{"id":"https://openalex.org/W2024925929","doi":"https://doi.org/10.1111/j.1600-0854.2007.00692.x","title":"RACK1 Regulates the Cell Surface Expression of the G Protein\u2010Coupled Receptor for Thromboxane A2","display_name":"RACK1 Regulates the Cell Surface Expression of the G Protein\u2010Coupled Receptor for Thromboxane A2","publication_year":2007,"publication_date":"2007-12-14","ids":{"openalex":"https://openalex.org/W2024925929","doi":"https://doi.org/10.1111/j.1600-0854.2007.00692.x","mag":"2024925929","pmid":"https://pubmed.ncbi.nlm.nih.gov/18088317"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0854.2007.00692.x","doi":"https://doi.org/10.1111/j.1600-0854.2007.00692.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0854.2007.00692.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2007.00692.x","source":{"id":"https://openalex.org/S174148068","display_name":"Traffic","issn_l":"1398-9219","issn":["1398-9219","1600-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2007.00692.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024695957","display_name":"Audrey V. Parent","orcid":"https://orcid.org/0000-0003-4506-6268","observed_orcids":["https://orcid.org/0000-0003-4506-6268"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Audrey Parent","raw_affiliation_strings":["Service de Rhumatologie, D\u00e9partement de M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada. jean-luc.parent@usherbrooke.ca","Service de Rhumatologie, D\u00e9partement de M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Rhumatologie, D\u00e9partement de M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada. jean-luc.parent@usherbrooke.ca","institution_ids":["https://openalex.org/I135117807"]},{"raw_affiliation_string":"Service de Rhumatologie, D\u00e9partement de M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada","institution_ids":["https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074354899","display_name":"Genevi\u00e8ve Laroche","orcid":"https://orcid.org/0000-0002-5979-6344","observed_orcids":["https://orcid.org/0000-0002-5979-6344"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]},{"id":"https://openalex.org/I2801825082","display_name":"Centre Hospitalier Universitaire de Sherbrooke","ror":"https://ror.org/020r51985","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801825082","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Genevi\u00e8ve Laroche","raw_affiliation_strings":["Service de Rhumatologie, De\u0301partement de Me\u0301decine, Faculte\u0301 de Me\u0301decine, Universite\u0301 de Sherbrooke, and Centre de Recherche Clinique-E\u0301tienne Lebel, Centre Hospitalier Universitaire de l\u2019Universite\u0301 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada","Service de Rhumatologie, D\u00e9partement de M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Sherbrooke, and Centre de Recherche Clinique\u2010\u00c9tienne Lebel, Centre Hospitalier Universitaire de l\u2019Universit\u00e9 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Rhumatologie, De\u0301partement de Me\u0301decine, Faculte\u0301 de Me\u0301decine, Universite\u0301 de Sherbrooke, and Centre de Recherche Clinique-E\u0301tienne Lebel, Centre Hospitalier Universitaire de l\u2019Universite\u0301 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada","institution_ids":["https://openalex.org/I135117807","https://openalex.org/I2801825082"]},{"raw_affiliation_string":"Service de Rhumatologie, D\u00e9partement de M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Sherbrooke, and Centre de Recherche Clinique\u2010\u00c9tienne Lebel, Centre Hospitalier Universitaire de l\u2019Universit\u00e9 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada","institution_ids":["https://openalex.org/I135117807","https://openalex.org/I2801825082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003359968","display_name":"\u00c9milie Hamelin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]},{"id":"https://openalex.org/I2801825082","display_name":"Centre Hospitalier Universitaire de Sherbrooke","ror":"https://ror.org/020r51985","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801825082","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"\u00c9milie Hamelin","raw_affiliation_strings":["Service de Rhumatologie, De\u0301partement de Me\u0301decine, Faculte\u0301 de Me\u0301decine, Universite\u0301 de Sherbrooke, and Centre de Recherche Clinique-E\u0301tienne Lebel, Centre Hospitalier Universitaire de l\u2019Universite\u0301 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada","Service de Rhumatologie, D\u00e9partement de M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Sherbrooke, and Centre de Recherche Clinique\u2010\u00c9tienne Lebel, Centre Hospitalier Universitaire de l\u2019Universit\u00e9 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Rhumatologie, De\u0301partement de Me\u0301decine, Faculte\u0301 de Me\u0301decine, Universite\u0301 de Sherbrooke, and Centre de Recherche Clinique-E\u0301tienne Lebel, Centre Hospitalier Universitaire de l\u2019Universite\u0301 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada","institution_ids":["https://openalex.org/I135117807","https://openalex.org/I2801825082"]},{"raw_affiliation_string":"Service de Rhumatologie, D\u00e9partement de M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Sherbrooke, and Centre de Recherche Clinique\u2010\u00c9tienne Lebel, Centre Hospitalier Universitaire de l\u2019Universit\u00e9 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada","institution_ids":["https://openalex.org/I135117807","https://openalex.org/I2801825082"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113573054","display_name":"Jean\u2010Luc