},{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.8870612382888794},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.8583704233169556},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7407119274139404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6829108595848083},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6616165637969971},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.6476125717163086},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.6135947704315186},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5173398852348328},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.5026636123657227},{"id":"https://openalex.org/C2779004600","wikidata":"https://www.wikidata.org/wiki/Q18357784","display_name":"Opioidergic","level":5,"score":0.45895108580589294},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09873899817466736},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09640064835548401},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008614","descriptor_name":"Meperidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008614","descriptor_name":"Meperidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014795","descriptor_name":"Visual Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0304-3959(89)90109-7","doi":"https://doi.org/10.1016/0304-3959(89)90109-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3959(89)90109-7","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},{"id":"pmid:2919093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2919093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W15515072","https://openalex.org/W1483005194","https://openalex.org/W1906520502","https://openalex.org/W1973566592","https://openalex.org/W1976382294","https://openalex.org/W1993557467","https://openalex.org/W2007388357","https://openalex.org/W2011187641","https://openalex.org/W2032819971","https://openalex.org/W2034780336","https://openalex.org/W2037397874","https://openalex.org/W2070182120","https://openalex.org/W2082895047","https://openalex.org/W2084536694","https://openalex.org/W2127704027","https://openalex.org/W2158767242","https://openalex.org/W2170029299","https://openalex.org/W2170862369","https://openalex.org/W4250347724","https://openalex.org/W4253934128","https://openalex.org/W6671883239"],"related_works":["https://openalex.org/W2055960847","https://openalex.org/W1968988996","https://openalex.org/W2441143941","https://openalex.org/W2161265567","https://openalex.org/W2040589240","https://openalex.org/W2168061169","https://openalex.org/W2070490316","https://openalex.org/W1969077967","https://openalex.org/W2042105119","https://openalex.org/W2466136238"],"abstract_inverted_index":{"The":[0,32,75],"analgesic":[1,30,64,85],"efficiency":[2],"of":[3,58,66,87,99],"ketamine":[4,43,73,88],"and":[5,13,46],"pethidine":[6,47],"was":[7,24],"compared":[8],"in":[9,78],"experimental":[10],"ischemic":[11],"pain":[12,15,36,59],"postoperative":[14],"after":[16],"oral":[17],"surgery.":[18],"Naloxone":[19,61],"1.6":[20],"mg":[21],"or":[22],"placebo":[23],"given":[25],"5":[26],"min":[27],"before":[28],"the":[29,55,63,81,84,100],"drug.":[31],"subjects":[33],"recorded":[34],"their":[35],"on":[37,72],"a":[38,92],"visual":[39],"analogue":[40],"scale.":[41],"Both":[42],"0.3":[44],"mg/kg":[45,49],"0.7":[48],"were":[50],"effective":[51],"as":[52],"analgesics":[53],"against":[54],"two":[56],"types":[57],"studied.":[60],"prevented":[62],"effect":[65,71,86],"pethidine,":[67],"but":[68],"had":[69],"no":[70],"analgesia.":[74],"results":[76],"are":[77],"accordance":[79],"with":[80],"hypothesis":[82],"that":[83],"is":[89],"mediated":[90],"by":[91],"non-opioid":[93],"mechanism,":[94],"possibly":[95],"involving":[96],"PCP-receptor-mediated":[97],"blockade":[98],"NMDA-receptor-operated":[101],"ion":[102],"channel.":[103]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}