{"id":"https://openalex.org/W2024673361","doi":"https://doi.org/10.1126/science.493982","title":"Lens Epithelial Cell Elongation in the Absence of Microtubules: Evidence for a New Effect of Colchicine","display_name":"Lens Epithelial Cell Elongation in the Absence of Microtubules: Evidence for a New Effect of Colchicine","publication_year":1979,"publication_date":"1979-11-16","ids":{"openalex":"https://openalex.org/W2024673361","doi":"https://doi.org/10.1126/science.493982","mag":"2024673361","pmid":"https://pubmed.ncbi.nlm.nih.gov/493982"},"language":"en","primary_location":{"id":"doi:10.1126/science.493982","doi":"https://doi.org/10.1126/science.493982","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.493982","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069375705","display_name":"David C. Beebe","orcid":"https://orcid.org/0000-0002-9587-3802","observed_orcids":["https://orcid.org/0000-0002-9587-3802"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C. Beebe","raw_affiliation_strings":["Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045642065","display_name":"Douglas E. Feagans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas E. Feagans","raw_affiliation_strings":["Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111590873","display_name":"E. Joan Blanchette\u2010Mackie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Joan Blanchette-Mackie","raw_affiliation_strings":["Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110211361","display_name":"Martin E. Nau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin E. Nau","raw_affiliation_strings":["Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I148314036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I148314036"],"apc_list":null,"apc_paid":null,"fwci":6.2251,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.9684528,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"206","issue":"4420","first_page":"836","last_page":"838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cell-elongation","display_name":"cell elongation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.8629999756813049},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.968999981880188},{"id":"https://openalex.org/keywords/nocodazole","display_name":"nocodazole","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cell-volume-regulation","display_name":"cell volume regulation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cell-volume","display_name":"cell volume","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2779363559","wikidata":"https://www.wikidata.org/wiki/Q2506092","display_name":"Nocodazole","level":4,"score":0.959120512008667},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.9305181503295898},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.8543528914451599},{"id":"https://openalex.org/C33947775","wikidata":"https://www.wikidata.org/wiki/Q271439","display_name":"Elongation","level":3,"score":0.7399628758430481},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6531839370727539},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5682660341262817},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.5249707102775574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4443862736225128},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38935649394989014},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.36802011728286743},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34241217374801636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15734624862670898},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08670264482498169},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0703691840171814},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002219","descriptor_name":"Carbamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.493982","doi":"https://doi.org/10.1126/science.493982","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.493982","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:493982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/493982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1007566278","https://openalex.org/W1963536978","https://openalex.org/W1967550048","https://openalex.org/W1971415317","https://openalex.org/W1971838860","https://openalex.org/W1974174776","https://openalex.org/W1987222740","https://openalex.org/W1992601659","https://openalex.org/W1992660304","https://openalex.org/W1994796676","https://openalex.org/W1995189675","https://openalex.org/W1995941865","https://openalex.org/W2001091317","https://openalex.org/W2001494468","https://openalex.org/W2006002944","https://openalex.org/W2016548100","https://openalex.org/W2019077750","https://openalex.org/W2023174889","https://openalex.org/W2030004024","https://openalex.org/W2038339246","https://openalex.org/W2041374030","https://openalex.org/W2045134662","https://openalex.org/W2059697726","https://openalex.org/W2065265764","https://openalex.org/W2071043618","https://openalex.org/W2073250481","https://openalex.org/W2089307761","https://openalex.org/W2090278122","https://openalex.org/W2097891818","https://openalex.org/W2104611667","https://openalex.org/W2107979967","https://openalex.org/W2109929601","https://openalex.org/W2111816225","https://openalex.org/W2115216273","https://openalex.org/W2162918788","https://openalex.org/W2329563962","https://openalex.org/W2410275903","https://openalex.org/W2411339929","https://openalex.org/W2415360914","https://openalex.org/W2427149881","https://openalex.org/W6600553700"],"related_works":["https://openalex.org/W2115216273","https://openalex.org/W2152844024","https://openalex.org/W7099302631","https://openalex.org/W2396902107","https://openalex.org/W2041374030","https://openalex.org/W2032682378","https://openalex.org/W2344890367","https://openalex.org/W2070531137","https://openalex.org/W1980172400","https://openalex.org/W751485659"],"abstract_inverted_index":{"Embryonic":[0],"chick":[1],"lens":[2,55],"epithelial":[3],"cells":[4],"cultured":[5],"in":[6,10,38,47],"serum-supplemented":[7],"medium":[8],"elongated":[9],"the":[11,18,35],"absence":[12],"of":[13,64],"microtubules":[14],"after":[15],"treatment":[16],"with":[17],"antimicrotubule":[19],"drug":[20],"nocodazole.":[21],"Colchicine,":[22],"at":[23],"concentrations":[24],"lower":[25],"than":[26],"those":[27],"that":[28,44],"dissociate":[29],"microtubules,":[30,51],"blocks":[31],"cell":[32,39,48,56,67],"elongation":[33,57],"and":[34,58],"associated":[36],"increase":[37,46],"volume.":[40],"These":[41],"results":[42],"indicate":[43],"an":[45],"volume,":[49],"not":[50],"is":[52],"responsible":[53],"for":[54],"suggest":[59],"a":[60],"previously":[61],"undescribed":[62],"effect":[63],"colchicine":[65],"on":[66],"volume":[68],"regulation.":[69]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
