{"id":"https://openalex.org/W2024917768","doi":"https://doi.org/10.1016/s0014-5793(00)01302-8","title":"Vascular endothelial cells synthesize and secrete brain\u2010derived neurotrophic factor","display_name":"Vascular endothelial cells synthesize and secrete brain\u2010derived neurotrophic factor","publication_year":2000,"publication_date":"2000-03-20","ids":{"openalex":"https://openalex.org/W2024917768","doi":"https://doi.org/10.1016/s0014-5793(00)01302-8","mag":"2024917768","pmid":"https://pubmed.ncbi.nlm.nih.gov/10734218"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-5793(00)01302-8","doi":"https://doi.org/10.1016/s0014-5793(00)01302-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-5793(00)01302-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2800%2901302-8","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2800%2901302-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090548474","display_name":"Takeshi Nakahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086062","display_name":"Otsuka (United States)","ror":"https://ror.org/00ew4na22","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210086062"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takeshi Nakahashi","raw_affiliation_strings":["Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA","institution_ids":["https://openalex.org/I4210086062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000562919","display_name":"Hironobu Fujimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086062","display_name":"Otsuka (United States)","ror":"https://ror.org/00ew4na22","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210086062"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hironobu Fujimura","raw_affiliation_strings":["Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA","institution_ids":["https://openalex.org/I4210086062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112235983","display_name":"C. Anthony Altar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086062","display_name":"Otsuka (United States)","ror":"https://ror.org/00ew4na22","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210086062"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.Anthony Altar","raw_affiliation_strings":["Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA","institution_ids":["https://openalex.org/I4210086062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107329717","display_name":"Jess Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086062","display_name":"Otsuka (United States)","ror":"https://ror.org/00ew4na22","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210086062"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jess Li","raw_affiliation_strings":["Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA","institution_ids":["https://openalex.org/I4210086062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002302890","display_name":"J. Kambayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086062","display_name":"Otsuka (United States)","ror":"https://ror.org/00ew4na22","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210086062"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun-ichi Kambayashi","raw_affiliation_strings":["Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA","institution_ids":["https://openalex.org/I4210086062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109187254","display_name":"Narendra N. Tandon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086062","display_name":"Otsuka (United States)","ror":"https://ror.org/00ew4na22","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210086062"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Narendra N Tandon","raw_affiliation_strings":["Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA","institution_ids":["https://openalex.org/I4210086062"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102722001","display_name":"Bing Sun","orcid":"https://orcid.org/0000-0002-1992-3767","observed_orcids":["https://orcid.org/0000-0002-1992-3767","https://orcid.org/0009-0009-2639-2237"]},"institutions":[{"id":"https://openalex.org/I4210086062","display_name":"Otsuka (United States)","ror":"https://ror.org/00ew4na22","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210086062"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bing Sun","raw_affiliation_strings":["Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maryland Research Laboratories, Otsuka America Pharmaceutical, Inc., 9900 Medical Center Drive, Rockville, MD 20850, USA","institution_ids":["https://openalex.org/I4210086062"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102722001"],"corresponding_institution_ids":["https://openalex.org/I4210086062"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":2.3718,"has_fulltext":true,"cited_by_count":430,"citation_normalized_percentile":{"value":0.88565127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"470","issue":"2","first_page":"113","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":1.0},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/endothelial-cell-secretion","display_name":"endothelial cell secretion","score":0.6179999709129333},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8289999961853027},{"id":"https://openalex.org/keywords/calcium-ionophore","display_name":"calcium ionophore","score":0.890999972820282},{"id":"https://openalex.org/keywords/laminar-shear-stress","display_name":"laminar