{"id":"https://openalex.org/W2024958380","doi":"https://doi.org/10.1074/jbc.m113.496950","title":"Bone Morphogenetic Proteins Signal Via SMAD and Mitogen-activated Protein (MAP) Kinase Pathways at Distinct Times during Osteoclastogenesis","display_name":"Bone Morphogenetic Proteins Signal Via SMAD and Mitogen-activated Protein (MAP) Kinase Pathways at Distinct Times during Osteoclastogenesis","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2024958380","doi":"https://doi.org/10.1074/jbc.m113.496950","mag":"2024958380","pmid":"https://pubmed.ncbi.nlm.nih.gov/24235143","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3873576"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m113.496950","doi":"https://doi.org/10.1074/jbc.m113.496950","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.496950","pdf_url":"http://www.jbc.org/article/S0021925820552952/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820552952/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027105192","display_name":"Aaron Broege","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Broege","raw_affiliation_strings":["From the Departments of Diagnostic and Biological Sciences","Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Diagnostic and Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008200539","display_name":"Lan Pham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lan Pham","raw_affiliation_strings":["Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103258332","display_name":"Eric D. Jensen","orcid":"https://orcid.org/0000-0003-0323-9706","observed_orcids":["https://orcid.org/0000-0003-0323-9706"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric D. Jensen","raw_affiliation_strings":["Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ann Emery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Emery","raw_affiliation_strings":["Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102922305","display_name":"Tsang\u2010Hai Huang","orcid":"https://orcid.org/0000-0002-7353-8560","observed_orcids":["https://orcid.org/0000-0002-7353-8560"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tsang-Hai Huang","raw_affiliation_strings":["Institute of Physical Education, Health and Leisure Studies, National Cheng-kung University, Tainan City 701, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physical Education, Health and Leisure Studies, National Cheng-kung University, Tainan City 701, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018703883","display_name":"Melissa Stemig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Stemig","raw_affiliation_strings":["Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111609394","display_name":"Hideyuki Beppu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Beppu","raw_affiliation_strings":["Department of Clinical and Molecular Pathology, University of Toyama, Toyama 930-0887, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Pathology, University of Toyama, Toyama 930-0887, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044937761","display_name":"Anna Petryk","orcid":"https://orcid.org/0000-0001-8017-0170","observed_orcids":["https://orcid.org/0000-0001-8017-0170"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Petryk","raw_affiliation_strings":["Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455","Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056336149","display_name":"Michael B. O\u2019Connor","orcid":"https://orcid.org/0000-0002-3067-5506","observed_orcids":["https://orcid.org/0000-0002-3067-5506","https://orcid.org/0000-0002-4883-1706"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael O'Connor","raw_affiliation_strings":["Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025360487","display_name":"Kim C. Mansky","orcid":"https://orcid.org/0000-0002-2826-5030","observed_orcids":["https://orcid.org/0000-0002-2826-5030"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kim Mansky","raw_affiliation_strings":["Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":null,"display_name":"Raj Gopalakrishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raj Gopalakrishnan","raw_affiliation_strings":["Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025360487"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5396,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.81983951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"288","issue":"52","first_page":"37230","last_page":"37240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13328","display_name":"Osteomyelitis and Bone Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-morphogenetic-proteins","display_name":"bone morphogenetic proteins","score":0.9049999713897705},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.8579999804496765},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/bmpr2","display_name":"BMPR2","score":0.8640000224113464},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.824999988079071},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8569999933242798},{"id":"https://openalex.org/keywords/p38-phosphorylation","display_name":"p38 phosphorylation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/bone-homeostasis","display_name":"bone homeostasis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/osteopetrosis","display_name":"osteopetrosis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/compound-c","display_name":"compound C","score":0.8550000190734863},{"id":"https://openalex.org/keywords/bone-marrow-derived-macrophages","display_name":"bone marrow-derived macrophages","score":0.7620000243186951},{"id":"https://openalex.org/keywords/rank-ligand","display_name":"RANK ligand","score":0.765999972820282},{"id":"https://openalex.org/keywords/macrophage-colony-stimulating-factor","display_name":"macrophage colony-stimulating factor","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.8821991682052612},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.7141290903091431},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6874472498893738},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.680884838104248},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.6358897686004639},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.5518341064453125},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5407668352127075},{"id":"https://openalex.org/C2781228645","wikidata":"https://www.wikidata.org/wiki/Q4941575","display_name":"Bone