{"id":"https://openalex.org/W2024923210","doi":"https://doi.org/10.1115/sbc2011-53873","title":"Association of Mechanical Properties and Collagen Content With Valve Morphology in Ascending Thoracic Aortic Aneurysmal Tissue","display_name":"Association of Mechanical Properties and Collagen Content With Valve Morphology in Ascending Thoracic Aortic Aneurysmal Tissue","publication_year":2011,"publication_date":"2011-06-22","ids":{"openalex":"https://openalex.org/W2024923210","doi":"https://doi.org/10.1115/sbc2011-53873","mag":"2024923210"},"language":"en","primary_location":{"id":"doi:10.1115/sbc2011-53873","doi":"https://doi.org/10.1115/sbc2011-53873","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2011-53873","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2011 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083370040","display_name":"Joseph E. Pichamuthu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Pichamuthu","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA","[University of Pittsburgh, Pittsburgh, PA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"[University of Pittsburgh, Pittsburgh, PA]","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027652711","display_name":"Julie A. Phillippi","orcid":"https://orcid.org/0000-0002-9879-2039","observed_orcids":["https://orcid.org/0000-0002-9879-2039"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A. Phillippi","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA","[University of Pittsburgh, Pittsburgh, PA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"[University of Pittsburgh, Pittsburgh, PA]","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085712076","display_name":"Deborah A. Cleary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah A. Cleary","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA","[University of Pittsburgh, Pittsburgh, PA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"[University of Pittsburgh, Pittsburgh, PA]","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026380504","display_name":"Douglas W. Chew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas W. Chew","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA","[University of Pittsburgh, Pittsburgh, PA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"[University of Pittsburgh, Pittsburgh, PA]","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108785909","display_name":"John D. Hempel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hempel","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA","[University of Pittsburgh, Pittsburgh, PA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"[University of Pittsburgh, Pittsburgh, PA]","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060547232","display_name":"Thomas G. Gleason","orcid":"https://orcid.org/0000-0001-5858-6073","observed_orcids":["https://orcid.org/0000-0001-5858-6073"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas G. Gleason","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA","[University of Pittsburgh, Pittsburgh, PA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"[University of Pittsburgh, Pittsburgh, PA]","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006318631","display_name":"David A. Vorp","orcid":"https://orcid.org/0000-0002-6467-2151","observed_orcids":["https://orcid.org/0000-0002-6467-2151"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Vorp","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA","[University of Pittsburgh, Pittsburgh, PA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"[University of Pittsburgh, Pittsburgh, PA]","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11732606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"69","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.8217999935150146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.8217999935150146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.1599999964237213,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ascending-thoracic-aortic-aneurysm","display_name":"ascending thoracic aortic aneurysm","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bicuspid-aortic-valve","display_name":"bicuspid aortic valve","score":0.9929999709129333},{"id":"https://openalex.org/keywords/aortic-root-dilation","display_name":"aortic root dilatation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/collagen-content","display_name":"collagen content","score":0.8379999995231628},{"id":"https://openalex.org/keywords/mechanical-properties","display_name":"mechanical properties","score":0.8759999871253967},{"id":"https://openalex.org/keywords/valve-morphology","display_name":"valve