shear stress","score":0.8889999985694885},{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.7553598880767822},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.7228584289550781},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.6515382528305054},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.635905385017395},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5771169662475586},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5714634656906128},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5494888424873352},{"id":"https://openalex.org/C15215337","wikidata":"https://www.wikidata.org/wiki/Q18032325","display_name":"Vascular endothelial growth factor B","level":5,"score":0.45749980211257935},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43628451228141785},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4344329535961151},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.41745448112487793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3847615718841553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3738316297531128},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.3209863305091858},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24507814645767212},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12985903024673462},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.1048310399055481},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09939885139465332},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09487476944923401}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002457","descriptor_name":"Cell Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002457","descriptor_name":"Cell Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002457","descriptor_name":"Cell Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-5793(00)01302-8","doi":"https://doi.org/10.1016/s0014-5793(00)01302-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-5793(00)01302-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2800%2901302-8","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:10734218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10734218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0014-5793(00)01302-8","doi":"https://doi.org/10.1016/s0014-5793(00)01302-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-5793(00)01302-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2800%2901302-8","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.44999998807907104,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332500","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024917768.pdf","grobid_xml":"https://content.openalex.org/works/W2024917768.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W308791769","https://openalex.org/W1578648368","https://openalex.org/W1602494224","https://openalex.org/W1894943419","https://openalex.org/W1936770188","https://openalex.org/W1963969857","https://openalex.org/W1966311061","https://openalex.org/W1978139625","https://openalex.org/W1984333176","https://openalex.org/W2006227380","https://openalex.org/W2011050809","https://openalex.org/W2015450452","https://openalex.org/W2028916006","https://openalex.org/W2033367566","https://openalex.org/W2047960520","https://openalex.org/W2049920605","https://openalex.org/W2053287079","https://openalex.org/W2056205520","https://openalex.org/W2057192712","https://openalex.org/W2057269156","https://openalex.org/W2057850960","https://openalex.org/W2061824832","https://openalex.org/W2062493900","https://openalex.org/W2081975691","https://openalex.org/W2091222457","https://openalex.org/W2120819751","https://openalex.org/W2144756700","https://openalex.org/W2162710298","https://openalex.org/W4246545334"],"related_works":["https://openalex.org/W3021434253","https://openalex.org/W2333522106","https://openalex.org/W2130489472","https://openalex.org/W1980772020","https://openalex.org/W2014363182","https://openalex.org/W1256176685","https://openalex.org/W3041676359","https://openalex.org/W2072353392","https://openalex.org/W2393860336","https://openalex.org/W2090763994"],"abstract_inverted_index":{"Brain-derived":[0],"neurotrophic":[1],"factor":[2],"(BDNF)":[3],"is":[4,38],"an":[5],"abundant":[6],"neurotrophin":[7],"in":[8,27,47,51],"brain":[9,78],"and":[10,19,29,43,50,72,80],"peripheral":[11],"nerves,":[12],"where":[13],"it":[14],"affects":[15],"neural":[16],"development,":[17],"survival":[18],"repair":[20],"after":[21],"injury.":[22],"BDNF":[23,37,41,64],"has":[24],"been":[25],"detected":[26,46],"rat":[28],"human":[30,56],"blood,":[31],"but":[32],"the":[33,52],"source":[34],"of":[35,55,63,69],"circulating":[36,95],"not":[39],"established.":[40],"messenger":[42],"peptide":[44],"were":[45],"cultured":[48],"cells":[49,91],"culture":[53],"medium":[54],"umbilical":[57],"vein":[58],"endothelial":[59,90],"cells.":[60],"The":[61],"expression":[62],"was":[65],"up-regulated":[66],"by":[67,74],"elevation":[68],"intracellular":[70],"cAMP":[71],"down-regulated":[73],"Ca(2+)":[75],"ionophore,":[76],"bovine":[77],"extract":[79],"laminar":[81],"fluid":[82],"shear":[83],"stress.":[84],"These":[85],"results":[86],"suggest":[87],"that":[88],"vascular":[89],"may":[92],"contribute":[93],"to":[94],"BDNF.":[96]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":16}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