Parent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]},{"id":"https://openalex.org/I2801825082","display_name":"Centre Hospitalier Universitaire de Sherbrooke","ror":"https://ror.org/020r51985","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801825082","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Jean\u2010Luc Parent","raw_affiliation_strings":["Service de Rhumatologie, De\u0301partement de Me\u0301decine, Faculte\u0301 de Me\u0301decine, Universite\u0301 de Sherbrooke, and Centre de Recherche Clinique-E\u0301tienne Lebel, Centre Hospitalier Universitaire de l\u2019Universite\u0301 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada","Service de Rhumatologie, D\u00e9partement de M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Sherbrooke, and Centre de Recherche Clinique\u2010\u00c9tienne Lebel, Centre Hospitalier Universitaire de l\u2019Universit\u00e9 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Rhumatologie, De\u0301partement de Me\u0301decine, Faculte\u0301 de Me\u0301decine, Universite\u0301 de Sherbrooke, and Centre de Recherche Clinique-E\u0301tienne Lebel, Centre Hospitalier Universitaire de l\u2019Universite\u0301 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada","institution_ids":["https://openalex.org/I135117807","https://openalex.org/I2801825082"]},{"raw_affiliation_string":"Service de Rhumatologie, D\u00e9partement de M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Sherbrooke, and Centre de Recherche Clinique\u2010\u00c9tienne Lebel, Centre Hospitalier Universitaire de l\u2019Universit\u00e9 de Sherbrooke, Fleurimont, Quebec, J1H 5N4, Canada","institution_ids":["https://openalex.org/I135117807","https://openalex.org/I2801825082"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113573054"],"corresponding_institution_ids":["https://openalex.org/I135117807","https://openalex.org/I2801825082"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":1.6787,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.82715016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"3","first_page":"394","last_page":"407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rack1","display_name":"RACK1","score":1.0},{"id":"https://openalex.org/keywords/thromboxane-a2-receptor","display_name":"thromboxane A2 receptor","score":0.9779999852180481},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9670000076293945},{"id":"https://openalex.org/keywords/receptor-trafficking","display_name":"receptor trafficking","score":0.6579999923706055},{"id":"https://openalex.org/keywords/cell-surface-expression","display_name":"cell surface expression","score":0.9399999976158142},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9160000085830688},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8460000157356262},{"id":"https://openalex.org/keywords/receptor-c-terminus","display_name":"receptor C-terminus","score":0.7710000276565552},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7408292889595032},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.7065808773040771},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6706870794296265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6558424234390259},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4884106516838074},{"id":"https://openalex.org/C125268873","wikidata":"https://www.wikidata.org/wiki/Q17918484","display_name":"Protease-activated receptor 2","level":4,"score":0.4879421591758728},{"id":"https://openalex.org/C17971392","wikidata":"https://www.wikidata.org/wiki/Q18027445","display_name":"5-HT5A receptor","level":3,"score":0.48149430751800537},{"id":"https://openalex.org/C149577978","wikidata":"https://www.wikidata.org/wiki/Q24777577","display_name":"Protease-activated receptor","level":4,"score":0.4584995210170746},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.45463672280311584},{"id":"https://openalex.org/C51603380","wikidata":"https://www.wikidata.org/wiki/Q411978","display_name":"Thromboxane receptor","level":4,"score":0.453940212726593},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.4518529772758484},{"id":"https://openalex.org/C178592051","wikidata":"https://www.wikidata.org/wiki/Q28208812","display_name":"Prostaglandin E2 receptor","level":4,"score":0.41166234016418457},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31616494059562683},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23168450593948364},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.1957477629184723},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.12702777981758118},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.1113971471786499},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.08329108357429504},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075370","descriptor_name":"Receptors for Activated C Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075370","descriptor_name":"Receptors for Activated C Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075370","descriptor_name":"Receptors for Activated C Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008301","descriptor_name":"Maleimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008301","descriptor_name":"Maleimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008301","descriptor_name":"Maleimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044244","descriptor_name":"Receptors, Thromboxane A2, Prostaglandin H2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044244","descriptor_name":"Receptors, Thromboxane A2, Prostaglandin H2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044244","descriptor_name":"Receptors, Thromboxane A2, Prostaglandin H2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044244","descriptor_name":"Receptors, Thromboxane A2, Prostaglandin H2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044244","descriptor_name":"Receptors, Thromboxane A2, Prostaglandin H2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044244","descriptor_name":"Receptors, Thromboxane A2, Prostaglandin H2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0854.2007.00692.x","doi":"https://doi.org/10.1111/j.1600-0854.2007.00692.