{"id":"https://openalex.org/W2024901915","doi":"https://doi.org/10.1007/s00204-011-0742-x","title":"Effects of salubrinal on cadmium-induced apoptosis in HK-2 human renal proximal tubular cells","display_name":"Effects of salubrinal on cadmium-induced apoptosis in HK-2 human renal proximal tubular cells","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2024901915","doi":"https://doi.org/10.1007/s00204-011-0742-x","mag":"2024901915","pmid":"https://pubmed.ncbi.nlm.nih.gov/21809093"},"language":"en","primary_location":{"id":"doi:10.1007/s00204-011-0742-x","doi":"https://doi.org/10.1007/s00204-011-0742-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00204-011-0742-x","pdf_url":null,"source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073760236","display_name":"Yuta Komoike","orcid":"https://orcid.org/0000-0002-3374-4255","observed_orcids":["https://orcid.org/0000-0002-3374-4255"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Komoike","raw_affiliation_strings":["Department of Hygiene and Public Health I, Tokyo Women's Medical University, Japan","Department of Hygiene and Public Health I, Tokyo Women\u2019s Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Public Health I, Tokyo Women's Medical University, Japan","institution_ids":["https://openalex.org/I4210136522"]},{"raw_affiliation_string":"Department of Hygiene and Public Health I, Tokyo Women\u2019s Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002633588","display_name":"Hisako Inamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisako Inamura","raw_affiliation_strings":["Department of Hygiene and Public Health I, Tokyo Women\u2019s Medical University, Tokyo, 162-8666, Japan","Department of Hygiene and Public Health I, Tokyo Women\u2019s Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Public Health I, Tokyo Women\u2019s Medical University, Tokyo, 162-8666, Japan","institution_ids":["https://openalex.org/I4210136522"]},{"raw_affiliation_string":"Department of Hygiene and Public Health I, Tokyo Women\u2019s Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049846578","display_name":"Masato Matsuoka","orcid":"https://orcid.org/0000-0002-4217-3730","observed_orcids":["https://orcid.org/0000-0002-4217-3730"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masato Matsuoka","raw_affiliation_strings":["Department of Hygiene and Public Health I, Tokyo Women\u2019s Medical University, Tokyo, 162-8666, Japan","Department of Hygiene and Public Health I, Tokyo Women\u2019s Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Public Health I, Tokyo Women\u2019s Medical University, Tokyo, 162-8666, Japan","institution_ids":["https://openalex.org/I4210136522"]},{"raw_affiliation_string":"Department of Hygiene and Public Health I, Tokyo Women\u2019s Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049846578"],"corresponding_institution_ids":["https://openalex.org/I4210136522"],"apc_list":{"value":5690,"currency":"USD","value_usd":5690},"apc_paid":null,"fwci":1.9926,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.84214913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"86","issue":"1","first_page":"37","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salubrinal","display_name":"salubrinal","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cadmium-toxicity","display_name":"cadmium toxicity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hk-2-cells","display_name":"HK-2 cells","score":0.8489999771118164},{"id":"https://openalex.org/keywords/renal-proximal-tubular-cells","display_name":"renal proximal tubular cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/eif2alpha-dephosphorylation","display_name":"eIF2\u03b1 dephosphorylation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/atf4","display_name":"ATF4","score":0.8429999947547913},{"id":"https://openalex.org/keywords/chop","display_name":"CHOP","score":0.9700000286102295},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.890999972820282},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9779999852180481},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9419999718666077},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.7549999952316284},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8870000243186951},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.5719048380851746},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5382971167564392},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.537601888179779},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5079646706581116},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5073136687278748},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4984753131866455},{"id":"https://openalex.org/C2780900454","wikidata":"https://www.wikidata.org/wiki/Q21102119","display_name":"ATF4","level":4,"score":0.49037861824035645},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4796474575996399},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47917333245277405},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4234761893749237},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.42174461483955383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3617154359817505},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34339529275894165},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.3214051127433777},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16915228962898254}],"mesh":[{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002934","descriptor_name":"Cinnamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015852","descriptor_name":"Eukaryotic Initiation Factor-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015852","descriptor_name":"Eukaryotic Initiation Factor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019256","descriptor_name":"Cadmium Chloride","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00204-011-0742-x","doi":"https://doi.org/10.1007/s00204-011-0742-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00204-011-0742-x","pdf_url":null,"source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},{"id":"pmid:21809093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21809093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8210164067","display_name":"Expansion of the study of the endoplasmic reticulum stress using zebrafish into environmental toxicology","funder_award_id":"23710082","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1538177922","https://openalex.org/W1568601713","https://openalex.org/W1966793098","https://openalex.org/W1979164049","https://openalex.org/W1983760632","https://openalex.org/W1989829992","https://openalex.org/W1992361007","https://openalex.org/W1998809668","https://openalex.org/W2009003493","https://openalex.org/W2011451556","https://openalex.org/W2025511820","https://openalex.org/W2032379590","https://openalex.org/W2034580062","https://openalex.org/W2036411709","https://openalex.org/W2038500334","https://openalex.org/W2042130521","https://openalex.org/W2059655067","https://openalex.org/W2059980335","https://openalex.org/W2065926887","https://openalex.org/W2067481392","https://openalex.org/W2081872347","https://openalex.org/W2089198803","https://openalex.org/W2090556647","https://openalex.org/W2093526428","https://openalex.org/W2127848114","https://openalex.org/W2137662702","https://openalex.org/W2140487984","https://openalex.org/W2152398979","https://openalex.org/W2160873790","https://openalex.org/W2175665845","https://openalex.org/W2580399379"],"related_works":["https://openalex.org/W7124314049","https://openalex.org/W4283031909","https://openalex.org/W1025004510","https://openalex.org/W2059980335","https://openalex.org/W4396999191","https://openalex.org/W66911190","https://openalex.org/W1522290843","https://openalex.org/W7097414432","https://openalex.org/W2917798522","https://openalex.org/W2014424166"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}