{"id":"https://openalex.org/W2024965845","doi":"https://doi.org/10.1021/jm010045q","title":"Radioiodinated Styrylbenzenes and Thioflavins as Probes for Amyloid Aggregates","display_name":"Radioiodinated Styrylbenzenes and Thioflavins as Probes for Amyloid Aggregates","publication_year":2001,"publication_date":"2001-05-04","ids":{"openalex":"https://openalex.org/W2024965845","doi":"https://doi.org/10.1021/jm010045q","mag":"2024965845","pmid":"https://pubmed.ncbi.nlm.nih.gov/11384236"},"language":"en","primary_location":{"id":"doi:10.1021/jm010045q","doi":"https://doi.org/10.1021/jm010045q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm010045q","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.7270/q2v69hv8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Z.-P. Zhuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z.-P. Zhuang","raw_affiliation_strings":["Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108431942","display_name":"M.\u2010P. KUNG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.-P. Kung","raw_affiliation_strings":["Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082627212","display_name":"Catherine Hou","orcid":"https://orcid.org/0000-0001-8905-8492","observed_orcids":["https://orcid.org/0000-0001-8905-8492"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Hou","raw_affiliation_strings":["Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047687122","display_name":"Daniel Skovronsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. M. Skovronsky","raw_affiliation_strings":["Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079942007","display_name":"Tamar Gur","orcid":"https://orcid.org/0000-0002-5559-0226","observed_orcids":["https://orcid.org/0000-0002-5559-0226"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. L. Gur","raw_affiliation_strings":["Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112418107","display_name":"Karl Pl\u00f6\u00dfl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Pl\u00f6ssl","raw_affiliation_strings":["Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021394368","display_name":"John Q. Trojanowski","orcid":"https://orcid.org/0000-0002-9239-8794","observed_orcids":["https://orcid.org/0000-0002-9239-8794"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Q. Trojanowski","raw_affiliation_strings":["Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109059098","display_name":"Virginia M.-Y. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. M.-Y. Lee","raw_affiliation_strings":["Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055131918","display_name":"Hank F. Kung","orcid":"https://orcid.org/0000-0003-3254-8049","observed_orcids":["https://orcid.org/0000-0003-3254-8049"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. F. Kung","raw_affiliation_strings":["Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Pathology and Laboratory Medicine, and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":8.652,"has_fulltext":false,"cited_by_count":198,"citation_normalized_percentile":{"value":0.98258475,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"44","issue":"12","first_page":"1905","last_page":"1914"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6259999871253967},{"id":"https://openalex.org/keywords/abeta-1-40","display_name":"A\u03b2(1-40)","score":0.8700000047683716},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.9909999966621399},{"id":"https://openalex.org/keywords/amyloid-aggregates","display_name":"amyloid aggregates","score":0.7519999742507935},{"id":"https://openalex.org/keywords/iodine-125-labeling","display_name":"iodine-125 labeling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.6819999814033508},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.652999997138977},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/competitive-binding","display_name":"competitive binding","score":0.41499999165534973},{"id":"https://openalex.org/keywords/binding-sites","display_name":"binding sites","score":0.4790000021457672},{"id":"https://openalex.org/keywords/autoradiography","display_name":"autoradiography","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9273864030838013},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5636137127876282},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34540948271751404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013343","descriptor_name":"Styrenes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013343","descriptor_name":"Styrenes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013343","descriptor_name":"Styrenes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013343","descriptor_name":"Styrenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013343","descriptor_name":"Styrenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013343","descriptor_name":"Styrenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013343","descriptor_name":"Styrenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013343","descriptor_name":"Styrenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013343","descriptor_name":"Styrenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/jm010045q","doi":"https://doi.org/10.1021/jm010045q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm010045q","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:11384236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11384236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"doi:10.7270/q2v69hv8","doi":"https://doi.org/10.7270/q2v69hv8","is_oa":true,"landing_page_url":"https://doi.org/10.7270/q2v69hv8","pdf_url":null,"source":{"id":"https://openalex.org/S7407050887","display_name":"UC San Diego","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36258959","host_organization_name":"University