{"id":"https://openalex.org/W2024916715","doi":"https://doi.org/10.1210/jcem.84.2.5435","title":"Messenger Ribonucleic Acidin SituHybridization Analysis of Estrogen Receptors \u03b1 and \u03b2 in Human Breast Carcinoma1","display_name":"Messenger Ribonucleic Acidin SituHybridization Analysis of Estrogen Receptors \u03b1 and \u03b2 in Human Breast Carcinoma1","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W2024916715","doi":"https://doi.org/10.1210/jcem.84.2.5435","mag":"2024916715","pmid":"https://pubmed.ncbi.nlm.nih.gov/10022453"},"language":"en","primary_location":{"id":"doi:10.1210/jcem.84.2.5435","doi":"https://doi.org/10.1210/jcem.84.2.5435","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.84.2.5435","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015575554","display_name":"Hironobu Sasano","orcid":"https://orcid.org/0000-0002-6600-8641","observed_orcids":["https://orcid.org/0000-0002-6600-8641"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hironobu Sasano","raw_affiliation_strings":["Department of Pathology, Tohoku University School of Medicine, Sendai, Japan. hsasano@patholo2.med.tohoku.ac.jp","Department of Pathology Tohoku University School of Medicine. Sendai. Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tohoku University School of Medicine, Sendai, Japan. hsasano@patholo2.med.tohoku.ac.jp","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Department of Pathology Tohoku University School of Medicine. Sendai. Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049751347","display_name":"Takashi Suzuki","orcid":"https://orcid.org/0000-0003-0195-815X","observed_orcids":["https://orcid.org/0000-0003-0195-815X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi Suzuki","raw_affiliation_strings":["Departments of Pathology (H.S., T.S., H.N.), Sendai, Japan 980-0803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology (H.S., T.S., H.N.), Sendai, Japan 980-0803","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112211929","display_name":"Yukiko Matsuzaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukiko Matsuzaki","raw_affiliation_strings":["Obstetrics and Gynecology (Y.M., T.F.), Tohoku University School of Medicine, Sendai, Japan 980-0803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology (Y.M., T.F.), Tohoku University School of Medicine, Sendai, Japan 980-0803","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111820389","display_name":"Takao Fukaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Fukaya","raw_affiliation_strings":["Obstetrics and Gynecology (Y.M., T.F.), Tohoku University School of Medicine, Sendai, Japan 980-0803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology (Y.M., T.F.), Tohoku University School of Medicine, Sendai, Japan 980-0803","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003050865","display_name":"Mareyuki Endoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I4405286073","display_name":"Institute of Development, Aging and Cancer, Tohoku University","ror":"https://ror.org/012s2xh05","country_code":"JP","type":"facility","lineage":["https://openalex.org/I201537933","https://openalex.org/I4405286073"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mareyuki Endoh","raw_affiliation_strings":["Department of Pathology (M.E.), Institute of Development, Aging and Cancer, Tohoku University 980-8575, Sendai, Japan 980-0803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology (M.E.), Institute of Development, Aging and Cancer, Tohoku University 980-8575, Sendai, Japan 980-0803","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I4405286073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111366509","display_name":"Hiroshi Nagura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Nagura","raw_affiliation_strings":["Departments of Pathology (H.S., T.S., H.N.), Sendai, Japan 980-0803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology (H.S., T.S., H.N.), Sendai, Japan 980-0803","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035212958","display_name":"Michio Kimura","orcid":"https://orcid.org/0000-0002-9967-5336","observed_orcids":["https://orcid.org/0000-0002-9967-5336"]},"institutions":[{"id":"https://openalex.org/I4210087932","display_name":"KKR Tohoku Kosai Hospital","ror":"https://ror.org/0050g6f93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087932"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michio Kimura","raw_affiliation_strings":["Department of Surgery (M.K.), Tohoku Kousai Hospital, Sendai, Japan 980-0803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery (M.K.), Tohoku Kousai Hospital, Sendai, Japan 980-0803","institution_ids":["https://openalex.org/I4210087932"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015575554"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.5546,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.81624185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"84","issue":"2","first_page":"781","last_page":"785"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.9150000214576721},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8320000171661377},{"id":"https://openalex.org/keywords/invasive-ductal-carcinoma","display_name":"invasive ductal carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.5619999766349792},{"id":"https://openalex.org/keywords/stromal-cells","display_name":"stromal cells","score":0.7720000147819519},{"id":"https://openalex.org/keywords/estrogen-dependence","display_name":"estrogen