{"id":"https://openalex.org/W2024715752","doi":"https://doi.org/10.7164/antibiotics.39.978","title":"Susceptibility of bacteria to serum lysis or phagocytosis following growth in subinhibitory levels of lincosaminide or spectinomycin related antibiotics.","display_name":"Susceptibility of bacteria to serum lysis or phagocytosis following growth in subinhibitory levels of lincosaminide or spectinomycin related antibiotics.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2024715752","doi":"https://doi.org/10.7164/antibiotics.39.978","mag":"2024715752","pmid":"https://pubmed.ncbi.nlm.nih.gov/2944862"},"language":"en","primary_location":{"id":"doi:10.7164/antibiotics.39.978","doi":"https://doi.org/10.7164/antibiotics.39.978","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.39.978","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/39/7/39_7_978/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/39/7/39_7_978/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019503017","display_name":"Joyce I. Cialdella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JOYCE I. CIALDELLA","raw_affiliation_strings":["Infectious Diseases Research, The Upjohn Company, Kalamazoo, Michigan, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research, The Upjohn Company, Kalamazoo, Michigan, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010285458","display_name":"James J. Vavra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JAMES J. VAVRA","raw_affiliation_strings":["Infectious Diseases Research, The Upjohn Company"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research, The Upjohn Company","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016572767","display_name":"VINCENT P. MARSHALL","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"VINCENT P. MARSHALL","raw_affiliation_strings":["Infectious Diseases Research, The Upjohn Company"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research, The Upjohn Company","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":1.0805,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.78307376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"39","issue":"7","first_page":"978","last_page":"984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.26809999346733093,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.26809999346733093,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.16869999468326569,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.11940000206232071,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subinhibitory-antibiotic-concentrations","display_name":"subinhibitory antibiotic concentrations","score":0.9179999828338623},{"id":"https://openalex.org/keywords/spectinomycin","display_name":"spectinomycin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/clindamycin","display_name":"clindamycin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/lincomycin","display_name":"lincomycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pirlimycin","display_name":"pirlimycin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.902999997138977},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.906000018119812},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":1.0},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/antibiotic-pretreatment","display_name":"antibiotic pretreatment","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2778063948","wikidata":"https://www.wikidata.org/wiki/Q416154","display_name":"Spectinomycin","level":4,"score":0.9086520671844482},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8282175064086914},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.7465486526489258},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7333186864852905},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7228700518608093},{"id":"https://openalex.org/C2777458120","wikidata":"https://www.wikidata.org/wiki/Q422273","display_name":"Clindamycin","level":3,"score":0.6617094278335571},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.5877490043640137},{"id":"https://openalex.org/C2778985905","wikidata":"https://www.wikidata.org/wiki/Q423428","display_name":"Lincomycin","level":3,"score":0.568894624710083},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5151849985122681},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49072539806365967},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.47011247277259827},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4217946231365204},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2149966061115265},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.20390081405639648},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08411163091659546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000198","descriptor_name":"Spectinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001770","descriptor_name":"Blood Bactericidal Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002981","descriptor_name":"Clindamycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008034","descriptor_name":"Lincomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.7164/antibiotics.39.978","doi":"https://doi.org/10.7164/antibiotics.39.978","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.39.978","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/39/7/39_7_978/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},{"id":"pmid:2944862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2944862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antibiotics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7164/antibiotics.39.978","doi":"https://doi.org/10.7164/antibiotics.39.978","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.39.978","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/39/7/39_7_978/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024715752.pdf","grobid_xml":"https://content.openalex.org/works/W2024715752.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1796075337","https://openalex.org/W1965906749","https://openalex.org/W1993258464","https://openalex.org/W2002508503","https://openalex.org/W2027191229","https://openalex.org/W2036978284","https://openalex.org/W2084892948","https://openalex.org/W2118159339","https://openalex.org/W2125018722","https://openalex.org/W2137770400","https://openalex.org/W2145506229","https://openalex.org/W2158514015","https://openalex.org/W2169166546","https://openalex.org/W2334627296"],"related_works":["https://openalex.org/W2027191229","https://openalex.org/W12390060","https://openalex.org/W2411333792","https://openalex.org/W2067943388","https://openalex.org/W2411892597","https://openalex.org/W2073209045","https://openalex.org/W7098903025","https://openalex.org/W2141430117","https://openalex.org/W7096192736","https://openalex.org/W2045368123"],"abstract_inverted_index":{"The":[0,107],"effects":[1],"of":[2,5,14,28,34,75,131,143],"subinhibitory":[3,32,73],"concentrations":[4,74],"antibiotics":[6],"on":[7,92],"polymorphonuclear":[8],"leukocyte":[9],"(PML)":[10],"and":[11,20,121],"serum":[12,113,135],"killing":[13,84,94,142],"Staphylococcus":[15],"aureus":[16,66,99,109],"502A":[17],"(UC":[18],"9116)":[19],"Escherichia":[21],"coli":[22,133,145],"UC":[23],"9451":[24],"were":[25],"studied.":[26],"Exposure":[27],"these":[29,44],"bacteria":[30],"to":[31,43,50,60,83,112,134],"levels":[33],"certain":[35],"lincosaminides,":[36],"spectinomycin,":[37,103],"or":[38,78,105],"6'-n-propylspectinomycin":[39,122],"altered":[40],"their":[41],"susceptibility":[42,130],"host":[45],"defense":[46],"mechanisms,":[47],"while":[48],"exposure":[49],"gentamicin":[51],"had":[52],"no":[53],"effect.":[54],"However,":[55],"each":[56],"organism":[57],"responded":[58],"differently":[59],"treatment":[61],"with":[62,72,102],"the":[63,129],"antibiotics.":[64],"S.":[65,98,108],"pretreated":[67,101],"during":[68],"log":[69],"phase":[70],"growth":[71],"clindamycin,":[76],"lincomycin,":[77],"pirlimycin":[79],"was":[80,95,100,148],"more":[81],"susceptible":[82],"by":[85,146],"PMLs":[86,147],"than":[87,138],"untreated":[88],"bacteria.":[89],"No":[90],"effect":[91],"phagocytic":[93],"found":[96],"when":[97],"6'-n-propylspectinomycin,":[104],"gentamicin.":[106],"remained":[110],"resistant":[111],"lysis":[114,136],"despite":[115],"antibiotic":[116],"treatment.":[117],"In":[118],"contrast,":[119],"spectinomycin":[120],"as":[123,125],"well":[124],"clindamycin":[126],"dramatically":[127],"increased":[128],"E.":[132,144],"(greater":[137],"99%":[139],"destroyed).":[140],"Moderate":[141],"also":[149],"found.":[150]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}