{"id":"https://openalex.org/W2024714738","doi":"https://doi.org/10.1016/0024-3205(77)90453-2","title":"Evidence for a factor in liver cytosol which controls the competition between progesterone and triamcinolone acetonide for the glucocorticoid receptor","display_name":"Evidence for a factor in liver cytosol which controls the competition between progesterone and triamcinolone acetonide for the glucocorticoid receptor","publication_year":1977,"publication_date":"1977-05-01","ids":{"openalex":"https://openalex.org/W2024714738","doi":"https://doi.org/10.1016/0024-3205(77)90453-2","mag":"2024714738","pmid":"https://pubmed.ncbi.nlm.nih.gov/875634"},"language":"en","primary_location":{"id":"doi:10.1016/0024-3205(77)90453-2","doi":"https://doi.org/10.1016/0024-3205(77)90453-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(77)90453-2","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052689017","display_name":"Dennis M. DiSorbo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis M. DiSorbo","raw_affiliation_strings":["Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263, USA","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I1298060332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049801834","display_name":"Richard J. Milholland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Milholland","raw_affiliation_strings":["Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263, USA","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I1298060332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062999597","display_name":"Richard P. McPartland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard P. McPartland","raw_affiliation_strings":["Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263, USA","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I1298060332"]}]},{"author_position":"last","author":{"id":null,"display_name":"Fred Rosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fred Rosen","raw_affiliation_strings":["Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263, USA","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I1298060332"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I1298060332"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":0.6188,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.67556813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"9","first_page":"1593","last_page":"1598"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8870000243186951},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9300000071525574},{"id":"https://openalex.org/keywords/triamcinolone-acetonide","display_name":"triamcinolone acetonide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/receptor-binding-competition","display_name":"receptor binding competition","score":0.6520000100135803},{"id":"https://openalex.org/keywords/inhibiting-factors","display_name":"inhibiting factors","score":0.8090000152587891},{"id":"https://openalex.org/keywords/liver-cytosol","display_name":"liver cytosol","score":0.9890000224113464},{"id":"https://openalex.org/keywords/progesterone-analogs","display_name":"progesterone analogs","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C2778903070","wikidata":"https://www.wikidata.org/wiki/Q2211240","display_name":"Triamcinolone acetonide","level":2,"score":0.9048148393630981},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.7823227643966675},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.695084810256958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6443960070610046},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.5525743365287781},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5342219471931458},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4955519437789917},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49126309156417847},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.46616750955581665},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.44335705041885376},{"id":"https://openalex.org/C193363816","wikidata":"https://www.wikidata.org/wiki/Q1617865","display_name":"Size-exclusion chromatography","level":3,"score":0.4328767955303192},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3981753885746002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26617786288261414},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23331278562545776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22086718678474426},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09906396269798279},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0713968575000763},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000315","descriptor_name":"Adrenalectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011987","descriptor_name":"Receptors, Steroid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014222","descriptor_name":"Triamcinolone Acetonide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0024-3205(77)90453-2","doi":"https://doi.org/10.1016/0024-3205(77)90453-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(77)90453-2","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:875634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/875634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1574319011","https://openalex.org/W1578995842","https://openalex.org/W1775749144","https://openalex.org/W2000562323","https://openalex.org/W2008407242","https://openalex.org/W2025746727","https://openalex.org/W2042851875","https://openalex.org/W2077857833"],"related_works":["https://openalex.org/W2073882664","https://openalex.org/W2045213760","https://openalex.org/W2011276792","https://openalex.org/W2023857949","https://openalex.org/W1968050809","https://openalex.org/W2082355577","https://openalex.org/W2054348180","https://openalex.org/W2042546307","https://openalex.org/W2002180467","https://openalex.org/W2470652475"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}