{"id":"https://openalex.org/W2024917435","doi":"https://doi.org/10.1637/9001-072309-reg.1","title":"Interferon \u03b1\u2013Induced Inhibition of Infectious Bursal Disease Virus in Chicken Embryo Fibroblast Cultures Differing inMxGenotype","display_name":"Interferon \u03b1\u2013Induced Inhibition of Infectious Bursal Disease Virus in Chicken Embryo Fibroblast Cultures Differing inMxGenotype","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W2024917435","doi":"https://doi.org/10.1637/9001-072309-reg.1","mag":"2024917435","pmid":"https://pubmed.ncbi.nlm.nih.gov/20608522"},"language":"en","primary_location":{"id":"doi:10.1637/9001-072309-reg.1","doi":"https://doi.org/10.1637/9001-072309-reg.1","is_oa":false,"landing_page_url":"https://doi.org/10.1637/9001-072309-reg.1","pdf_url":null,"source":{"id":"https://openalex.org/S68792902","display_name":"Avian Diseases","issn_l":"0005-2086","issn":["0005-2086","1938-4351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4320800605","host_organization_name":"American Association of Avian Pathologists","host_organization_lineage":["https://openalex.org/P4320800605"],"host_organization_lineage_names":["American Association of Avian Pathologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Avian Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031312182","display_name":"Ann Marie O\u2019Neill","orcid":"https://orcid.org/0000-0003-4738-0824","observed_orcids":["https://orcid.org/0000-0003-4738-0824"]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Marie O'Neill","raw_affiliation_strings":["Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA. oneilam@auburn.edu","Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA. oneilam@auburn.edu","institution_ids":["https://openalex.org/I82497590"]},{"raw_affiliation_string":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849","institution_ids":["https://openalex.org/I82497590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042139029","display_name":"Emily J. Livant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily J. Livant","raw_affiliation_strings":["Department of Poultry Science, Auburn University, Auburn, AL 36849"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Poultry Science, Auburn University, Auburn, AL 36849","institution_ids":["https://openalex.org/I82497590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112144291","display_name":"Sandra J. Ewald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra J. Ewald","raw_affiliation_strings":["Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849","Department of Poultry Science, Auburn University, Auburn, AL 36849"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849","institution_ids":["https://openalex.org/I82497590"]},{"raw_affiliation_string":"Department of Poultry Science, Auburn University, Auburn, AL 36849","institution_ids":["https://openalex.org/I82497590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I82497590"],"apc_list":null,"apc_paid":null,"fwci":0.5869,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.65647688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"54","issue":"2","first_page":"802","last_page":"806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9779999852180481},{"id":"https://openalex.org/keywords/infectious-bursal-disease-virus","display_name":"infectious bursal disease virus","score":0.9570000171661377},{"id":"https://openalex.org/keywords/mx-protein","display_name":"Mx protein","score":0.7379999756813049},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/chicken-embryo-fibroblasts","display_name":"chicken embryo fibroblasts","score":0.968999981880188},{"id":"https://openalex.org/keywords/virus-yield","display_name":"virus yield","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2777810641","wikidata":"https://www.wikidata.org/wiki/Q707615","display_name":"Infectious bursal disease","level":4,"score":0.9380723237991333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8835420608520508},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8432435989379883},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7985010743141174},{"id":"https://openalex.org/C2779057330","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular stomatitis virus","level":3,"score":0.6839262247085571},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5655996203422546},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5498936772346497},{"id":"https://openalex.org/C2778765379","wikidata":"https://www.wikidata.org/wiki/Q17055931","display_name":"In ovo","level":3,"score":0.5392481088638306},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.44742751121520996},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.31053876876831055},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1808963119983673},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1276473104953766}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007243","descriptor_name":"Infectious bursal disease virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007243","descriptor_name":"Infectious bursal disease virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007243","descriptor_name":"Infectious bursal disease virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007243","descriptor_name":"Infectious bursal disease virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007243","descriptor_name":"Infectious bursal disease virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007243","descriptor_name":"Infectious bursal disease virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064547","descriptor_name":"Myxovirus Resistance Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064547","descriptor_name":"Myxovirus Resistance Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064547","descriptor_name":"Myxovirus Resistance Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1637/9001-072309-reg.1","doi":"https://doi.org/10.1637/9001-072309-reg.1","is_oa":false,"landing_page_url":"https://doi.org/10.1637/9001-072309-reg.1","pdf_url":null,"source":{"id":"https://openalex.org/S68792902","display_name":"Avian Diseases","issn_l":"0005-2086","issn":["0005-2086","1938-4351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4320800605","host_organization_name":"American Association of Avian Pathologists","host_organization_lineage":["https://openalex.org/P4320800605"],"host_organization_lineage_names":["American Association of Avian Pathologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Avian Diseases","raw_type":"journal-article"},{"id":"pmid:20608522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20608522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Avian diseases","raw_type":"Journal Article"},{"id":"pmh:10.1637/9001-072309-Reg.1","doi":null,"is_oa":false,"landing_page_url":"http://www.bioone.org/doi/10.1637/9001-072309-Reg.1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402358","display_name":"BioOne Complete (BioOne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210111627","host_organization_name":"BioOne","host_organization_lineage":["https://openalex.org/I4210111627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W117352181","https://openalex.org/W1585420923","https://openalex.org/W1605500799","https://openalex.org/W1628781333","https://openalex.org/W1653080210","https://openalex.org/W1820564933","https://openalex.org/W1901115683","https://openalex.org/W1965111847","https://openalex.org/W1965294562","https://openalex.org/W1998557124","https://openalex.org/W1998657702","https://openalex.org/W2003306878","https://openalex.org/W2008038877","https://openalex.org/W2026656142","https://openalex.org/W2039745774","https://openalex.org/W2050717638","https://openalex.org/W2055090682","https://openalex.org/W2089537743","https://openalex.org/W2090023448","https://openalex.org/W2096729929","https://openalex.org/W2115883205","https://openalex.org/W2116239308","https://openalex.org/W2119484307","https://openalex.org/W2124486956","https://openalex.org/W2126728919","https://openalex.org/W2134133994","https://openalex.org/W2154682739","https://openalex.org/W2155180080","https://openalex.org/W2160063406","https://openalex.org/W2169382411","https://openalex.org/W2256756668","https://openalex.org/W2316461908","https://openalex.org/W2319984590","https://openalex.org/W2345499595","https://openalex.org/W3217730596"],"related_works":["https://openalex.org/W1963883483","https://openalex.org/W2005605537","https://openalex.org/W2107230345","https://openalex.org/W2745611800","https://openalex.org/W79650307","https://openalex.org/W1708046828","https://openalex.org/W2136046700","https://openalex.org/W1797140256","https://openalex.org/W2006660108","https://openalex.org/W2024917435"],"abstract_inverted_index":{"Interferon":[0],"(IFN)-induced":[1],"antiviral":[2,28,57,145],"activity":[3,58,146],"in":[4,21,52,66,112,147,150,159,185],"cells":[5],"forms":[6],"an":[7,86],"important":[8,87],"early":[9],"line":[10],"of":[11,25,36,71,89,95,152,178,183],"defense":[12],"against":[13,59,103],"viral":[14,129,160],"pathogens.":[15],"IFN-induced":[16],"mediators":[17],"are":[18],"well":[19],"documented":[20],"mammals,":[22],"with":[23,78,126,135],"one":[24],"the":[26,44,53,93,99,157],"best-characterized":[27],"proteins":[29],"being":[30],"Mx.":[31],"In":[32],"chickens,":[33],"many":[34],"alleles":[35],"Mx":[37,73,113,117,122,167,171],"have":[38,143],"been":[39,76],"described,":[40],"but":[41],"functionally":[42],"only":[43],"polymorphism":[45,102],"at":[46],"a":[47,175],"site":[48],"encoding":[49],"residue":[50],"631":[51],"protein":[54],"determines":[55],"differential":[56],"vesicular":[60],"stomatitis":[61],"virus":[62,65,84,154],"and":[63,98,128],"influenza":[64],"transfection":[67],"experiments.":[68],"The":[69],"role":[70,94],"chicken":[72,96,105],"has":[74],"not":[75,163,174],"assessed":[77,132],"regard":[79],"to":[80,142,180],"infectious":[81],"bursal":[82],"disease":[83],"(IBDV),":[85],"pathogen":[88],"chickens.":[90],"To":[91],"examine":[92],"IFNalpha":[97,127,139],"Mx631":[100],"single-nucleotide":[101],"IBDV,":[104],"embryo":[106],"fibroblast":[107],"cultures":[108],"(CEF)":[109],"that":[110,170],"differed":[111],"genotype":[114],"(antivirally":[115],"positive":[116],"Asn631":[118,172],"or":[119],"antivirally":[120],"negative":[121],"Ser631)":[123],"were":[124],"treated":[125],"yield":[130,161],"was":[131,140],"following":[133],"infection":[134],"D78":[136],"vaccine-strain":[137],"IBDV.":[138],"shown":[141],"strong":[144],"this":[148,181],"system":[149],"terms":[151],"reduced":[153],"yield.":[155],"Furthermore,":[156],"reduction":[158],"did":[162],"differ":[164],"significantly":[165],"among":[166],"genotypes,":[168],"indicating":[169],"is":[173],"pivotal":[176],"determinant":[177],"resistance":[179],"strain":[182],"IBDV":[184],"CEF.":[186]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
