{"id":"https://openalex.org/W2024947462","doi":"https://doi.org/10.1158/0008-5472.can-04-2983","title":"Expression of Human Endogenous Retrovirus K in Melanomas and Melanoma Cell Lines","display_name":"Expression of Human Endogenous Retrovirus K in Melanomas and Melanoma Cell Lines","publication_year":2005,"publication_date":"2005-05-15","ids":{"openalex":"https://openalex.org/W2024947462","doi":"https://doi.org/10.1158/0008-5472.can-04-2983","mag":"2024947462","pmid":"https://pubmed.ncbi.nlm.nih.gov/15899808"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-04-2983","doi":"https://doi.org/10.1158/0008-5472.can-04-2983","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-04-2983","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/10/4172/2530860/4172-4180.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/65/10/4172/2530860/4172-4180.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015195786","display_name":"Kristina B\u00fcscher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24359323","display_name":"Robert Koch Institute","ror":"https://ror.org/01k5qnb77","country_code":"DE","type":"government","lineage":["https://openalex.org/I24359323"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kristina Bu\u0308scher","raw_affiliation_strings":["1Robert Koch-Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Robert Koch-Institute and","institution_ids":["https://openalex.org/I24359323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000840495","display_name":"Uwe Trefzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Trefzer","raw_affiliation_strings":["2Department of Dermatology, Campus Charite\u0301-Mitte, Charite\u0301-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Dermatology, Campus Charite\u0301-Mitte, Charite\u0301-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065762235","display_name":"Maja A. Hofmann","orcid":"https://orcid.org/0000-0003-3859-234X","observed_orcids":["https://orcid.org/0000-0003-3859-234X"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maja Hofmann","raw_affiliation_strings":["2Department of Dermatology, Campus Charite\u0301-Mitte, Charite\u0301-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Dermatology, Campus Charite\u0301-Mitte, Charite\u0301-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110049863","display_name":"Wolfram Sterry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfram Sterry","raw_affiliation_strings":["2Department of Dermatology, Campus Charite\u0301-Mitte, Charite\u0301-University Medicine Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Dermatology, Campus Charite\u0301-Mitte, Charite\u0301-University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061996061","display_name":"Reinhard Kurth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24359323","display_name":"Robert Koch Institute","ror":"https://ror.org/01k5qnb77","country_code":"DE","type":"government","lineage":["https://openalex.org/I24359323"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Reinhard Kurth","raw_affiliation_strings":["1Robert Koch-Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Robert Koch-Institute and","institution_ids":["https://openalex.org/I24359323"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079303125","display_name":"Joachim Denner","orcid":"https://orcid.org/0000-0003-3244-6085","observed_orcids":["https://orcid.org/0000-0003-3244-6085"]},"institutions":[{"id":"https://openalex.org/I24359323","display_name":"Robert Koch Institute","ror":"https://ror.org/01k5qnb77","country_code":"DE","type":"government","lineage":["https://openalex.org/I24359323"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Denner","raw_affiliation_strings":["1Robert Koch-Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Robert Koch-Institute and","institution_ids":["https://openalex.org/I24359323"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":15.2742,"has_fulltext":true,"cited_by_count":249,"citation_normalized_percentile":{"value":0.99085972,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"65","issue":"10","first_page":"4172","last_page":"4180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.5957000255584717,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.5957000255584717,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13385","display_name":"Infectious Diseases and Mycology","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-endogenous-retrovirus-k","display_name":"HERV-K","score":0.9729999899864197},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8849999904632568},{"id":"https://openalex.org/keywords/melanoma-cell-lines","display_name":"melanoma cell lines","score":0.8479999899864197},{"id":"https://openalex.org/keywords/spliced-mrna","display_name":"spliced mRNA","score":0.8149999976158142},{"id":"https://openalex.org/keywords/env-protein","display_name":"Env protein","score":0.6959999799728394},{"id":"https://openalex.org/keywords/gag-protein","display_name":"Gag protein","score":0.8759999871253967},{"id":"https://openalex.org/keywords/reverse-transcriptase","display_name":"reverse transcriptase","score":0.9240000247955322},{"id":"https://openalex.org/keywords/teratocarcinoma","display_name":"teratocarcinoma","score":0.8240000009536743},{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.7839999794960022},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7629293203353882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6755229830741882},{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.6033422350883484},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5279941558837891},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5138614177703857},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.4921647906303406},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45804139971733093},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4459119439125061},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4283408224582672},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3256022334098816},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31043606996536255},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2864752411842346},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2837938070297241},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17642521858215332},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11288145184516907}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020077","descriptor_name":"Endogenous Retroviruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020077","descriptor_name":"Endogenous Retroviruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020077","descriptor_name":"Endogenous Retroviruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020077","descriptor_name":"Endogenous Retroviruses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020077","descriptor_name":"Endogenous Retroviruses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020077","descriptor_name":"Endogenous Retroviruses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020077","descriptor_name":"Endogenous Retroviruses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020077","descriptor_name":"Endogenous Retroviruses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020077","descriptor_name":"Endogenous Retroviruses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-04-2983","doi":"https://doi.org/10.1158/0008-5472.can-04-2983","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-04-2983","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/10/4172/2530860/4172-4180.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:15899808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15899808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-04-2983","doi":"https://doi.org/10.1158/0008-5472.can-04-2983","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-04-2983","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/10/4172/2530860/4172-4180.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316943","display_name":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology","ror":"https://ror.org/01xd6q208"},{"id":"https://openalex.org/F4320332132","display_name":"Robert Koch Institut","ror":"https://ror.org/01k5qnb77"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024947462.pdf","grobid_xml":"https://content.openalex.org/works/W2024947462.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1506075988","https://openalex.org/W1514509695","https://openalex.org/W1547687872","https://openalex.org/W1568723069","https://openalex.org/W1926501429","https://openalex.org/W1964997986","https://openalex.org/W1967414895","https://openalex.org/W1979692119","https://openalex.org/W1989275902","https://openalex.org/W2006063808","https://openalex.org/W2009338952","https://openalex.org/W2016838416","https://openalex.org/W2020302113","https://openalex.org/W2028305820","https://openalex.org/W2034516018","https://openalex.org/W2038292059","https://openalex.org/W2039160584","https://openalex.org/W2056255385","https://openalex.org/W2058991578","https://openalex.org/W2067477900","https://openalex.org/W2086605012","https://openalex.org/W2090212265","https://openalex.org/W2102042543","https://openalex.org/W2105436480","https://openalex.org/W2123531690","https://openalex.org/W2143045093","https://openalex.org/W2143733226","https://openalex.org/W2146527174","https://openalex.org/W2154121432","https://openalex.org/W2168909179","https://openalex.org/W2186324938","https://openalex.org/W2320803949","https://openalex.org/W2438707056"],"related_works":["https://openalex.org/W2219682716","https://openalex.org/W1966288685","https://openalex.org/W2016688375","https://openalex.org/W58301269","https://openalex.org/W2076952785","https://openalex.org/W1965200570","https://openalex.org/W139501173","https://openalex.org/W1979100108","https://openalex.org/W2372523691","https://openalex.org/W2015827800"],"abstract_inverted_index":{"The":[0],"human":[1,24,115,202],"endogenous":[2,25],"retrovirus":[3],"K":[4],"family":[5],"(HERV-K)":[6],"comprises":[7],"30":[8],"to":[9,21,41,162,199],"50":[10],"closely":[11],"related":[12],"proviruses,":[13],"most":[14],"of":[15,78,82,103,119,133,141,212],"which":[16],"are":[17],"defective.":[18],"In":[19,39,146],"contrast":[20],"all":[22,36,114],"other":[23],"retroviruses,":[26],"some":[27],"HERV-K":[28,189],"proviruses":[29,110],"have":[30,58],"maintained":[31],"open":[32],"reading":[33],"frames":[34],"for":[35],"viral":[37],"proteins.":[38],"addition":[40,198],"the":[42,49,64,76,134,142,184,205],"structural":[43],"proteins":[44,54,159],"Gag":[45],"and":[46,48,56,70,92,95,99,108,122,138,169,176,201],"Env":[47],"reverse":[50],"transcriptase,":[51],"two":[52],"regulatory":[53],"(Rec":[55],"Np9)":[57],"been":[59],"described.":[60],"Malignant":[61],"melanoma":[62,136,143,170,193],"has":[63],"highest":[65],"mortality":[66],"among":[67],"skin":[68],"cancers":[69],"is":[71],"particularly":[72],"aggressive.":[73],"To":[74],"study":[75],"expression":[77,211],"HERV-K,":[79],"a":[80,127],"set":[81],"seven":[83],"primers":[84],"was":[85,111,124,152],"developed":[86],"that":[87],"allows":[88],"discrimination":[89],"between":[90],"full-length":[91,104],"spliced":[93,120,150,156],"mRNA":[94,96,105],"from":[97,106],"deleted":[98,107],"undeleted":[100,109],"proviruses.":[101],"Expression":[102,118],"detected":[112,125,153],"in":[113,126,131,139,165,192,197],"cells":[116],"investigated.":[117],"env":[121],"rec":[123,151],"teratocarcinoma":[128],"cell":[129,144,171],"line,":[130],"45%":[132],"metastatic":[135],"biopsies,":[137],"44%":[140],"lines.":[145],"normal":[147],"neonatal":[148],"melanocytes,":[149],"but":[154],"not":[155],"env.":[157],"Viral":[158],"were":[160,190],"shown":[161],"be":[163],"expressed":[164],"primary":[166],"melanomas,":[167],"metastases,":[168],"lines":[172],"by":[173],"immunohistochemistry,":[174],"immunofluorescence,":[175],"Western":[177],"blot":[178],"analyses":[179],"using":[180],"specific":[181],"antisera.":[182],"For":[183],"first":[185],"time,":[186],"antibodies":[187],"against":[188],"found":[191],"patients.":[194],"Melanomas":[195],"are,":[196],"teratocarcinomas":[200],"breast":[203],"cancer,":[204],"third":[206],"tumor":[207],"type":[208],"with":[209],"enhanced":[210],"HERV-K.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2016-06-24T00:00:00"}