{"id":"https://openalex.org/W2024677076","doi":"https://doi.org/10.1038/sj.bjp.0703942","title":"Role of nitric oxide synthases in the infarct size\u2010reducing effect conferred by heat stress in isolated rat hearts","display_name":"Role of nitric oxide synthases in the infarct size\u2010reducing effect conferred by heat stress in isolated rat hearts","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W2024677076","doi":"https://doi.org/10.1038/sj.bjp.0703942","mag":"2024677076","pmid":"https://pubmed.ncbi.nlm.nih.gov/11309257","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1572712"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjp.0703942","doi":"https://doi.org/10.1038/sj.bjp.0703942","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0703942","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0703942","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0703942","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008548334","display_name":"Claire Arnaud","orcid":"https://orcid.org/0000-0003-0964-9423","observed_orcids":["https://orcid.org/0000-0003-0964-9423"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claire Arnaud","raw_affiliation_strings":["Laboratoire Stress Cardiovasculaires et Pathologies Associ\u00e9es, Facult\u00e9 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Stress Cardiovasculaires et Pathologies Associ\u00e9es, Facult\u00e9 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078038963","display_name":"Aline Laubriet","orcid":"https://orcid.org/0000-0002-3225-4916","observed_orcids":["https://orcid.org/0000-0002-3225-4916"]},"institutions":[{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aline Laubriet","raw_affiliation_strings":["Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaire Expe\u0301rimentale, Faculte\u0301 de Me\u0301decine, 21033 Dijon, France","Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaire Exp\u00e9rimentale, Facult\u00e9 de M\u00e9decine, 21033 Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaire Expe\u0301rimentale, Faculte\u0301 de Me\u0301decine, 21033 Dijon, France","institution_ids":["https://openalex.org/I177064439"]},{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaire Exp\u00e9rimentale, Facult\u00e9 de M\u00e9decine, 21033 Dijon, France","institution_ids":["https://openalex.org/I177064439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028541125","display_name":"Marie Joyeux\u2010Faure","orcid":"https://orcid.org/0000-0001-8298-0038","observed_orcids":["https://orcid.org/0000-0001-8298-0038"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie Joyeux","raw_affiliation_strings":["Laboratoire Stress Cardiovasculaires et Pathologies Associe\u0301es, Faculte\u0301 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","Laboratoire Stress Cardiovasculaires et Pathologies Associ\u00e9es, Facult\u00e9 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Stress Cardiovasculaires et Pathologies Associe\u0301es, Faculte\u0301 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","institution_ids":[]},{"raw_affiliation_string":"Laboratoire Stress Cardiovasculaires et Pathologies Associ\u00e9es, Facult\u00e9 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039726599","display_name":"Diane Godin\u2010Ribuot","orcid":"https://orcid.org/0000-0001-7589-932X","observed_orcids":["https://orcid.org/0000-0001-7589-932X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diane Godin\u2010Ribuot","raw_affiliation_strings":["Laboratoire Stress Cardiovasculaires et Pathologies Associe\u0301es, Faculte\u0301 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","Laboratoire Stress Cardiovasculaires et Pathologies Associ\u00e9es, Facult\u00e9 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Stress Cardiovasculaires et Pathologies Associe\u0301es, Faculte\u0301 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","institution_ids":[]},{"raw_affiliation_string":"Laboratoire Stress Cardiovasculaires et Pathologies Associ\u00e9es, Facult\u00e9 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064783426","display_name":"Luc Rochette","orcid":"https://orcid.org/0000-0001-9973-8803","observed_orcids":["https://orcid.org/0000-0001-9973-8803"]},"institutions":[{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Luc Rochette","raw_affiliation_strings":["Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaire Expe\u0301rimentale, Faculte\u0301 de Me\u0301decine, 21033 Dijon, France","Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaire Exp\u00e9rimentale, Facult\u00e9 de M\u00e9decine, 21033 Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaire Expe\u0301rimentale, Faculte\u0301 de Me\u0301decine, 21033 Dijon, France","institution_ids":["https://openalex.org/I177064439"]},{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaire Exp\u00e9rimentale, Facult\u00e9 de M\u00e9decine, 21033 Dijon, France","institution_ids":["https://openalex.org/I177064439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025501014","display_name":"Pierre