{"id":"https://openalex.org/W2024919277","doi":"https://doi.org/10.1111/j.1476-5381.2009.00320.x","title":"Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology","display_name":"Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology","publication_year":2009,"publication_date":"2009-07-08","ids":{"openalex":"https://openalex.org/W2024919277","doi":"https://doi.org/10.1111/j.1476-5381.2009.00320.x","mag":"2024919277","pmid":"https://pubmed.ncbi.nlm.nih.gov/19594752","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2765325"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.2009.00320.x","doi":"https://doi.org/10.1111/j.1476-5381.2009.00320.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.2009.00320.x","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2765325","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108089364","display_name":"G Morissette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"G Morissette","raw_affiliation_strings":["Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec QC, Canada","Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec QC, Canada and Department of Medicine, Universit\u00e9 Laval, Qu\u00e9bec QC, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec QC, Canada","institution_ids":["https://openalex.org/I4210093650"]},{"raw_affiliation_string":"Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec QC, Canada and Department of Medicine, Universit\u00e9 Laval, Qu\u00e9bec QC, Canada,","institution_ids":["https://openalex.org/I4210093650","https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049812967","display_name":"Alfred Ammoury","orcid":"https://orcid.org/0000-0001-8260-1261","observed_orcids":["https://orcid.org/0000-0001-8260-1261"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210138343","display_name":"H\u00f4pital Purpan","ror":"https://ror.org/03vcx3f97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210138343"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Ammoury","raw_affiliation_strings":["Service de Dermatologie, Ho\u0302pital Purpan, Centre Hospitalier Universitaire de Toulouse, Toulouse, France and","Service de Dermatologie, H\u00f4pital Purpan, Centre Hospitalier Universitaire de Toulouse, Toulouse, France and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Dermatologie, Ho\u0302pital Purpan, Centre Hospitalier Universitaire de Toulouse, Toulouse, France and","institution_ids":["https://openalex.org/I3019448017","https://openalex.org/I4210138343"]},{"raw_affiliation_string":"Service de Dermatologie, H\u00f4pital Purpan, Centre Hospitalier Universitaire de Toulouse, Toulouse, France and","institution_ids":["https://openalex.org/I3019448017","https://openalex.org/I4210138343"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D Rusu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D Rusu","raw_affiliation_strings":["Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Que\u0301bec, Que\u0301bec QC, Canada and Department of Medicine, Universite\u0301 Laval, Que\u0301bec QC, Canada,","Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec QC, Canada and Department of Medicine, Universit\u00e9 Laval, Qu\u00e9bec QC, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Que\u0301bec, Que\u0301bec QC, Canada and Department of Medicine, Universite\u0301 Laval, Que\u0301bec QC, Canada,","institution_ids":["https://openalex.org/I4210093650","https://openalex.org/I43406934"]},{"raw_affiliation_string":"Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec QC, Canada and Department of Medicine, Universit\u00e9 Laval, Qu\u00e9bec QC, Canada,","institution_ids":["https://openalex.org/I4210093650","https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113713097","display_name":"M.C. Marguery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210138343","display_name":"H\u00f4pital Purpan","ror":"https://ror.org/03vcx3f97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210138343"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"MC Marguery","raw_affiliation_strings":["Service de Dermatologie, Ho\u0302pital Purpan, Centre Hospitalier Universitaire de Toulouse, Toulouse, France and","Service de Dermatologie, H\u00f4pital Purpan, Centre Hospitalier Universitaire de Toulouse, Toulouse, France and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Dermatologie, Ho\u0302pital Purpan, Centre Hospitalier Universitaire de Toulouse, Toulouse, France and","institution_ids":["https://openalex.org/I3019448017","https://openalex.org/I4210138343"]},{"raw_affiliation_string":"Service de Dermatologie, H\u00f4pital Purpan, Centre Hospitalier Universitaire de Toulouse, Toulouse, France and","institution_ids":["https://openalex.org/I3019448017","https://openalex.org/I4210138343"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035750330","display_name":"Robert Lodge","orcid":"https://orcid.org/0000-0002-9908-0850","observed_orcids":["https://orcid.org/0000-0002-9908-0850"]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R Lodge","raw_affiliation_strings":["Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Que\u0301bec, Que\u0301bec QC, Canada","Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Que\u0301bec, Que\u0301bec QC, Canada","institution_ids":["https://openalex.org/I4210093650"]},{"raw_affiliation_string":"Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec QC, Canada","institution_ids":["https://openalex.org/I4210093650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049465666","display_name":"Patrice E. Poubelle","orcid":"https://orcid.org/0000-0003-4317-4812","observed_orcids":["https://orcid.org/0000-0003-4317-4812"]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"PE