{"id":"https://openalex.org/W2024911595","doi":"https://doi.org/10.1007/pl00009041","title":"Improvement of artemisinin accumulation in hairy root cultures of","display_name":"Improvement of artemisinin accumulation in hairy root cultures of","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2024911595","doi":"https://doi.org/10.1007/pl00009041","mag":"2024911595"},"language":"en","primary_location":{"id":"doi:10.1007/pl00009041","doi":"https://doi.org/10.1007/pl00009041","is_oa":false,"landing_page_url":"https://doi.org/10.1007/pl00009041","pdf_url":null,"source":{"id":"https://openalex.org/S154076131","display_name":"Bioprocess Engineering","issn_l":"0178-515X","issn":["0178-515X","1432-0797"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioprocess Engineering","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2024911595"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/s004490050575","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007867505","display_name":"C. Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"C. Liu","raw_affiliation_strings":["State Key Laboratory of Biochemical Engineering, Institute of Chemical Metallurgy, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China, CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biochemical Engineering, Institute of Chemical Metallurgy, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China, CN","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028697990","display_name":"Y. Wang X. Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Wang X. Xu","raw_affiliation_strings":["State Key Laboratory of Biochemical Engineering, Institute of Chemical Metallurgy, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China, CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biochemical Engineering, Institute of Chemical Metallurgy, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China, CN","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101614553","display_name":"Fan Ouyang","orcid":"https://orcid.org/0009-0004-9710-7951","observed_orcids":["https://orcid.org/0009-0004-9710-7951"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"F. Ouyang","raw_affiliation_strings":["State Key Laboratory of Biochemical Engineering, Institute of Chemical Metallurgy, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China, CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biochemical Engineering, Institute of Chemical Metallurgy, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, China, CN","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111348823","display_name":"H. Ye","orcid":"https://orcid.org/0009-0002-2629-2278","observed_orcids":["https://orcid.org/0009-0002-2629-2278"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210158097","display_name":"Institute of Botany","ror":"https://ror.org/05hr3ch11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210158097"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H. Ye","raw_affiliation_strings":["Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China, CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China, CN","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210158097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006301902","display_name":"G. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210158097","display_name":"Institute of Botany","ror":"https://ror.org/05hr3ch11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210158097"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"G. Li","raw_affiliation_strings":["Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China, CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China, CN","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210158097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4876,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.69888493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"2","first_page":"161","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14150","display_name":"Biochemical and biochemical processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artemisinin-production","display_name":"artemisinin production","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hairy-root-culture","display_name":"hairy root culture","score":0.8370000123977661},{"id":"https://openalex.org/keywords/artemisia-annua","display_name":"Artemisia annua","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fungal-elicitors","display_name":"fungal elicitors","score":0.9330000281333923},{"id":"https://openalex.org/keywords/penicillium-chrysogenum","display_name":"Penicillium chrysogenum","score":0.9869999885559082},{"id":"https://openalex.org/keywords/elicitation","display_name":"elicitation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/secondary-metabolite-accumulation","display_name":"secondary metabolite accumulation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/plant-cell-culture","display_name":"plant cell