{"id":"https://openalex.org/W2024765629","doi":"https://doi.org/10.1126/science.1170179","title":"Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis","display_name":"Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis","publication_year":2009,"publication_date":"2009-03-26","ids":{"openalex":"https://openalex.org/W2024765629","doi":"https://doi.org/10.1126/science.1170179","mag":"2024765629","pmid":"https://pubmed.ncbi.nlm.nih.gov/19325080","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3761877"},"language":"en","primary_location":{"id":"doi:10.1126/science.1170179","doi":"https://doi.org/10.1126/science.1170179","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1170179","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3761877","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001010126","display_name":"Akihiko Nishikimi","orcid":"https://orcid.org/0000-0001-9497-7557","observed_orcids":["https://orcid.org/0000-0001-9497-7557"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Akihiko Nishikimi","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085468767","display_name":"Hideo Fukuhara","orcid":"https://orcid.org/0000-0002-7035-8206","observed_orcids":["https://orcid.org/0000-0002-7035-8206"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hideo Fukuhara","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046268516","display_name":"Wenjuan Su","orcid":"https://orcid.org/0000-0002-2398-5100","observed_orcids":["https://orcid.org/0000-0002-2398-5100"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Wenjuan Su","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091364390","display_name":"Tsunaki Hongu","orcid":"https://orcid.org/0000-0002-8772-8111","observed_orcids":["https://orcid.org/0000-0002-8772-8111","https://orcid.org/0000-0003-1923-1709"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Tsunaki Hongu","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030934079","display_name":"Shunsuke Takasuga","orcid":"https://orcid.org/0000-0003-0420-3959","observed_orcids":["https://orcid.org/0000-0003-0420-3959"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Shunsuke Takasuga","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hisashi Mihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hisashi Mihara","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qinhong Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Qinhong Cao","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050769136","display_name":"Fumiyuki Sanematsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Fumiyuki Sanematsu","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088288669","display_name":"Motomu Kanai","orcid":"https://orcid.org/0000-0003-1977-7648","observed_orcids":["https://orcid.org/0000-0003-1977-7648"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Motomu Kanai","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101724929","display_name":"Hiroshi Hasegawa","orcid":"https://orcid.org/0000-0002-2014-8737","observed_orcids":["https://orcid.org/0000-0002-2014-8737"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hiroshi Hasegawa","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064038725","display_name":"Yoshihiko Tanaka","orcid":"https://orcid.org/0000-0002-6458-5082","observed_orcids":["https://orcid.org/0000-0002-6458-5082"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yoshihiko Tanaka","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masakatsu Shibasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Masakatsu Shibasaki","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042371488","display_name":"Yasunori Kanaho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yasunori Kanaho","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074588035","display_name":"Takehiko Sasaki","orcid":"https://orcid.org/0000-0003-1837-3748","observed_orcids":["https://orcid.org/0000-0003-1837-3748"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Takehiko Sasaki","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087789028","display_name":"Michael A. Frohman","orcid":"https://orcid.org/0000-0001-5891-4372","observed_orcids":["https://orcid.org/0000-0001-5891-4372"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Michael A. Frohman","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030952055","display_name":"Yoshinori Fukui","orcid":"https://orcid.org/0000-0003-2335-8745","observed_orcids":["https://orcid.org/0000-0003-2335-8745"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405264796","display_name":"Medical Institute of Bioregulation, Kyushu University","ror":"https://ror.org/02zmxpe85","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405264796"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Yoshinori Fukui","raw_affiliation_strings":["Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794\u20135140, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405264796"]},{"raw_affiliation_string":"Division of Microbiology, Department of Pathology and Immunology, Akita University School of Medicine, Akita 010-8543, Japan","institution_ids":["https://openalex.org/I203765153"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5030952055"],"corresponding_institution_ids":["https://openalex.org/I135598925","https://openalex.org/I146399215","https://openalex.org/I203765153","https://openalex.org/I4210086780","https://openalex.org/I4405264796","https://openalex.org/I59553526"],"apc_list":null,"apc_paid":null,"fwci":9.1197,"has_fulltext":false,"cited_by_count":275,"citation_normalized_percentile":{"value":0.98926597,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"324","issue":"5925","first_page":"384","last_page":"387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dock2","display_name":"DOCK2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neutrophil-chemotaxis","display_name":"neutrophil chemotaxis","score":0.972000002861023},{"id":"https://openalex.org/keywords/guanine-nucleotide-exchange-factor","display_name":"guanine nucleotide exchange factor","score":0.9259999990463257},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-4-5-trisphosphate","display_name":"phosphatidylinositol 3,4,5-trisphosphate","score":0.9879999756813049},{"id":"https://openalex.org/keywords/phosphatidic-acid","display_name":"phosphatidic