Poubelle","raw_affiliation_strings":["Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Que\u0301bec, Que\u0301bec QC, Canada and Department of Medicine, Universite\u0301 Laval, Que\u0301bec QC, Canada,","Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec QC, Canada and Department of Medicine, Universit\u00e9 Laval, Qu\u00e9bec QC, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Que\u0301bec, Que\u0301bec QC, Canada and Department of Medicine, Universite\u0301 Laval, Que\u0301bec QC, Canada,","institution_ids":["https://openalex.org/I4210093650","https://openalex.org/I43406934"]},{"raw_affiliation_string":"Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec QC, Canada and Department of Medicine, Universit\u00e9 Laval, Qu\u00e9bec QC, Canada,","institution_ids":["https://openalex.org/I4210093650","https://openalex.org/I43406934"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087629766","display_name":"Fran\u00e7ois Marceau","orcid":"https://orcid.org/0000-0003-1691-6083","observed_orcids":["https://orcid.org/0000-0003-1691-6083"]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"F Marceau","raw_affiliation_strings":["Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Que\u0301bec, Que\u0301bec QC, Canada and Department of Medicine, Universite\u0301 Laval, Que\u0301bec QC, Canada,","Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec QC, Canada and Department of Medicine, Universit\u00e9 Laval, Qu\u00e9bec QC, Canada,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Que\u0301bec, Que\u0301bec QC, Canada and Department of Medicine, Universite\u0301 Laval, Que\u0301bec QC, Canada,","institution_ids":["https://openalex.org/I4210093650","https://openalex.org/I43406934"]},{"raw_affiliation_string":"Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec QC, Canada and Department of Medicine, Universit\u00e9 Laval, Qu\u00e9bec QC, Canada,","institution_ids":["https://openalex.org/I4210093650","https://openalex.org/I43406934"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087629766"],"corresponding_institution_ids":["https://openalex.org/I4210093650","https://openalex.org/I43406934"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":1.1922,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.74035163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"157","issue":"8","first_page":"1531","last_page":"1540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amiodarone","display_name":"amiodarone","score":1.0},{"id":"https://openalex.org/keywords/vacuolar-atpase","display_name":"vacuolar ATPase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/macroautophagy","display_name":"macroautophagy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/drug-sequestration","display_name":"drug sequestration","score":0.6800000071525574},{"id":"https://openalex.org/keywords/phospholipidosis","display_name":"phospholipidosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/lc3","display_name":"LC3","score":0.8679999709129333},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7250000238418579},{"id":"https://openalex.org/keywords/skin-discoloration","display_name":"skin discoloration","score":0.7419999837875366},{"id":"https://openalex.org/keywords/bafilomycin-a1","display_name":"bafilomycin A1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/late-endosomes","display_name":"late endosomes","score":0.7760000228881836},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.9330000281333923},{"id":"https://openalex.org/keywords/antiarrhythmic-drug-toxicity","display_name":"antiarrhythmic drug toxicity","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2777722557","wikidata":"https://www.wikidata.org/wiki/Q4841341","display_name":"Bafilomycin","level":4,"score":0.8489832878112793},{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.8173362612724304},{"id":"https://openalex.org/C2779934242","wikidata":"https://www.wikidata.org/wiki/Q7187520","display_name":"Phospholipidosis","level":4,"score":0.7519663572311401},{"id":"https://openalex.org/C191678065","wikidata":"https://www.wikidata.org/wiki/Q7905656","display_name":"V-ATPase","level":4,"score":0.5971672534942627},{"id":"https://openalex.org/C2778614373","wikidata":"https://www.wikidata.org/wiki/Q7908033","display_name":"Vacuolization","level":2,"score":0.5095903873443604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5049389004707336},{"id":"https://openalex.org/C2778654104","wikidata":"https://www.wikidata.org/wiki/Q1881849","display_name":"Cytopathology","level":3,"score":0.42946791648864746},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.42226406931877136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4045809507369995},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4005938768386841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39951854944229126},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.32249993085861206},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1893157660961151},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C18823058","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cytology","level":2,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000638","descriptor_name":"Amiodarone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000638","descriptor_name":"Amiodarone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018942","descriptor_name":"Macrolides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D025262","descriptor_name":"Vacuolar Proton-Translocating ATPases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D025262","descriptor_name":"Vacuolar Proton-Translocating ATPases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1476-5381.2009.00320.x","doi":"https://doi.org/10.1111/j.1476-5381.2009.00320.