{"id":"https://openalex.org/W2024929585","doi":"https://doi.org/10.1021/jm100022r","title":"Discovery of a Biaryl Cyclohexene Carboxylic Acid (MK-6892): A Potent and Selective High Affinity Niacin Receptor Full Agonist with Reduced Flushing Profiles in Animals as a Preclinical Candidate","display_name":"Discovery of a Biaryl Cyclohexene Carboxylic Acid (MK-6892): A Potent and Selective High Affinity Niacin Receptor Full Agonist with Reduced Flushing Profiles in Animals as a Preclinical Candidate","publication_year":2010,"publication_date":"2010-02-25","ids":{"openalex":"https://openalex.org/W2024929585","doi":"https://doi.org/10.1021/jm100022r","mag":"2024929585","pmid":"https://pubmed.ncbi.nlm.nih.gov/20184326"},"language":"en","primary_location":{"id":"doi:10.1021/jm100022r","doi":"https://doi.org/10.1021/jm100022r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm100022r","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066546362","display_name":"Hong C. Shen","orcid":"https://orcid.org/0000-0002-3477-8932","observed_orcids":["https://orcid.org/0000-0002-3477-8932"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hong C. Shen","raw_affiliation_strings":["Departments of Medicinal Chemistry","Department of Medicinal Chemistry, Merck Research Laboratories,Merck & Co, Inc, Rahway, New Jersey 07065-0900, USA. mail: hong_shen@merck.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicinal Chemistry","institution_ids":[]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories,Merck & Co, Inc, Rahway, New Jersey 07065-0900, USA. mail: hong_shen@merck.com","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016418186","display_name":"Fa\u2010Xiang Ding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fa-Xiang Ding","raw_affiliation_strings":["Departments of Medicinal Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicinal Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102136913","display_name":"Subharekha Raghavan","orcid":"https://orcid.org/0009-0005-7954-1559","observed_orcids":["https://orcid.org/0009-0005-7954-1559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Subharekha Raghavan","raw_affiliation_strings":["Departments of Medicinal Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicinal Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qiaolin Deng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiaolin Deng","raw_affiliation_strings":["Departments of Medicinal Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicinal Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073997383","display_name":"Silvi Luell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvi Luell","raw_affiliation_strings":["Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111989536","display_name":"Michael J. Forrest","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Forrest","raw_affiliation_strings":["Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026400631","display_name":"Ester Carballo\u2010Jane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ester Carballo-Jane","raw_affiliation_strings":["Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008243563","display_name":"Larissa C. Wilsie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larissa C. Wilsie","raw_affiliation_strings":["Cardiovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054610785","display_name":"Mihajlo L. Krsmanovic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mihajlo L. Krsmanovic","raw_affiliation_strings":["Cardiovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041133825","display_name":"Andrew K.P. Taggart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew K. Taggart","raw_affiliation_strings":["Cardiovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103506802","display_name":"Kenneth K. Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth K. Wu","raw_affiliation_strings":["Cardiovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031362389","display_name":"Tsuei-Ju Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsuei-Ju Wu","raw_affiliation_strings":["Cardiovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100628398","display_name":"Kang Cheng","orcid":"https://orcid.org/0000-0002-3114-271X","observed_orcids":["https://orcid.org/0000-0002-3114-271X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kang Cheng","raw_affiliation_strings":["Cardiovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023974447","display_name":"Ning Ren","orcid":"https://orcid.org/0009-0008-7262-4978","observed_orcids":["https://orcid.org/0009-0008-7262-4978","https://orcid.org/0000-0003-2104-6158"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ning Ren","raw_affiliation_strings":["Cardiovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109126437","display_name":"Tian\u2010Quan Cai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tian-Quan Cai","raw_affiliation_strings":["Cardiovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371367","display_name":"Qing Chen","orcid":"https://orcid.org/0000-0002-7360-5700","observed_orcids":["https://orcid.org/0000-0002-7360-5700"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing Chen","raw_affiliation_strings":["Drug Metabolism"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101598044","display_name":"Junying Wang","orcid":"https://orcid.org/0000-0002-9289-7702","observed_orcids":["https://orcid.org/0000-0002-9289-7702"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junying Wang","raw_affiliation_strings":["Drug Metabolism"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107484281","display_name":"Michael S. Wolff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael S. Wolff","raw_affiliation_strings":["Drug Metabolism"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110048208","display_name":"Xinchun Tong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinchun Tong","raw_affiliation_strings":["Drug Metabolism"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054565318","display_name":"Tom G. Holt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tom G. Holt","raw_affiliation_strings":["Drug Metabolism"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053116098","display_name":"M. Gerard Waters","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Gerard Waters","raw_affiliation_strings":["Cardiovascular Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071129219","display_name":"Milton L. Hammond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Milton L. Hammond","raw_affiliation_strings":["Departments of Medicinal Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicinal Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030052359","display_name":"James R. Tata","orcid":"https://orcid.org/0009-0006-3191-3197","observed_orcids":["https://orcid.org/0009-0006-3191-3197"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James R. Tata","raw_affiliation_strings":["Departments of Medicinal Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicinal Chemistry","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109937004","display_name":"Steven L. Colletti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven L. Colletti","raw_affiliation_strings":["Departments of Medicinal Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicinal Chemistry","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066546362"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.0828,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.86322083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"53","issue":"6","first_page":"2666","last_page":"2670"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.23579999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.23579999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.23430000245571136,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.1720000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpr109a","display_name":"GPR109A","score":0.847000002861023},{"id":"https://openalex.org/keywords/free-fatty-acid-reduction","display_name":"free fatty acid reduction","score":0.6449999809265137},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7080000042915344},{"id":"https://openalex.org/keywords/off-target-selectivity","display_name":"off-target selectivity","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9000414609909058},{"id":"https://openalex.org/C2780092750","wikidata":"https://www.wikidata.org/wiki/Q134658","display_name":"Niacin","level":2,"score":0.8388868570327759},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7528132796287537},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6573259830474854},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6093391180038452},{"id":"https://openalex.org/C2779484182","wikidata":"https://www.wikidata.org/wiki/Q413328","display_name":"Cyclohexene","level":3,"score":0.5361034870147705},{"id":"https://openalex.org/C2779074116","wikidata":"https://www.wikidata.org/wiki/Q134856","display_name":"Carboxylic acid","level":2,"score":0.5134835839271545},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33693927526474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29214048385620117},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053138","descriptor_name":"Cyclohexenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm100022r","doi":"https://doi.org/10.1021/jm100022r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm100022r","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:20184326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20184326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1485967434","https://openalex.org/W1972693920","https://openalex.org/W1973053270","https://openalex.org/W1979134292","https://openalex.org/W1996819821","https://openalex.org/W2004243328","https://openalex.org/W2032574293","https://openalex.org/W2033075266","https://openalex.org/W2076090516","https://openalex.org/W2087130015","https://openalex.org/W2090600090","https://openalex.org/W2091214663","https://openalex.org/W2094621463","https://openalex.org/W2103682415","https://openalex.org/W2125512697","https://openalex.org/W2158025896","https://openalex.org/W2168443670","https://openalex.org/W2409067422"],"related_works":["https://openalex.org/W1979134292","https://openalex.org/W2005531594","https://openalex.org/W2071911442","https://openalex.org/W3011665061","https://openalex.org/W1979066761","https://openalex.org/W2087130015","https://openalex.org/W2037637780","https://openalex.org/W2051427616","https://openalex.org/W1982134384","https://openalex.org/W2087807234"],"abstract_inverted_index":{"Biaryl":[0],"cyclohexene":[1],"carboxylic":[2],"acids":[3],"were":[4],"discovered":[5],"as":[6],"full":[7],"and":[8,32,46],"potent":[9],"niacin":[10,37],"receptor":[11,19],"(GPR109A)":[12],"agonists.":[13],"Compound":[14],"1e":[15],"(MK-6892)":[16],"displayed":[17],"excellent":[18],"activity,":[20],"good":[21,29],"PK":[22],"across":[23],"species,":[24],"remarkably":[25],"clean":[26],"off-target":[27],"profiles,":[28],"ancillary":[30],"pharmacology,":[31],"superior":[33],"therapeutic":[34],"window":[35],"over":[36],"regarding":[38],"the":[39],"FFA":[40],"reduction":[41],"versus":[42],"vasodilation":[43],"in":[44],"rats":[45],"dogs.":[47]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}