morphology","score":0.9240000247955322},{"id":"https://openalex.org/keywords/aortic-dissection","display_name":"aortic dissection","score":0.7699999809265137},{"id":"https://openalex.org/keywords/aneurysm-rupture","display_name":"aneurysm rupture","score":0.843999981880188},{"id":"https://openalex.org/keywords/biomechanical-modeling","display_name":"biomechanical modeling","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2781355080","wikidata":"https://www.wikidata.org/wiki/Q860167","display_name":"Bicuspid aortic valve","level":3,"score":0.7982580661773682},{"id":"https://openalex.org/C2778249958","wikidata":"https://www.wikidata.org/wiki/Q2349469","display_name":"Ascending aorta","level":3,"score":0.6749863624572754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6574602723121643},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6489655375480652},{"id":"https://openalex.org/C2780847584","wikidata":"https://www.wikidata.org/wiki/Q3616648","display_name":"Thoracic aortic aneurysm","level":4,"score":0.6463719010353088},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.603533923625946},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.563133955001831},{"id":"https://openalex.org/C2775862295","wikidata":"https://www.wikidata.org/wiki/Q2660911","display_name":"Dissection (medical)","level":2,"score":0.5332649946212769},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.511910080909729},{"id":"https://openalex.org/C2779993142","wikidata":"https://www.wikidata.org/wiki/Q594660","display_name":"Aortic dissection","level":3,"score":0.48020753264427185},{"id":"https://openalex.org/C2776864027","wikidata":"https://www.wikidata.org/wiki/Q615993","display_name":"Thoracic aorta","level":3,"score":0.47539055347442627},{"id":"https://openalex.org/C2993369777","wikidata":"https://www.wikidata.org/wiki/Q2349469","display_name":"Aortic root","level":3,"score":0.4545400142669678},{"id":"https://openalex.org/C2777323849","wikidata":"https://www.wikidata.org/wiki/Q616003","display_name":"Aortic aneurysm","level":3,"score":0.4309210479259491},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.3607032299041748},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25663620233535767},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24286210536956787}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1115/sbc2011-53873","doi":"https://doi.org/10.1115/sbc2011-53873","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2011-53873","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2011 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5699999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043632467","https://openalex.org/W2348583374","https://openalex.org/W2080589020","https://openalex.org/W3026416409","https://openalex.org/W185438291","https://openalex.org/W2114325598","https://openalex.org/W2146161288","https://openalex.org/W2004897594","https://openalex.org/W2075387500","https://openalex.org/W2763715176"],"abstract_inverted_index":{"Bicuspid":[0],"aortic":[1,34,56,80],"valve":[2],"(BAV)":[3],"is":[4,25,50,60,86,114],"the":[5,15,33,44,66,139],"most":[6],"common":[7],"congenital":[8],"heart":[9],"malformation":[10],"occurring":[11],"in":[12,36,99],"1\u20132%":[13],"of":[14,21,30,32,65,142],"population":[16,46],"with":[17,38,53,106],"a":[18,26,39],"high":[19],"rate":[20,29],"morbidity":[22],"[1].":[23],"There":[24],"significantly":[27],"higher":[28],"dilation":[31],"root":[35],"adults":[37],"BAV":[40],"when":[41,91,111],"compared":[42],"to":[43,68,79,132],"normal":[45,71],"and":[47,122],"this":[48],"condition":[49],"often":[51],"associated":[52],"ascending":[54],"thoracic":[55],"aneurysm":[57],"(ATAA).":[58],"ATAA":[59,76,85,108,120],"characterized":[61],"as":[62,104],"an":[63],"enlargement":[64],"aorta":[67],"twice":[69],"its":[70,92,112],"diameter.":[72],"If":[73],"left":[74],"untreated,":[75],"can":[77],"lead":[78],"dissection":[81,121],"or":[82],"rupture.":[83],"Therefore,":[84],"recommended":[87],"for":[88],"prophylactic":[89],"surgery":[90],"diameter":[93,113,143],"reaches":[94],"about":[95],"5.5":[96,117],"cm.":[97,118],"However,":[98],"certain":[100],"high-risk":[101],"cases,":[102],"such":[103],"patients":[105],"BAV,":[107],"may":[109],"rupture":[110,123],"less":[115],"than":[116],"Since":[119],"are":[124,130],"biomechanical":[125],"phenomena,":[126],"better":[127],"mechanical":[128],"models":[129],"needed":[131],"more":[133],"accurately":[134],"predict":[135],"these":[136],"events":[137],"over":[138],"predictive":[140],"capability":[141],"alone.":[144]},"counts_by_year":[],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2025-10-10T00:00:00"}