culture","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2779012821","wikidata":"https://www.wikidata.org/wiki/Q1329233","display_name":"Elicitor","level":3,"score":0.9909411668777466},{"id":"https://openalex.org/C2779691961","wikidata":"https://www.wikidata.org/wiki/Q1308044","display_name":"Artemisia annua","level":5,"score":0.9224575757980347},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.8974041938781738},{"id":"https://openalex.org/C157428477","wikidata":"https://www.wikidata.org/wiki/Q5639642","display_name":"Hairy root culture","level":5,"score":0.7438716292381287},{"id":"https://openalex.org/C133479454","wikidata":"https://www.wikidata.org/wiki/Q326228","display_name":"Mycelium","level":2,"score":0.6507150530815125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5053256154060364},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.42097893357276917},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3548619747161865},{"id":"https://openalex.org/C144027150","wikidata":"https://www.wikidata.org/wiki/Q48803","display_name":"Horticulture","level":1,"score":0.3431850075721741},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3258500099182129},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1164812445640564},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.0850030779838562},{"id":"https://openalex.org/C2779656422","wikidata":"https://www.wikidata.org/wiki/Q2700446","display_name":"Agrobacterium","level":4,"score":0.06261298060417175},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06200516223907471},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.052344441413879395},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/pl00009041","doi":"https://doi.org/10.1007/pl00009041","is_oa":false,"landing_page_url":"https://doi.org/10.1007/pl00009041","pdf_url":null,"source":{"id":"https://openalex.org/S154076131","display_name":"Bioprocess Engineering","issn_l":"0178-515X","issn":["0178-515X","1432-0797"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioprocess Engineering","raw_type":"journal-article"},{"id":"doi:10.1007/s004490050575","doi":"https://doi.org/10.1007/s004490050575","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s004490050575","pdf_url":null,"source":{"id":"https://openalex.org/S154076131","display_name":"Bioprocess Engineering","issn_l":"0178-515X","issn":["0178-515X","1432-0797"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioprocess Engineering","raw_type":"journal-article"},{"id":"pmh:oai:ir.ipe.ac.cn:122111/5964","doi":null,"is_oa":true,"landing_page_url":"http://ir.ipe.ac.cn/handle/122111/5964","pdf_url":null,"source":{"id":"https://openalex.org/S7407064443","display_name":"Institute of Process Engineering, CAS Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"}],"best_oa_location":{"id":"doi:10.1007/s004490050575","doi":"https://doi.org/10.1007/s004490050575","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s004490050575","pdf_url":null,"source":{"id":"https://openalex.org/S154076131","display_name":"Bioprocess Engineering","issn_l":"0178-515X","issn":["0178-515X","1432-0797"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioprocess Engineering","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5666999816894531,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1220601193","https://openalex.org/W1983005144","https://openalex.org/W1984504714","https://openalex.org/W1990934751","https://openalex.org/W1998066249","https://openalex.org/W2005260141","https://openalex.org/W2006192326","https://openalex.org/W2007742023","https://openalex.org/W2030610170","https://openalex.org/W2053844688","https://openalex.org/W2066899459","https://openalex.org/W2088866026","https://openalex.org/W2098184601","https://openalex.org/W2114731556","https://openalex.org/W2147009233","https://openalex.org/W2416533985","https://openalex.org/W2776801810"],"related_works":["https://openalex.org/W243993736","https://openalex.org/W2385094381","https://openalex.org/W2370621875","https://openalex.org/W2050401521","https://openalex.org/W2066899459","https://openalex.org/W2944635136","https://openalex.org/W3160805922","https://openalex.org/W2912057480","https://openalex.org/W2062198428","https://openalex.org/W2883811707"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,9,20,28,49,56,66],"fungal":[3],"elicitor,":[4],"derived":[5],"from":[6],"mycelial":[7],"extracts":[8],"Penicillium":[10],"chysogenum":[11],"3446,":[12],"on":[13],"artemisinin":[14],"production":[15,72],"in":[16,73],"hairy":[17,57,75],"root":[18,58,76],"cultures":[19,59,77],"Artemisia":[21],"annua":[22],"L":[23],"was":[24],"studied.":[25],"Various":[26,54],"concentrations":[27],"elicitor":[29,50,67,85],"were":[30,42,60],"added":[31],"to":[32,90],"the":[33],"culture":[34],"medium":[35,84],"after":[36,51],"18":[37,52],"days.":[38,53,70],"Time":[39],"course":[40],"experiments":[41],"carried":[43],"out":[44],"using":[45,62],"a":[46,63],"defined":[47,64],"concentration":[48,65],"ages":[55],"elicited":[61],"for":[68,86],"3":[69,87],"Artemisinin":[71],"21-day":[74],"treated":[78],"with":[79],"0.3":[80],"mg":[81],"total":[82],"sugar/ml":[83],"days":[88],"reached":[89],"549.1":[91],"mg/l.":[92]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}