{"id":"https://openalex.org/W2024860331","doi":"https://doi.org/10.1074/jbc.m110.198374","title":"Growth and Metastases of Human Lung Cancer Are Inhibited in Mouse Xenografts by a Transition State Analogue of 5\u2032-Methylthioadenosine Phosphorylase","display_name":"Growth and Metastases of Human Lung Cancer Are Inhibited in Mouse Xenografts by a Transition State Analogue of 5\u2032-Methylthioadenosine Phosphorylase","publication_year":2010,"publication_date":"2010-12-07","ids":{"openalex":"https://openalex.org/W2024860331","doi":"https://doi.org/10.1074/jbc.m110.198374","mag":"2024860331","pmid":"https://pubmed.ncbi.nlm.nih.gov/21135097"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m110.198374","doi":"https://doi.org/10.1074/jbc.m110.198374","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.198374","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m110.198374","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036442105","display_name":"Indranil Basu","orcid":"https://orcid.org/0000-0003-1057-8888","observed_orcids":["https://orcid.org/0000-0003-1057-8888"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Indranil Basu","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040178560","display_name":"Joseph D. Locker","orcid":"https://orcid.org/0000-0002-4190-188X","observed_orcids":["https://orcid.org/0000-0002-4190-188X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Locker","raw_affiliation_strings":["Pathology, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Bronx, New York 10461","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052174107","display_name":"Mar\u00eda B. Cassera","orcid":"https://orcid.org/0000-0001-6341-3169","observed_orcids":["https://orcid.org/0000-0001-6341-3169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria B. Cassera","raw_affiliation_strings":["From the Departments of Biochemistry, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Biochemistry, Bronx, New York 10461","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060111774","display_name":"Thomas James Belbin","orcid":"https://orcid.org/0000-0001-6867-654X","observed_orcids":["https://orcid.org/0000-0001-6867-654X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas J. Belbin","raw_affiliation_strings":["Pathology, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Bronx, New York 10461","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103437838","display_name":"Emilio F. Merino","orcid":"https://orcid.org/0000-0002-5400-7377","observed_orcids":["https://orcid.org/0000-0002-5400-7377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emilio F. Merino","raw_affiliation_strings":["From the Departments of Biochemistry, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Biochemistry, Bronx, New York 10461","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102202035","display_name":"Xinyuan Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinyuan Dong","raw_affiliation_strings":["Radiation Oncology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032038806","display_name":"Ivan Hemeon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivan Hemeon","raw_affiliation_strings":["From the Departments of Biochemistry, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Biochemistry, Bronx, New York 10461","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067610098","display_name":"Gary B. Evans","orcid":"https://orcid.org/0000-0002-6973-2002","observed_orcids":["https://orcid.org/0000-0002-6973-2002"]},"institutions":[{"id":"https://openalex.org/I4387155704","display_name":"Industrial Research Limited","ror":"https://ror.org/011bwkg92","country_code":null,"type":"government","lineage":["https://openalex.org/I150510651","https://openalex.org/I4210126329","https://openalex.org/I4387155704"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Gary B. Evans","raw_affiliation_strings":["Carbohydrate Chemistry Team, Industrial Research Limited, Lower Hutt 5040, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carbohydrate Chemistry Team, Industrial Research Limited, Lower Hutt 5040, New Zealand","institution_ids":["https://openalex.org/I4387155704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055510159","display_name":"Chandan Guha","orcid":"https://orcid.org/0000-0002-1906-2186","observed_orcids":["https://orcid.org/0000-0002-1906-2186"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandan Guha","raw_affiliation_strings":["Radiation Oncology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I19772626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018522950","display_name":"Vern L. Schramm","orcid":"https://orcid.org/0000-0002-8056-1929","observed_orcids":["https://orcid.org/0000-0002-8056-1929"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vern L. Schramm","raw_affiliation_strings":["From the Departments of Biochemistry, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Biochemistry, Bronx, New York 10461","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018522950"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5356,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.81031533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"286","issue":"6","first_page":"4902","last_page":"4911"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-methylthioadenosine-phosphorylase","display_name":"5'-methylthioadenosine phosphorylase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mtap","display_name":"MTAP","score":0.6610000133514404},{"id":"https://openalex.org/keywords/transition-state-analogs","display_name":"transition state analogues","score":0.828000009059906},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7599999904632568},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/5-methylthioadenosine","display_name":"5'-methylthioadenosine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7940000295639038},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/polyamines","display_name":"polyamines","score":0.7129999995231628},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8270000219345093},{"id":"https://openalex.org/keywords/antitumor-drug-targets","display_name":"antitumor drug targets","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.6323282718658447},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5140248537063599},{"id":"https://openalex.org/C204779464","wikidata":"https://www.wikidata.org/wiki/Q412061","display_name":"Glycogen