{"id":"https://openalex.org/W2024930772","doi":"https://doi.org/10.4143/crt.2004.36.1.43","title":"The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray","display_name":"The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2024930772","doi":"https://doi.org/10.4143/crt.2004.36.1.43","mag":"2024930772","pmid":"https://pubmed.ncbi.nlm.nih.gov/20396564","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2855115"},"language":"en","primary_location":{"id":"doi:10.4143/crt.2004.36.1.43","doi":"https://doi.org/10.4143/crt.2004.36.1.43","is_oa":true,"landing_page_url":"https://doi.org/10.4143/crt.2004.36.1.43","pdf_url":"http://www.e-crt.org/upload/pdf/crt-36-43.pdf","source":{"id":"https://openalex.org/S21122719","display_name":"Cancer Research and Treatment","issn_l":"1598-2998","issn":["1598-2998","2005-9256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","kci-candidate","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319474","host_organization_name":"Korean Cancer Association","host_organization_lineage":["https://openalex.org/P4310319474"],"host_organization_lineage_names":["Korean Cancer Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research and Treatment","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.e-crt.org/upload/pdf/crt-36-43.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111764407","display_name":"Myung-Ju Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myung-Ju Ahn","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007989453","display_name":"Ki-Hwan Lee","orcid":"https://orcid.org/0000-0002-4894-7047","observed_orcids":["https://orcid.org/0000-0002-4894-7047"]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki-Hwan Lee","raw_affiliation_strings":["Department of Biochemistry, College of Medicine, Hanyang University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Medicine, Hanyang University, Seoul, Korea","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048877271","display_name":"Joon\u2010Ik Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joon-Ik Ahn","raw_affiliation_strings":["Department of Biochemistry, College of Medicine, Hanyang University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Medicine, Hanyang University, Seoul, Korea","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065060434","display_name":"Dong\u2010Hyun Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Hyun Yu","raw_affiliation_strings":["Department of Biochemistry, College of Medicine, Hanyang University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Medicine, Hanyang University, Seoul, Korea","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046605791","display_name":"Hye-Sook Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye-Sook Lee","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103581872","display_name":"Jung-Hye Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung-Hye Choi","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112169350","display_name":"Joung Soon Jang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joung Soon Jang","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, GyeongSang National University, Jinju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, GyeongSang National University, Jinju, Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057179551","display_name":"Jong Min Bae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Min Bae","raw_affiliation_strings":["Department of Computer Science, College of Natural Science, GyeongSang National University, Jinju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, College of Natural Science, GyeongSang National University, Jinju, Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060948953","display_name":"Yong\u2010Sung Lee","orcid":"https://orcid.org/0000-0002-1980-1225","observed_orcids":["https://orcid.org/0000-0002-1980-1225"]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-Sung Lee","raw_affiliation_strings":["Department of Biochemistry, College of Medicine, Hanyang University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Medicine, Hanyang University, Seoul, Korea","institution_ids":["https://openalex.org/I4575257"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3208,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.6237262,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"36","issue":"1","first_page":"43","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.32589998841285706,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8029999732971191},{"id":"https://openalex.org/keywords/doxorubicin-resistance","display_name":"doxorubicin resistance","score":0.9079999923706055},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8320000171661377},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6880000233650208},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8360000252723694},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/grk5","display_name":"GRK5","score":0.9390000104904175},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":1.0},{"id":"https://openalex.org/keywords/foxm1","display_name":"FOXM1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-superfamily","display_name":"tumor necrosis factor superfamily","score":0.9589999914169312},{"id":"https://openalex.org/keywords/chemoresistance-mechanisms","display_name":"chemoresistance mechanisms","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5805554986000061},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5561119318008423},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5308749675750732},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5292496085166931},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5200443267822266},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4702058434486389},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46861204504966736},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.445936918258667},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.42017343640327454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4153096079826355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3689149022102356},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33610546588897705},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1285932958126068}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4143/crt.2004.36.1.43","doi":"https://doi.org/10.4143/crt.2004.36.1.43","is_oa":true,"landing_page_url":"https://doi.org/10.4143/crt.2004.36.1.43","pdf_url":"http://www.e-crt.org/upload/pdf/crt-36-43.pdf","source":{"id":"https://openalex.org/S21122719","display_name":"Cancer