{"id":"https://openalex.org/W2024828699","doi":"https://doi.org/10.1158/1538-7445.prca2012-b48","title":"Abstract B48: Integrin \u03b16 S-nitrosylation induces prostate cancer cell migration by loss of adhesion to laminin-1","display_name":"Abstract B48: Integrin \u03b16 S-nitrosylation induces prostate cancer cell migration by loss of adhesion to laminin-1","publication_year":2012,"publication_date":"2012-02-06","ids":{"openalex":"https://openalex.org/W2024828699","doi":"https://doi.org/10.1158/1538-7445.prca2012-b48","mag":"2024828699"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.prca2012-b48","doi":"https://doi.org/10.1158/1538-7445.prca2012-b48","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.prca2012-b48","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jared Isaac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared Isaac","raw_affiliation_strings":["University of Cincinnati, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cincinnati, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111899805","display_name":"Ying Wai Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Wai Lam","raw_affiliation_strings":["University of Cincinnati, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cincinnati, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080536451","display_name":"Pheruza Tarapore","orcid":"https://orcid.org/0000-0003-0911-3661","observed_orcids":["https://orcid.org/0000-0003-0911-3661"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pheruza Tarapore","raw_affiliation_strings":["University of Cincinnati, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cincinnati, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028510658","display_name":"Shuk\u2010Mei Ho","orcid":"https://orcid.org/0000-0001-9369-7342","observed_orcids":["https://orcid.org/0000-0001-9369-7342"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuk-mei Ho","raw_affiliation_strings":["University of Cincinnati, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cincinnati, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"4_Supplement","first_page":"B48","last_page":"B48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alpha6","display_name":"CD49f","score":0.906000018119812},{"id":"https://openalex.org/keywords/s-nitrosylation","display_name":"S-nitrosylation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9549999833106995},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9020000100135803},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/laminin-beta1","display_name":"laminin beta1","score":0.7770000100135803},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.781000018119812},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8032458424568176},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7135152816772461},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6919272541999817},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5606722235679626},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5215811133384705},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5191370844841003},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.516800045967102},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.46975281834602356},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.4640098810195923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4362228214740753},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4167347550392151},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3915824890136719},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36262133717536926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3432409167289734},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24463745951652527}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.prca2012-b48","doi":"https://doi.org/10.1158/1538-7445.prca2012-b48","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.prca2012-b48","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1969156397","https://openalex.org/W70242334","https://openalex.org/W2543038368","https://openalex.org/W7001576540","https://openalex.org/W1970304122","https://openalex.org/W2917873722","https://openalex.org/W2263694429","https://openalex.org/W4387184596","https://openalex.org/W2156291910","https://openalex.org/W2332527080"],"abstract_inverted_index":{"Abstract":[0],"Prostate":[1,191],"cancer":[2,8,58,95,101,144,153,171],"is":[3,147],"the":[4,23,54,184],"second":[5],"most":[6],"common":[7],"in":[9,93,126,190],"American":[10],"males.":[11],"Elevated":[12],"nitric":[13,16,31,46,50,70,76,81],"oxide":[14,17,32,47,51,71,77,82,98],"and":[15,48,68,79,106],"synthase":[18,52,72,83],"levels":[19],"are":[20],"associated":[21],"with":[22],"progression":[24],"of":[25,35,56,123,131,142,151,176,183],"prostate":[26,57,94,100,143,152,170],"tumors.":[27],"S-nitrosylation,":[28],"a":[29,148],"reversible":[30],"post-translational":[33],"modification":[34],"cysteines,":[36],"was":[37,61],"investigated":[38],"here.":[39],"This":[40],"report":[41],"showed":[42],"that":[43],"low":[44],"dose":[45],"inducible":[49,69,80],"induced":[53],"migration":[55,141,173],"cells,":[59,145],"which":[60,146],"blocked":[62],"using":[63],"selective":[64],"integrin":[65,85,107,127,132],"alpha":[66,86,108,128,133],"6":[67,87,109,134],"inhibitors.":[73],"Furthermore,":[74],"both":[75],"donor":[78],"targeted":[84],"for":[88],"S-nitrosylation":[89,130,168],"on":[90,188],"cysteine":[91,124,135],"86":[92,125,136],"cells.":[96],"Nitric":[97],"reduced":[99],"cell":[102,172],"adhesion":[103,177],"to":[104,111,139,178],"laminin-1":[105,179],"binding":[110],"laminin":[112],"beta":[113],"1":[114],"but":[115],"theses":[116],"effects":[117],"were":[118],"not":[119],"seen":[120],"after":[121],"mutation":[122],"6.":[129],"ultimately":[137],"led":[138],"increased":[140],"potential":[149],"mechanism":[150],"metastasis.":[154],"Citation":[155],"Format:":[156],"Jared":[157],"Isaac,":[158],"Ying":[159],"Wai":[160],"Lam,":[161],"Pheruza":[162],"Tarapore,":[163],"Shuk-mei":[164],"Ho.":[165],"Integrin":[166],"\u03b16":[167],"induces":[169],"by":[174],"loss":[175],"[abstract].":[180],"In:":[181],"Proceedings":[182],"AACR":[185],"Special":[186],"Conference":[187],"Advances":[189],"Cancer":[192,202],"Research;":[193],"2012":[194],"Feb":[195],"6-9;":[196],"Orlando,":[197],"FL.":[198],"Philadelphia":[199],"(PA):":[200],"AACR;":[201],"Res":[203],"2012;72(4":[204],"Suppl):Abstract":[205],"nr":[206],"B48.":[207]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}