{"id":"https://openalex.org/W2024874130","doi":"https://doi.org/10.1002/hep.25902","title":"Pituitary adenylate cyclase-activating polypeptide: A neuromodulator of hepatic ischemia-reperfusion injury?","display_name":"Pituitary adenylate cyclase-activating polypeptide: A neuromodulator of hepatic ischemia-reperfusion injury?","publication_year":2012,"publication_date":"2012-06-22","ids":{"openalex":"https://openalex.org/W2024874130","doi":"https://doi.org/10.1002/hep.25902","mag":"2024874130","pmid":"https://pubmed.ncbi.nlm.nih.gov/22729815"},"language":"en","primary_location":{"id":"doi:10.1002/hep.25902","doi":"https://doi.org/10.1002/hep.25902","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.25902","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25902","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25902","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053733739","display_name":"Allan Tsung","orcid":"https://orcid.org/0000-0002-3916-8965","observed_orcids":["https://orcid.org/0000-0002-3916-8965"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan Tsung","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA","fax: 412-692-2002"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"fax: 412-692-2002","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083441114","display_name":"Gary Nace","orcid":"https://orcid.org/0000-0002-4468-2950","observed_orcids":["https://orcid.org/0000-0002-4468-2950"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary W. Nace","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051148693","display_name":"David A. Geller","orcid":"https://orcid.org/0000-0003-0735-1068","observed_orcids":["https://orcid.org/0000-0003-0735-1068"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Geller","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053733739"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"57","issue":"3","first_page":"878","last_page":"880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pituitary-adenylate-cyclase-activating-polypeptide","display_name":"pituitary adenylate cyclase-activating polypeptide","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pacap","display_name":"PACAP","score":0.7059999704360962},{"id":"https://openalex.org/keywords/hepatic-ischemia-reperfusion-injury","display_name":"hepatic ischemia-reperfusion injury","score":0.9810000061988831},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cholinergic-anti-inflammatory-pathway","display_name":"cholinergic anti-inflammatory pathway","score":0.824999988079071},{"id":"https://openalex.org/keywords/vagal-signaling","display_name":"vagal signaling","score":0.6010000109672546},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.7649999856948853},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.7210000157356262},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.7139999866485596},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.8040000200271606},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.421999990940094},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.6029999852180481},{"id":"https://openalex.org/keywords/neuroimmune-interactions","display_name":"neuroimmune interactions","score":0.4129999876022339},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5995913743972778},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5811614990234375},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.5304457545280457},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.4960413873195648},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.47927922010421753},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4483649432659149},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.42988717555999756},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4221786856651306},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3963524401187897},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38394805788993835},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3468184471130371},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3356829583644867}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051219","descriptor_name":"Pituitary Adenylate Cyclase-Activating Polypeptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.25902","doi":"https://doi.org/10.1002/hep.25902","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.25902","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25902","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:22729815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22729815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1002/hep.25902","doi":"https://doi.org/10.1002/hep.25902","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.25902","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25902","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024874130.pdf","grobid_xml":"https://content.openalex.org/works/W2024874130.