Research and Treatment","issn_l":"1598-2998","issn":["1598-2998","2005-9256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","kci-candidate","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319474","host_organization_name":"Korean Cancer Association","host_organization_lineage":["https://openalex.org/P4310319474"],"host_organization_lineage_names":["Korean Cancer Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research and Treatment","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2855115","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2855115","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Res Treat","raw_type":"Text"},{"id":"pmid:20396564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20396564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research and treatment","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4143/crt.2004.36.1.43","doi":"https://doi.org/10.4143/crt.2004.36.1.43","is_oa":true,"landing_page_url":"https://doi.org/10.4143/crt.2004.36.1.43","pdf_url":"http://www.e-crt.org/upload/pdf/crt-36-43.pdf","source":{"id":"https://openalex.org/S21122719","display_name":"Cancer Research and Treatment","issn_l":"1598-2998","issn":["1598-2998","2005-9256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","kci-candidate","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319474","host_organization_name":"Korean Cancer Association","host_organization_lineage":["https://openalex.org/P4310319474"],"host_organization_lineage_names":["Korean Cancer Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research and Treatment","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322348","display_name":"Korea Science and Engineering Foundation","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024930772.pdf","grobid_xml":"https://content.openalex.org/works/W2024930772.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W184549435","https://openalex.org/W238668910","https://openalex.org/W1487423556","https://openalex.org/W1523426892","https://openalex.org/W1528751727","https://openalex.org/W1562335567","https://openalex.org/W1747605242","https://openalex.org/W1922105785","https://openalex.org/W1968746186","https://openalex.org/W1974980101","https://openalex.org/W1975129989","https://openalex.org/W1983546164","https://openalex.org/W1999303971","https://openalex.org/W1999792244","https://openalex.org/W2034660092","https://openalex.org/W2038118195","https://openalex.org/W2042263343","https://openalex.org/W2042677337","https://openalex.org/W2082163465","https://openalex.org/W2119297613","https://openalex.org/W2154049530","https://openalex.org/W2167621975","https://openalex.org/W2176573833","https://openalex.org/W2203276755","https://openalex.org/W2413207407"],"related_works":["https://openalex.org/W2370627816","https://openalex.org/W4407306537","https://openalex.org/W2004036687","https://openalex.org/W2374637210","https://openalex.org/W2155619104","https://openalex.org/W2357174332","https://openalex.org/W1981987902","https://openalex.org/W2105728472","https://openalex.org/W2324736690","https://openalex.org/W1965568460"],"abstract_inverted_index":{"PURPOSE:":[0],"Adriamycin":[1],"is":[2],"one":[3],"of":[4,13,25,115,134,162,176,180,195],"the":[5,11,22,38,160,174,193],"most":[6],"commonly":[7],"used":[8,153],"drugs":[9,164,189],"in":[10,28,69,95,127,137,192],"treatment":[12],"breast":[14,29,40,72,166],"cancer.":[15],"This":[16],"study":[17],"was":[18,139],"performed":[19],"to":[20,154,173,188,199],"understand":[21],"molecular":[23],"mechanisms":[24],"drug":[26,96,201],"resistance":[27],"cancer":[30,73,167],"cells.":[31,74,98,130,168],"MATERIALS":[32],"AND":[33],"METHODS:":[34],"We":[35,56],"have":[36],"analyzed":[37],"MCF-7":[39],"cell":[41],"line":[42],"and":[43,120,190],"its":[44],"adriamycin-resistant":[45],"variants,":[46],"MCF-7/ADR":[47],"using":[48],"human":[49],"10":[50],"K":[51],"element":[52],"cDNA":[53,148],"microarrays.":[54],"RESULTS:":[55],"defined":[57],"68":[58],"genes":[59,135],"that":[60,147],"were":[61],"up-regulated":[62,94],"(14":[63],"genes)":[64,68],"or":[65],"down-regulated":[66,126],"(54":[67],"adriamycin":[70,128],"resistant":[71,97,129],"Several":[75,99],"genes,":[76,100],"such":[77,101],"as":[78,102],"G":[79],"protein-coupled":[80],"receptor":[81],"kinase":[82,112],"5,":[83],"phospholipase":[84],"A2,":[85],"guanylate":[86],"cyclase":[87],"1,":[88],"vimentin,":[89],"matrix":[90],"metalloproteinase":[91],"1":[92,119],"are":[93,125],"interferon,":[103],"alpha-inducible":[104],"protein":[105,111],"27,":[106],"forkhead":[107],"box":[108],"M1,":[109],"mitogen-activated":[110],"6,":[113],"regulator":[114],"mitotic":[116],"spindle":[117],"assembly":[118],"tumor":[121],"necrosis":[122],"factor":[123],"superfamily":[124],"The":[131],"altered":[132],"expression":[133,157,178],"observed":[136],"microarray":[138,149],"verified":[140],"by":[141],"RT-PCR.":[142],"CONCLUSION:":[143],"These":[144],"findings":[145],"show":[146],"analysis":[150],"can":[151],"be":[152],"obtain":[155],"gene":[156],"profiles":[158,179],"reflecting":[159],"effect":[161],"anticancer":[163],"on":[165],"Such":[169],"data":[170],"may":[171,184],"lead":[172],"assigning":[175],"signature":[177],"drug-resistant":[181],"tumors":[182],"which":[183],"help":[185],"predict":[186],"responses":[187],"assist":[191],"design":[194],"tailored":[196],"therapeutic":[197],"regimens":[198],"overcome":[200],"resistance.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
