{"id":"https://openalex.org/W2024938749","doi":"https://doi.org/10.1074/jbc.271.28.16734","title":"Cloning, Characterization, and Modeling of Mouse and Human Guanylate Kinases","display_name":"Cloning, Characterization, and Modeling of Mouse and Human Guanylate Kinases","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W2024938749","doi":"https://doi.org/10.1074/jbc.271.28.16734","mag":"2024938749","pmid":"https://pubmed.ncbi.nlm.nih.gov/8663313"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.271.28.16734","doi":"https://doi.org/10.1074/jbc.271.28.16734","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.271.28.16734","pdf_url":"http://www.jbc.org/article/S0021925818319380/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925818319380/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041556492","display_name":"William Brady","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William A. Brady","raw_affiliation_strings":["Darwin Molecular Corporation, Bothell, Washington 98021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Darwin Molecular Corporation, Bothell, Washington 98021, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014338649","display_name":"Mark S. Kokoris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark S. Kokoris","raw_affiliation_strings":["Darwin Molecular Corporation, Bothell, Washington 98021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Darwin Molecular Corporation, Bothell, Washington 98021","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058179747","display_name":"Matthew J. Fitzgibbon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matt Fitzgibbon","raw_affiliation_strings":["Darwin Molecular Corporation, Bothell, Washington 98021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Darwin Molecular Corporation, Bothell, Washington 98021","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102786813","display_name":"Margaret E. Black","orcid":"https://orcid.org/0000-0002-3152-5112","observed_orcids":["https://orcid.org/0000-0002-3152-5112"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Margaret E. Black","raw_affiliation_strings":["Darwin Molecular Corporation, Bothell, Washington 98021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Darwin Molecular Corporation, Bothell, Washington 98021","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5102786813"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.3165,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.49284776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"271","issue":"28","first_page":"16734","last_page":"16740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/guanylate-kinase","display_name":"guanylate kinase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nucleotide-metabolism","display_name":"nucleotide metabolism","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.4180000126361847},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sequence-identity","display_name":"sequence identity","score":0.5559999942779541},{"id":"https://openalex.org/keywords/molecular-modeling","display_name":"molecular modeling","score":0.6259999871253967},{"id":"https://openalex.org/keywords/active-site-conservation","display_name":"active site conservation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.6010000109672546},{"id":"https://openalex.org/keywords/chemotherapy-targets","display_name":"chemotherapeutic target","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.8157414793968201},{"id":"https://openalex.org/C172078151","wikidata":"https://www.wikidata.org/wiki/Q24784833","display_name":"Guanylate kinase","level":4,"score":0.7513381242752075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6450662016868591},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.598459780216217},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.521393358707428},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5178847312927246},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.4944124221801758},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4821302890777588},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.46970030665397644},{"id":"https://openalex.org/C19924922","wikidata":"https://www.wikidata.org/wiki/Q408351","display_name":"Molecular cloning","level":4,"score":0.44179999828338623},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4268282651901245},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2877640724182129},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009703","descriptor_name":"Nucleoside-Phosphate Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009703","descriptor_name":"Nucleoside-Phosphate Kinase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009703","descriptor_name":"Nucleoside-Phosphate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009703","descriptor_name":"Nucleoside-Phosphate Kinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051528","descriptor_name":"Guanylate Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.271.28.16734","doi":"https://doi.org/10.1074/jbc.271.28.16734","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.271.28.16734","pdf_url":"http://www.jbc.org/article/S0021925818319380/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8663313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8663313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.271.28.16734","doi":"https://doi.org/10.1074/jbc.271.28.16734","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.271.28.16734","pdf_url":"http://www.jbc.org/article/S0021925818319380/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024938749.pdf","grobid_xml":"https://content.openalex.org/works/W2024938749.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W863550049","https://openalex.org/W1489215358","https://openalex.org/W1501921984","https://openalex.org/W1531398313","https://openalex.org/W1540585850","https://openalex.org/W1573671253","https://openalex.org/W1580476552","https://openalex.org/W1580979140","https://openalex.org/W1594700207","https://openalex.org/W1873199501","https://openalex.org/W1980943354","https://openalex.org/W1992322591","https://openalex.org/W2009761919","https://openalex.org/W2028547310","https://openalex.org/W2060271430","https://openalex.org/W2072699715","https://openalex.org/W2073360590","https://openalex.org/W2088028188","https://openalex.org/W2100350999","https://openalex.org/W2134812217","https://openalex.org/W2144634347","https://openalex.org/W2157195501","https://openalex.org/W2314225431","https://openalex.org/W2576734941","https://openalex.org/W2584373698","https://openalex.org/W4206302388","https://openalex.org/W4406985012"],"related_works":["https://openalex.org/W181402401","https://openalex.org/W2004510362","https://openalex.org/W1971102110","https://openalex.org/W7098193418","https://openalex.org/W1511322026","https://openalex.org/W2036196371","https://openalex.org/W2118454573","https://openalex.org/W1900608493","https://openalex.org/W1983579414","https://openalex.org/W2073351208"],"abstract_inverted_index":{"Guanylate":[0],"kinase":[1,60],"catalyzes":[2],"the":[3,43,145,152,163,169,179,182],"phosphorylation":[4],"of":[5,82,111,129,160,168,176,181],"either":[6],"GMP":[7],"to":[8,12,101,119],"GDP":[9],"or":[10],"dGMP":[11],"dGDP":[13],"and":[14,32,37,45,67,89,141,166],"is":[15,99,117],"an":[16,79],"essential":[17],"enzyme":[18],"in":[19,26,30,33,91],"nucleotide":[20],"metabolism":[21],"pathways.":[22],"Despite":[23],"its":[24],"involvement":[25],"antiviral":[27],"drug":[28],"activation":[29],"humans":[31,90],"mouse":[34,46,64,97],"model":[35],"systems":[36],"as":[38],"a":[39,103,108,121,126,157,174],"target":[40],"for":[41,86],"chemotherapy,":[42],"human":[44,68,115],"primary":[47],"structures":[48],"have":[49],"never":[50],"been":[51],"elucidated.":[52],"Full-length":[53],"cDNA":[54,72,98,116],"clones":[55],"encoding":[56],"enzymatically":[57],"active":[58,164],"guanylate":[59,147],"were":[61],"isolated":[62],"from":[63],"B-cell":[65],"lymphoma":[66],"peripheral":[69],"blood":[70],"lymphocyte":[71],"libraries.":[73],"Multiple":[74],"tissue":[75,93],"Northern":[76],"blots":[77],"demonstrated":[78],"mRNA":[80],"species":[81],"approximately":[83],"1":[84],"kilobase":[85],"both":[87],"mice":[88],"all":[92],"types":[94],"examined.":[95],"The":[96,114],"predicted":[100,118],"encode":[102,120],"198-amino":[104],"acid":[105,123],"protein":[106,124],"with":[107,125,138,144],"molecular":[109,127],"mass":[110,128],"21,904":[112],"daltons.":[113,131],"197-amino":[122],"21,696":[130],"These":[132],"proteins":[133],"share":[134],"88%":[135],"sequence":[136],"identity":[137,143],"each":[139],"other":[140],"52-54%":[142],"yeast":[146,153],"kinase.":[148],"Molecular":[149],"modeling":[150],"using":[151],"diffraction":[154],"coordinates":[155],"indicates":[156],"high":[158],"degree":[159],"conservation":[161],"within":[162],"site":[165],"maintenance":[167],"overall":[170],"structural":[171],"integrity,":[172],"despite":[173],"lack":[175],"similarity":[177],"along":[178],"periphery":[180],"enzyme.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