Demenge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Demenge","raw_affiliation_strings":["Laboratoire Stress Cardiovasculaires et Pathologies Associe\u0301es, Faculte\u0301 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","Laboratoire Stress Cardiovasculaires et Pathologies Associ\u00e9es, Facult\u00e9 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Stress Cardiovasculaires et Pathologies Associe\u0301es, Faculte\u0301 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","institution_ids":[]},{"raw_affiliation_string":"Laboratoire Stress Cardiovasculaires et Pathologies Associ\u00e9es, Facult\u00e9 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015148423","display_name":"Christophe Ribuot","orcid":"https://orcid.org/0000-0003-4425-6203","observed_orcids":["https://orcid.org/0000-0003-4425-6203"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christophe Ribuot","raw_affiliation_strings":["Laboratoire Stress Cardiovasculaires et Pathologies Associe\u0301es, Faculte\u0301 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","Laboratoire Stress Cardiovasculaires et Pathologies Associ\u00e9es, Facult\u00e9 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Stress Cardiovasculaires et Pathologies Associe\u0301es, Faculte\u0301 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","institution_ids":[]},{"raw_affiliation_string":"Laboratoire Stress Cardiovasculaires et Pathologies Associ\u00e9es, Facult\u00e9 de Pharmacie, Domaine de la Merci, 38706 La Tronche, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015148423"],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.7327,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.90687603,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"132","issue":"8","first_page":"1845","last_page":"1851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9649999737739563},{"id":"https://openalex.org/keywords/heat-stress","display_name":"heat stress","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8629999756813049},{"id":"https://openalex.org/keywords/myocardial-infarct-size","display_name":"myocardial infarct size","score":0.906000018119812},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.7820000052452087},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6570000052452087},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hsp27","display_name":"HSP27","score":0.843999981880188},{"id":"https://openalex.org/keywords/hsp72","display_name":"HSP72","score":0.9990000128746033},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.8870000243186951},{"id":"https://openalex.org/keywords/l-nil","display_name":"L-NIL","score":0.8939999938011169},{"id":"https://openalex.org/keywords/langendorff-preparation","display_name":"isolated perfused heart","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.8162796497344971},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.7761068344116211},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7123463153839111},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4936734139919281},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4681292772293091},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45794007182121277},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4500952363014221},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42323198914527893},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.4158981740474701},{"id":"https://openalex.org/C2987418964","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Heat stress","level":2,"score":0.4105467200279236},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3997388780117035},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3324693441390991},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2781282961368561},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21514341235160828},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.10007181763648987},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018882","descriptor_name":"Heat Stress Disorders","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018882","descriptor_name":"Heat Stress Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018882","descriptor_name":"Heat Stress Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050884","descriptor_name":"HSP72 Heat-Shock Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/sj.bjp.0703942","doi":"https://doi.org/10.1038/sj.bjp.0703942","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0703942","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0703942","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1572712","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1572712","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:11309257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11309257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:inserm-00266313v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00266313","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Pharmacology, 2001, 132 (8), pp.1845-51. ⟨10.1038/sj.bjp.0703942⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/sj.bjp.0703942","doi":"https://doi.org/10.1038/sj.bjp.0703942","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0703942","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0703942","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024677076.pdf","grobid_xml":"https://content.openalex.org/works/W2024677076.