of California San Diego","host_organization_lineage":["https://openalex.org/I36258959"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.7270/q2v69hv8","doi":"https://doi.org/10.7270/q2v69hv8","is_oa":true,"landing_page_url":"https://doi.org/10.7270/q2v69hv8","pdf_url":null,"source":{"id":"https://openalex.org/S7407050887","display_name":"UC San Diego","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36258959","host_organization_name":"University of California San Diego","host_organization_lineage":["https://openalex.org/I36258959"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1471184362","display_name":null,"funder_award_id":"P01 AG11542","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1486705631","display_name":"NEW TC-99M LABELED BRAIN IMAGING AGENTS","funder_award_id":"2r01ns018509-18","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2850222565","display_name":"In Vitro in Vivo Models of Alzheimer's Disease","funder_award_id":"5p01ag011542-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G496285611","display_name":null,"funder_award_id":"NS 18509","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W179188620","https://openalex.org/W1646659232","https://openalex.org/W1972856649","https://openalex.org/W1975237239","https://openalex.org/W1981570625","https://openalex.org/W1984059331","https://openalex.org/W1985323612","https://openalex.org/W1990939643","https://openalex.org/W1992470039","https://openalex.org/W1994653867","https://openalex.org/W2000582255","https://openalex.org/W2000706612","https://openalex.org/W2002668624","https://openalex.org/W2014515679","https://openalex.org/W2019321365","https://openalex.org/W2020579433","https://openalex.org/W2027356620","https://openalex.org/W2031519731","https://openalex.org/W2035146506","https://openalex.org/W2036094586","https://openalex.org/W2041006513","https://openalex.org/W2043813981","https://openalex.org/W2044485752","https://openalex.org/W2046680150","https://openalex.org/W2053546096","https://openalex.org/W2054605844","https://openalex.org/W2055859393","https://openalex.org/W2065553960","https://openalex.org/W2084626714","https://openalex.org/W2087035014","https://openalex.org/W2091385244","https://openalex.org/W2130393399","https://openalex.org/W2133019124","https://openalex.org/W2172164111","https://openalex.org/W2399749275","https://openalex.org/W4322700972","https://openalex.org/W4323966388"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487","https://openalex.org/W1986764834","https://openalex.org/W657579294"],"abstract_inverted_index":{"We":[0],"report":[1],"for":[2,105,116,141,179,247],"the":[3,18,44,164,187,211,229],"first":[4],"time":[5],"that":[6,167,201,228],"small":[7],"molecule-based":[8],"radiodiodinated":[9],"ligands,":[10,232],"showing":[11,28],"selective":[12,178],"binding":[13,86,93,128],"to":[14,158],"Abeta":[15],"aggregates,":[16,134,181],"cross":[17],"intact":[19],"blood-brain":[20],"barrier":[21],"by":[22],"simple":[23],"diffusion.":[24],"Four":[25],"novel":[26],"ligands":[27,90],"preferential":[29],"labeling":[30,185],"of":[31,34,46,88,98,107,118,147,151,186,213,220,255],"amyloid":[32],"aggregates":[33,106,117,162,254],"Abeta(1-40)":[35,108,131,180,249],"and":[36,60,64,71,102,109,113,132,143,170,203,209,222,239],"Abeta(1-42)":[37,133,161,253],"peptides,":[38],"commonly":[39],"associated":[40],"with":[41,48,95,154],"plaques":[42],"in":[43,163,193,257],"brain":[45,149,165,174,189,207],"people":[47],"Alzheimer's":[49],"disease":[50],"(AD),":[51],"were":[52,75,139,215],"developed.":[53],"Two":[54],"125I-labeled":[55,66],"styrylbenzenes,":[56],"(E,E)-1-iodo-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene,":[57],"12":[58],"(ISB),":[59,234],"(E,E)-1-iodo-2,5-bis(3-hydroxycarbonyl-4-methoxy)styrylbenzene,":[61],"13":[62],"(IMSB),":[63,236],"two":[65],"thioflavins,":[67],"2-[4'-(dimethylamino)phenyl]-6-iodobenzothiazole,":[68],"18a":[69],"(TZDM),":[70,238],"2-[4'-(4''-methylpiperazin-1-yl)phenyl]-6-iodobenzothiazole,":[72],"18b":[73],"(TZPI),":[74,241],"prepared":[76],"at":[77],"a":[78,123,152],"high":[79],"specific":[80],"activity":[81],"(2200":[82],"Ci/mmol).":[83],"In":[84],"vitro":[85],"studies":[87,146,192],"these":[89,173],"showed":[91,166,200],"excellent":[92,206],"affinities":[94],"Kd":[96],"values":[97],"0.08,":[99],"0.13,":[100],"0.06,":[101],"0.13":[103],"nM":[104,115],"0.15,":[110],"0.73,":[111],"0.14,":[112],"0.15":[114],"Abeta(1-42),":[119],"respectively.":[120],"Interestingly,":[121],"under":[122],"competitive-binding":[124],"assaying":[125],"condition,":[126],"different":[127],"sites":[129],"on":[130],"which":[135,214],"are":[136],"mutually":[137],"exclusive,":[138],"observed":[140],"styrylbenzenes":[142],"thioflavins.":[144],"Autoradiography":[145],"postmortem":[148],"sections":[150],"patient":[153],"Down's":[155],"syndrome":[156],"known":[157],"contain":[159],"primarily":[160],"both":[168],"[(125)I]18a":[169],"[125I]18b":[171,240],"labeled":[172],"sections,":[175],"but":[176],"[125I]13,":[177],"exhibited":[182,205],"very":[183],"low":[184],"comparable":[188],"section.":[190],"Biodistribution":[191],"normal":[194],"mice":[195],"after":[196],"an":[197],"iv":[198],"injection":[199],"[125I]18a":[202,237],"[(125)I]18b":[204],"uptake":[208],"retention,":[210],"levels":[212],"much":[216],"higher":[217],"than":[218],"those":[219],"[125I]12":[221,233],"[125I]13.":[223],"These":[224],"findings":[225],"strongly":[226],"suggest":[227],"new":[230],"radioiodinated":[231],"[125I]13":[235],"may":[242],"be":[243],"useful":[244],"as":[245,250,252],"biomarkers":[246],"studying":[248],"well":[251],"amyloidogenesis":[256],"AD":[258],"patients.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}