{"id":"https://openalex.org/W2024913341","doi":"https://doi.org/10.1126/science.286.5439.487","title":"Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics","display_name":"Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics","publication_year":1999,"publication_date":"1999-10-15","ids":{"openalex":"https://openalex.org/W2024913341","doi":"https://doi.org/10.1126/science.286.5439.487","mag":"2024913341","pmid":"https://pubmed.ncbi.nlm.nih.gov/10521338"},"language":"en","primary_location":{"id":"doi:10.1126/science.286.5439.487","doi":"https://doi.org/10.1126/science.286.5439.487","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.286.5439.487","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034189317","display_name":"William Edward Evans","orcid":"https://orcid.org/0000-0002-9333-5322","observed_orcids":["https://orcid.org/0000-0002-9333-5322"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William E. Evans","raw_affiliation_strings":["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA, and Colleges of Pharmacy and Medicine, University of Tennessee, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA, and Colleges of Pharmacy and Medicine, University of Tennessee, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009866488","display_name":"Mary V. Relling","orcid":"https://orcid.org/0000-0002-3720-9591","observed_orcids":["https://orcid.org/0000-0002-3720-9591"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary V. Relling","raw_affiliation_strings":["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA, and Colleges of Pharmacy and Medicine, University of Tennessee, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA, and Colleges of Pharmacy and Medicine, University of Tennessee, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034189317"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":null,"apc_paid":null,"fwci":106.8751,"has_fulltext":false,"cited_by_count":2476,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"286","issue":"5439","first_page":"487","last_page":"491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":1.0},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8320000171661377},{"id":"https://openalex.org/keywords/drug-metabolizing-enzymes","display_name":"drug-metabolizing enzymes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.9769999980926514},{"id":"https://openalex.org/keywords/drug-receptors","display_name":"drug receptors","score":0.953000009059906},{"id":"https://openalex.org/keywords/drug-response-variability","display_name":"drug response variability","score":0.8410000205039978},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.828000009059906},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.8730000257492065},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.6169999837875366},{"id":"https://openalex.org/keywords/personalized-pharmacotherapy","display_name":"individualized drug therapy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/drug-disposition","display_name":"drug disposition","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.9530781507492065},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.6237549781799316},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5604739785194397},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5256651043891907},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5027761459350586},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.5021746158599854},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4967651963233948},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4550805985927582},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.45028573274612427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4395972192287445},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.4263283610343933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41432735323905945},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3703710436820984},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27075883746147156},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1814015507698059},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1569499969482422},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1363472044467926}],"mesh":[{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.286.5439.487","doi":"https://doi.org/10.1126/science.286.5439.487","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.286.5439.487","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:10521338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10521338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7300000190734863,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1281835685","display_name":null,"funder_award_id":"R01 CA 51001","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1322097379","display_name":null,"funder_award_id":"R01 