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W30790896","https://openalex.org/W61333496","https://openalex.org/W1571362754","https://openalex.org/W1575152637","https://openalex.org/W1966502113","https://openalex.org/W1967245379","https://openalex.org/W1970884159","https://openalex.org/W1978221784","https://openalex.org/W1982260690","https://openalex.org/W1984219835","https://openalex.org/W1991615080","https://openalex.org/W1996653696","https://openalex.org/W1996807630","https://openalex.org/W2003396317","https://openalex.org/W2007086982","https://openalex.org/W2014086876","https://openalex.org/W2020377054","https://openalex.org/W2020773136","https://openalex.org/W2030667474","https://openalex.org/W2047568877","https://openalex.org/W2048543877","https://openalex.org/W2051654992","https://openalex.org/W2053274955","https://openalex.org/W2055642563","https://openalex.org/W2058113436","https://openalex.org/W2070637832","https://openalex.org/W2073682731","https://openalex.org/W2079321385","https://openalex.org/W2079871996","https://openalex.org/W2082365607","https://openalex.org/W2082398104","https://openalex.org/W2106169085","https://openalex.org/W2106649791","https://openalex.org/W2126562704","https://openalex.org/W2131974729","https://openalex.org/W2151884159","https://openalex.org/W2160696128","https://openalex.org/W2189455942","https://openalex.org/W2210726304","https://openalex.org/W2228719365"],"related_works":["https://openalex.org/W2055176650","https://openalex.org/W2404566110","https://openalex.org/W2347649584","https://openalex.org/W2365145828","https://openalex.org/W2028028080","https://openalex.org/W2603833853","https://openalex.org/W2010005604","https://openalex.org/W232407047","https://openalex.org/W2399888064","https://openalex.org/W2060123811"],"abstract_inverted_index":{"Nitric":[0],"oxide":[1],"(NO)":[2],"donors":[3],"are":[4,220],"known":[5],"to":[6,46,68,116,140,202,222],"induce":[7],"both":[8],"delayed":[9],"cardioprotection":[10],"and":[11,78,114,158,174,195,215],"myocardial":[12,47,171],"heat":[13,19,69,106,208],"stress":[14,20,70],"protein":[15],"(HSP)":[16],"expression.":[17],"Moreover,":[18],"(HS),":[21],"which":[22,183],"also":[23],"protects":[24],"myocardium":[25],"against":[26],"ischaemic":[27],"damages,":[28],"is":[29],"associated":[30],"with":[31,82],"a":[32,85,95,117,204],"NO":[33,42,89,101,193],"release.":[34],"Therefore,":[35],"we":[36],"have":[37],"investigated":[38],"the":[39,50,99,121,198,207,224],"implication":[40],"of":[41,88,98,120,129,170,180,212,227],"in":[43,49,58,62,136,148,151,155,161,165,196,206,229],"HS-induced":[44,178],"resistance":[45],"infarction,":[48],"isolated":[51],"rat":[52],"heart":[53],"model.":[54],"Rats":[55],"were":[56,110],"divided":[57],"six":[59],"groups":[60],"(n=10":[61],"each":[63],"group),":[64],"subjected":[65,115],"or":[66,80,92],"not":[67,81,185],"(42":[71],"degrees":[72],"C":[73],"internal":[74],"temperature,":[75],"15":[76],"min)":[77],"treated":[79],"nitro-L-arginine-methylester":[83],"(L-NAME)":[84],"non-selective":[86],"inhibitor":[87,97],"synthase":[90],"isoforms,":[91],"L-N(6)-(1-imino-ethyl)lysine":[93],"(L-NIL),":[94],"selective":[96],"inducible":[100,199],"synthase.":[102],"Twenty-four":[103],"hours":[104],"after":[105],"stress,":[107],"their":[108],"hearts":[109],"isolated,":[111],"retrogradely":[112],"perfused,":[113],"30-min":[118],"occlusion":[119],"left":[122],"coronary":[123],"artery":[124],"followed":[125],"by":[126,187],"120":[127],"min":[128],"reperfusion.":[130],"Infarct-to-risk":[131],"ratio":[132],"was":[133,146,184],"significantly":[134],"reduced":[135],"HS":[137],"(18.7+/-1.6%)":[138],"compared":[139],"Sham":[141],"(33.0+/-1.7%)":[142],"hearts.":[143],"This":[144],"effect":[145],"abolished":[147],"L-NAME-treated":[149],"(41.7+/-3.1%":[150],"HS+L-NAME":[152],"vs":[153,163],"35.2+/-3.0%":[154],"Sham+L-NAME":[156],")":[157],"L-NIL-treated":[159],"(36.1+/-3.4%":[160],"HS+L-NIL":[162],"42.1+/-4.6%":[164],"Sham+L-NIL)":[166],"groups.":[167],"Immunohistochemical":[168],"analysis":[169],"HSP":[172,213],"27":[173,214],"72":[175,216],"showed":[176],"an":[177],"increase":[179],"these":[181],"proteins,":[182],"modified":[186],"L-NAME":[188],"pretreatment.":[189],"We":[190],"conclude":[191],"that":[192],"synthases,":[194],"particular":[197],"isoform,":[200],"appear":[201],"play":[203],"role":[205,226],"stress-induced":[209],"cardioprotection,":[210],"independently":[211],"levels.":[217],"Further":[218],"investigations":[219],"required":[221],"elucidate":[223],"precise":[225],"HSPs":[228],"this":[230],"adaptive":[231],"response.":[232]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}