morphogenetic protein receptor","level":4,"score":0.5229626297950745},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5215396881103516},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4859260618686676},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.45143020153045654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3001394271850586},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2419087290763855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16540932655334473},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052006","descriptor_name":"Bone Morphogenetic Protein Receptors, Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052006","descriptor_name":"Bone Morphogenetic Protein Receptors, Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053245","descriptor_name":"RANK Ligand","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053245","descriptor_name":"RANK Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m113.496950","doi":"https://doi.org/10.1074/jbc.m113.496950","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.496950","pdf_url":"http://www.jbc.org/article/S0021925820552952/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3241574","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3873576","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3873576","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3873576","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:24235143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24235143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m113.496950","doi":"https://doi.org/10.1074/jbc.m113.496950","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.496950","pdf_url":"http://www.jbc.org/article/S0021925820552952/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2396839909","display_name":"Role of HDAC7 in Osteoclast Differentiation","funder_award_id":"R01AR061352","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4289054926","display_name":"Minnesota Craniofacial Research Training Program","funder_award_id":"T32DE007288","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G7147220886","display_name":"Minnesota Craniofacial Research Training Program","funder_award_id":"T90DE022732","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G8216591857","display_name":"Role of Twisted Gastrulation in Osteoclastogenesis","funder_award_id":"R01AR056642","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8549491550","display_name":"TWISTED GASTRULATION AND MANDIBULAR ARCH MORPHOGENESIS","funder_award_id":"R01DE016601","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024958380.pdf","grobid_xml":"https://content.openalex.org/works/W2024958380.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1522753405","https://openalex.org/W1533185644","https://openalex.org/W1963782060","https://openalex.org/W1964399247","https://openalex.org/W1972950008","https://openalex.org/W1973661281","https://openalex.org/W1980582973","https://openalex.org/W1982395713","https://openalex.org/W1995833718","https://openalex.org/W1996176602","https://openalex.org/W2003764631","https://openalex.org/W2022056770","https://openalex.org/W2045100170","https://openalex.org/W2056124301","https://openalex.org/W2060324382","https://openalex.org/W2078409020","https://openalex.org/W2079562282","https://openalex.org/W2087665466","https://openalex.org/W2096425957","https://openalex.org/W2098085126","https://openalex.org/W2119838074","https://openalex.org/W2120642348","https://openalex.org/W2140375355","https://openalex.org/W2157783701","https://openalex.org/W2163504684"],"related_works":["https://openalex.org/W1980582973","https://openalex.org/W2133455379","https://openalex.org/W2980686444","https://openalex.org/W2156426372","https://openalex.org/W3095064354","https://openalex.org/W2022056770","https://openalex.org/W1887078028","https://openalex.org/W2891569702","https://openalex.org/W2528464236","https://openalex.org/W2131350538"],"abstract_inverted_index":{"To":[0],"investigate":[1],"the":[2,63,122,127,130,134,141,155],"role":[3],"of":[4,65,70,90,109,136],"bone":[5,150],"morphogenetic":[6],"protein":[7],"(BMP)":[8],"signaling":[9,145,157,162],"in":[10,12,17,40,54,62,97,113,146],"osteoclastogenesis":[11],"vivo,":[13],"we":[14],"eliminated":[15],"BMPRII":[16],"osteoclasts":[18,61,99,147],"by":[19,160],"creating":[20],"a":[21,38],"BMPRII(fl/fl);lysM-Cre":[22],"mouse":[23],"strain.":[24],"Conditional":[25],"knock-out":[26],"(cKO)":[27],"mice":[28,50],"are":[29,51,85],"osteopetrotic":[30],"when":[31],"compared":[32],"with":[33,121],"WT":[34],"controls":[35],"due":[36],"to":[37,57],"decrease":[39],"osteoclast":[41,91,105,164],"activity.":[42],"Bone":[43],"marrow":[44],"macrophages":[45],"(BMMs)":[46],"isolated":[47],"from":[48,116],"cKO":[49,117],"severely":[52],"inhibited":[53],"their":[55],"capacity":[56],"differentiate":[58],"into":[59],"mature":[60],"presence":[64],"M-CSF":[66],"and":[67,81,100,152],"receptor":[68],"activator":[69],"NF-\u03baB":[71],"(RANK)":[72],"ligand.":[73],"We":[74],"also":[75,153],"show":[76],"that":[77],"BMP":[78,144,161],"noncanonical":[79],"(MAPK)":[80],"canonical":[82,131],"(SMAD)":[83],"pathways":[84],"utilized":[86],"at":[87],"different":[88],"stages":[89],"differentiation.":[92,165],"BMP2":[93],"induces":[94],"p38":[95],"phosphorylation":[96,103],"pre-fusion":[98],"increases":[101],"SMAD":[102,123],"around":[104,133],"precursor":[106],"fusion.":[107,137],"Phosphorylation":[108],"MAPKs":[110],"was":[111],"decreased":[112],"differentiated":[114],"BMMs":[115,120],"animals.":[118],"Treating":[119],"inhibitor":[124],"dorsomorphin":[125],"confirms":[126],"requirement":[128,142],"for":[129,143,148],"pathway":[132],"time":[135],"These":[138],"results":[139],"demonstrate":[140],"proper":[149],"homeostasis":[151],"explore":[154],"complex":[156],"mechanisms":[158],"employed":[159],"during":[163]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}