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0854.2007.00692.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2007.00692.x","source":{"id":"https://openalex.org/S174148068","display_name":"Traffic","issn_l":"1398-9219","issn":["1398-9219","1600-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic","raw_type":"journal-article"},{"id":"pmid:18088317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18088317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic (Copenhagen, Denmark)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1600-0854.2007.00692.x","doi":"https://doi.org/10.1111/j.1600-0854.2007.00692.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0854.2007.00692.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2007.00692.x","source":{"id":"https://openalex.org/S174148068","display_name":"Traffic","issn_l":"1398-9219","issn":["1398-9219","1600-0854"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traffic","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024925929.pdf","grobid_xml":"https://content.openalex.org/works/W2024925929.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1483456869","https://openalex.org/W1516963519","https://openalex.org/W1566771367","https://openalex.org/W1802267091","https://openalex.org/W1815010795","https://openalex.org/W1964148867","https://openalex.org/W1967085548","https://openalex.org/W1968167396","https://openalex.org/W1968555901","https://openalex.org/W1970689030","https://openalex.org/W1980973069","https://openalex.org/W1982921266","https://openalex.org/W1986542931","https://openalex.org/W1993389065","https://openalex.org/W1999987807","https://openalex.org/W2009997286","https://openalex.org/W2020515198","https://openalex.org/W2030571587","https://openalex.org/W2037185437","https://openalex.org/W2041287064","https://openalex.org/W2048009051","https://openalex.org/W2050135377","https://openalex.org/W2056601446","https://openalex.org/W2057720246","https://openalex.org/W2062310887","https://openalex.org/W2063840368","https://openalex.org/W2067424234","https://openalex.org/W2084009771","https://openalex.org/W2099603138","https://openalex.org/W2103908315","https://openalex.org/W2105041061","https://openalex.org/W2108081370","https://openalex.org/W2119419445","https://openalex.org/W2121612337","https://openalex.org/W2129029860","https://openalex.org/W2130963215","https://openalex.org/W2160059448","https://openalex.org/W2160332942","https://openalex.org/W2161992241","https://openalex.org/W2327883130","https://openalex.org/W2398616444","https://openalex.org/W2415218211"],"related_works":["https://openalex.org/W1997958887","https://openalex.org/W2167669406","https://openalex.org/W2113564677","https://openalex.org/W1983233834","https://openalex.org/W2471695409","https://openalex.org/W4247317352","https://openalex.org/W1984964116","https://openalex.org/W1685438413","https://openalex.org/W2037583192","https://openalex.org/W1603740866"],"abstract_inverted_index":{"We":[0,77],"used":[1],"the":[2,13,16,20,47,50,75,109,119,125,144,154,178,198,217,220,227,230],"yeast":[3],"two-hybrid":[4],"system":[5],"to":[6,46,153,158,161,229],"screen":[7,26],"for":[8,29,197,214],"proteins":[9],"that":[10,42,79,118,136],"interact":[11],"with":[12],"C-terminus":[14,48],"of":[15,19,54,74,83,114,148,169,177,188,219,222],"beta":[17],"isoform":[18],"thromboxane":[21],"A(2)":[22],"receptor":[23,28,151,183,225],"(TPbeta).":[24],"This":[25],"identified":[27],"activated":[30],"C-kinase":[31],"1":[32,182],"(RACK1)":[33],"as":[34],"a":[35,137,201,207,211,223],"new":[36],"TPbeta-interacting":[37],"protein.":[38],"Here,":[39],"we":[40],"show":[41],"RACK1":[43,88,97,149,170,205,215],"directly":[44],"binds":[45],"and":[49,68,116,184,190,206,209],"first":[51,199],"intracellular":[52],"loop":[53],"TPbeta.":[55],"The":[56,146],"TPbeta-RACK1":[57,139],"association":[58,140],"was":[59,69,85,89,93,99],"further":[60],"confirmed":[61,108],"by":[62,72,102],"co-immunoprecipitation":[63],"studies":[64],"in":[65,124,129,143,216],"HEK293":[66],"cells":[67],"not":[70,187],"modulated":[71],"stimulation":[73],"receptor.":[76],"observed":[78],"cell":[80,111,155,174,231],"surface":[81,112,156,175],"expression":[82,98,113,171],"TPbeta":[84,115],"increased":[86],"when":[87,95],"overexpressed,":[90],"while":[91],"it":[92],"inhibited":[94],"endogenous":[96],"knocked":[100],"down":[101],"small":[103],"interfering":[104],"RNA.":[105],"Confocal":[106,132],"microscopy":[107,133],"impaired":[110],"suggested":[117],"receptors":[120,165],"remained":[121],"predominantly":[122],"localized":[123],"endoplasmic":[126],"reticulum":[127],"(ER)":[128],"RACK1-depleted":[130],"cells.":[131],"also":[134,172],"revealed":[135],"transient":[138],"takes":[141],"place":[142],"ER.":[145],"effect":[147],"on":[150],"trafficking":[152],"appears":[157],"be":[159],"selective":[160],"some":[162],"G":[163],"protein-coupled":[164],"(GPCRs)":[166],"because":[167],"inhibition":[168],"affected":[173],"targeting":[176],"angiotensin":[179],"II":[180],"type":[181],"CXCR4":[185],"but":[186],"beta(2)-adrenergic":[189],"prostanoid":[191],"DP":[192],"receptors.":[193],"Our":[194],"data":[195],"demonstrate":[196],"time":[200],"direct":[202],"interaction":[203],"between":[204],"GPCR":[208],"identify":[210],"novel":[212],"role":[213],"regulation":[218],"transport":[221],"membrane":[224],"from":[226],"ER":[228],"surface.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}