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1983590721","https://openalex.org/W2007450401","https://openalex.org/W2022782996","https://openalex.org/W2029051866","https://openalex.org/W2036941062","https://openalex.org/W2047759256","https://openalex.org/W2059944604","https://openalex.org/W2069368135","https://openalex.org/W2130529820","https://openalex.org/W2135131688","https://openalex.org/W2151875422"],"related_works":["https://openalex.org/W2047759256","https://openalex.org/W2772127876","https://openalex.org/W2937952592","https://openalex.org/W2393267109","https://openalex.org/W2354231234","https://openalex.org/W2122025387","https://openalex.org/W1710789735","https://openalex.org/W2002783887","https://openalex.org/W2349016613","https://openalex.org/W2093785115"],"abstract_inverted_index":{"Recently,":[0],"there":[1],"has":[2,55,94,126,418,446],"been":[3,56,95,127,419,716,738],"the":[4,31,34,42,67,71,77,84,102,120,156,159,180,186,282,337,374,404,411,422,429,434,442,520,540,563,590,613,618,642,660,674,696,722,760,768,777,787,801,805],"realization":[5],"that":[6,26,58,203,222,421,584,690,753],"neurobiology":[7],"and":[8,122,166,192,212,296,306,312,318,331,385,441,529,555,573,595,617,634,669,734,772,782,817,831],"inflammatory":[9,43,80,310,414,431,542,784],"signaling":[10,93],"are":[11,61,204,623],"intimately":[12],"interrelated":[13],"with":[14,63,129,255,336,387,403,532,569,601,747,776,848],"one":[15],"another;":[16],"however,":[17],"this":[18,148,280,401],"field":[19],"remains":[20],"in":[21,38,65,169,185,214,237,258,526,589,700,744,790,811,815],"its":[22,167],"infancy.":[23],"Many":[24],"studies":[25],"have":[27,45,715,736],"sought":[28],"to":[29,97,100,107,216,239,266,288,325,368,448,537,562,612,625,692,702,718,740,751,767,803,827,843],"elucidate":[30],"role":[32,157,250,522,806],"of":[33,41,49,69,79,150,158,197,226,241,251,284,302,340,345,354,376,390,413,523,558,565,592,603,621,687,759,770,780,807,825],"autonomic":[35,423,443],"nervous":[36,121,181,424,444],"system":[37,425],"neural":[39],"modulation":[40],"response":[44,432,445,543,654,763],"used":[46],"various":[47],"models":[48],"septic":[50],"shock.":[51,609],"For":[52],"example,":[53],"it":[54,417],"seen":[57],"when":[59],"macrophages":[60],"stimulated":[62],"LPS":[64],"vitro,":[66],"addition":[68,215,238,283,344,701],"acetylcholine,":[70],"principle":[72],"vagal":[73,92,435],"neurotransmitter,":[74],"significantly":[75,263],"attenuates":[76],"release":[78,375],"cytokines,":[81,663],"but":[82,183,599,671],"not":[83,176,587,657],"anti-inflammatory":[85,104],"cytokine":[86,110,311],"interleukin":[87],"(IL)-10.1":[88],"In":[89,147],"vivo,":[90],"intact":[91],"shown":[96,324,420,717,739],"be":[98,449,719,741,836],"necessary":[99,720],"activate":[101,380,832],"cholinergic":[103],"pathway,":[105],"leading":[106],"decreased":[108,304,309,319,630],"proinflammatory":[109,391,662],"expression":[111,240,769],"after":[112,229,235,544,641],"endotoxin-induced":[113],"shock.2":[114],"Thus,":[115],"a":[116,248,262,347,397,524,533,548,580,840],"physiologic":[117],"connection":[118],"between":[119,439],"innate":[123,430,566,650,724,761],"immune":[124,207,567,651,725,762,829],"systems":[125],"confirmed,":[128],"potential":[130],"for":[131,245,399,721],"therapeutic":[132,535],"exploitation.":[133],"DAMP,":[134,460,698],"damage-associated":[135,461,681],"molecular":[136,462,682],"pattern;":[137],"IL,":[138],"interleukin;":[139],"I/R,":[140,230],"ischemia/reperfusion;":[141],"PACAP,":[142,490],"pituitary":[143,161,491],"adenylate":[144,162,492],"cyclase-activating":[145,163,493],"polypeptide.":[146],"issue":[149],"HEPATOLOGY,":[151],"Ji":[152,218,393,516,797],"et":[153,219,394,517,798],"al.3":[154,395],"investigate":[155],"neuropeptide":[160,405,525,810],"polypeptide":[164],"(PACAP)":[165],"receptors":[168,202,244,714,729],"warm":[170],"hepatic":[171,355,364,408,527,813],"ischemia/reperfusion":[172],"(I/R).":[173],"PACAP":[174,194,227,252,260,286,303,322,341,406,440,826],"is":[175,195,547,579,646,655,800],"only":[177,588,658],"expressed":[178],"throughout":[179],"system,":[182],"also":[184,427,600,672],"adrenal":[187],"gland,":[188],"gastrointestinal":[189],"tract,":[190],"pancreas,":[191],"liver.4":[193],"capable":[196],"binding":[198],"several":[199,360],"G":[200],"protein\u2013coupled":[201],"found":[205],"on":[206],"cells":[208,785],"such":[209,382,606,664,707,730],"as":[210,291,383,607,665,708,731,839],"lymphocytes":[211],"macrophages,":[213],"hepatocytes.4":[217],"al.":[220,518,799],"determined":[221],"both":[223],"endogenous":[224,677],"levels":[225,295,330],"increased":[228,264,315,635,693],"peaking":[231],"at":[232],"12-24":[233],"hours":[234],"reperfusion,":[236],"all":[242,737],"known":[243],"PACAP.3":[246],"Interestingly,":[247],"protective":[