phosphorylase","level":3,"score":0.5093437433242798},{"id":"https://openalex.org/C13053905","wikidata":"https://www.wikidata.org/wiki/Q17087414","display_name":"Transition state analog","level":4,"score":0.5047847032546997},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4711942672729492},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4447581171989441},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41551944613456726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3383687138557434},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32621651887893677},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2683526873588562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25823646783828735},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23309719562530518},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08759590983390808},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013872","descriptor_name":"Thionucleosides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013872","descriptor_name":"Thionucleosides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013872","descriptor_name":"Thionucleosides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m110.198374","doi":"https://doi.org/10.1074/jbc.m110.198374","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.198374","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:21135097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21135097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2283235","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3039339","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3039339","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3039339","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m110.198374","doi":"https://doi.org/10.1074/jbc.m110.198374","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.198374","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2484806106","display_name":null,"funder_award_id":"R01 CA085953","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4285811448","display_name":null,"funder_award_id":"CA135405","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4626604277","display_name":null,"funder_award_id":"CA85953","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8372175733","display_name":null,"funder_award_id":"R01 CA135405","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000877850","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA013330","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W180482503","https://openalex.org/W776824761","https://openalex.org/W1486850664","https://openalex.org/W1823272702","https://openalex.org/W1983820813","https://openalex.org/W1990320777","https://openalex.org/W1990821578","https://openalex.org/W1993168177","https://openalex.org/W1998628096","https://openalex.org/W2001375177","https://openalex.org/W2004959159","https://openalex.org/W2009389248","https://openalex.org/W2028953339","https://openalex.org/W2029285030","https://openalex.org/W2030067084","https://openalex.org/W2037874673","https://openalex.org/W2044761859","https://openalex.org/W2053823503","https://openalex.org/W2058510727","https://openalex.org/W2059706603","https://openalex.org/W2068384749","https://openalex.org/W2077717752","https://openalex.org/W2084618926","https://openalex.org/W2087989446","https://openalex.org/W2097655753","https://openalex.org/W2100260797","https://openalex.org/W2101995865","https://openalex.org/W2104152602","https://openalex.org/W2105712639","https://openalex.org/W2110590052","https://openalex.org/W2113731575","https://openalex.org/W2120434825","https://openalex.org/W2128048179","https://openalex.org/W2138386102","https://openalex.org/W2147621980","https://openalex.org/W2154496747","https://openalex.org/W2225045400","https://openalex.org/W2262495602","https://openalex.org/W2949604784","https://openalex.org/W4229539731","https://openalex.org/W4230795754"],"related_works":["https://openalex.org/W106074972","https://openalex.org/W2054135341","https://openalex.org/W1966658797","https://openalex.org/W1977186710","https://openalex.org/W2073139109","https://openalex.org/W2324785351","https://openalex.org/W2500905914","https://openalex.org/W2325320324","https://openalex.org/W195001029","https://openalex.org/W1977604782"],"abstract_inverted_index":{"The":[0],"S-adenosylmethionine":[1],"(AdoMet)":[2],"salvage":[3],"enzyme":[4],"5'-methylthioadenosine":[5,34],"phosphorylase":[6],"(MTAP)":[7],"has":[8],"been":[9],"implicated":[10,97],"as":[11,98,167],"both":[12],"a":[13,17,168],"cancer":[14,172],"target":[15,169],"and":[16,55,75,90,113,124,144,154],"tumor":[18,56,85],"suppressor.":[19],"We":[20],"tested":[21],"these":[22],"hypotheses":[23],"in":[24,61,87,107,130,163],"mouse":[25],"xenografts":[26,164],"of":[27,40,58,110,139],"human":[28],"lung":[29,73,81,171],"cancers.":[30],"AdoMet":[31],"recycling":[32],"from":[33,118,142],"(MTA)":[35],"was":[36],"blocked":[37],"by":[38],"inhibition":[39],"MTAP":[41,166],"with":[42,151],"methylthio-DADMe-Immucillin-A":[43],"(MTDIA),":[44],"an":[45],"orally":[46],"available,":[47],"nontoxic,":[48],"picomolar":[49],"transition":[50],"state":[51],"analogue.":[52],"Blood,":[53],"urine,":[54],"levels":[57],"MTA":[59,94,123],"increased":[60,122],"response":[62],"to":[63],"MTDIA":[64,66,103,160],"treatment.":[65],"treatment":[67,109],"inhibited":[68],"A549":[69,111,140],"(human":[70,77],"non-small":[71,79],"cell":[72,80],"carcinoma)":[74],"H358":[76,114],"bronchioloalveolar":[78],"carcinoma":[82],"cells)":[83],"xenograft":[84],"growth":[86],"immunodeficient":[88],"Rag2(-/-)\u03b3C(-/-)":[89],"NCr-nu":[91],"mice.":[92],"Systemic":[93],"accumulation":[95],"is":[96,104],"the":[99],"tumor-suppressive":[100],"metabolite":[101],"because":[102],"effective":[105],"for":[106,170],"vivo":[108],"MTAP(-/-)":[112],"MTAP(+/+)":[115],"tumors.":[116],"Tumors":[117],"treated":[119,143],"mice":[120,146],"showed":[121],"decreased":[125],"polyamines":[126],"but":[127],"little":[128],"alteration":[129],"AdoMet,":[131],"methionine,":[132],"or":[133],"adenine":[134],"levels.":[135],"Gene":[136],"expression":[137],"profiles":[138],"tumors":[141],"untreated":[145],"revealed":[147],"only":[148],"modest":[149],"alterations":[150],"62":[152],"up-regulated":[153],"63":[155],"down-regulated":[156],"mRNAs":[157],"(\u2265":[158],"3-fold).":[159],"antitumor":[161],"activity":[162],"supports":[165],"therapy.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}