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.2009.00320.x","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3479394","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2765325","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:19594752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19594752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2765325","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2765325/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3479394","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2765325","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1516814093","https://openalex.org/W1596924664","https://openalex.org/W1795186414","https://openalex.org/W1863391704","https://openalex.org/W1877268608","https://openalex.org/W1963938060","https://openalex.org/W1964178900","https://openalex.org/W1967068450","https://openalex.org/W1968037013","https://openalex.org/W1968122938","https://openalex.org/W1969927222","https://openalex.org/W1976498095","https://openalex.org/W1977767269","https://openalex.org/W1978804708","https://openalex.org/W1982273142","https://openalex.org/W1988312840","https://openalex.org/W1997458334","https://openalex.org/W2002136581","https://openalex.org/W2011738802","https://openalex.org/W2012246741","https://openalex.org/W2020006388","https://openalex.org/W2020404695","https://openalex.org/W2031134295","https://openalex.org/W2038918730","https://openalex.org/W2041385320","https://openalex.org/W2049743274","https://openalex.org/W2059597638","https://openalex.org/W2061994459","https://openalex.org/W2070926277","https://openalex.org/W2077732560","https://openalex.org/W2079910865","https://openalex.org/W2108928593","https://openalex.org/W2125373391","https://openalex.org/W2140096077","https://openalex.org/W2143826114","https://openalex.org/W2154718053","https://openalex.org/W2155360142","https://openalex.org/W2156160866","https://openalex.org/W2337183889","https://openalex.org/W2468119228","https://openalex.org/W2743254891"],"related_works":["https://openalex.org/W4388793885","https://openalex.org/W1514511377","https://openalex.org/W1863391704","https://openalex.org/W2062554355","https://openalex.org/W2122518772","https://openalex.org/W2011738802","https://openalex.org/W2172189012","https://openalex.org/W1991629596","https://openalex.org/W2079552893","https://openalex.org/W2168303270"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,211],"PURPOSE:":[2],"Tissue":[3],"deposits":[4],"of":[5,14,24,27,45,83,93,101,145,156,182,198,215],"the":[6,22,25,33,76,91,102,199],"anti-arrhythmic":[7],"drug":[8,134],"amiodarone":[9,28,46,103,173,216],"are":[10],"a":[11],"major":[12],"source":[13],"side":[15],"effects":[16],"(skin":[17],"discoloration,":[18],"etc.).":[19],"We":[20],"addressed":[21],"mechanism":[23],"concentration":[26],"in":[29,47,118,137,191,206],"cells,":[30,53],"and":[31,37,63,133,148,152,164,185,228,233],"characterized":[32],"resulting":[34],"vacuolar":[35,123],"cytopathology":[36,64,236],"its":[38,60],"evolution":[39],"towards":[40,230],"macroautophagy.":[41],"EXPERIMENTAL":[42],"APPROACH:":[43],"Sequestration":[44],"human":[48],"cells":[49,111,140],"(macrophages,":[50],"smooth":[51],"muscle":[52],"HEK":[54,138],"293a":[55,139],"cells)":[56],"was":[57,71,88,116],"evaluated":[58],"using":[59,65],"violet":[61],"fluorescence":[62],"GFP-conjugated":[66],"subcellular":[67],"markers.":[68],"Autophagic":[69],"signalling":[70],"probed":[72],"by":[73,109,226],"immunoblotting":[74],"for":[75,90,96,143,153],"effector":[77,155],"protein":[78],"LC3.":[79],"A":[80],"patient":[81],"biopsy":[82],"amiodarone-induced":[84],"blue-gray":[85],"skin":[86,201],"discoloration":[87],"investigated":[89],"presence":[92],"macroautophagy":[94,232],"(immunofluorescence":[95],"LC3).":[97],"KEY":[98],"RESULTS:":[99],"Most":[100],"(1-20":[104],"microM,":[105],"4-24":[106],"h)":[107],"captured":[108],"cultured":[110],"(macrophages":[112],"were":[113,141],"most":[114],"avid)":[115],"present":[117],"enlarged":[119],"vacuoles.":[120],"The":[121,159,179],"specific":[122],"ATPase":[124],"(V-ATPase)":[125],"inhibitors,":[126],"bafilomycin":[127],"A1":[128],"or":[129,176],"FR167356,":[130],"prevented":[131],"vacuolization":[132],"uptake.":[135],"Vacuoles":[136],"positive":[142],"markers":[144],"late":[146],"endosomes":[147],"lysosomes":[149],"(GFP-Rab7,":[150],"-CD63)":[151],"an":[154],"macroautophagy,":[157],"GFP-LC3.":[158],"vacuoles":[160],"accumulated":[161],"endogenous":[162,186],"LC3":[163,187,204],"filled":[165],"with":[166],"lipids":[167],"(Nile":[168],"red":[169],"staining)":[170],"following":[171],"longer":[172],"treatments":[174],"(>":[175],"=24":[177],"h).":[178],"electrophoretic":[180],"mobility":[181],"both":[183],"GFP-LC3":[184],"changed,":[188],"showing":[189],"activation":[190],"response":[192],"to":[193,221,246],"amiodarone.":[194],"Paraffin":[195],"tissue":[196,243],"sections":[197],"pigmented":[200],"exhibited":[202],"granular":[203],"accumulation":[205],"superficial":[207],"dermis":[208],"macrophages.":[209],"CONCLUSION":[210],"IMPLICATIONS:":[212],"Vacuolar":[213],"sequestration":[214],"occurs":[217],"at":[218],"concentrations":[219],"close":[220],"therapeutic":[222],"levels,":[223],"is":[224,237],"mediated":[225],"V-ATPase":[227],"evolves":[229],"persistent":[231],"phospholipidosis.":[234],"This":[235],"not":[238],"cell":[239],"type":[240],"specific,":[241],"but":[242],"macrophages":[244],"appear":[245],"be":[247],"particularly":[248],"susceptible.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}