249],"was":[253,323],"found,":[254],"mice":[256,752],"deficient":[257],"functional":[259],"having":[261],"susceptibility":[265],"IR":[267],"(wild-type":[268],"versus":[269,274],"knockout;":[270],"4,680":[271],"\u00b1":[272,276],"554":[273],"31,172":[275],"6,994":[277],"IU/L).3":[278],"Confirming":[279],"finding,":[281],"exogenous":[285,300],"led":[287],"significant":[289,748],"protection":[290,749],"seem":[292],"by":[293,343,410,515,648,659,673,796],"ALT":[294],"liver":[297,597,821,845],"histology.3":[298],"Furthermore,":[299],"administration":[301],"neutrophil":[305],"macrophage":[307],"infiltration,":[308],"chemokine":[313],"expression,":[314],"IL-10":[316],"levels,":[317],"apoptosis.3":[320],"Mechanistically,":[321],"increase":[326],"cyclic":[327],"adenosine":[328,456,631],"monophosphate":[329],"protein":[332,348,453,474,496],"kinase":[333,349,497],"A":[334,350],"activity,":[335],"hepatoprotective":[338],"effects":[339],"negated":[342],"H-89,":[346],"inhibitor.31":[351],"Schematic":[352],"overview":[353],"ischemia-reperfusion.":[356],"Simplified":[357],"illustration":[358],"demonstrating":[359],"critical":[361],"factors":[362],"regulating":[363],"IR.":[365],"Ischemia-reperfusion":[366],"leads":[367,561,766],"many":[369],"simultaneous":[370],"homeostatic":[371],"perturbances":[372],"including":[373],"DAMPs,":[377],"which":[378],"may":[379,426,585],"PRR,":[381,502],"TLRs":[384],"NLRs,":[386],"ultimate":[388],"upregulation":[389],"mediators.":[392,415],"describe":[396],"mechanism":[398],"balancing":[400],"response,":[402],"decreasing":[407],"injury":[409],"down-regulation":[412],"Alternatively,":[416],"downregulate":[428],"via":[433,764],"inputs.11":[436],"The":[437,513,757,794,823],"relationship":[438],"yet":[447],"elucidated.":[450],"AP-1,":[451],"activator":[452],"1;":[454],"ATP,":[455],"triphosphate;":[457],"Casp-1,":[458],"caspase-1;":[459],"pattern":[463,503,683,712],"molecules;":[464],"IL-1\u03b2,":[465,670],"interleukin-1\u03b2;":[466],"IRF-3,":[467],"interferon":[468],"regulatory":[469],"factor":[470,482],"3;":[471],"MAPK,":[472],"mitogen-associated":[473],"kinase;":[475],"MPT,":[476],"mitochondrial":[477,636],"permeability":[478,637],"transition;":[479],"NF-\u03baB,":[480],"nuclear":[481],"\u03baB;":[483],"NK,":[484],"natural":[485],"killer;":[486],"NLR,":[487],"NOD-like":[488],"receptors;":[489,505],"polypeptides;":[494],"PKA,":[495],"A;":[498],"PMN,":[499],"polymorphonuclear":[500],"neutrophils;":[501],"recognition":[504,713,728],"ROS,":[506],"reactive":[507,626],"oxygen":[508,627],"species;":[509],"TLR,":[510],"Toll-like":[511],"receptors.":[512],"work":[514],"describes":[519],"novel":[521,841],"I/R":[528,546,578,645],"provides":[530],"us":[531],"new":[534],"avenue":[536],"potentially":[538],"abrogate":[539],"sterile":[541],"I/R.":[545,822,849],"process":[549],"whereby":[550],"an":[551,649,808],"initial":[552,614,643],"hypoxic":[553],"insult":[554,616],"subsequent":[556,778],"return":[557],"blood":[559],"flow":[560],"propagation":[564],"responses":[568,830],"resultant":[570],"tissue":[571],"damage":[572,819],"possible":[574],"organ":[575,593,818],"dysfunction.":[576],"Hepatic":[577],"clinically":[581],"relevant":[582],"condition":[583],"occur":[586],"setting":[591],"transplantation":[594],"elective":[596],"resection":[598],"episodes":[602],"global":[604],"hypoperfusion,":[605],"hemorrhagic":[608],"Damage":[610],"related":[611],"ischemic":[615],"early":[619],"phases":[620],"reperfusion":[622],"secondary":[624],"species":[628],"generation,":[629],"triphosphate":[632],"production,":[633],"transition.5,":[638],"6":[639],"However,":[640],"insult,":[644],"perpetuated":[647],"response.":[652,726],"This":[653],"mediated":[656],"classical":[661],"tumor":[666],"necrosis":[667],"factor-\u03b1":[668],"recently":[675,704],"described":[676,705],"danger":[678],"signals":[679],"or":[680],"(DAMP)":[684],"molecules.":[685],"Examples":[686],"DAMP":[688],"molecules":[689,706,775],"lead":[691],"inflammation":[694,816,846],"include":[695],"canonical":[697],"HMGB1,":[699],"more":[703],"histones.6,":[709],"7":[710],"Additionally,":[711],"I/R-associated":[723,745,792],"Pattern":[727],"TLR4,":[732],"TLR9,":[733],"NALP3":[735],"key":[742],"components":[743],"injury,":[746],"afforded":[750],"lack":[754],"these":[755],"receptors.7-10":[756],"activation":[758],"PRRs":[765],"chemokines":[771],"intercellular":[773],"adhesion":[774],"infiltration":[779],"neutrophils":[781],"other":[783],"into":[786],"liver,":[788],"resulting":[789],"further":[791,838],"injury.":[793],"study":[795],"first":[802],"demonstrate":[804],"intrinsic":[809],"maintaining":[812],"homeostasis":[814],"following":[820],"use":[824],"regulate":[828],"cytoprotective":[833],"mechanisms":[834],"should":[835],"investigated":[837],"therapy":[842],"manage":[844],"associated":[847]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
