{"id":"https://openalex.org/W2024922998","doi":"https://doi.org/10.1203/01.pdr.0000214892.13788.74","title":"Deep Inhalation Prevents the Respiratory Elastance Response to Methacholine in Rats","display_name":"Deep Inhalation Prevents the Respiratory Elastance Response to Methacholine in Rats","publication_year":2006,"publication_date":"2006-04-20","ids":{"openalex":"https://openalex.org/W2024922998","doi":"https://doi.org/10.1203/01.pdr.0000214892.13788.74","mag":"2024922998","pmid":"https://pubmed.ncbi.nlm.nih.gov/16627875"},"language":"en","primary_location":{"id":"doi:10.1203/01.pdr.0000214892.13788.74","doi":"https://doi.org/10.1203/01.pdr.0000214892.13788.74","is_oa":false,"landing_page_url":"https://doi.org/10.1203/01.pdr.0000214892.13788.74","pdf_url":null,"source":{"id":"https://openalex.org/S167664057","display_name":"Pediatric Research","issn_l":"0031-3998","issn":["0031-3998","1530-0447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008949272","display_name":"Cyril Schweitzer","orcid":"https://orcid.org/0000-0003-0895-774X","observed_orcids":["https://orcid.org/0000-0003-0895-774X"]},"institutions":[{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cyril Schweitzer","raw_affiliation_strings":["Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, F-54505 Vandoeuvre les Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, F-54505 Vandoeuvre les Nancy, France","institution_ids":["https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004851575","display_name":"Bruno Demoulin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Demoulin","raw_affiliation_strings":["Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, F-54505, France","Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, F-54505, France","institution_ids":["https://openalex.org/I90183372"]},{"raw_affiliation_string":"Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, France","institution_ids":["https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065850756","display_name":"Ga\u00eblle Bello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gaelle Bello","raw_affiliation_strings":["Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, F-54505, France","Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, F-54505, France","institution_ids":["https://openalex.org/I90183372"]},{"raw_affiliation_string":"Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, France","institution_ids":["https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069697429","display_name":"No\u00eblle Bertin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Noelle Bertin","raw_affiliation_strings":["Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, F-54505, France","Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, F-54505, France","institution_ids":["https://openalex.org/I90183372"]},{"raw_affiliation_string":"Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, France","institution_ids":["https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108399117","display_name":"Anne Laure Leblanc","orcid":"https://orcid.org/0009-0002-7803-6938","observed_orcids":["https://orcid.org/0009-0002-7803-6938"]},"institutions":[{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne Laure Leblanc","raw_affiliation_strings":["Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, F-54505, France","Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, F-54505, France","institution_ids":["https://openalex.org/I90183372"]},{"raw_affiliation_string":"Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, France","institution_ids":["https://openalex.org/I90183372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109136755","display_name":"Fran\u00e7cois Marchal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fran\u00e7cois Marchal","raw_affiliation_strings":["Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, F-54505, France","Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, F-54505, France","institution_ids":["https://openalex.org/I90183372"]},{"raw_affiliation_string":"Laboratoire de Physiologie, Facult\u00e9 de M\u00e9decine, Vandoeuvre les Nancy, France","institution_ids":["https://openalex.org/I90183372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109136755"],"corresponding_institution_ids":["https://openalex.org/I90183372"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":1.0567,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.79757947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"59","issue":"5","first_page":"646","last_page":"649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.1949000060558319,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.1655000001192093,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-inhalation","display_name":"deep inhalation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/respiratory-elastance","display_name":"respiratory system elastance","score":0.8889999985694885},{"id":"https://openalex.org/keywords/methacholine-challenge","display_name":"methacholine challenge","score":0.9079999923706055},{"id":"https://openalex.org/keywords/respiratory-resistance","display_name":"respiratory resistance","score":0.6899999976158142},{"id":"https://openalex.org/keywords/respiratory-reactance","display_name":"respiratory reactance","score":0.8429999947547913},{"id":"https://openalex.org/keywords/bronchodilator-effect","display_name":"bronchodilator effect","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tidal-ventilation","display_name":"tidal ventilation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/viscoelasticity","display_name":"viscoelasticity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/forced-oscillation-technique","display_name":"forced oscillation technique","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C2781260171","wikidata":"https://www.wikidata.org/wiki/Q413188","display_name":"Methacholine","level":4,"score":0.9119106531143188},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.7002103924751282},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.6906136870384216},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6903140544891357},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.663741946220398},{"id":"https://openalex.org/C2780729457","wikidata":"https://www.wikidata.org/wiki/Q20180462","display_name":"Elastance","level":3,"score":0.5941355228424072},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.5430324673652649},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.5416370630264282},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.509491503238678},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.31304705142974854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2898643910884857},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2672305107116699},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.17549297213554382},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000403","descriptor_name":"Airway Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000403","descriptor_name":"Airway Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001239","descriptor_name":"Inhalation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011914","descriptor_name":"Rats, Inbred BN","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016085","descriptor_name":"Bronchoconstrictor Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016210","descriptor_name":"Methacholine Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1203/01.pdr.0000214892.13788.74","doi":"https://doi.org/10.1203/01.pdr.0000214892.13788.74","is_oa":false,"landing_page_url":"https://doi.org/10.1203/01.pdr.0000214892.13788.74","pdf_url":null,"source":{"id":"https://openalex.org/S167664057","display_name":"Pediatric Research","issn_l":"0031-3998","issn":["0031-3998","1530-0447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Research","raw_type":"journal-article"},{"id":"pmid:16627875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16627875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1960703293","https://openalex.org/W1991524561","https://openalex.org/W2002115013","https://openalex.org/W2003556888","https://openalex.org/W2006857223","https://openalex.org/W2009263098","https://openalex.org/W2015060516","https://openalex.org/W2015064899","https://openalex.org/W2018809994","https://openalex.org/W2029792174","https://openalex.org/W2033551925","https://openalex.org/W2046375276","https://openalex.org/W2050903584","https://openalex.org/W2051368466","https://openalex.org/W2054834251","https://openalex.org/W2058346310","https://openalex.org/W2076735595","https://openalex.org/W2081775840","https://openalex.org/W2102252471","https://openalex.org/W2111839509","https://openalex.org/W2120386364","https://openalex.org/W2121199401","https://openalex.org/W2133473147","https://openalex.org/W2140850086","https://openalex.org/W2143645698","https://openalex.org/W2151231557","https://openalex.org/W2157022248","https://openalex.org/W2157831072","https://openalex.org/W2160808191","https://openalex.org/W2165321017","https://openalex.org/W2174024472","https://openalex.org/W2187630870","https://openalex.org/W2225376363","https://openalex.org/W2238614384","https://openalex.org/W2261019224","https://openalex.org/W2339255964","https://openalex.org/W2408477343","https://openalex.org/W2410439523","https://openalex.org/W2416494668","https://openalex.org/W2417453699"],"related_works":["https://openalex.org/W2018809994","https://openalex.org/W2006857223","https://openalex.org/W1994007036","https://openalex.org/W2131279196","https://openalex.org/W2227216773","https://openalex.org/W2013406271","https://openalex.org/W7096066743","https://openalex.org/W2761576145","https://openalex.org/W2120386364","https://openalex.org/W2123708410"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}