acid","score":0.9580000042915344},{"id":"https://openalex.org/keywords/phospholipase-d","display_name":"phospholipase D","score":0.9810000061988831},{"id":"https://openalex.org/keywords/leading-edge","display_name":"leading edge","score":0.7120000123977661},{"id":"https://openalex.org/keywords/actin-polymerization","display_name":"actin polymerization","score":0.9800000190734863},{"id":"https://openalex.org/keywords/plasma-membrane-translocation","display_name":"plasma membrane translocation","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.8924375772476196},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6860153675079346},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.6714722514152527},{"id":"https://openalex.org/C2776909261","wikidata":"https://www.wikidata.org/wiki/Q66000256","display_name":"Phosphatidic acid","level":4,"score":0.6565513610839844},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.5563896894454956},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.5467991232872009},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5120695233345032},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4446316659450531},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3671920895576477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35543572902679443},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2914019227027893},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.258203387260437},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.22483739256858826},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14897963404655457}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010712","descriptor_name":"Phosphatidic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010712","descriptor_name":"Phosphatidic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010739","descriptor_name":"Phospholipase D","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010739","descriptor_name":"Phospholipase D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018129","descriptor_name":"Phosphatidylinositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020001","descriptor_name":"1-Butanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020744","descriptor_name":"rac GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1126/science.1170179","doi":"https://doi.org/10.1126/science.1170179","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1170179","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:19325080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19325080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2755504","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3761877","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3761877","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3761877/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2755504","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3761877","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2923643110","display_name":"Lipid-signaling pathways regulating mitochondrial morphology, energetics, and mov","funder_award_id":"R01GM084251","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G448935504","display_name":"Role of Phospholipase D1 in regulated exocytosis","funder_award_id":"R01GM071520","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G721700502","display_name":"Establishment of a new paradigm in the phosphoinositide research","funder_award_id":"21200075","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1966397048","https://openalex.org/W1973108551","https://openalex.org/W1982501876","https://openalex.org/W1984387240","https://openalex.org/W1987252087","https://openalex.org/W1991307931","https://openalex.org/W1994377649","https://openalex.org/W2009718333","https://openalex.org/W2009756576","https://openalex.org/W2011764708","https://openalex.org/W2022157262","https://openalex.org/W2025894679","https://openalex.org/W2026653301","https://openalex.org/W2030284897","https://openalex.org/W2040857731","https://openalex.org/W2063220206","https://openalex.org/W2069986934","https://openalex.org/W2088375097","https://openalex.org/W2111986642","https://openalex.org/W2122108815","https://openalex.org/W2148324690","https://openalex.org/W2150097452","https://openalex.org/W2154655439","https://openalex.org/W4211224007"],"related_works":["https://openalex.org/W2148324690","https://openalex.org/W4380631180","https://openalex.org/W2009718333","https://openalex.org/W2088375097","https://openalex.org/W7098183621","https://openalex.org/W4407179039","https://openalex.org/W1540273720","https://openalex.org/W2082050404","https://openalex.org/W2112867313","https://openalex.org/W7065479267"],"abstract_inverted_index":{"During":[0],"chemotaxis,":[1],"activation":[2,27,122],"of":[3,16,22,59,69,78],"the":[4,14,20,48,62],"small":[5],"guanosine":[6],"triphosphatase":[7],"Rac":[8,26,121],"is":[9,28],"spatially":[10],"regulated":[11,115],"to":[12,47,99,119],"organize":[13],"extension":[15],"membrane":[17,50],"protrusions":[18],"in":[19,51,87,107],"direction":[21],"migration.":[23],"In":[24],"neutrophils,":[25],"primarily":[29],"mediated":[30],"by":[31,76,116],"DOCK2,":[32],"an":[33],"atypical":[34],"guanine":[35],"nucleotide":[36],"exchange":[37],"factor.":[38],"Upon":[39],"stimulation,":[40],"we":[41],"found":[42],"that":[43],"DOCK2":[44,60,74,111],"rapidly":[45],"translocated":[46],"plasma":[49],"a":[52,81],"phosphatidylinositol":[53],"3,4,5-trisphosphate-dependent":[54],"manner.":[55],"However,":[56],"subsequent":[57],"accumulation":[58],"at":[61],"leading":[63,101],"edge":[64],"required":[65],"phospholipase":[66],"D-mediated":[67],"synthesis":[68],"phosphatidic":[70],"acid,":[71],"which":[72],"stabilized":[73],"there":[75],"means":[77],"interaction":[79,94],"with":[80],"polybasic":[82],"amino":[83],"acid":[84],"cluster,":[85],"resulting":[86],"increased":[88],"local":[89],"actin":[90],"polymerization.":[91],"When":[92],"this":[93],"was":[95],"blocked,":[96],"neutrophils":[97],"failed":[98],"form":[100],"edges":[102],"properly":[103],"and":[104],"exhibited":[105],"defects":[106],"chemotaxis.":[108,125],"Thus,":[109],"intracellular":[110],"dynamics":[112],"are":[113],"sequentially":[114],"distinct":[117],"phospholipids":[118],"localize":[120],"during":[123],"neutrophil":[124]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":29},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}