CA-78224","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2218658011","display_name":null,"funder_award_id":"R37-CA36401","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7121342158","display_name":"PHARMACODYNAMICS OF ANTILEUKEMIC AGENTS IN CHILDREN","funder_award_id":"R01CA078224","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7777329513","display_name":"PHARMACOGENOMICS OF CHILDHOOD LEUKEMIA (ALL)","funder_award_id":"R37CA036401","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G987445084","display_name":"Anticancer Agent Pharmacodynamics in Acute Leukemia","funder_award_id":"5r01ca051001-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1256525631","https://openalex.org/W1580134332","https://openalex.org/W1787076927","https://openalex.org/W1910484136","https://openalex.org/W1972073156","https://openalex.org/W1981046943","https://openalex.org/W1985232100","https://openalex.org/W1995762908","https://openalex.org/W1999382644","https://openalex.org/W2000967958","https://openalex.org/W2003020809","https://openalex.org/W2006744192","https://openalex.org/W2009053553","https://openalex.org/W2012287896","https://openalex.org/W2015371796","https://openalex.org/W2017060960","https://openalex.org/W2019973925","https://openalex.org/W2027524654","https://openalex.org/W2034595467","https://openalex.org/W2034917494","https://openalex.org/W2037770545","https://openalex.org/W2040716003","https://openalex.org/W2042280647","https://openalex.org/W2043220342","https://openalex.org/W2045005389","https://openalex.org/W2045069466","https://openalex.org/W2045176691","https://openalex.org/W2046508780","https://openalex.org/W2049137269","https://openalex.org/W2055786949","https://openalex.org/W2058783998","https://openalex.org/W2059544569","https://openalex.org/W2061764105","https://openalex.org/W2062402174","https://openalex.org/W2062792922","https://openalex.org/W2063102011","https://openalex.org/W2063632290","https://openalex.org/W2064600045","https://openalex.org/W2067106041","https://openalex.org/W2071332031","https://openalex.org/W2072150523","https://openalex.org/W2072467180","https://openalex.org/W2075941319","https://openalex.org/W2076605730","https://openalex.org/W2076959644","https://openalex.org/W2077510533","https://openalex.org/W2084686194","https://openalex.org/W2086401995","https://openalex.org/W2090910729","https://openalex.org/W2091517601","https://openalex.org/W2093714545","https://openalex.org/W2094714679","https://openalex.org/W2100021150","https://openalex.org/W2113911127","https://openalex.org/W2124871541","https://openalex.org/W2143039477","https://openalex.org/W2147665080","https://openalex.org/W2151774137","https://openalex.org/W2269910519","https://openalex.org/W2271456353","https://openalex.org/W2317711144","https://openalex.org/W2319249430","https://openalex.org/W2327951273","https://openalex.org/W2339428433","https://openalex.org/W2404210544","https://openalex.org/W2411576815","https://openalex.org/W2925654603","https://openalex.org/W2986121682","https://openalex.org/W3147913464","https://openalex.org/W4242108431","https://openalex.org/W4244900749","https://openalex.org/W4251383293","https://openalex.org/W4300407353"],"related_works":["https://openalex.org/W2019271482","https://openalex.org/W1559085367","https://openalex.org/W2323964980","https://openalex.org/W2491014769","https://openalex.org/W2036094388","https://openalex.org/W4361242895","https://openalex.org/W1508732282","https://openalex.org/W2318262866","https://openalex.org/W1967016477","https://openalex.org/W2068142083"],"abstract_inverted_index":{"Genetic":[0],"polymorphisms":[1],"in":[2,17,36],"drug-metabolizing":[3],"enzymes,":[4],"transporters,":[5],"receptors,":[6],"and":[7,20,39,45],"other":[8],"drug":[9,37,43,53],"targets":[10],"have":[11],"been":[12],"linked":[13],"to":[14],"interindividual":[15],"differences":[16,35],"the":[18,30,56],"efficacy":[19],"toxicity":[21],"of":[22,33,58],"many":[23],"medications.":[24],"Pharmacogenomic":[25],"studies":[26],"are":[27],"rapidly":[28],"elucidating":[29],"inherited":[31],"nature":[32],"these":[34],"disposition":[38],"effects,":[40],"thereby":[41],"enhancing":[42],"discovery":[44],"providing":[46],"a":[47],"stronger":[48],"scientific":[49],"basis":[50,57],"for":[51],"optimizing":[52],"therapy":[54],"on":[55],"each":[59],"patient's":[60],"genetic":[61],"constitution.":[62]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":29},{"year":2024,"cited_by_count":42},{"year":2023,"cited_by_count":44},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":45},{"year":2020,"cited_by_count":66},{"year":2019,"cited_by_count":60},{"year":2018,"cited_by_count":54},{"year":2017,"cited_by_count":70},{"year":2016,"cited_by_count":87},{"year":2015,"cited_by_count":89},{"year":2014,"cited_by_count":96},{"year":2013,"cited_by_count":103},{"year":2012,"cited_by_count":123}],"updated_date":"2026-10-20T09:52:01.089006","created_date":"2025-10-10T00:00:00"}