dependence","score":0.5870000123977661},{"id":"https://openalex.org/keywords/breast-cancer-subtypes","display_name":"breast cancer subtypes","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.752982497215271},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.6736592054367065},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.627223014831543},{"id":"https://openalex.org/C96307122","wikidata":"https://www.wikidata.org/wiki/Q15329133","display_name":"Estrogen receptor beta","level":5,"score":0.5656350255012512},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5440127849578857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5356615781784058},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5342997908592224},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5289157629013062},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.5147521495819092},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.49154385924339294},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.47275811433792114},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.45598793029785156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3802010416984558},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36860212683677673},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.366848886013031},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21452507376670837},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1231035590171814},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06032213568687439}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem.84.2.5435","doi":"https://doi.org/10.1210/jcem.84.2.5435","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.84.2.5435","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:10022453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10022453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1020171890","https://openalex.org/W1618559390","https://openalex.org/W1883586942","https://openalex.org/W1966428567","https://openalex.org/W1969969891","https://openalex.org/W1971423810","https://openalex.org/W1973350140","https://openalex.org/W1974357996","https://openalex.org/W1979903836","https://openalex.org/W1985549816","https://openalex.org/W1991570855","https://openalex.org/W1993913378","https://openalex.org/W2008724101","https://openalex.org/W2010855830","https://openalex.org/W2018190464","https://openalex.org/W2065643273","https://openalex.org/W2070907292","https://openalex.org/W2072836824","https://openalex.org/W2073353512","https://openalex.org/W2073883348","https://openalex.org/W2080321597","https://openalex.org/W2088587953","https://openalex.org/W2104293738","https://openalex.org/W2125284749","https://openalex.org/W2128840922","https://openalex.org/W2135560336","https://openalex.org/W2161492813","https://openalex.org/W2161623422","https://openalex.org/W2172256092","https://openalex.org/W4233052079"],"related_works":["https://openalex.org/W7096078060","https://openalex.org/W2029135353","https://openalex.org/W1985549816","https://openalex.org/W2355872643","https://openalex.org/W2003392840","https://openalex.org/W2381568847","https://openalex.org/W1517548121","https://openalex.org/W2001884040","https://openalex.org/W2074169649","https://openalex.org/W2073522152"],"abstract_inverted_index":{"We":[0],"examined":[1],"the":[2,21,32,111,133,178,184,189,198,204],"expression":[3,179,225],"of":[4,16,20,36,70,75,87,96,101,116,135,180,186,192,200,206,221,237],"a":[5],"recently":[6],"characterized":[7],"novel":[8],"estrogen":[9],"receptor":[10],"(ER)":[11],"beta":[12],"in":[13,27,47,60,64,68,82,124,146,157,169,188,226],"25":[14,71,76,97,102],"cases":[15,81,104,112,150,202],"invasive":[17],"ductal":[18],"carcinoma":[19,61,88,136,158,173,201,207,227],"breast,":[22],"using":[23],"messenger":[24],"RNA":[25],"(mRNA)":[26],"situ":[28],"hybridization,":[29],"and":[30,42,52,63,73,99,107,123,131,223],"compared":[31],"findings":[33],"with":[34,167],"those":[35,215],"ERalpha,":[37],"to":[38,232],"study":[39],"its":[40,43],"localization":[41],"possible":[44],"biological":[45,235],"significance":[46],"human":[48,193,238],"breast":[49,172,194,239],"cancer.":[50,195,240],"ERalpha":[51,106,121,130,139,153,168,187,210,222],"ERbeta":[53,145,164,181,224],"hybridization":[54,92,155],"signals":[55,93,156],"were":[56,94],"both":[57,129],"detected,":[58],"predominantly":[59],"cells":[62,89,137,208,228],"some":[65],"stromal":[66],"cells,":[67,174],"18":[69],"(72%)":[72],"11":[74,117],"(44%)":[77],"cases,":[78,127],"respectively.":[79,109],"The":[80,218],"which":[83,175],"more":[84],"than":[85,142,214],"25%":[86],"demonstrated":[90,151],"mRNA":[91,154],"13":[95],"(52%)":[98],"2":[100],"(8%)":[103],"for":[105],"ERbeta,":[108,114],"Among":[110],"expressing":[113,138,144,209,216],"10":[115,126],"(91%)":[118],"also":[119],"expressed":[120],"mRNA;":[122],"these":[125],"coexpressing":[128],"beta,":[132],"number":[134,199],"was":[140,211],"greater":[141,213],"that":[143,163,177],"9":[147],"cases.":[148],"Eight":[149],"only":[152],"cells.":[159],"These":[160],"results":[161],"indicate":[162],"is":[165],"coexpressed":[166],"most":[170],"ERbeta-positive":[171],"suggests":[176],"depends":[182],"on":[183],"presence":[185],"great":[190],"majority":[191],"In":[196],"addition,":[197],"and/or":[203],"ratio":[205,220],"much":[212],"ERbeta.":[217],"relative":[219],"may":[229],"be":[230],"related":[231],"various":[233],"estrogen-dependent":[234],"features":[236]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}