{"id":"https://openalex.org/W2024924991","doi":"https://doi.org/10.1038/208255a0","title":"Effect of a Pyrimidopyrimidine Derivative on Thrombus Formation in the Rabbit","display_name":"Effect of a Pyrimidopyrimidine Derivative on Thrombus Formation in the Rabbit","publication_year":1965,"publication_date":"1965-10-01","ids":{"openalex":"https://openalex.org/W2024924991","doi":"https://doi.org/10.1038/208255a0","mag":"2024924991","pmid":"https://pubmed.ncbi.nlm.nih.gov/5882451"},"language":"en","primary_location":{"id":"doi:10.1038/208255a0","doi":"https://doi.org/10.1038/208255a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/208255a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078384515","display_name":"P.R. Emmons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. R. EMMONS","raw_affiliation_strings":["Department of the Regius Professor of Medicine, Radcliffe Infirmary, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of the Regius Professor of Medicine, Radcliffe Infirmary, Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101594699","display_name":"Michael J. Harrison","orcid":"https://orcid.org/0000-0002-9046-7450","observed_orcids":["https://orcid.org/0000-0002-9046-7450"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. J. G. HARRISON","raw_affiliation_strings":["Department of the Regius Professor of Medicine, Radcliffe Infirmary, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of the Regius Professor of Medicine, Radcliffe Infirmary, Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072805875","display_name":"A. John Honour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. J. HONOUR","raw_affiliation_strings":["Department of the Regius Professor of Medicine, Radcliffe Infirmary, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of the Regius Professor of Medicine, Radcliffe Infirmary, Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111870841","display_name":"J.R.A. Mitchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. R. A. MITCHELL","raw_affiliation_strings":["Department of the Regius Professor of Medicine, Radcliffe Infirmary, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of the Regius Professor of Medicine, Radcliffe Infirmary, Oxford","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":10.7935,"has_fulltext":false,"cited_by_count":136,"citation_normalized_percentile":{"value":0.98635711,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"208","issue":"5007","first_page":"255","last_page":"257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.6884999871253967,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.6884999871253967,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.27320000529289246,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombus-formation","display_name":"thrombus formation","score":0.890999972820282},{"id":"https://openalex.org/keywords/antithrombotic-agents","display_name":"antithrombotic agents","score":0.8429999947547913},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.3199999928474426},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.746999979019165},{"id":"https://openalex.org/keywords/anticoagulant-activity","display_name":"anticoagulant activity","score":0.578000009059906},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2779884254","wikidata":"https://www.wikidata.org/wiki/Q492162","display_name":"Rabbit (cipher)","level":2,"score":0.6846281290054321},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.5672484636306763},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.5470252633094788},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48711657524108887},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2638394236564636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23578307032585144},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16188916563987732},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.13126975297927856},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08316376805305481},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004176","descriptor_name":"Dipyridamole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/208255a0","doi":"https://doi.org/10.1038/208255a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/208255a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:5882451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5882451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W126429755","https://openalex.org/W1982830554","https://openalex.org/W1991960704","https://openalex.org/W2024103005","https://openalex.org/W2040832372","https://openalex.org/W2046243012","https://openalex.org/W2271223080","https://openalex.org/W2405887519","https://openalex.org/W2409878761","https://openalex.org/W2416785527","https://openalex.org/W2470001802","https://openalex.org/W2552255626"],"related_works":["https://openalex.org/W2418636695","https://openalex.org/W1567164313","https://openalex.org/W2058322637","https://openalex.org/W2462580679","https://openalex.org/W7095501242","https://openalex.org/W7028154410","https://openalex.org/W2042932937","https://openalex.org/W2417402068","https://openalex.org/W2406927595","https://openalex.org/W2412757909"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}