{"id":"https://openalex.org/W2024955519","doi":"https://doi.org/10.1016/j.jss.2005.11.197","title":"A novel role of notch pathway in region-specific induction of pancreatogenesis by regulating ptf1a expression","display_name":"A novel role of notch pathway in region-specific induction of pancreatogenesis by regulating ptf1a expression","publication_year":2006,"publication_date":"2006-01-27","ids":{"openalex":"https://openalex.org/W2024955519","doi":"https://doi.org/10.1016/j.jss.2005.11.197","mag":"2024955519"},"language":"en","primary_location":{"id":"doi:10.1016/j.jss.2005.11.197","doi":"https://doi.org/10.1016/j.jss.2005.11.197","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jss.2005.11.197","pdf_url":null,"source":{"id":"https://openalex.org/S45161156","display_name":"Journal of Surgical Research","issn_l":"0022-4804","issn":["0022-4804","1095-8673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A. Fukuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A. Fukuda","raw_affiliation_strings":["Kyoto University Hospital, Kyoto, JAPAN","Kyoto University Hospital; Kyoto Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University Hospital, Kyoto, JAPAN","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Kyoto University Hospital; Kyoto Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112211648","display_name":"Y. Kawaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Kawaguchi","raw_affiliation_strings":["Kyoto University Hospital, Kyoto, JAPAN","Kyoto University Hospital; Kyoto Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University Hospital, Kyoto, JAPAN","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Kyoto University Hospital; Kyoto Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002822159","display_name":"Kenichiro Furuyama","orcid":"https://orcid.org/0000-0003-4878-2841","observed_orcids":["https://orcid.org/0000-0003-4878-2841"]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Furuyama","raw_affiliation_strings":["Kyoto University Hospital, Kyoto, JAPAN","Kyoto University Hospital; Kyoto Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University Hospital, Kyoto, JAPAN","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Kyoto University Hospital; Kyoto Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Kodama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Kodama","raw_affiliation_strings":["Kyoto University Hospital, Kyoto, JAPAN","Kyoto University Hospital; Kyoto Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University Hospital, Kyoto, JAPAN","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Kyoto University Hospital; Kyoto Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112473449","display_name":"M. Horiguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Horiguchi","raw_affiliation_strings":["Kyoto University Hospital, Kyoto, JAPAN","Kyoto University Hospital; Kyoto Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University Hospital, Kyoto, JAPAN","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Kyoto University Hospital; Kyoto Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065466337","display_name":"Takeshi Kuhara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Kuhara","raw_affiliation_strings":["Kyoto University Hospital, Kyoto, JAPAN","Kyoto University Hospital; Kyoto Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University Hospital, Kyoto, JAPAN","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Kyoto University Hospital; Kyoto Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Koizumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Koizumi","raw_affiliation_strings":["Kyoto University Hospital, Kyoto, JAPAN","Kyoto University Hospital; Kyoto Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University Hospital, Kyoto, JAPAN","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Kyoto University Hospital; Kyoto Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063846860","display_name":"Koichi Fujimoto","orcid":"https://orcid.org/0000-0001-6473-7990","observed_orcids":["https://orcid.org/0000-0001-6473-7990"]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Fujimoto","raw_affiliation_strings":["Kyoto University Hospital, Kyoto, JAPAN","Kyoto University Hospital; Kyoto Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University Hospital, Kyoto, JAPAN","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Kyoto University Hospital; Kyoto Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018917055","display_name":"Ryoichiro Kageyama","orcid":"https://orcid.org/0000-0002-5985-1120","observed_orcids":["https://orcid.org/0000-0002-5985-1120"]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Kageyama","raw_affiliation_strings":["Kyoto University Hospital, Kyoto, JAPAN","Kyoto University Hospital; Kyoto Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University Hospital, Kyoto, JAPAN","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Kyoto University Hospital; Kyoto Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026978419","display_name":"Christopher V.E. Wright","orcid":"https://orcid.org/0000-0002-9260-4009","observed_orcids":["https://orcid.org/0000-0002-9260-4009"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.V. Wright","raw_affiliation_strings":["Vanderbilt University, Nashville, TN","Vanderbilt University,Nashville,TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University,Nashville,TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109627824","display_name":"Tsutomu Chiba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Chiba","raw_affiliation_strings":["Kyoto University Hospital, Kyoto, JAPAN","Kyoto University Hospital; Kyoto Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University Hospital, Kyoto, JAPAN","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Kyoto University Hospital; Kyoto Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078261662","display_name":"Ryuichiro Doi","orcid":"https://orcid.org/0000-0002-7298-2301","observed_orcids":["https://orcid.org/0000-0002-7298-2301"]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Doi","raw_affiliation_strings":["Kyoto University Hospital, Kyoto, JAPAN","Kyoto University Hospital; Kyoto Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University Hospital, Kyoto, JAPAN","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Kyoto University Hospital; Kyoto Japan","institution_ids":["https://openalex.org/I4210150196"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10086468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"130","issue":"2","first_page":"232","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8109999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8109999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.18250000476837158,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ptf1a","display_name":"Ptf1a","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ectopic-pancreas","display_name":"heterotopic pancreas","score":0.9110000133514404},{"id":"https://openalex.org/keywords/bhlh-transcription-factors","display_name":"bHLH transcription factors","score":0.847000002861023},{"id":"https://openalex.org/keywords/foregut-endoderm","display_name":"foregut endoderm","score":0.9279999732971191},{"id":"https://openalex.org/keywords/lineage-tracing","display_name":"lineage tracing","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2780283210","wikidata":"https://www.wikidata.org/wiki/Q18027301","display_name":"HES1","level":4,"score":0.89630526304245},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.7788978815078735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7426944375038147},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.721736490726471},{"id":"https://openalex.org/C63101894","wikidata":"https://www.wikidata.org/wiki/Q604095","display_name":"Fate mapping","level":4,"score":0.7069028615951538},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.657656729221344},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5948719382286072},{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.5871623754501343},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5838520526885986},{"id":"https://openalex.org/C2778635641","wikidata":"https://www.wikidata.org/wiki/Q5334293","display_name":"Ectopic pancreas","level":3,"score":0.47633105516433716},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.44897735118865967},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4291721284389496},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3820590376853943},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32966670393943787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32165539264678955},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23685204982757568},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.22729191184043884},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22609522938728333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13540124893188477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07691556215286255}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jss.2005.11.197","doi":"https://doi.org/10.1016/j.jss.2005.11.197","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jss.2005.11.197","pdf_url":null,"source":{"id":"https://openalex.org/S45161156","display_name":"Journal of Surgical Research","issn_l":"0022-4804","issn":["0022-4804","1095-8673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.46000000834465027,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2180812410","https://openalex.org/W2901458271","https://openalex.org/W2969998161","https://openalex.org/W2045980853","https://openalex.org/W4251701033","https://openalex.org/W1970621119","https://openalex.org/W2941332545","https://openalex.org/W4200422867","https://openalex.org/W2159265403","https://openalex.org/W2024955519"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}