{"id":"https://openalex.org/W2024908724","doi":"https://doi.org/10.1038/nbt0908-983","title":"Data completeness\u2014the Achilles heel of drug-target networks","display_name":"Data completeness\u2014the Achilles heel of drug-target networks","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W2024908724","doi":"https://doi.org/10.1038/nbt0908-983","mag":"2024908724","pmid":"https://pubmed.ncbi.nlm.nih.gov/18779805"},"language":"en","primary_location":{"id":"doi:10.1038/nbt0908-983","doi":"https://doi.org/10.1038/nbt0908-983","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nbt0908-983","pdf_url":null,"source":{"id":"https://openalex.org/S106963461","display_name":"Nature Biotechnology","issn_l":"0733-222X","issn":["0733-222X","1087-0156","1546-1696","2331-3684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Biotechnology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2024908724"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052116809","display_name":"Jordi Mestres","orcid":"https://orcid.org/0000-0002-5202-4501","observed_orcids":["https://orcid.org/0000-0002-5202-4501"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Mestres","raw_affiliation_strings":["Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Catalonia, Spain","Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210136145"]},{"raw_affiliation_string":"Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210136145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082875568","display_name":"Elisabet Gregori\u2010Puigjan\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elisabet Gregori-Puigjan\u00e9","raw_affiliation_strings":["Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Catalonia, Spain","Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210136145"]},{"raw_affiliation_string":"Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210136145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074561818","display_name":"Sergi Valverde","orcid":"https://orcid.org/0000-0002-2150-9610","observed_orcids":["https://orcid.org/0000-0002-2150-9610"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]}],"countries":["ES","FR"],"is_corresponding":false,"raw_author_name":"Sergi Valverde","raw_affiliation_strings":["CNRS-UMR, Universit\u00e9 Paul Sabatier, Toulouse, France","Complex Systems Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Catalonia, Spain","Complex Systems Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS-UMR, Universit\u00e9 Paul Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555"]},{"raw_affiliation_string":"Complex Systems Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210136145"]},{"raw_affiliation_string":"Complex Systems Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046878011","display_name":"Ricard V. Sol\u00e9","orcid":"https://orcid.org/0000-0001-6974-1008","observed_orcids":["https://orcid.org/0000-0001-6974-1008"]},"institutions":[{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Ricard V Sol\u00e9","raw_affiliation_strings":["Complex Systems Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Catalonia, Spain","Santa Fe Institute, New Mexico, USA","Complex Systems Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Systems Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210136145"]},{"raw_affiliation_string":"Santa Fe Institute, New Mexico, USA","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"Complex Systems Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research (IMIM) and University Pompeu Fabra, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":5.8809,"has_fulltext":false,"cited_by_count":269,"citation_normalized_percentile":{"value":0.98074866,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"26","issue":"9","first_page":"983","last_page":"984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.1818999946117401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-target-interaction-networks","display_name":"drug-target network","score":0.9419999718666077},{"id":"https://openalex.org/keywords/data-completeness","display_name":"data completeness","score":0.9430000185966492},{"id":"https://openalex.org/keywords/drug-target-interactions","display_name":"drug-target interactions","score":0.5809999704360962},{"id":"https://openalex.org/keywords/network-inference","display_name":"network inference","score":0.453000009059906},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.6819999814033508},{"id":"https://openalex.org/keywords/polypharmacology","display_name":"polypharmacology","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2777248721","wikidata":"https://www.wikidata.org/wiki/Q174647","display_name":"Heel","level":2,"score":0.8761038780212402},{"id":"https://openalex.org/C17231256","wikidata":"https://www.wikidata.org/wiki/Q5156540","display_name":"Completeness (order theory)","level":2,"score":0.5833943486213684},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49957776069641113},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4176481366157532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3842196762561798},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3272102475166321},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2813681960105896},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18639498949050903},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.09833469986915588},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004345","descriptor_name":"Drug Industry","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D004345","descriptor_name":"Drug Industry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nbt0908-983","doi":"https://doi.org/10.1038/nbt0908-983","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nbt0908-983","pdf_url":null,"source":{"id":"https://openalex.org/S106963461","display_name":"Nature Biotechnology","issn_l":"0733-222X","issn":["0733-222X","1087-0156","1546-1696","2331-3684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Biotechnology","raw_type":"journal-article"},{"id":"pmid:18779805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18779805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature biotechnology","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W633690959","https://openalex.org/W1544009106","https://openalex.org/W1972821149","https://openalex.org/W1984627852","https://openalex.org/W2074370114","https://openalex.org/W2083045667","https://openalex.org/W2115702862","https://openalex.org/W2116249365","https://openalex.org/W2122995608","https://openalex.org/W2156779720","https://openalex.org/W2159847871","https://openalex.org/W2165160727","https://openalex.org/W2170146596","https://openalex.org/W2497748342"],"related_works":["https://openalex.org/W2954095298","https://openalex.org/W7098778218","https://openalex.org/W2121953357","https://openalex.org/W1992578437","https://openalex.org/W2089486914","https://openalex.org/W7025134856","https://openalex.org/W2123531184","https://openalex.org/W2237630736","https://openalex.org/W2111076982","https://openalex.org/W2766687549"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":25},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
